Sihong Song, Ph.D.
Professor
Teaching Profile
Courses Taught
2013-2020,2022-2024
PHA5172 Biotech and Drug Devlp
2016,2019-2024,2024
PHA6910 Supervised Research
2016,2020-2022
GMS6251 Molecular Therapy I ? Vectors and Molecular Mechanisms
2014-2023
PHA6938 Research Seminar
2008-2024
PHA7979 Advanced Research
2008-2022
PHA7980 Research for Doctoral Dissertation
2010-2014,2020-2021
PHA6971 Research for Master’s Thesis
2007,2009-2011,2011-2015,2013-2019,2015-2021,2017-2024,2019-2024,2023-2024
PHA6183 Pharmaceutical Gene Delivery
2019-2021
PHA7939 Journal Club in Pharmaceutical Sciences
2014,2016
PHA5905 Clin Pharm Research
2016
PHA6894 Introduction to Graduate Studies
2009-2014
PHA5451 Clinical Biochemistry
2011,2023-2024
PHA6935 Selected Topics in Pharmacy
2021
PHA6936 Advanced Topics in Pharmaceutical Sciences
2022-2023
PHA6740 Fundamentals of Grant Writing in the Pharmaceutical Sciences
Research Profile
Song’s interests are in 1) improvement of safety and efficiency of rAAV vector by understanding molecular mechanisms of persistence and integration of the AAV genome in mammalian cells and 2) the use of recombinant Adeno-Associated Virus (rAAV) vectors mediated gene transfer to develop gene therapy approaches for common diseases such as diabetes and arthritis.
His research interests include: molecular and cell biology, gene expression and gene regulation, liver and muscle gene delivery, gene therapy for type 1 diabetes and alpha 1 antitrypsin deficiency, adeno-associated virus (AAV) vector biology: DNA persistence, integration and interaction with cellular factors; host immune responses to transgene products
Open Researcher and Contributor ID (ORCID)
0000-0001-6523-165X
Publications
2023
The under-appreciated world of the serpin family of serine proteinase inhibitors.
EMBO molecular medicine.
15(6)
[DOI] 10.15252/emmm.202217144.
[PMID] 37158379.
2022
Human Alpha 1 Antitrypsin Suppresses NF-κB Activity and Extends Lifespan in Adult Drosophila
Biomolecules.
12(10)
[DOI] 10.3390/biom12101347.
[PMID] 36291555.
2022
Human Alpha-1 Antitrypsin Attenuates ENaC and MARCKS and Lowers Blood Pressure in Hypertensive Diabetic db/db Mice.
Biomolecules.
13(1)
[DOI] 10.3390/biom13010066.
[PMID] 36671451.
2021
Transgenic Mice Overexpressing Human Alpha-1 Antitrypsin Exhibit Low Blood Pressure and Altered Epithelial Transport Mechanisms in the Inactive and Active Cycles.
Frontiers in physiology.
12
[DOI] 10.3389/fphys.2021.710313.
[PMID] 34630137.
2019
Alpha-1-Antitrypsin Ameliorates Pristane Induced Diffuse Alveolar Hemorrhage in Mice.
Journal of clinical medicine.
8(9)
[DOI] 10.3390/jcm8091341.
[PMID] 31470606.
2019
Regulated hAAT Expression from a Novel rAAV Vector and Its Application in the Prevention of Type 1 Diabetes.
Journal of clinical medicine.
8(9)
[DOI] 10.3390/jcm8091321.
[PMID] 31466263.
2018
Alpha 1 Antitrypsin Gene Therapy Extends the Lifespan of Lupus-Prone Mice.
Molecular therapy. Methods & clinical development.
11:131-142
[DOI] 10.1016/j.omtm.2018.10.007.
[PMID] 30547047.
2018
Alpha-1 Antitrypsin Therapy for Autoimmune Disorders.
Chronic obstructive pulmonary diseases (Miami, Fla.).
5(4):289-301
[DOI] 10.15326/jcopdf.5.4.2018.0131.
[PMID] 30723786.
2018
Anti-inflammaging effects of human alpha-1 antitrypsin.
Aging cell.
17(1)
[DOI] 10.1111/acel.12694.
[PMID] 29045001.
2018
Gene Delivery of Alpha-1-Antitrypsin Using Recombinant Adeno-Associated Virus (rAAV).
Methods in molecular biology (Clifton, N.J.).
1826:183-196
[DOI] 10.1007/978-1-4939-8645-3_12.
[PMID] 30194601.
2018
In Vivo Analysis of Alpha-1-Antitrypsin Functions in Autoimmune Disease Models.
Methods in molecular biology (Clifton, N.J.).
1826:143-155
[DOI] 10.1007/978-1-4939-8645-3_10.
[PMID] 30194599.
2017
Alpha-1 antitrypsin inhibits RANKL-induced osteoclast formation and functions.
Molecular medicine (Cambridge, Mass.).
23:57-69
[DOI] 10.2119/molmed.2016.00170.
[PMID] 28332697.
2017
Electroacupuncture Relieves Depression-Like Symptoms in Rats Exposed to Chronic Unpredictable Mild Stress By Activating Erk Signaling Pathway
Neuroscience Letters.
642:43-50
[DOI] 10.1016/j.neulet.2017.01.060.
2017
Ischemia-responsive protein 94 is a key mediator of ischemic neuronal injury-induced microglial activation.
Journal of neurochemistry.
142(6):908-919
[DOI] 10.1111/jnc.14111.
[PMID] 28640931.
2017
Transplantation of Adipose Tissue-Derived Mesenchymal Stem Cell (ATMSC) Expressing Alpha-1 Antitrypsin Reduces Bone Loss in Ovariectomized Osteoporosis Mice.
Human gene therapy.
28(2):179-189
[DOI] 10.1089/hum.2016.069.
[PMID] 27802778.
2016
Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus.
PloS one.
11(5)
[DOI] 10.1371/journal.pone.0156583.
[PMID] 27232337.
2016
Alpha-1 Antitrypsin Gene Therapy Ameliorates Bone Loss in Ovariectomy-Induced Osteoporosis Mouse Model.
Human gene therapy.
27(9):679-86
[DOI] 10.1089/hum.2016.029.
[PMID] 27158796.
2015
In Situ Transplantation of Alginate Bioencapsulated Adipose Tissues Derived Stem Cells (ADSCs) via Hepatic Injection in a Mouse Model.
PloS one.
10(9)
[DOI] 10.1371/journal.pone.0138184.
[PMID] 26372641.
2014
Alpha 1-antitrypsin therapy mitigated ischemic stroke damage in rats.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.
23(5):e355-63
[DOI] 10.1016/j.jstrokecerebrovasdis.2013.12.029.
[PMID] 24582784.
2014
Reprogramming adipose tissue-derived mesenchymal stem cells into pluripotent stem cells by a mutant adeno-associated viral vector.
Human gene therapy methods.
25(1):72-82
[DOI] 10.1089/hgtb.2013.011.
[PMID] 24191859.
2013
Retinoid X receptor agonists modulate Foxp3⁺ regulatory T cell and Th17 cell differentiation with differential dependence on retinoic acid receptor activation.
Journal of immunology (Baltimore, Md. : 1950).
191(7):3725-33
[DOI] 10.4049/jimmunol.1300032.
[PMID] 23980207.
2012
Alpha-1 Antitrypsin Reduces Ovariectomy-Induced Bone Loss in Mice
The FASEB's Journal.
26
2011
Adipose tissue-derived mesenchymal stem cell-based liver gene delivery.
Journal of hepatology.
54(5):930-8
[DOI] 10.1016/j.jhep.2010.07.051.
[PMID] 21168381.
2011
Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model.
Journal of translational medicine.
9
[DOI] 10.1186/1479-5876-9-21.
[PMID] 21345239.
2011
Alpha-1 antitrypsin reduces ovariectomy-induced bone loss in mice.
Annals of the New York Academy of Sciences.
1240:E31-5
[DOI] 10.1111/j.1749-6632.2011.06370.x.
[PMID] 22360827.
2011
The protective effects of plasma gelsolin on stroke outcome in rats.
Experimental & translational stroke medicine.
3(1)
[DOI] 10.1186/2040-7378-3-13.
[PMID] 22047744.
2010
Combination of alpha-1 antitrypsin and doxycycline suppresses collagen-induced arthritis.
The journal of gene medicine.
12(1):35-44
[DOI] 10.1002/jgm.1409.
[PMID] 19866480.
2010
Efficient induction of CCR9 on T cells requires coactivation of retinoic acid receptors and retinoid X receptors (RXRs): exaggerated T Cell homing to the intestine by RXR activation with organotins.
Journal of immunology (Baltimore, Md. : 1950).
185(9):5289-99
[DOI] 10.4049/jimmunol.1000101.
[PMID] 20881191.
2010
Ex vivo transduction and transplantation of bone marrow cells for liver gene delivery of alpha1-antitrypsin.
Molecular therapy : the journal of the American Society of Gene Therapy.
18(8):1553-8
[DOI] 10.1038/mt.2010.116.
[PMID] 20551917.
2010
Feasibility of Localized Immunosuppression: 2. Pla Microspheres for the Sustained Local Delivery of a Soft Immunosuppressant
Die Pharmazie.
65(6):429-435
[DOI] 10.1691/ph.2010.0033R.
[PMID] 20614691.
2010
Intradermal Alpha 1-Antitrypsin Therapy Avoids Fatal Anaphylaxis, Prevents Type 1 Diabetes and Reverses Hyperglycaemia in the Nod Mouse Model of the Disease
Diabetologia.
53(10):2198-2204
[DOI] 10.1007/s00125-010-1829-2.
[PMID] 20593162.
2010
The effect of DNA-dependent protein kinase on adeno-associated virus replication.
PloS one.
5(12)
[DOI] 10.1371/journal.pone.0015073.
[PMID] 21188139.
2009
Distinct immune responses to transgene products from rAAV1 and rAAV8 vectors.
Proceedings of the National Academy of Sciences of the United States of America.
106(40):17158-62
[DOI] 10.1073/pnas.0909520106.
[PMID] 19805176.
2009
Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice.
Diabetes.
58(10):2277-84
[DOI] 10.2337/db09-0557.
[PMID] 19628781.
2008
Alpha-1 Antitrypsin Treatment of Spontaneously Diabetic Nonobese Diabetic Mice Receiving Islet Allografts
Transplantation proceedings.
40(2):457-458
[DOI] 10.1016/j.transproceed.2008.02.010.
[PMID] 18374100.
2008
Human Alpha 1-Antitrypsin Therapy Induces Fatal Anaphylaxis in Non-Obese Diabetic Mice
Clinical and Experimental Immunology.
154(1):15-21
[DOI] 10.1111/j.1365-2249.2008.03721.x.
[PMID] 18759852.
2008
Prolonged Islet Allograft Survival By Alpha-1 Antitrypsin: the Role of Humoral Immunity
Transplantation proceedings.
40(2):455-456
[DOI] 10.1016/j.transproceed.2008.02.009.
[PMID] 18374099.
2007
Alpha1-antitrypsin protects beta-cells from apoptosis.
Diabetes.
56(5):1316-23
[PMID] 17360983.
2007
Development of immunocompetent lymphocytes in vivo from murine umbilical cord blood cells.
Transplantation.
84(1):23-30
[PMID] 17627233.
2006
A novel antiapoptotic role for alpha1-antitrypsin in the prevention of pulmonary emphysema.
American journal of respiratory and critical care medicine.
173(11):1222-8
[PMID] 16514110.
2006
Alpha1-antitrypsin gene therapy modulates cellular immunity and efficiently prevents type 1 diabetes in nonobese diabetic mice.
Human gene therapy.
17(6):625-34
[PMID] 16776571.
2006
Phase I trial of intramuscular injection of a recombinant adeno-associated virus serotype 2 alphal-antitrypsin (AAT) vector in AAT-deficient adults.
Human gene therapy.
17(12):1177-86
[PMID] 17115945.
2006
Therapeutic level of functional human alpha 1 antitrypsin (hAAT) secreted from murine muscle transduced by adeno-associated virus (rAAV1) vector.
The journal of gene medicine.
8(6):730-5
[PMID] 16518879.
2005
Efficient hepatic delivery and expression from a recombinant adeno-associated virus 8 pseudotyped alpha1-antitrypsin vector.
Molecular therapy : the journal of the American Society of Gene Therapy.
12(5):867-75
[PMID] 16085464.
2005
Enhancing rAAV vector expression in the lung.
The journal of gene medicine.
7(7):842-50
[PMID] 15838934.
2005
Glucose transporter-2 (GLUT2) promoter mediated transgenic insulin production reduces hyperglycemia in diabetic mice.
FEBS letters.
579(25):5759-64
[PMID] 16223491.
2004
DNA-dependent PK inhibits adeno-associated virus DNA integration.
Proceedings of the National Academy of Sciences of the United States of America.
101(7):2112-6
[PMID] 14766968.
2004
Ex vivo transduced liver progenitor cells as a platform for gene therapy in mice.
Hepatology (Baltimore, Md.).
40(4):918-24
[PMID] 15382177.
2003
Full reconstitution of hematopoietic system by murine umbilical cord blood.
Transplantation.
75(11):1820-6
[PMID] 12811240.
2003
Successful cryopreservation of mouse ovaries by vitrification.
Biology of reproduction.
68(3):881-7
[PMID] 12604638.
2003
Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion.
Journal of immunology (Baltimore, Md. : 1950).
171(5):2270-8
[PMID] 12928371.
2002
Improved method of recombinant AAV2 delivery for systemic targeted gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy.
6(1):106-12
[PMID] 12095310.
2002
Intramuscular administration of recombinant adeno-associated virus 2 alpha-1 antitrypsin (rAAV-SERPINA1) vectors in a nonhuman primate model: safety and immunologic aspects.
Molecular therapy : the journal of the American Society of Gene Therapy.
6(3):329-35
[PMID] 12231168.
Grants
Feb 2022
ACTIVE
Computationally designed IL-10 mutants for the treatment of inflammatory bowel diseases
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION
Jul 2020
ACTIVE
The circadian clock protein BMAL and post-translational regulation of ENaC in the kidney
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Jun 2020
– Nov 2022
Development of a novel gene therapy for lupus
Role: Principal Investigator
Funding: SAREPTA THERAPEUTICS
Mar 2018
– Nov 2018
Testing of AAV-hAAT Vectors in Mice
Role: Principal Investigator
Funding: APPLIED GENETICS TECH CORP
Aug 2016
– Aug 2018
Study on the inter and intra generic transmission of drug resistance determinants
Role: Principal Investigator
Funding: EGYPTIAN CULTURAL AND EDU BUR
Jun 2015
– May 2018
60919270Alpha 1 antitrypsin for the treatment of osteoporosis
Role: Principal Investigator
Funding: UF DSR OPPORTUNITY FUND
Jan 2015
– Jan 2017
The Protective Effect of Prolostin C for the Treatment of Lupus
Role: Principal Investigator
Funding: GRIFOLS SA
Education
Post Doctoral Associate in Gene Therapy
1999
·
University of Florida
Ph.D.
1996
·
University of Florida
M.S.
1989
·
Jilin Agricultural University
B.S.
1982
·
Jilin Agricultural University
Contact Details
Phones:
- Business:
- (352) 273-7867
Emails:
- Business:
- shsong@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100494
GAINESVILLE FL 32610 - Business Street:
-
1600 SW ARCHER RD
MSB P3-31
GAINESVILLE FL 326103003