Peter W Swaan, Ph.D., M.Pharm.
Dean And Professor
About Peter W Swaan
Peter W. Swaan, Ph.D., M.Pharm., began his tenure as the eighth dean of the University of Florida College of Pharmacy on Dec. 1, 2022. Swaan previously served as the associate dean for research and advanced graduate education as well as a professor and chair in the department of pharmaceutical sciences at the University of Maryland School of Pharmacy. While at Maryland, he was appointed a distinguished university professor in recognition of his extraordinary leadership and significant contributions to the pharmaceutical sciences.
Swaan is well connected to many of the nation’s largest and most prestigious pharmacy colleges. His academic and professional career includes stops at the University of Michigan; the University of California, San Francisco; the Ohio State University; and the University of Maryland. All four of these pharmacy colleges are featured in the top 15 of the U.S. News & World Report best pharmacy college rankings.
A highly cited researcher, Swaan has published more than 150 original research articles. He has been continuously funded by the National Institutes of Health since 1998 and has secured more than $25 million in grant funding during his career. His research focuses on all aspects of transporters in drug targeting and delivery, pharmacokinetics and pharmacodynamics, with his major contributions to this research area involving the application of transporters as targets for prodrugs. He has pioneered the use of computational techniques to determine the structural requirements of membrane transporters, which has paved the way for the discovery of novel substrates and inhibitors. He also holds several U.S. patents on these and related technologies.
Since 2015, Swaan has chaired the Board of Grants for the American Foundation for Pharmaceutical Education, or AFPE. He has also chaired multiple committees within the American Association for Pharmaceutical Scientists and served on multiple NIH study sections. More than two dozen master’s and Ph.D. students have trained under his guidance, and in July 2022, he was awarded the AFPE William M. Heller Mentor of the Year Award.
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0003-1767-1487
Publications
2024
Report of the 2023 AACP Council of Deans Taskforce on Pharmacy Research and Scholarship.
American journal of pharmaceutical education.
88(2)
[DOI] 10.1016/j.ajpe.2024.100641.
[PMID] 38185465.
2023
The Report of the 2022-2023 AACP Research and Graduate Affairs Committee.
American journal of pharmaceutical education.
87(8)
[DOI] 10.1016/j.ajpe.2023.100556.
[PMID] 37442437.
2021
Identification of Key Amino Acids that Impact Organic Solute Transporter α/β (OSTα/β).
Molecular pharmacology.
100(6):599-608
[DOI] 10.1124/molpharm.121.000345.
[PMID] 34599072.
2021
S-acylation status of bile acid transporter hASBT regulates its function, metabolic stability, membrane expression, and phosphorylation state.
Biochimica et biophysica acta. Biomembranes.
1863(2)
[DOI] 10.1016/j.bbamem.2020.183510.
[PMID] 33189717.
2020
Farewell Message from the Editor-in-Chief.
Pharmaceutical research.
37(7)
[DOI] 10.1007/s11095-020-02870-4.
[PMID] 32642849.
2020
Quantification of common and planar bile acids in tissues and cultured cells.
Journal of lipid research.
61(11):1524-1535
[DOI] 10.1194/jlr.D120000726.
[PMID] 32718973.
2020
Trends in Research and Graduate Affairs in Schools and Colleges of Pharmacy, Part 2: Students.
American journal of pharmaceutical education.
84(5)
[DOI] 10.5688/ajpe7642.
[PMID] 32577032.
2020
Trends in Research and Graduate Affairs in Schools and Colleges of Pharmacy, Part 3: Underrepresented Minorities.
American journal of pharmaceutical education.
84(5)
[DOI] 10.5688/ajpe7641.
[PMID] 32577031.
2020
Trends in Research and Graduate Programs in Schools and Colleges of Pharmacy, Part 1: Programs.
American journal of pharmaceutical education.
84(5)
[DOI] 10.5688/ajpe7643.
[PMID] 32577033.
2019
Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor.
Molecular pharmacology.
96(3):345-354
[DOI] 10.1124/mol.119.116616.
[PMID] 31436536.
2019
Set of Highly Stable Amine- and Carboxylate-Terminated Dendronized Au Nanoparticles with Dense Coating and Nontoxic Mixed-Dendronized Form.
Langmuir : the ACS journal of surfaces and colloids.
35(9):3391-3403
[DOI] 10.1021/acs.langmuir.8b03196.
[PMID] 30712354.
2019
Tyrosine Phosphorylation Regulates Plasma Membrane Expression and Stability of the Human Bile Acid Transporter ASBT (SLC10A2).
Molecular pharmaceutics.
16(8):3569-3576
[DOI] 10.1021/acs.molpharmaceut.9b00426.
[PMID] 31194565.
2018
Human bile acid transporter ASBT (SLC10A2) forms functional non-covalent homodimers and higher order oligomers.
Biochimica et biophysica acta. Biomembranes.
1860(3):645-653
[DOI] 10.1016/j.bbamem.2017.11.016.
[PMID] 29198943.
2018
Molecular Modeling of Drug-Transporter Interactions-An International Transporter Consortium Perspective.
Clinical pharmacology and therapeutics.
104(5):818-835
[DOI] 10.1002/cpt.1174.
[PMID] 29981151.
2018
Post-translational modifications of transporters.
Pharmacology & therapeutics.
192:88-99
[DOI] 10.1016/j.pharmthera.2018.06.013.
[PMID] 29966598.
2017
Identification of novel MRP3 inhibitors based on computational models and validation using an in vitro membrane vesicle assay.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
103:52-59
[DOI] 10.1016/j.ejps.2017.02.011.
[PMID] 28238947.
2017
Molecular Basis of Metabolism-Mediated Conversion of PK11195 from an Antagonist to an Agonist of the Constitutive Androstane Receptor.
Molecular pharmacology.
92(1):75-87
[DOI] 10.1124/mol.117.108621.
[PMID] 28442602.
2017
Planar bile acids in health and disease.
Biochimica et biophysica acta. Biomembranes.
1859(11):2269-2276
[DOI] 10.1016/j.bbamem.2017.08.019.
[PMID] 28887043.
2015
Internalization and Subcellular Trafficking of Poly-l-lysine Dendrimers Are Impacted by the Site of Fluorophore Conjugation.
Molecular pharmaceutics.
12(6):1961-9
[DOI] 10.1021/mp500765e.
[PMID] 25950742.
2015
Obituary: Paul M. Bummer (1955 – 2015).
Pharmaceutical research.
32(9)
[DOI] 10.1007/s11095-015-1757-4.
[PMID] 26195008.
2015
Potent and Selective Inhibition of Plasma Membrane Monoamine Transporter by HIV Protease Inhibitors.
Drug metabolism and disposition: the biological fate of chemicals.
43(11):1773-80
[DOI] 10.1124/dmd.115.064824.
[PMID] 26285765.
2015
Toward predicting drug-induced liver injury: parallel computational approaches to identify multidrug resistance protein 4 and bile salt export pump inhibitors.
Drug metabolism and disposition: the biological fate of chemicals.
43(5):725-34
[DOI] 10.1124/dmd.114.062539.
[PMID] 25735837.
2014
Activation of the constitutive androstane receptor inhibits gluconeogenesis without affecting lipogenesis or fatty acid synthesis in human hepatocytes.
Toxicology and applied pharmacology.
279(1):33-42
[DOI] 10.1016/j.taap.2014.05.009.
[PMID] 24878338.
2014
Intracellular Ca2+ release mediates cationic but not anionic poly(amidoamine) (PAMAM) dendrimer-induced tight junction modulation.
Pharmaceutical research.
31(9):2429-38
[DOI] 10.1007/s11095-014-1338-y.
[PMID] 24648136.
2014
Microfluidic preparation of liposomes to determine particle size influence on cellular uptake mechanisms.
Pharmaceutical research.
31(2):401-13
[DOI] 10.1007/s11095-013-1171-8.
[PMID] 24092051.
2014
Resveratrol promotes degradation of the human bile acid transporter ASBT (SLC10A2).
The Biochemical journal.
459(2):301-12
[DOI] 10.1042/BJ20131428.
[PMID] 24498857.
2014
Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4.
Drug metabolism and disposition: the biological fate of chemicals.
42(4):665-74
[DOI] 10.1124/dmd.113.054304.
[PMID] 24154606.
2014
The role of transporters in toxicity and disease.
Drug metabolism and disposition: the biological fate of chemicals.
42(4):541-5
[DOI] 10.1124/dmd.114.057539.
[PMID] 24598705.
2013
Identification of novel activators of constitutive androstane receptor from FDA-approved drugs by integrated computational and biological approaches.
Pharmaceutical research.
30(2):489-501
[DOI] 10.1007/s11095-012-0895-1.
[PMID] 23090669.
2013
Identification of novel breast cancer resistance protein (BCRP) inhibitors by virtual screening.
Molecular pharmaceutics.
10(4):1236-48
[DOI] 10.1021/mp300547h.
[PMID] 23418667.
2013
ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans.
Clinical pharmacology and therapeutics.
94(1):64-79
[DOI] 10.1038/clpt.2013.45.
[PMID] 23588311.
2013
Riboflavin-targeted polymer conjugates for breast tumor delivery.
Pharmaceutical research.
30(7):1799-812
[DOI] 10.1007/s11095-013-1024-5.
[PMID] 23568523.
2013
The solute carrier family 10 (SLC10): beyond bile acid transport.
Molecular aspects of medicine.
34(2-3):252-69
[DOI] 10.1016/j.mam.2012.07.004.
[PMID] 23506869.
2013
Transmembrane domain II of the human bile acid transporter SLC10A2 coordinates sodium translocation.
The Journal of biological chemistry.
288(45):32394-32404
[DOI] 10.1074/jbc.M113.518555.
[PMID] 24045943.
2013
Transmembrane domain V plays a stabilizing role in the function of human bile acid transporter SLC10A2.
Biochemistry.
52(30):5117-24
[DOI] 10.1021/bi400028q.
[PMID] 23815591.
2012
Computational modeling to accelerate the identification of substrates and inhibitors for transporters that affect drug disposition.
Clinical pharmacology and therapeutics.
92(5):661-5
[DOI] 10.1038/clpt.2012.164.
[PMID] 23010651.
2012
Putative irreversible inhibitors of the human sodium-dependent bile acid transporter (hASBT; SLC10A2) support the role of transmembrane domain 7 in substrate binding/translocation.
Pharmaceutical research.
29(7):1821-31
[DOI] 10.1007/s11095-012-0706-8.
[PMID] 22354836.
2011
ATP-binding cassette transporter expression in human placenta as a function of pregnancy condition.
Drug metabolism and disposition: the biological fate of chemicals.
39(6):1000-7
[DOI] 10.1124/dmd.111.038166.
[PMID] 21430233.
2011
G3.5 PAMAM dendrimers enhance transepithelial transport of SN38 while minimizing gastrointestinal toxicity.
Journal of controlled release : official journal of the Controlled Release Society.
150(3):318-25
[DOI] 10.1016/j.jconrel.2010.11.022.
[PMID] 21115079.
2011
Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening.
Drug metabolism and disposition: the biological fate of chemicals.
39(2):337-44
[DOI] 10.1124/dmd.110.035808.
[PMID] 21068194.
2011
Molecular analysis and structure-activity relationship modeling of the substrate/inhibitor interaction site of plasma membrane monoamine transporter.
The Journal of pharmacology and experimental therapeutics.
339(2):376-85
[DOI] 10.1124/jpet.111.184036.
[PMID] 21816955.
2011
Transmembrane helix 1 contributes to substrate translocation and protein stability of bile acid transporter SLC10A2.
The Journal of biological chemistry.
286(31):27322-32
[DOI] 10.1074/jbc.M110.217802.
[PMID] 21646357.
2010
Cellular entry of G3.5 poly (amido amine) dendrimers by clathrin- and dynamin-dependent endocytosis promotes tight junctional opening in intestinal epithelia.
Pharmaceutical research.
27(8):1547-57
[DOI] 10.1007/s11095-010-0153-3.
[PMID] 20411406.
2010
Human effector/initiator gene sets that regulate myometrial contractility during term and preterm labor.
American journal of obstetrics and gynecology.
202(5):474.e1-20
[DOI] 10.1016/j.ajog.2010.02.034.
[PMID] 20452493.
2010
Membrane transporters in drug development.
Nature reviews. Drug discovery.
9(3):215-36
[DOI] 10.1038/nrd3028.
[PMID] 20190787.
2010
Publication ethics–a guide for submitting manuscripts to Pharmaceutical Research.
Pharmaceutical research.
27(9):1757-8
[DOI] 10.1007/s11095-010-0188-5.
[PMID] 20552254.
2010
Structural requirements of the ASBT by 3D-QSAR analysis using aminopyridine conjugates of chenodeoxycholic acid.
Bioconjugate chemistry.
21(11):2038-48
[DOI] 10.1021/bc100273w.
[PMID] 20968316.
2010
Targeting drug transporters – combining in silico and in vitro approaches to predict in vivo.
Methods in molecular biology (Clifton, N.J.).
637:65-103
[DOI] 10.1007/978-1-60761-700-6_4.
[PMID] 20419430.
2010
The ethanol metabolite acetaldehyde increases paracellular drug permeability in vitro and oral bioavailability in vivo.
The Journal of pharmacology and experimental therapeutics.
332(1):326-33
[DOI] 10.1124/jpet.109.158642.
[PMID] 19820208.
2009
Pharmaceutical research-looking ahead.
Pharmaceutical research.
26(3)
[DOI] 10.1007/s11095-009-9836-z.
[PMID] 19160027.
2009
Science beyond impact factors.
Pharmaceutical research.
26(4):743-5
[DOI] 10.1007/s11095-009-9856-8.
[PMID] 19224342.
2009
The cytosolic half of helix III forms the substrate exit route during permeation events of the sodium/bile acid cotransporter ASBT.
Biochemistry.
48(36):8528-39
[DOI] 10.1021/bi900616w.
[PMID] 19653651.
2009
Transepithelial transport of PEGylated anionic poly(amidoamine) dendrimers: implications for oral drug delivery.
Journal of controlled release : official journal of the Controlled Release Society.
138(1):78-85
[DOI] 10.1016/j.jconrel.2009.04.022.
[PMID] 19393702.
2008
Bacterial peptide recognition and immune activation facilitated by human peptide transporter PEPT2.
American journal of respiratory cell and molecular biology.
39(5):536-42
[DOI] 10.1165/rcmb.2008-0059OC.
[PMID] 18474668.
2008
Conformational flexibility of helix VI is essential for substrate permeation of the human apical sodium-dependent bile acid transporter.
Molecular pharmacology.
73(2):305-13
[DOI] 10.1124/mol.107.041640.
[PMID] 17971420.
2008
Conserved aspartic acid residues lining the extracellular loop 1 of sodium-coupled bile acid transporter ASBT Interact with Na+ and 7alpha-OH moieties on the ligand cholestane skeleton.
The Journal of biological chemistry.
283(30):20653-63
[DOI] 10.1074/jbc.M802885200.
[PMID] 18508772.
2008
Cytosolic half of transmembrane domain IV of the human bile acid transporter hASBT (SLC10A2) forms part of the substrate translocation pathway.
Biochemistry.
47(12):3606-14
[DOI] 10.1021/bi702498w.
[PMID] 18311924.
2008
Design of high-affinity peptide conjugates with optimized fluorescence quantum yield as markers for small peptide transporter PEPT1 (SLC15A1).
Bioorganic & medicinal chemistry letters.
18(8):2555-7
[DOI] 10.1016/j.bmcl.2008.03.044.
[PMID] 18374571.
2008
Design, synthesis, cytoselective toxicity, structure-activity relationships, and pharmacophore of thiazolidinone derivatives targeting drug-resistant lung cancer cells.
Journal of medicinal chemistry.
51(5):1242-51
[DOI] 10.1021/jm7012024.
[PMID] 18257542.
2008
Electrostatic and potential cation-pi forces may guide the interaction of extracellular loop III with Na+ and bile acids for human apical Na+-dependent bile acid transporter.
The Biochemical journal.
410(2):391-400
[PMID] 18028035.
2008
Endocytosis inhibitors prevent poly(amidoamine) dendrimer internalization and permeability across Caco-2 cells.
Molecular pharmaceutics.
5(2):364-9
[DOI] 10.1021/mp700089s.
[PMID] 18173246.
2008
Evaluation of the effect of ethanol’s toxic metabolite acetaldehyde on the gastrointestinal oligopeptide transporter, PEPT1: in vitro and in vivo studies.
Alcoholism, clinical and experimental research.
32(1):162-70
[PMID] 18028524.
2008
Intracellular processing of riboflavin in human breast cancer cells.
Molecular pharmaceutics.
5(5):839-48
[DOI] 10.1021/mp800046m.
[PMID] 18754669.
2008
Machine learning methods and docking for predicting human pregnane X receptor activation.
Chemical research in toxicology.
21(7):1457-67
[DOI] 10.1021/tx800102e.
[PMID] 18547065.
2008
Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination.
The Journal of biological chemistry.
283(13):8654-63
[DOI] 10.1074/jbc.M708615200.
[PMID] 18174163.
2008
Potential oral delivery of 7-ethyl-10-hydroxy-camptothecin (SN-38) using poly(amidoamine) dendrimers.
Pharmaceutical research.
25(7):1723-9
[DOI] 10.1007/s11095-008-9572-9.
[PMID] 18438703.
2007
Analogs of methyllycaconitine as novel noncompetitive inhibitors of nicotinic receptors: pharmacological characterization, computational modeling, and pharmacophore development.
Molecular pharmacology.
71(5):1288-97
[PMID] 17308033.
2007
Bias in estimation of transporter kinetic parameters from overexpression systems: Interplay of transporter expression level and substrate affinity.
The Journal of pharmacology and experimental therapeutics.
320(1):133-44
[PMID] 17038509.
2007
Computational models to assign biopharmaceutics drug disposition classification from molecular structure.
Pharmaceutical research.
24(12):2249-62
[PMID] 17846869.
2007
Dynamin 2 regulates riboflavin endocytosis in human placental trophoblasts.
Molecular pharmacology.
72(3):553-62
[PMID] 17565002.
2007
Endocytic mechanisms for targeted drug delivery.
Advanced drug delivery reviews.
59(8):748-58
[PMID] 17659804.
2007
Endocytosis and interaction of poly (amidoamine) dendrimers with Caco-2 cells.
Pharmaceutical research.
24(11):2138-45
[PMID] 17701324.
2007
Future directions for drug transporter modelling.
Xenobiotica; the fate of foreign compounds in biological systems.
37(10-11):1152-70
[PMID] 17968741.
2007
Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites.
Molecular pharmacology.
72(3):592-603
[PMID] 17576789.
2007
Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members.
The Journal of biological chemistry.
282(33):23841-53
[DOI] 10.1074/jbc.M703467200.
[PMID] 17553798.
2007
Surface acetylation of polyamidoamine (PAMAM) dendrimers decreases cytotoxicity while maintaining membrane permeability.
Bioconjugate chemistry.
18(6):2054-60
[PMID] 17960872.
2006
cAMP-Coupled riboflavin trafficking in placental trophoblasts: a dynamic and ordered process.
Biochemistry.
45(19):6095-104
[PMID] 16681382.
2006
Computational approaches to modeling drug transporters.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
27(5):411-24
[PMID] 16274971.
2006
Cytoskeletal scaffolds regulate riboflavin endocytosis and recycling in placental trophoblasts.
The Journal of nutritional biochemistry.
17(12):821-9
[PMID] 16563724.
2006
Design of novel synthetic MTS conjugates of bile acids for site-directed sulfhydryl labeling of cysteine residues in bile acid binding and transporting proteins.
Bioorganic & medicinal chemistry letters.
16(6):1473-6
[PMID] 16387497.
2006
Electrophysiological characterization and modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 (hCNT3).
Molecular pharmacology.
69(5):1542-53
[PMID] 16446384.
2006
Identification of interactive gene networks: a novel approach in gene array profiling of myometrial events during guinea pig pregnancy.
American journal of obstetrics and gynecology.
194(6):1513-23
[PMID] 16731067.
2006
Membrane topology of human ASBT (SLC10A2) determined by dual label epitope insertion scanning mutagenesis. New evidence for seven transmembrane domains.
Biochemistry.
45(3):943-53
[PMID] 16411770.
2006
Pharmacophore-based discovery of ligands for drug transporters.
Advanced drug delivery reviews.
58(12-13):1431-50
[PMID] 17097188.
2006
Pregnancy and estradiol modulate myometrial G-protein pathways in the guinea pig.
American journal of obstetrics and gynecology.
195(1):275-87
[PMID] 16681987.
2006
Rapid identification of P-glycoprotein substrates and inhibitors.
Drug metabolism and disposition: the biological fate of chemicals.
34(12):1976-84
[PMID] 16997908.
2006
Recognition, co-internalization, and recycling of an avian riboflavin carrier protein in human placental trophoblasts.
The Journal of pharmacology and experimental therapeutics.
317(2):465-72
[PMID] 16399883.
2006
Transmembrane domain VII of the human apical sodium-dependent bile acid transporter ASBT (SLC10A2) lines the substrate translocation pathway.
Molecular pharmacology.
70(5):1565-74
[PMID] 16899538.
2006
Transport of poly(amidoamine) dendrimers across Caco-2 cell monolayers: Influence of size, charge and fluorescent labeling.
Pharmaceutical research.
23(12):2818-26
[PMID] 17094034.
2005
Comparative pharmacophore modeling of organic anion transporting polypeptides: a meta-analysis of rat Oatp1a1 and human OATP1B1.
The Journal of pharmacology and experimental therapeutics.
314(2):533-41
[PMID] 15845861.
2005
Efflux of depsipeptide FK228 (FR901228, NSC-630176) is mediated by P-glycoprotein and multidrug resistance-associated protein 1.
The Journal of pharmacology and experimental therapeutics.
313(1):268-76
[PMID] 15634944.
2005
Functional characterization of the peptide transporter PEPT2 in primary cultures of human upper airway epithelium.
American journal of respiratory cell and molecular biology.
32(4):319-25
[PMID] 15626774.
2005
In silico strategies for modeling membrane transporter function.
Drug discovery today.
10(9):663-71
[PMID] 15894231.
2005
In vitro and pharmacophore-based discovery of novel hPEPT1 inhibitors.
Pharmaceutical research.
22(4):512-7
[PMID] 15846457.
2005
Molecular determinants of substrate/inhibitor binding to the human and rabbit renal organic cation transporters hOCT2 and rbOCT2.
Molecular pharmacology.
67(4):1067-77
[PMID] 15630081.
2005
Reengineering the pharmaceutical industry by crash-testing molecules.
Drug discovery today.
10(17):1191-200
[PMID] 16182212.
2005
Site-directed mutagenesis and use of bile acid-MTS conjugates to probe the role of cysteines in the human apical sodium-dependent bile acid transporter (SLC10A2).
Biochemistry.
44(24):8908-17
[PMID] 15952798.
2004
A ligand-based approach to identify quantitative structure-activity relationships for the androgen receptor.
Journal of medicinal chemistry.
47(15):3765-76
[PMID] 15239655.
2004
A novel rhodamine-riboflavin conjugate probe exhibits distinct fluorescence resonance energy transfer that enables riboflavin trafficking and subcellular localization studies.
Molecular pharmaceutics.
1(4):257-66
[PMID] 15981585.
2004
Molecular requirements of the human nucleoside transporters hCNT1, hCNT2, and hENT1.
Molecular pharmacology.
65(3):558-70
[PMID] 14978234.
2004
Topology scanning and putative three-dimensional structure of the extracellular binding domains of the apical sodium-dependent bile acid transporter (SLC10A2).
Biochemistry.
43(36):11380-92
[PMID] 15350125.
2003
Current perspectives on the cellular uptake and trafficking of riboflavin.
Advanced drug delivery reviews.
55(11):1467-83
[PMID] 14597141.
2003
Cytoskeletal motors and cargo in membrane trafficking: opportunities for high specificity in drug intervention.
Drug discovery today.
8(11):494-502
[PMID] 12818519.
2003
Involvement of endocytic organelles in the subcellular trafficking and localization of riboflavin.
The Journal of pharmacology and experimental therapeutics.
306(2):681-7
[PMID] 12721324.
2003
Microfabricated porous silicon particles enhance paracellular delivery of insulin across intestinal Caco-2 cell monolayers.
Pharmaceutical research.
20(1):110-6
[PMID] 12608544.
2003
Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration.
The Journal of biological chemistry.
278(44):43508-15
[PMID] 12917400.
2003
Structural determinants of P-glycoprotein-mediated transport of glucocorticoids.
Pharmaceutical research.
20(11):1794-803
[PMID] 14661924.
2002
Camptothecins: a review of their chemotherapeutic potential.
Drugs.
62(14):2039-57
[PMID] 12269849.
2002
Modeling of active transport systems.
Advanced drug delivery reviews.
54(3):329-54
[PMID] 11922951.
2002
Structural biology and function of solute transporters: implications for identifying and designing substrates.
Drug metabolism reviews.
34(4):709-50
[PMID] 12487148.
2002
Towards a new age of virtual ADME/TOX and multidimensional drug discovery.
Journal of computer-aided molecular design.
16(5-6):381-401
[PMID] 12489686.
2002
Towards a new age of virtual ADME/TOX and multidimensional drug discovery.
Molecular diversity.
5(4):255-75
[PMID] 12549676.
2000
Involvement of a receptor-mediated component in cellular translocation of riboflavin.
The Journal of pharmacology and experimental therapeutics.
294(1):117-25
[PMID] 10871302.
2000
Progress in predicting human ADME parameters in silico.
Journal of pharmacological and toxicological methods.
44(1):251-72
[PMID] 11274894.
1999
Determination of membrane protein glycation in diabetic tissue.
AAPS pharmSci.
1(4)
[PMID] 11741216.
1998
Mapping the binding site of the small intestinal peptide carrier (PepT1) using comparative molecular field analysis.
Receptors & channels.
6(3):189-200
[PMID] 10100327.
1998
Recent advances in intestinal macromolecular drug delivery via receptor-mediated transport pathways.
Pharmaceutical research.
15(6):826-34
[PMID] 9647346.
1997
Enhanced transepithelial transport of peptides by conjugation to cholic acid.
Bioconjugate chemistry.
8(4):520-5
[PMID] 9258450.
1997
Molecular determinants of recognition for the intestinal peptide carrier.
Journal of pharmaceutical sciences.
86(5):596-602
[PMID] 9145385.
1997
Molecular modeling of the intestinal bile acid carrier: a comparative molecular field analysis study.
Journal of computer-aided molecular design.
11(6):581-8
[PMID] 9491350.
1997
Use of the intestinal bile acid transporter for the uptake of cholic acid conjugates with HIV-1 protease inhibitory activity.
Pharmaceutical research.
14(2):176-80
[PMID] 9090705.
1995
Carrier-mediated transport mechanism of foscarnet (trisodium phosphonoformate hexahydrate) in rat intestinal tissue.
The Journal of pharmacology and experimental therapeutics.
272(1):242-7
[PMID] 7815338.
1995
Molecular mechanism for the relative binding affinity to the intestinal peptide carrier. Comparison of three ACE-inhibitors: enalapril, enalaprilat, and lisinopril.
Biochimica et biophysica acta.
1236(1):31-8
[PMID] 7794953.
1994
Determination of transport rates for arginine and acetaminophen in rabbit intestinal tissues in vitro.
Pharmaceutical research.
11(2):283-7
[PMID] 8165189.
Grants
May 2023
ACTIVE
Identification of eye-homing peptides and their use for targeted liposomal drug delivery in posterior uveitis
Role: Principal Investigator
Funding: UNIV OF MARYLAND BALTIMORE
via NATL INST OF HLTH NEI
Contact Details
Phones:
- Business:
- (352) 273-6309
Emails:
- Business:
- peter.swaan@ufl.edu
Administrative Specialist I:
Addresses:
- Business Street:
-
PO Box 100484
GAINESVILLE FL 32610