Hendrik Luesch

Hendrik Luesch, Ph.D.

Professor And Chair, Debbie And Sylvia DeSantis Chair In Natural Products Drug Discovery And Development

Department: Medicinal Chemistry
Business Phone: (352) 273-7738
Business Email: luesch@cop.ufl.edu

About Hendrik Luesch

Hendrik Luesch, Ph.D., a professor of medicinal chemistry, received his Diplom in Chemistry at the University of Siegen (Germany) in 1997. He attended the University of Hawaii at Manoa to study marine natural products chemistry and obtained his Ph.D. in Chemistry under the supervision of Professor Richard E. Moore in 2002. He then undertook three years of postdoctoral studies as an Irving S. Sigal Fellow at The Scripps Research Institute in La Jolla working with Professor Peter G. Schultz in the area of functional genomics and chemical biology. In 2005 he joined the faculty of the Department of Medicinal Chemistry at the University of Florida as an assistant professor and was tenured and promoted to associate professor in 2010 and to full professor in 2015. He combines his interest in marine natural products chemistry with genomics and proteomics approaches for the discovery and characterization of potential drugs and molecular drug targets.

Research Profile

Dr. Luesch’s multidisciplinary research program at the interface of chemistry and biology combines classical natural products chemistry with high-throughput screening and chemical genomics. It involves most aspects of drug discovery ranging from the collection of promising marine organisms, bioassay development, NMR spectroscopic structure determination, total synthesis, mechanism-of-action studies, and pharmacology, up to the preclinical and clinical development of candidate molecules. His lab is producing a small but increasing pipeline of bioactive compounds that are at various developmental stages. He also uses functional genomics approaches to identify and characterize genes associated with disease processes, especially cancer.

Publications

2014 Bioorganic & Medicinal Chemistry Letters
2011 Future Medicinal Chemistry
2009 Journal of the Neurological Sciences
2007 Proceedings of the National Academy of Sciences

Grants

Jun 2020 ACTIVE
NMR console upgrade for structural biology and metabolomics
NATL INST OF HLTH OD ·
Sep 2019 ACTIVE
Novel Targeted Anticancer Agents from Marine Cyanobacteria
NATL INST OF HLTH NCI · Principal Investigator
Aug 2019 – Mar 2020
Potential Anticancer Drug Leads from the Marine Sponges Collected off the Coast of Surigao City
MINDANAO STATE UNIVERSITY · Principal Investigator
Dec 2018 – Nov 2019
Identifying CxCR4 Receptor Agonists to Improve Diabetic Healing
UNIVERSITY OF COLORADO DENVER · Project Manager
Dec 2018 ACTIVE
Small Molecule Discovery for Particulate Guanylyl Cyclase Receptor B Enhancers
MAYO CLINIC · Project Manager
Aug 2018 ACTIVE
MRI: Acquisition of an X-Ray Diffractometer for Next Generation Functional Molecules and Materials
NATL SCIENCE FOU ·
Jul 2018 ACTIVE
OR-DRPD-ROF2018: A C. elegans based drug discovery platform for modulators of re-mRNA processing
UF RESEARCH · Project Manager
Jul 2018 ACTIVE
Alkaloid Ring Distortion: A Platform for New Cancer Therapies
AMER CANCER SOC ·
Sep 2017 ACTIVE
Utilization of Phenotypic Precision Medicine to Identify Optimal Drug Combinations for the Treatment of Hepatocellular Carcinoma
NATL INST OF HLTH NCATS ·
Dec 2016 ACTIVE
UF PASS: Regulation of exercise transducers
NATL INST OF HLTH NIA ·
Sep 2016 ACTIVE
Development of Complex Natural Product Libraries and Multidimensional Anticancer Screening Platforms
NATL INST OF HLTH NCI ·
Jul 2016 – Jun 2018
NOVEL SYNTHETIC APRATOXINS ACTING THROUGH A NEW MECHANISM ASAN ALTERNATIVE TREATMENT OF CANCERS WITH ACTIVATED GROWTH…
OCALA ROYAL DAMES FOR CANCER RESEARCH · Principal Investigator
Jun 2014 – May 2017
Novel Therapeutics for activation of the antioxidant res
UF DSR OPPORTUNITY FUND · Project Manager
Dec 2013 – Nov 2015
Chemistry and Biology of Apratoxins
FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE · Principal Investigator
Mar 2013 – Aug 2019
Novel Targeted Anticancer Agents from Marine Cyanobacteria
NATL INST OF HLTH NCI · Principal Investigator
Mar 2011 – Feb 2016
Mitochondrial Oxidative Stress in the Retinal Pigment Ep
NATL INST OF HLTH NEI · Project Manager

Patents

Published March 2010
Macrocyclic Compounds, Protease Inhibition, and Methods of Treatment
#US2011-0124569A1
Published December 2010
Macrocyclic Compounds and Methods of Treatment (New App.)
#2011-0123644 A1
Published May 2011
Apratoxin Therapetuic Agents: Mechanism and Methods of Treatment
#US 2011-0294720 A1
Issued March 2012
Macrocyclic Compounds and Methods of Treatment
#8,129,418
Published November 2012
Macrocyclic Compounds and Methods of Treatment
#US2013-0281497 A1
Issued January 2013
Macrocyclic Compounds and Methods of Treatment (DIV of 12606)
#8,357,708
Issued October 2013
Structure and Protease Activity of Grassystatins
#8,569,245
Issued June 2014
Methods of Preparation of Macrocyclic Compounds
#8,759,512
Published August 2014
Macrocyclic Compounds
#US2015-0038404 A1
Issued May 2015
Macrocyclic Compounds and Methods of Treatment (DIV of UF#12606)
#9,023,875
Issued June 2015
Macrocyclic Antiproliferation Agents and Methods of Treatment
#9,051,350
Published October 2015
Macrocyclic Compounds and Methods of Treatment
#US 2016/0106720
Published November 2015
Potent New Synthetic Apratoxins
#US-2016-0060299-A1
Issued November 2015
Macrocyclic Compounds and Methods of Treatment
#9,181,304
Published August 2016
Macrocyclic Therapeutic Agents, Methods of Manufacture, and Methods of Treatment
#US-2017-0057996
Issued November 2016
Combination Compositions and Methods of Treatment
#9,492,434
Issued August 2017
Seaweed Extracts, Unsaturated Aldehydes, and Methods of Treatment
#9,730,970
Issued November 2017
Macrocyclic Compounds and Methods of Treatment
#9,815,852
Issued July 2018
Seaweed Extracts, Unsaturated Fatty Acids, and Methods of Treatment
#10,010,569

Education

Postdoctoral Fellow
2002-2005 · The Scripps Research Institute
Ph.D.
2002 · University of Hawaii at Manoa
Diplom in Chemistry
1997 · University of Siegen

Contact Details

Phones:
Business:
(352) 273-7738
Emails:
Business:
luesch@cop.ufl.edu

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Research

Lab Members

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