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UF Health University of Florida

College of Pharmacy

UNIVERSITY of FLORIDA

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Leslie Hendeles

Leslie Hendeles Pharm.D.

Professor Emeritus

Department: Pharmacotherapy & Translational Research
Business Email: hendeles@cop.ufl.edu

About Leslie Hendeles

Dr. Hendeles is a Professor Emeritus in the College of Pharmacy and also in the Department of Pediatrics at the University of Florida. Among his current research interests are the improvement of adherence to asthma medications and delivery of inhaled drugs to young children. He is a consultant to FDA’s Pulmonary Division, and previously served on the Coordinating Committee of NIH’s Asthma Education Program, as well as CDC’s Expert Panel on Asthma Guidelines for Emergency Medical Services. Dr. Hendeles provides advice on drug therapy and teaches in the Pediatric Pulmonary Clinic at the University of Florida.

Publications

2019
A Statewide Study of the Epidemiology of Emergency Medical Services' Management of Pediatric Asthma
Pediatric Emergency Care
2018
Direct Observed Therapy of Inhaled Corticosteroids for Asthma at School or Daycare
Pediatric Allergy Immunology and Pulmonology
2018
Randomized, Double-Blind, Crossover, Clinical-End-Point Pilot Study to Examine the Use of Exhaled Nitric Oxide as a Bioassay for Dose Separation of Inhaled Fluticasone Propionate
Journal of Clinical Pharmacology
2018
Nonprescription Medications for Respiratory Symptoms: Facts and Marketing Fictions
Allergy and Asthma Proceedings
2017
Benzalkonium Chloride: a Bronchoconstricting Preservative in Continuous Albuterol Nebulizer Solutions
Pharmacotherapy
2016
Bioassay of Salmeterol in Children Using Methacholine Challenge With Impulse Oscillometry
Pediatric Pulmonology
2015
Application of Multicategory Exposure Marginal Structural Models To Investigate the Association Between Long-Acting Beta-Agonists and Prescribing of Oral Corticosteroids for Asthma Exacerbations in the Clinical Practice Research Datalink
2015
Pharmacokinetics of Orally Inhaled Drug Products
Aaps Journal
2015
Pharmacodynamic Studies To Demonstrate Bioequivalence of Oral Inhalation Products
Aaps Journal
2015
Omalizumab Therapy for Asthma Patients With Poor Adherence To Inhaled Corticosteroid Therapy
Annals of Allergy Asthma & Immunology
2014
Nonprescription Racemic Epinephrine for Asthma
2014
Comparison of Rates of Prescribing Oral Corticosteroids for Asthma Exacerbations Between Step-Down Therapy Approaches Among Initiators of Inhaled Corticosteroids and Long-Acting Beta-Agonist Combination Therapy
2013
Long-Acting Beta-Agonists and Asthma Exacerbations Requiring Short Courses of Oral Corticosteroids: a Multi-Category Exposure Marginal Structural Models Analysis
2012
Delivery of Medications By Metered Dose Inhaler Through a Chamber/Mask To Young Children With Asthma
Pediatric Allergy Immunology and Pulmonology
2012
Bioavailability of Inhaled Fluticasone Propionate Via Chambers/Masks in Young Children
2012
Response To Albuterol Mdi Delivered Through An Anti-Static Chamber During Nocturnal Bronchospasm
Respiratory Care
2011
Systemic Exposure To Fluticasone Mdi Delivered Through Antistatic Chambers
2011
Response To Albuterol Delivered Through An Anti-Static Valved Holding Chamber During Nocturnal Bronchospasm
2011
Methacholine Challenge as a Clinical Bioassay of Pulmonary Delivery of a Long-Acting Beta(2)-Adrenergic Agonist
Pharmacotherapy
2010
Pancreatic Enzyme Products
Pediatric Allergy Immunology and Pulmonology
2010
Reply To Discussion of `Empirical Vs Natural Weighting in Random Effects Meta-Analysis'
Statistics in Medicine
2007
Anti-immunoglobulin E therapy with omalizumab for asthma.
Annals of Pharmacotherapy
2007
Withdrawal of albuterol inhalers containing chlorofluorocarbon propellants.
New England Journal of Medicine
2007
Efficacy and safety of oral phenylephrine: systematic review and meta-analysis.
Annals of Pharmacotherapy
2005
Automatic replacement of albuterol nebulizer therapy by metered-dose inhaler and valved holding chamber.
American Journal of Health-System Pharmacy
2005
Response to nonprescription epinephrine inhaler during nocturnal asthma.
Annals of Allergy Asthma & Immunology
2004
Response to inhaled albuterol during nocturnal asthma.
2004
Evaluation of cytokine modulators for asthma.
Paediatric respiratory reviews
2003
Selecting a systemic corticosteroid for acute asthma in young children.
Journal of Pediatrics
2003
Are inhaled corticosteroids effective for acute exacerbations of asthma in children?
Journal of Pediatrics
2002
Stability of frozen methacholine solutions in unit-dose syringes for bronchoprovocation.
Chest
2001
Adherence to oral montelukast and inhaled fluticasone in children with persistent asthma.
Pharmacotherapy
1997
Zafirlukast for chronic asthma: convenient and generally safe, but is it effective?
Annals of Pharmacotherapy

Grants

August 2014 – July 2016
A Three-week, Multicenter, Randomized, Double-blind, Pla
PHARMACEUTICAL RES ASSO · Principal Investigator
May 2014 – July 2016
A 26 Week, Randomized, Active-controlled Safety Study of
NOVARTIS PHARMACEUTICALS CORP · Principal Investigator
August 2012 – February 2016
A 6-month Safety and Benefit Study of Inhaled Fluticason
PAREXEL INTERNATIONAL CORP · Principal Investigator
January 2002 – June 2017
MISCELLANEOUS RESIDUAL
UF RESEARCH FOU MISC · Principal Investigator