Guangrong Zheng

Guangrong Zheng, Ph.D.

Associate Professor

Department: Medicinal Chemistry
Business Phone: (352) 294-8953
Business Email: zhengg@cop.ufl.edu

About Guangrong Zheng

Guangrong Zheng, Ph.D., is an associate professor in the department of medicinal chemistry at the University of Florida College of Pharmacy. He received his B.S. in medicinal chemistry from Fudan University and his Ph.D. in synthetic organic chemistry from Shanghai Institute of Materia Medica. He then completed his postdoc training in drug design and discovery at the University of Kentucky College of Pharmacy. Before he joined UF in March 2018, he was a faculty member at University of Arkansas for Medical Sciences College of Pharmacy.

Research Profile

Dr. Zheng’s lab focuses on the design, synthesis and structure-activity relationship study of both synthetically derived and natural product-based compounds for potential therapeutic uses or as molecular probes for biochemical/pharmacological research. His research also involves the development of efficient synthetic methodologies and strategies to facilitate the rapid construction of compound libraries. Ongoing projects in his lab include 1) development of small molecules that can induce targeted protein degradation as potential treatments for cancer; 2) development of senolytic agents, small molecules that can selectively kill senescent cells, as potential treatments for age-related diseases; and 3) development of radioprotective agents to improve the outcome of cancer radiotherapy or as radiation counter-measure agents.

Publications

2021
Overcoming Gemcitabine Resistance in Pancreatic Cancer Using the BCL-XL Specific Degrader DT2216
Molecular Cancer Therapeutics. [DOI] 10.1158/1535-7163.MCT-21-0474. [PMID] 34667112.
2021
Concise Synthesis of (S)-δ-CEHC, a Metabolite of Vitamin E
ACS Omega. 6(6):4355-4361 [DOI] 10.1021/acsomega.0c05658. [PMID] 33623846.
2021
Mitigation of late cardiovascular effects of oxygen ion radiation by gamma-tocotrienol in a mouse model
Life Sciences in Space Research. 31:43-50 [DOI] 10.1016/j.lssr.2021.07.006. [PMID] 34689949.
2021
Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells
Nature Communications. 12(1) [DOI] 10.1038/s41467-021-21573-x. [PMID] 33627663.
2021
Therapy-Induced Senescence: Opportunities to Improve Anti-Cancer Therapy
JNCI: Journal of the National Cancer Institute. [DOI] 10.1093/jnci/djab064.
2020
A Facile Semisynthesis and Evaluation of Garcinoic Acid and Its Analogs for the Inhibition of Human DNA Polymerase β
Molecules. 25(24) [DOI] 10.3390/molecules25245847. [PMID] 33322249.
2020
Assays and technologies for developing proteolysis targeting chimera degraders
Future Medicinal Chemistry. [DOI] 10.4155/fmc-2020-0073. [PMID] 32431173.
2020
Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production
Bioorganic & Medicinal Chemistry. 28(11) [DOI] 10.1016/j.bmc.2020.115498. [PMID] 32291146.
2020
Discovery of histone deacetylase 3 (HDAC3)-specific PROTACs
Chemical Communications. 56(68):9866-9869 [DOI] 10.1039/d0cc03243c. [PMID] 32840532.
2020
Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines
European Journal of Medicinal Chemistry. 199 [DOI] 10.1016/j.ejmech.2020.112397. [PMID] 32388279.
2020
Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity
European Journal of Medicinal Chemistry. 192 [DOI] 10.1016/j.ejmech.2020.112186. [PMID] 32145645.
2020
DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas
Journal of Hematology & Oncology. 13(1) [DOI] 10.1186/s13045-020-00928-9. [PMID] 32677976.
2020
Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity
Aging Cell. 19(3) [DOI] 10.1111/acel.13117. [PMID] 32064756.
2020
Licochalcone A is a Natural Selective Inhibitor of Arginine Methyltransferase 6
Biochemical Journal. [DOI] 10.1042/BCJ20200411. [PMID] 33245113.
2020
PROTACs are effective in addressing the platelet toxicity associated with BCL-XL inhibitors
Exploration of Targeted Anti-tumor Therapy. 1(4):259-272 [DOI] 10.37349/etat.2020.00017.
2020
Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies
Journal of Hematology & Oncology. 13(1) [DOI] 10.1186/s13045-020-00924-z. [PMID] 32718354.
2020
PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics
Oncogene. 39(26):4909-4924 [DOI] 10.1038/s41388-020-1336-y. [PMID] 32475992.
2020
Synthesis and Liver Microsomal Metabolic Stability Studies of a Fluorine‐Substituted δ‐Tocotrienol Derivative
ChemMedChem. 15(6):506-516 [DOI] 10.1002/cmdc.201900676. [PMID] 31957223.
2020
Targeting anti-apoptotic BCL-2 family proteins for cancer treatment
Future Medicinal Chemistry.
2020
Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity
Nature Communications. 11(1) [DOI] 10.1038/s41467-020-15838-0. [PMID] 32332723.
2019
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity
Nature Medicine. 25(12):1938-1947 [DOI] 10.1038/s41591-019-0668-z. [PMID] 31792461.
2019
Cellular senescence and radiation-induced pulmonary fibrosis
Translational Research. 209:14-21 [DOI] 10.1016/j.trsl.2019.03.006. [PMID] 30981698.
2019
GZ-11608, a Vesicular Monoamine Transporter-2 Inhibitor, Decreases the Neurochemical and Behavioral Effects of Methamphetamine
Journal of Pharmacology and Experimental Therapeutics. 371(2):526-543 [DOI] 10.1124/jpet.119.258699. [PMID] 31413138.
2019
The curcumin analog EF24 is a novel senolytic agent
Aging. 11(2):771-782 [DOI] 10.18632/aging.101787. [PMID] 30694217.
2019
Utilizing PROTAC technology to address the on-target platelet toxicity associated with inhibition of BCL-XL
Chemical Communications. 55(98):14765-14768 [DOI] 10.1039/c9cc07217a. [PMID] 31754664.
2018
An improved model of ethanol and nicotine co-use in female P rats: Effects of naltrexone, varenicline, and the selective nicotinic α6β2* antagonist r-bPiDI
Drug and Alcohol Dependence. 193:154-161
2018
Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats
Psychopharmacology. 235(5):1439-1453 [DOI] 10.1007/s00213-018-4853-4. [PMID] 29455292.
2018
Muscarinic agonist, (±)-quinuclidin-3-yl-(4-fluorophenethyl)(phenyl)carbamate: High affinity, but low subtype selectivity for human M1 – M5 muscarinic acetylcholine receptors
Bioorganic & Medicinal Chemistry. 29(3):471-476 [DOI] 10.1016/j.bmcl.2018.12.022. [PMID] 30554957.
2018
New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma cells by downregulating Sox2 expression
Bioorganic & Medicinal Chemistry. 26:1523-1537
2018
Novel scaffold for lead compounds to treat methamphetamine use disorders
Aaps Journal. 20(2) [DOI] 10.1208/s12248-018-0192-y. [PMID] 29427069.
2018
Oxidation Resistance 1 Is a Novel Senolytic Target
Aging cell. 17(4) [DOI] 10.1111/acel.12780. [PMID] 29766639.
2018
Senolytic activity of piperlongumine analogues: Synthesis and biological evaluation
Bioorganic & Medicinal Chemistry. 26(14):3925-3938 [DOI] 10.1016/j.bmc.2018.06.013. [PMID] 29925484.
2018
Varenicline and GZ-793A differentially decrease methamphetamine self-administration under a multiple schedule of reinforcement in rats
Behavioural Pharmacology. 29(1):87-97 [DOI] 10.1097/fbp.0000000000000340.
2018
Varenicline and GZ-793A differentially decrease methamphetamine self-administration under a multiple schedule of reinforcement in rats
. 29:87-97
2017
GZ-793A inhibits the neurochemical effects of methamphetamine via a selective interaction with the vesicular monoamine transporter-2
European Journal of Pharmacology. 795:143-149 [DOI] 10.1016/j.ejphar.2016.12.016. [PMID] 27986625.
2017
Novel Linear Lipopeptide Paenipeptins with Potential for Eradicating Biofilms and Sensitizing Gram-Negative Bacteria to Rifampicin and Clarithromycin
Journal of Medicinal Chemistry. 60(23):9630-9640 [DOI] 10.1021/acs.jmedchem.7b01064.
2016
1,4-Diphenalkylpiperidines: A new scaffold for the design of potent inhibitors of the vesicular monoamine transporter-2
Bioorganic & Medicinal Chemistry Letters. 26(13):2997-3000 [DOI] 10.1016/j.bmcl.2016.05.025. [PMID] 27212067.
2016
Discovery of piperlongumine as a potential novel lead for the development of senolytic agents
Aging. 8(11):2915-2926 [DOI] 10.18632/aging.101100. [PMID] 27913811.
2016
Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [3H]dopamine uptake at the vesicular monoamine transporter-2
Bioorganic & Medicinal Chemistry Letters. 26(10):2422-2427 [DOI] 10.1016/j.bmcl.2016.03.119. [PMID] 27080180.
2016
Synthesis and in vitro evaluation of water-soluble 1,4-diphenethylpiperazine analogs as novel inhibitors of the vesicular monoamine transporter-2
Bioorganic & Medicinal Chemistry Letters. 26(18):4441-4445 [DOI] 10.1016/j.bmcl.2016.08.001. [PMID] 27524311.
2016
Synthesis of (2 R ,8′ S ,3′ E )-δ-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to δ-tocotrienol
Tetrahedron. 72(27-28):4001-4006 [DOI] 10.1016/j.tet.2016.05.028. [PMID] 27773949.
2015
AgSbF6-catalyzed efficient propargylation/cycloisomerization tandem reaction for the synthesis of fully substituted furans and new insights into the reaction mechanism
Tetrahedron. 71(36):6183-6188 [DOI] 10.1016/j.tet.2015.06.090.
2015
Asymmetric synthesis of (S)- and (R)-norketamine via Sharpless asymmetric dihydroxylation/Ritter amination sequence
Tetrahedron Letters. 56(20):2608-2610 [DOI] 10.1016/j.tetlet.2015.04.050.
2015
Muscarinic acetylcholine receptor binding affinities of pethidine analogs
Bioorganic & Medicinal Chemistry Letters. 25(22):5032-5035 [DOI] 10.1016/j.bmcl.2015.10.029. [PMID] 26494260.
2015
r-bPiDI, an α6β2* Nicotinic Receptor Antagonist, Decreases Nicotine-Evoked Dopamine Release and Nicotine Reinforcement
Neurochemical Research. 40(10):2121-2130 [DOI] 10.1007/s11064-015-1680-4. [PMID] 26227997.
2015
Synthesis of Lobeline, Lobelane and their Analogues. A Review
Organic Preparations and Procedures International. 47(5):317-337 [DOI] 10.1080/00304948.2015.1066642. [PMID] 26858465.
2015
Synthesis of O- and N-alkylated products of 1,2,3,4-tetrahydrobenzo[c][2,7]naphthyrin-5(6H)-one
Tetrahedron Letters. 56(46):6472-6474 [DOI] 10.1016/j.tetlet.2015.09.156. [PMID] 26663991.
2014
A mild and efficient AgSbF6-catalyzed synthesis of fully substituted pyrroles through a sequential propargylation/amination/cycloisomerization reaction
Tetrahedron. 70(34):5267-5273 [DOI] 10.1016/j.tet.2014.05.073. [PMID] 25061238.
2014
Molecular Dynamics Guided Design of Tocoflexol: A New Radioprotectant Tocotrienol with Enhanced Bioavailability
Drug Development Research. 75(1):10-22 [DOI] 10.1002/ddr.21162. [PMID] 24648045.
2013
Amberlite IR-120H as an efficient and versatile solid phase catalyst for nucleophilic substitution of propargylic alcohols
Tetrahedron Letters. 54(27):3550-3553 [DOI] 10.1016/j.tetlet.2013.04.120.
2013
Effects of VMAT2 inhibitors lobeline and GZ-793A on methamphetamine-induced changes in dopamine release, metabolism and synthesis in vivo
Journal of Neurochemistry. 127(2):187-198 [DOI] 10.1111/jnc.12373. [PMID] 23875705.
2013
Exploring the effect of N-substitution in nor-lobelane on the interaction with VMAT2: discovery of a potential clinical candidate for treatment of methamphetamine abuse
MedChemComm. 4(3) [DOI] 10.1039/c3md20374c.
2013
GZ-793A, a lobelane analog, interacts with the vesicular monoamine transporter-2 to inhibit the effect of methamphetamine
Journal of Neurochemistry. 127(2):177-186 [DOI] 10.1111/jnc.12371. [PMID] 23875622.
2013
Oral administration of GZ-793A, a VMAT2 inhibitor, decreases methamphetamine self-administration in rats
Pharmacology Biochemistry and Behavior. 112:29-33 [DOI] 10.1016/j.pbb.2013.09.006. [PMID] 24075974.
2013
Structural Modifications to Tetrahydropyridine-3-carboxylate Esters en Route to the Discovery of M5-Preferring Muscarinic Receptor Orthosteric Antagonists
Journal of Medicinal Chemistry. 56(4):1693-1703 [DOI] 10.1021/jm301774u. [PMID] 23379472.
2012
Microscopic Binding of M5 Muscarinic Acetylcholine Receptor with Antagonists by Homology Modeling, Molecular Docking, and Molecular Dynamics Simulation
The Journal of Physical Chemistry B. 116(1):532-541 [DOI] 10.1021/jp210579b. [PMID] 22185605.
2012
The effect of a novel VMAT2 inhibitor, GZ-793A, on methamphetamine reward in rats
Psychopharmacology. 220(2):395-403 [DOI] 10.1007/s00213-011-2488-9. [PMID] 21938414.
2012
The effect of VMAT2 inhibitor GZ-793A on the reinstatement of methamphetamine-seeking in rats
Psychopharmacology. 224(2):255-262 [DOI] 10.1007/s00213-012-2748-3. [PMID] 22638813.
2011
(S)-1-(2-Chlorophenyl)-2-oxocyclohexan-1-aminiumD-tartrate
Acta Crystallographica Section E Structure Reports Online. 67(3):o736-o736 [DOI] 10.1107/s1600536811006131.
2011
Design, Synthesis and Interaction at the Vesicular Monoamine Transporter-2 of Lobeline Analogs: Potential Pharmacotherapies for the Treatment of Psychostimulant Abuse
Current Topics in Medicinal Chemistry. 11(9):1103-1127 [DOI] 10.2174/156802611795371332.
2011
Discovery of non-peptide, small molecule antagonists of α9α10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain
Bioorganic & Medicinal Chemistry Letters. 21(8):2476-2479 [DOI] 10.1016/j.bmcl.2011.02.043. [PMID] 21397497.
2011
Novel bis-, tris-, and tetrakis-tertiary amino analogs as antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release
Bioorganic & Medicinal Chemistry Letters. 21(1):88-91 [DOI] 10.1016/j.bmcl.2010.11.070. [PMID] 21147530.
2011
Novel N-1,2-Dihydroxypropyl Analogs of Lobelane Inhibit Vesicular Monoamine Transporter-2 Function and Methamphetamine-Evoked Dopamine Release
Journal of Pharmacology and Experimental Therapeutics. 339(1):286-297 [DOI] 10.1124/jpet.111.184770. [PMID] 21778282.
2011
Phenyl Ring-Substituted Lobelane Analogs: Inhibition of [3H]Dopamine Uptake at the Vesicular Monoamine Transporter-2
Journal of Pharmacology and Experimental Therapeutics. 336(3):724-733 [DOI] 10.1124/jpet.110.172882. [PMID] 20876747.
2010
(2S,6S)-1-Methyl-2,6-trans-distyrylpiperidinium chloride
Acta Crystallographica Section E Structure Reports Online. 66(1):o78-o78 [DOI] 10.1107/s1600536809049587.
2010
1-Methyl-2,6-cis-distyrylpiperidine
Acta Crystallographica Section E Structure Reports Online. 66(1):o77-o77 [DOI] 10.1107/s1600536809049617.
2010
Bis-azaaromatic quaternary ammonium salts as ligands for the blood–brain barrier choline transporter
Bioorganic & Medicinal Chemistry Letters. 20(11):3208-3210 [DOI] 10.1016/j.bmcl.2010.04.098. [PMID] 20462759.
2010
ChemInform Abstract: Absolute Configuration of Falcarinol, a Potent Antitumor Agent Commonly Occurring in Plants.
ChemInform. 30(25):no-no [DOI] 10.1002/chin.199925224.
2010
ChemInform Abstract: First Total Synthesis of Optically Active Panaxydol, a Potential Antitumor Agent Isolated from Panax ginseng.
ChemInform. 30(12):no-no [DOI] 10.1002/chin.199912252.
2010
Lobelane Inhibits Methamphetamine-Evoked Dopamine Release via Inhibition of the Vesicular Monoamine Transporter-2
Journal of Pharmacology and Experimental Therapeutics. 332(2):612-621 [DOI] 10.1124/jpet.109.160275. [PMID] 19855096.
2010
Repeated nicotine administration robustly increases bPiDDB inhibitory potency at α6β2-containing nicotinic receptors mediating nicotine-evoked dopamine release
Biochemical Pharmacology. 80(3):402-409 [DOI] 10.1016/j.bcp.2010.03.018. [PMID] 20346923.
2009
Computational neural network analysis of the affinity of N-n-alkylnicotinium salts for the α4β2* nicotinic acetylcholine receptor
Journal of Enzyme Inhibition and Medicinal Chemistry. 24(1):157-168 [DOI] 10.1080/14756360801945648. [PMID] 18629679.
2009
Selective Inhibition of Acetylcholine-Evoked Responses of α7 Neuronal Nicotinic Acetylcholine Receptors by Novel tris- and tetrakis-Azaaromatic Quaternary Ammonium Antagonists
Molecular Pharmacology. 76(3):652-666 [DOI] 10.1124/mol.109.056176. [PMID] 19556356.
2009
Stereocontrolled Synthesis and Pharmacological Evaluation ofcis-2,6-Diphenethyl-1-azabicyclo[2.2.2]octanes as Lobelane Analogues
The Journal of Organic Chemistry. 74(16):6072-6076 [DOI] 10.1021/jo901082r. [PMID] 20560567.
2008
Extending the analysis of nicotinic receptor antagonists with the study of α6 nicotinic receptor subunit chimeras
Neuropharmacology. 54(8):1189-1200 [DOI] 10.1016/j.neuropharm.2008.03.010. [PMID] 18448138.
2008
Synthesis and evaluation of a series of homologues of lobelane at the vesicular monoamine transporter-2
Bioorganic & Medicinal Chemistry Letters. 18(24):6509-6512 [DOI] 10.1016/j.bmcl.2008.10.042. [PMID] 18976906.
2008
Tetrakis-azaaromatic quaternary ammonium salts: Novel subtype-selective antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release
Bioorganic & Medicinal Chemistry Letters. 18(21):5753-5757 [DOI] 10.1016/j.bmcl.2008.09.084. [PMID] 18851914.
2007
Bis-azaaromatic quaternary ammonium salts as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release: An investigation of binding conformation
Bioorganic & Medicinal Chemistry Letters. 17(24):6734-6738 [DOI] 10.1016/j.bmcl.2007.10.052. [PMID] 18029180.
2007
Computational neural network analysis of the affinity of lobeline and tetrabenazine analogs for the vesicular monoamine transporter-2
Bioorganic & Medicinal Chemistry. 15(8):2975-2992 [DOI] 10.1016/j.bmc.2007.02.013. [PMID] 17331733.
2007
Contrast sensitivity and higher-order aberrations in patients with astigmatism.
Chinese medical journal. 120(10):882-5 [PMID] 17543177.
View on: PubMed
2007
Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: 1-(3-Picolinium)-12-triethylammonium-dodecane dibromide (TMPD)
Biochemical Pharmacology. 74(8):1271-1282 [DOI] 10.1016/j.bcp.2007.07.021. [PMID] 17727820.
2007
tris-Azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release
Bioorganic & Medicinal Chemistry Letters. 17(24):6701-6706 [DOI] 10.1016/j.bmcl.2007.10.062. [PMID] 17977723.
2006
Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters
Bioorganic & Medicinal Chemistry Letters. 16(19):5018-5021 [DOI] 10.1016/j.bmcl.2006.07.070. [PMID] 16905316.
2006
Vesicular monoamine transporter 2: Role as a novel target for drug development
The AAPS Journal. 8(4):E682-E692 [DOI] 10.1208/aapsj080478. [PMID] 17233532.
2005
Defunctionalized Lobeline Analogues:  Structure−Activity of Novel Ligands for the Vesicular Monoamine Transporter
Journal of Medicinal Chemistry. 48(17):5551-5560 [DOI] 10.1021/jm0501228. [PMID] 16107155.
2005
Lobelane analogues as novel ligands for the vesicular monoamine transporter-2
Bioorganic & Medicinal Chemistry. 13(12):3899-3909 [DOI] 10.1016/j.bmc.2005.04.013. [PMID] 15911306.
2005
Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands
Bioorganic & Medicinal Chemistry Letters. 15(20):4463-4466 [DOI] 10.1016/j.bmcl.2005.07.032. [PMID] 16112864.
2005
The characterization of a novel rigid nicotine analog with α7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion
Bioorganic & Medicinal Chemistry Letters. 15(17):3874-3880 [DOI] 10.1016/j.bmcl.2005.05.118. [PMID] 16005216.
2004
Indirect Trapping of the Retroconjugate Addition Reaction Intermediate Involved in the Epimerization of Lobeline:  Application to the Synthesis of (−)-Sedamine
The Journal of Organic Chemistry. 69(24):8514-8517 [DOI] 10.1021/jo048848j. [PMID] 15549833.
2004
Lobeline Analogs with Enhanced Affinity and Selectivity for Plasmalemma and Vesicular Monoamine Transporters
Journal of Pharmacology and Experimental Therapeutics. 310(3):1035-1045 [DOI] 10.1124/jpet.104.068098.
2004
The Preparation of 2‐Arylmethylidene‐8‐methyl‐8‐azabicyclo[3.2.1]octan‐3‐ones
Synthetic Communications. 34(11):1931-1942 [DOI] 10.1081/scc-120037905.
2004
Two isomers of 2,4-dibenzyl-8-azabicyclo[3.2.1]octan-3-ol
Acta Crystallographica Section C Crystal Structure Communications. 60(1):o9-o11 [DOI] 10.1107/s0108270103026520.
1999
Stereoselective Total Synthesis of (3R,8S)-Falcarindiol, a Common Polyacetylenic Compound from Umbellifers
Journal of Natural Products. 62(4):626-628 [DOI] 10.1021/np980418z.
1999
Syntheses of two diastereoisomers of panaxytriol, a potent antitumor agent isolated from panax ginseng
Tetrahedron. 55(23):7157-7168 [DOI] 10.1016/s0040-4020(99)00352-x.
1999
Syntheses of two enantiomers of eicos-(4E)-en-1-yn-3-ol, a bioactive component of the marine sponge Cribrochalina vasculum
Tetrahedron. 55(15):4649-4654 [DOI] 10.1016/s0040-4020(99)00163-5.
1998
First total synthesis of optically active panaxydol, a potential antitumor agent isolated from Panax ginseng
Tetrahedron Letters. 39(51):9521-9522 [DOI] 10.1016/s0040-4039(98)02212-6.

Grants

Apr 2021 ACTIVE
Proteolysis-targeting chimera against BCL-XL inhibits breast cancer metastasis
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Apr 2021 ACTIVE
Selecting a Drug Development Candidate for Cancer Treatment
Role: Principal Investigator
Funding: DIALECTIC THERAPEUTICS
Jan 2021 ACTIVE
Developing a Novel PROTAC-Based NR4A1 Degrader for Breast Cancer Therapy
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION
Dec 2020 ACTIVE
Sanofi 2020 iAwards
Role: Co-Investigator
Funding: SANOFI
Sep 2020 ACTIVE
Identifying Novel Senolytic Agents and Molecular Targets
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Jun 2020 ACTIVE
Intercollaborative Radiation Countermeasure (INTERACT) Consortium for Advanced Development of Medical Countermeasures to Mitigate/Treat Acute and Delayed Radiation Syndromes
Role: Co-Investigator
Funding: UNIV OF MARYLAND BALTIMORE via NATL INST OF HLTH NIAID
Apr 2020 ACTIVE
Inhibition of Bcl-xL by Targeted Degradation
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Sep 2019 ACTIVE
Use of BCL-xL Proteolysis targeting chimeras to treat pancreatic cancer
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Aug 2019 ACTIVE
Develop BCL-xL proteolysis targeting chimeras as safer and better senolytics
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Sep 2018 – Aug 2020
NCI Clinical and Translational Exploratory/ Developmental Studies
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Aug 2018 – Aug 2019
Discovery and Target Identification of Senolytic Agents
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Jul 2018 ACTIVE
Role of Senescent Cells in Radiation-induced Pulmonary Fibrosis
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI

Teaching Profile

Courses Taught
2018,2020-2021
PHA5878C Pt Care 3: Cv and Pulm
2019-2021
PHA6447 Drug Design
2019-2021
PHA7979 Advanced Research
2020
PHA7980 Research for Doctoral Dissertation
2020
PHA6971 Research for Master’s Thesis
2019-2021
PHA5782C Patient Care 2: Introduction to Infectious Disease and Oncology
2019-2021
PHA6910 Supervised Research
2019
PHA6934 Seminar in Medicinal Chemistry
2018,2020-2021
PHA5439 Prin Med Chem-Pcol I
2020-2021
PHA5930 Sem Pharm Research
2021
PHA6935 Selected Topics in Pharmacy

Contact Details

Phones:
Business:
(352) 294-8953
Emails:
Business:
zhengg@cop.ufl.edu