Jatinder Lamba

Jatinder Lamba Ph.D., M.Sc.

Professor And Graduate Coordinator

Department: Pharmacotherapy & Translational Research
Business Phone: (352) 273-6425
Business Email: jlamba@cop.ufl.edu

About Jatinder Lamba

Dr. Jatinder Lamba did her post-doctoral training at St. Jude Children’s Research Hospital in Memphis, Tennessee. She was an Associate Professor at University of Minnesota, Department of Experimental and Clinical Pharmacology and Director of the Pathway driven Pharmacogenomics; University of Minnesota Alliance (PUMA) Institute of Personalized Medicine prior to joining the University of Florida.

Dr. Lamba’s research is focused on identification, characterization and clinical validation of genomic/epigenomic markers predictive of therapeutic outcome cancer patients. Her research spans from preclinical basic research comprising the discovery phase to translational/clinical phase in patient populations from multi-institute clinical trials.

The long-term goal of her research is to move pharmacogenetic testing into the clinical setting to improve safety and efficacy of drug therapy. Dr. Lamba’s research on pharmacogenomics of anti-leukemic agents has been funded by NIH/NCI since 2008. Specifically, her current NCI funded R01 focuses on pharmacogenomics/ epigenomics of cytarabine (ara-C), a nucleoside analog that is the backbone of anti-leukemia chemotherapy in pediatric AML patients.

Another NCI funded project focuses on pharmacogenomics of Gemtuzumab ozogamicin (GO), an immunoconjugate utilized in treatment of AML. Other projects in her lab include integrative systems pharmacogenomics to identify predictive markers of response in ovarian cancer patients. Her research utilizes state of the art genomic measures as next-gen sequencing, gene-expression profiling, genome-wide methylation profiling and high-throughput siRNA screening etc.

Dr. Lamba has served as chair of Pharmacogenomics SIG at AACP (2013) and is currently vice-chair of Pharmacogenomics focus group with AAPS. She has also served as grant-reviewer for NIH and Italian Ministry of Health. She has published more than 65 research articles in peer-reviewed journals and is on the editorial boards of Leukemia and Lymphoma, Pharmacogenomics and Frontiers in Pharmacogenomics and genomics journal.

Grants

July 2019ACTIVE
Personalizing CD33-directed Immunotherapy for Pediatric AML
LEUKEMIA & LYMPHOMA SOC · Principal Investigator
April 2019ACTIVE
Pharmacogenomics and Toxicities of Thiotepa, Busulfan and Fludarabine in Pediatric HSCT Recipients
LIVE LIKE BELLA PEDIATRIC CANCER RESEARC · Principal Investigator
June 2018ACTIVE
OR-DRPD-ROD2018: Development of Leukemia-Oncotype Prototype CARS (Cytarabine AML Response Score) for Prediction of Relapse Risk in AML
UF OFFICE OF RESEARCH · Principal Investigator
February 2018 – January 2019
Impact of CD33 Genetics on Clinical Outcome in Pediatric AML Patients Treated on AAML0531 Clinical Trial
CHILDRENS ONCOLOGY GROUP · Principal Investigator
December 2016ACTIVE
Multiple Sponsors
MULTIPLE SPONSORS · Principal Investigator
January 2015 – January 2016
DNA ISOLATION/GENOTYPING COLLABORATION
UNIV OF MINNESOTA · Principal Investigator
September 2014ACTIVE
Pharmacogenomics of Ara-C in AML
NATL INST OF HLTH NCI · Principal Investigator
July 2014 – December 2015
Impact of genetic variation on response to GO therapy in
NATL INST OF HLTH NCI · Principal Investigator

Education

2000
Ph.D.
Postgraduate Institute of Medical Education and Research
1994
M.Sc.
Postgraduate Institute of Medical Education and Research
1992
B.Sc.
Panjab University