Guangrong Zheng

Guangrong Zheng, Ph.D.

Associate Professor

Department: Medicinal Chemistry
Business Phone: (352) 294-8953
Business Email:

About Guangrong Zheng

Guangrong Zheng, Ph.D., is an associate professor in the department of medicinal chemistry at the University of Florida College of Pharmacy. He received his B.S. in medicinal chemistry from Fudan University and his Ph.D. in synthetic organic chemistry from Shanghai Institute of Materia Medica. He then completed his postdoc training in drug design and discovery at the University of Kentucky College of Pharmacy. Before he joined UF in March 2018, he was a faculty member at University of Arkansas for Medical Sciences College of Pharmacy.

Research Profile

Dr. Zheng’s lab focuses on the design, synthesis and structure-activity relationship study of both synthetically derived and natural product-based compounds for potential therapeutic uses or as molecular probes for biochemical/pharmacological research. His research also involves the development of efficient synthetic methodologies and strategies to facilitate the rapid construction of compound libraries. Ongoing projects in his lab include 1) development of small molecules that can induce targeted protein degradation as potential treatments for cancer; 2) development of senolytic agents, small molecules that can selectively kill senescent cells, as potential treatments for age-related diseases; and 3) development of radioprotective agents to improve the outcome of cancer radiotherapy or as radiation counter-measure agents.



Apr 2020 ACTIVE
Inhibition of Bcl-xL by Targeted Degradation
NATL INST OF HLTH NCI · Principal Investigator
Sep 2019 ACTIVE
Use of BCL-xL Proteolysis targeting chimeras to treat pancreatic cancer
Aug 2019 ACTIVE
Develop BCL-xL proteolysis targeting chimeras as safer and better senolytics
Sep 2018 ACTIVE
NCI Clinical and Translational Exploratory/ Developmental Studies
NATL INST OF HLTH NCI · Principal Investigator
Aug 2018 – Aug 2019
Discovery and Target Identification of Senolytic Agents
NATL INST OF HLTH NIA · Principal Investigator
Jul 2018 ACTIVE
Role of Senescent Cells in Radiation-induced Pulmonary Fibrosis
NATL INST OF HLTH NCI · Project Manager

Contact Details

(352) 294-8953