Leslie Hendeles

Leslie Hendeles, Pharm.D.

Professor Emeritus

Department: MD-PEDIATRICS
Business Email: hendeles@cop.ufl.edu

About Leslie Hendeles

Dr. Hendeles is a Professor Emeritus in the College of Pharmacy and also in the Department of Pediatrics at the University of Florida. Among his current research interests are the improvement of adherence to asthma medications and delivery of inhaled drugs to young children. He is a consultant to FDA’s Pulmonary Division, and previously served on the Coordinating Committee of NIH’s Asthma Education Program, as well as CDC’s Expert Panel on Asthma Guidelines for Emergency Medical Services. Dr. Hendeles provides advice on drug therapy and teaches in the Pediatric Pulmonary Clinic at the University of Florida.

Publications

2020
Continuous Albuterol With Benzalkonium in Children Hospitalized With Severe Asthma.
Pediatrics. 145(4) [DOI] 10.1542/peds.2019-0107. [PMID] 32165556.
2020
Early administration of steroids in the ambulance setting: Protocol for a type I hybrid effectiveness-implementation trial with a stepped wedge design.
Contemporary clinical trials. 97 [DOI] 10.1016/j.cct.2020.106141. [PMID] 32931918.
2019
Emergency Medical Services Administration of Systemic Corticosteroids for Pediatric Asthma: A Statewide Study of Emergency Department Outcomes.
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 26(5):549-551 [DOI] 10.1111/acem.13660. [PMID] 30414344.
2019
A Statewide Study of the Epidemiology of Emergency Medical Services’ Management of Pediatric Asthma.
Pediatric emergency care. [DOI] 10.1097/PEC.0000000000001743. [PMID] 30829849.
2018
Direct Observed Therapy of Inhaled Corticosteroids for Asthma at School or Daycare.
Pediatric allergy, immunology, and pulmonology. 31(4):226-229 [DOI] 10.1089/ped.2018.0912. [PMID] 30595951.
2018
Nonprescription medications for respiratory symptoms: Facts and marketing fictions.
Allergy and asthma proceedings. 39(3):169-176 [DOI] 10.2500/aap.2018.39.4117. [PMID] 29669663.
2018
Oral corticosteroids should be available on-hand at home for the next asthma exacerbation!
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 121(1):18-21 [DOI] 10.1016/j.anai.2018.04.004. [PMID] 29653237.
2018
Randomized, Double-Blind, Crossover, Clinical-End-Point Pilot Study to Examine the Use of Exhaled Nitric Oxide as a Bioassay for Dose Separation of Inhaled Fluticasone Propionate.
Journal of clinical pharmacology. 58(4):448-456 [DOI] 10.1002/jcph.1043. [PMID] 29193247.
2017
Benzalkonium Chloride: A Bronchoconstricting Preservative in Continuous Albuterol Nebulizer Solutions.
Pharmacotherapy. 37(5):607-610 [DOI] 10.1002/phar.1929. [PMID] 28349590.
2016
Bioassay of salmeterol in children using methacholine challenge with impulse oscillometry.
Pediatric pulmonology. 51(6):570-5 [DOI] 10.1002/ppul.23345. [PMID] 26575323.
2016
Long-term variability of exhaled nitric oxide measurements.
The journal of allergy and clinical immunology. In practice. 4(1):147-8.e1 [DOI] 10.1016/j.jaip.2015.09.010. [PMID] 26563669.
2015
Pharmacokinetics of Orally Inhaled Drug Products.
The AAPS journal. 17(3):769-75 [DOI] 10.1208/s12248-015-9736-6. [PMID] 25762449.
2015
Over-the-Counter Oral Phenylephrine: A Placebo for Nasal Congestion.
The journal of allergy and clinical immunology. In practice. 3(5):709-10 [DOI] 10.1016/j.jaip.2015.06.014. [PMID] 26362551.
2015
Pharmacodynamic Studies to Demonstrate Bioequivalence of Oral Inhalation Products.
The AAPS journal. 17(3):758-68 [DOI] 10.1208/s12248-015-9735-7. [PMID] 25716149.
2015
Application of multicategory exposure marginal structural models to investigate the association between long-acting beta-agonists and prescribing of oral corticosteroids for asthma exacerbations in the Clinical Practice Research Datalink.
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. 18(2):260-70 [DOI] 10.1016/j.jval.2014.11.007. [PMID] 25773561.
2015
Omalizumab therapy for asthma patients with poor adherence to inhaled corticosteroid therapy.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 114(1):58-62.e2 [DOI] 10.1016/j.anai.2014.10.012. [PMID] 25528738.
2014
Comparison of Rates of Prescribing Oral Corticosteroids for Asthma Exacerbations Between Step-Down Therapy Approaches Among Initiators of Inhaled Corticosteroids and Long-Acting Beta-Agonist Combination Therapy
. 133(2, S)
2014
Nonprescription racemic epinephrine for asthma.
The journal of allergy and clinical immunology. In practice. 2(5):575-8 [DOI] 10.1016/j.jaip.2014.02.014. [PMID] 25213051.
2013
Long-Acting Beta-Agonists and Asthma Exacerbations Requiring Short Courses of Oral Corticosteroids: a Multi-Category Exposure Marginal Structural Models Analysis
Value in Health. 16
2013
Study design considerations for evaluating the efficacy and safety of pancreatic enzyme replacement therapy in patients with cystic fibrosis.
Clinical investigation. 3(8):731-741 [PMID] 25132954.
View on: PubMed
2012
Bioavailability of Inhaled Fluticasone Propionate Via Chambers/Masks in Young Children
The European respiratory journal. 39(1):97-103 [DOI] 10.1183/09031936.00185510. [PMID] 21933835.
2012
Delivery of Medications By Metered Dose Inhaler Through a Chamber/Mask To Young Children With Asthma
Pediatric Allergy Immunology and Pulmonology. 25(4):236-239 [DOI] 10.1089/ped.2012.0197.
2012
Management of patients with cystic fibrosis and allergic bronchopulmonary aspergillosis using anti-immunoglobulin e therapy (omalizumab).
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG. 17(1):88-92 [DOI] 10.5863/1551-6776-17.1.88. [PMID] 23118662.
2012
Response to albuterol MDI delivered through an anti-static chamber during nocturnal bronchospasm.
Respiratory care. 57(8):1291-6 [DOI] 10.4187/respcare.01572. [PMID] 22348270.
2011
Methacholine challenge as a clinical bioassay of pulmonary delivery of a long-acting β₂-adrenergic agonist.
Pharmacotherapy. 31(5):449-57 [DOI] 10.1592/phco.31.5.449. [PMID] 21923426.
2011
Systemic exposure to fluticasone MDI delivered through antistatic chambers.
The Journal of allergy and clinical immunology. 128(5):1113-5.e1 [DOI] 10.1016/j.jaci.2011.06.014. [PMID] 21783234.
2011
Methacholine challenge as a clinical bioassay of pulmonary delivery of a long-acting β₂-adrenergic agonist
Pharmacotherapy. [DOI] 10.1592/phco.31.5.449. [PMID] 21923426.
2011
Response To Albuterol Delivered Through An Anti-Static Valved Holding Chamber During Nocturnal Bronchospasm
Journal of Allergy and Clinical Immunology. 127(2):AB67-AB67 [DOI] 10.1016/j.jaci.2010.12.278.
2010
Pancreatic Enzyme Products
Pediatric Allergy Immunology and Pulmonology. 23(4):291-294 [DOI] 10.1089/ped.2010.0050.
2010
Reply To Discussion of `Empirical Vs Natural Weighting in Random Effects Meta-Analysis’
Statistics in Medicine. 29(12):1272-1281 [DOI] 10.1002/sim.3842.
2010
Demonstrating Bioequivalence of Locally Acting Orally Inhaled Drug Products (OIPs): Workshop Summary Report.
Journal of aerosol medicine and pulmonary drug delivery. 23(1):1-29 [DOI] 10.1089/jamp.2009.0803. [PMID] 20131983.
2008
Advocating for patients through clinical research.
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG. 13(1):4-16 [DOI] 10.5863/1551-6776-13.1.4. [PMID] 23055859.
2007
Anti-immunoglobulin E therapy with omalizumab for asthma.
The Annals of pharmacotherapy. 41(9):1397-410 [PMID] 17698897.
View on: PubMed
2007
Coefficients of fat and nitrogen absorption in healthy subjects and individuals with cystic fibrosis.
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG. 12(1):47-52 [DOI] 10.5863/1551-6776-12.1.47. [PMID] 23055842.
2007
Comparison of 2 dosimeters by methacholine challenge.
The Journal of allergy and clinical immunology. 120(5):1218-9 [PMID] 17637473.
View on: PubMed
2007
Efficacy and safety of oral phenylephrine: systematic review and meta-analysis.
The Annals of pharmacotherapy. 41(3):381-90 [PMID] 17264159.
View on: PubMed
2007
Withdrawal of albuterol inhalers containing chlorofluorocarbon propellants.
The New England journal of medicine. 356(13):1344-51 [PMID] 17392304.
View on: PubMed
2006
Safety and preliminary clinical activity of a novel pancreatic enzyme preparation in pancreatic insufficient cystic fibrosis patients.
Pancreas. 32(3):258-63 [PMID] 16628080.
View on: PubMed
2006
Oral phenylephrine: an ineffective replacement for pseudoephedrine?
The Journal of allergy and clinical immunology. 118(1):279-80 [PMID] 16815167.
View on: PubMed
2006
Lung bioavailability of hydrofluoroalkane fluticasone in young children when delivered by an antistatic chamber/mask.
The Journal of pediatrics. 149(6):793-7 [PMID] 17137894.
View on: PubMed
2006
Frequent toxicity from IV aminophylline infusions in critically ill patients. 1977.
The Annals of pharmacotherapy. 40(7-8):1417-23 [PMID] 16868215.
View on: PubMed
2006
Onset and duration of protection against exercise-induced bronchoconstriction by a single oral dose of montelukast.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 97(1):98-104 [PMID] 16892789.
View on: PubMed
2005
Automatic replacement of albuterol nebulizer therapy by metered-dose inhaler and valved holding chamber.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 62(10):1053-61 [PMID] 15901590.
View on: PubMed
2005
Nebulizer output for methacholine challenges with the KoKo Digidoser.
The Journal of allergy and clinical immunology. 116(4):924-6 [PMID] 16210072.
View on: PubMed
2005
Response to nonprescription epinephrine inhaler during nocturnal asthma.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 95(6):530-4 [PMID] 16400891.
View on: PubMed
2004
Evaluation of cytokine modulators for asthma.
Paediatric respiratory reviews. 5 Suppl A:S107-12 [PMID] 14980253.
View on: PubMed
2004
Methacholine challenge testing: comparison of the two American Thoracic Society-recommended methods.
Chest. 125(2):453-8 [PMID] 14769724.
View on: PubMed
2004
Response to inhaled albuterol during nocturnal asthma.
The Journal of allergy and clinical immunology. 113(6):1058-62 [PMID] 15208585.
View on: PubMed
2003
Are inhaled corticosteroids effective for acute exacerbations of asthma in children?
The Journal of pediatrics. 142(2 Suppl):S26-32; discussion S32 [PMID] 12584517.
View on: PubMed
2003
Levalbuterol is not more cost-effective than albuterol for COPD.
Chest. 124(3):1176; author reply 1176-8 [PMID] 12970057.
View on: PubMed
2003
Levalbuterol.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 91(6):587-8; author reply 588 [PMID] 14700446.
View on: PubMed
2003
Management of exercise-induced bronchospasm in children.
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG. 8(1):13-21 [DOI] 10.5863/1551-6776-8.1.13. [PMID] 23300391.
2003
Selecting a systemic corticosteroid for acute asthma in young children.
The Journal of pediatrics. 142(2 Suppl):S40-4 [PMID] 12584519.
View on: PubMed
2003
Self-administration at school of prescribed medications for asthma and anaphylaxis.
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG. 8(4):250-1 [DOI] 10.5863/1551-6776-8.4.250. [PMID] 23118680.
2002
Stability of frozen methacholine solutions in unit-dose syringes for bronchoprovocation.
Chest. 121(5):1634-7 [PMID] 12006455.
View on: PubMed
2002
Pharmacoeconomic studies of asthma controller drugs: marketing gimmick or icing on the cake?
Pharmacotherapy. 22(2):131-3 [PMID] 11837550.
View on: PubMed
2002
Levalbuterol has not been established to have therapeutic advantage over racemic albuterol.
The Journal of allergy and clinical immunology. 110(2):325; author reply 325-8 [PMID] 12170277.
View on: PubMed
2002
Accuracy of three electronic monitors for metered-dose inhalers.
Chest. 121(3):871-6 [PMID] 11888975.
View on: PubMed
2002
Differences in inhaled fluticasone bioavailability between holding chambers in children with asthma.
Pharmacotherapy. 22(8):947-53 [PMID] 12173797.
View on: PubMed
2002
Asthma therapies and Churg-Strauss syndrome.
The Journal of allergy and clinical immunology. 109(1):S1-19 [PMID] 11799357.
View on: PubMed
2002
Efficacy of calcium channel blockers as maintenance therapy for asthma.
British journal of clinical pharmacology. 53(3):243-9 [PMID] 11874387.
View on: PubMed
2001
Adherence to oral montelukast and inhaled fluticasone in children with persistent asthma.
Pharmacotherapy. 21(12):1464-7 [PMID] 11765298.
View on: PubMed
2001
Intervention strategies for children poorly adherent with asthma medications; one center’s experience.
Clinical pediatrics. 40(5):253-8 [PMID] 11388674.
View on: PubMed
2001
Pulmonary function response to EDTA, an additive in nebulized bronchodilators.
The Journal of allergy and clinical immunology. 107(1):68-72 [PMID] 11149993.
View on: PubMed
2000
Telephoning the patient’s pharmacy to assess adherence with asthma medications by measuring refill rate for prescriptions.
The Journal of pediatrics. 136(4):532-6 [PMID] 10753254.
View on: PubMed
2000
Practical pharmacotherapy for pediatric asthma.
Pediatric annals. 29(12):768-73 [PMID] 11131944.
View on: PubMed
2000
Levalbuterol nebulizer solution: is it worth five times the cost of albuterol?
Pharmacotherapy. 20(2):123-9 [PMID] 10678290.
View on: PubMed
2000
Dose selection and dosing interval determination for LTRA use in asthma.
Postgraduate medicine. 108(4 Suppl):12-21 [DOI] 10.3810/pgm.09.15.2000.suppl7.40. [PMID] 19667530.
1999
Bronchoconstrictor additives in bronchodilator solutions.
The Journal of allergy and clinical immunology. 104(2 Pt 2):S53-60 [PMID] 10452789.
View on: PubMed
1999
The effect of Cys LT1 receptor blockade on airway responses to allergen.
Pharmacotherapy. 19(11):1243-51 [PMID] 10555930.
View on: PubMed
1999
Degradation of histamine solutions used for bronchoprovocation.
Chest. 115(1):194-9 [PMID] 9925084.
View on: PubMed
1997
New frontiers in asthma therapy: leukotriene receptor antagonists and 5-lipoxygenase inhibitors. Introduction.
Pharmacotherapy. 17(1 Pt 2):1S-2S [PMID] 9017782.
View on: PubMed
1997
Reliability of the Medtrac MDI Chronolog.
The Journal of allergy and clinical immunology. 100(4):488-91 [PMID] 9338542.
View on: PubMed
1997
Use of allergen bronchoprovocation to screen drugs for anti-asthma activity.
Pharmacotherapy. 17(1 Pt 2):39S-49S [PMID] 9017787.
View on: PubMed
1997
Zafirlukast for chronic asthma: convenient and generally safe, but is it effective?
The Annals of pharmacotherapy. 31(9):1084-6 [PMID] 9296252.
View on: PubMed
1996
Zileuton: a new therapy for asthma or just the first of a new class of drugs.
The Annals of pharmacotherapy. 30(7-8):873-5 [PMID] 8826576.
View on: PubMed
1995
Revised FDA labeling guideline for theophylline oral dosage forms.
Pharmacotherapy. 15(4):409-27 [PMID] 7479193.
View on: PubMed
1995
Theophylline attenuation of airway responses to allergen: comparison with cromolyn metered-dose inhaler.
The Journal of allergy and clinical immunology. 95(2):505-14 [PMID] 7852666.
View on: PubMed
1995
Therapeutic equivalence of a generic slow-release theophylline tablet.
Pharmacotherapy. 15(1):26-35 [PMID] 7739942.
View on: PubMed
1994
Bioequivalence of a generic slow-release theophylline tablet in children.
The Journal of pediatrics. 125(6 Pt 1):987-91 [PMID] 7996375.
View on: PubMed
1993
Efficacy and safety of antihistamines and expectorants in nonprescription cough and cold preparations.
Pharmacotherapy. 13(2):154-8 [PMID] 8097037.
View on: PubMed
1993
Efficacy of intravenously administered theophylline in children hospitalized with severe asthma.
The Journal of pediatrics. 122(3):470-6 [PMID] 8441108.
View on: PubMed
1993
Emergency department treatment of severe asthma. Metered-dose inhaler plus holding chamber is equivalent in effectiveness to nebulizer.
Chest. 103(3):665-72 [PMID] 8449049.
View on: PubMed
1993
Generic and alternative brand-name pharmaceutical equivalents: select with caution.
American journal of hospital pharmacy. 50(2):323-9 [PMID] 8480793.
View on: PubMed
1993
Selecting a decongestant.
Pharmacotherapy. 13(6 Pt 2):129S-134S; discussion 143S [PMID] 7507590.
View on: PubMed
1993
Does aminophylline benefit adults admitted to the hospital for an acute exacerbation of asthma?
Annals of internal medicine. 119(12):1155-60 [PMID] 8239245.
View on: PubMed
1992
Evaluation of a generic albuterol metered-dose inhaler: importance of priming the MDI.
Annals of allergy. 68(2):169-74 [PMID] 1739192.
View on: PubMed
1992
Relative amount of albuterol delivered to lung receptors from a metered-dose inhaler and nebulizer solution. Bioassay by histamine bronchoprovocation.
Chest. 101(2):309-15 [PMID] 1310456.
View on: PubMed
1992
The effect of inhaled gallopamil, a potent calcium channel blocker, on the late-phase response in subjects with allergic asthma.
The Journal of allergy and clinical immunology. 89(3):688-95 [PMID] 1545089.
View on: PubMed
1991
Inhaled verapamil-induced bronchoconstriction in mild asthma.
Chest. 100(1):17-22 [PMID] 2060339.
View on: PubMed
1990
Treatment failure after substitution of generic pancrelipase capsules. Correlation with in vitro lipase activity.
JAMA. 263(18):2459-61 [PMID] 2329633.
View on: PubMed
1989
Measurement of plasma prednisolone level to evaluate a prednisone treatment failure in an adolescent with Crohn’s disease.
Journal of pediatric gastroenterology and nutrition. 8(3):404-7 [PMID] 2709273.
View on: PubMed
1989
Clinical relevance of the interaction of theophylline with diltiazem or nifedipine.
Chest. 95(2):309-13 [PMID] 2914480.
View on: PubMed
1988
Bioavailability of a slow-release theophylline capsule given twice daily to preschool children with chronic asthma: comparison with liquid theophylline.
Pediatrics. 81(1):116-20 [PMID] 3336577.
View on: PubMed
1988
Clinical assessment of an enzyme immunoassay (EMIT) for measurement of serum salicylate.
Journal of clinical pharmacy and therapeutics. 13(2):131-8 [PMID] 3292549.
View on: PubMed
1988
Death of a child associated with multiple overdoses of acetaminophen.
Clinical pharmacy. 7(5):391-7 [PMID] 3383545.
View on: PubMed
1988
Dose response of inhaled gallopamil (D600), a calcium channel blocker, in attenuating airway reactivity to methacholine and exercise.
The Journal of allergy and clinical immunology. 81(5 Pt 1):912-8 [PMID] 3286722.
View on: PubMed
1988
Dose-response of inhaled diltiazem on airway reactivity to methacholine and exercise in subjects with mild asthma.
Clinical pharmacology and therapeutics. 43(4):387-92 [PMID] 3281775.
View on: PubMed
1988
Duration of protection of calcium channel blockers against exercise-induced bronchospasm: comparison of oral diltiazem and inhaled gallopamil.
European journal of clinical pharmacology. 34(6):555-9 [PMID] 3169109.
View on: PubMed
1988
Evaluation of an office method of measuring theophylline serum concentrations.
The Journal of allergy and clinical immunology. 82(1):30-4 [PMID] 3392368.
View on: PubMed
1988
Relative efficacy of phenytoin and phenobarbital for the prevention of theophylline-induced seizures in mice.
Annals of emergency medicine. 17(10):1024-8 [PMID] 3177989.
View on: PubMed
1988
The effects of nalmefene, a potent oral opiate antagonist, on exercise-induced bronchospasm.
The Journal of allergy and clinical immunology. 82(6):1037-41 [PMID] 3204249.
View on: PubMed
1987
The effect of oral diltiazem on airway reactivity to methacholine and exercise in subjects with mild intermittent asthma.
The American review of respiratory disease. 136(5):1179-82 [PMID] 3314613.
View on: PubMed
1981
Effect of erythromycin on theophylline kinetics.
The Journal of allergy and clinical immunology. 68(6):427-31 [PMID] 7031111.
View on: PubMed

Grants

Aug 2014 – Jul 2016
A Three-week, Multicenter, Randomized, Double-blind, Placebo-controlled, Chronic-dose Safety and Efficacy Study of Albuterol Mulit-dose Dry Powder Inhaler (MDPI) Relative to Placebo in Pediatric Asmathics
Role: Principal Investigator
Funding: PHARMACEUTICAL RES ASSO via TEVA PHARMACEUTICALS USA
May 2014 – Jul 2016
A 26 Week, Randomized, Active-controlled Safety Study of Double-blind Formoterol Fumarate in Free Combination with an Inhaled Corticosteroid Versus an Inhaled Corticosteroid in Adolescent and Adult Patients with Persistent Asthma
Role: Principal Investigator
Funding: NOVARTIS PHARMACEUTICALS CORP
Aug 2012 – Feb 2016
A 6-month Safety and Benefit Study of Inhaled Fluticasone Propionate/Salmeterol Combination versus Inhaled Fluticasone Propionate in the Treatment of 6,200 Pediatric Subjects 4-11 Years Old with Persistent Asthma
Role: Principal Investigator
Funding: PAREXEL INTERNATIONAL CORP via GLAXO SMITHKLINE
Jan 2002 – Jun 2017
02013155
Role: Principal Investigator
Funding: UF RESEARCH FOU MISC

Education

Pharm.D. , clinical pharmacy
1969 · University of Southern California

Teaching Profile

Courses Taught
2011-2014
PHA5782 Pharmacotherapy 2
2011-2013
PHA5108L Pharmaceu Skls Lab 1
2013
PHA5907 Research in Phar Prac
2012
PHA3931 Honors Seminar in Pharmaceutical Research: In Search of Magic Bullets
2011
PHA5890 Intro Women’S Health

Contact Details

Emails: