Scott W Harden

Scott W Harden, D.M.D., Ph.D.

Research Scientist

Department: Pharmacodynamics
Business Phone: (352) 273-7704
Business Email: swharden@ufl.edu

About Scott W Harden

Scott W Harden, D.M.D., Ph.D., originally studied biology at the University of Central Florida in Orlando, where he received a Master of Science in molecular biology and microbiology. After moving to Gainesville for dental school, Scott entered the DMD/PhD program and completed a dental degree while also earning a PhD in the field of Neuroscience. As a scientist with academic and clinical training, Scott now uses advanced optical and electrophysiological techniques (such as whole-cell patch-clamp, optogenetics, and multi-photon calcium imaging) to pursue his core research goals involving identification and characterization of novel neurohormonal signaling pathways in the brain. Scott’s interest in cellular neurophysiology and affinity for technology lead him to adapt new and emerging electrophysiological, optical, and computational techniques to pursue answers for biological questions which lie at the intersection of science, medicine, and technology.

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-0757-1979

Publications

2020
Region-specific effects of HIV-1 Tat on intrinsic electrophysiological properties of pyramidal neurons in mouse prefrontal cortex and hippocampus.
Journal of neurophysiology. 123(4):1332-1341 [DOI] 10.1152/jn.00029.2020. [PMID] 32101482.
2020
Endogenous oxytocin inhibits hypothalamic corticotrophin-releasing hormone neurones following acute hypernatraemia.
Journal of neuroendocrinology. 32(3) [DOI] 10.1111/jne.12839. [PMID] 32133707.
2020
An Angiotensin-responsive Connection from the Lamina Terminalis to the Paraventricular Nucleus of the Hypothalamus Evokes Vasopressin Secretion to Increase Blood Pressure in Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience. [DOI] 10.1523/JNEUROSCI.1600-20.2020. [PMID] 33328294.
2019
Oxytocin Receptors Are Expressed by Glutamatergic Prefrontal Cortical Neurons That Selectively Modulate Social Recognition.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(17):3249-3263 [DOI] 10.1523/JNEUROSCI.2944-18.2019. [PMID] 30804095.
2019
Optogenetic dissection of basolateral amygdala contributions to intertemporal choice in young and aged rats.
eLife. 8 [DOI] 10.7554/eLife.46174. [PMID] 31017572.
2016
Oxytocin depolarizes fast-spiking hilar interneurons and induces GABA release onto mossy cells of the rat dentate gyrus.
Hippocampus. 26(9):1124-39 [DOI] 10.1002/hipo.22595. [PMID] 27068005.
2014
A method for high purity intestinal epithelial cell culture from adult human and murine tissues for the investigation of innate immune function.
Journal of immunological methods. 414:20-31 [DOI] 10.1016/j.jim.2014.08.002. [PMID] 25193428.
2013
Augmented LPS responsiveness in type 1 diabetes-derived osteoclasts.
Journal of cellular physiology. 228(2):349-61 [DOI] 10.1002/jcp.24138. [PMID] 22718269.
2010
Structural remodeling of vagal afferent innervation of aortic arch and nucleus ambiguus (NA) projections to cardiac ganglia in a transgenic mouse model of type 1 diabetes (OVE26).
The Journal of comparative neurology. 518(14):2771-93 [DOI] 10.1002/cne.22363. [PMID] 20506475.
2010
Maternal diabetes increases small conductance Ca2+-activated K+ (SK) currents that alter action potential properties and excitability of cardiac motoneurons in the nucleus ambiguus.
Journal of neurophysiology. 104(4):2125-38 [DOI] 10.1152/jn.00671.2009. [PMID] 20668269.
2010
Impairment of baroreflex control of heart rate in conscious transgenic mice of type 1 diabetes (OVE26).
Autonomic neuroscience : basic & clinical. 152(1-2):67-74 [DOI] 10.1016/j.autneu.2009.09.020. [PMID] 19910264.
2010
Impairment of baroreflex control of heart rate and structural changes of cardiac ganglia in conscious streptozotocin (STZ)-induced diabetic mice.
Autonomic neuroscience : basic & clinical. 155(1-2):39-48 [DOI] 10.1016/j.autneu.2010.01.004. [PMID] 20171940.
2009
Vagal afferent innervation and remodeling in the aortic arch of young-adult fischer 344 rats following chronic intermittent hypoxia.
Neuroscience. 164(2):658-66 [DOI] 10.1016/j.neuroscience.2009.06.066. [PMID] 19580847.
2009
Impaired baroreflex control of renal sympathetic nerve activity in type 1 diabetic mice (OVE26).
Neuroscience. 161(1):78-85 [DOI] 10.1016/j.neuroscience.2009.02.083. [PMID] 19303918.
2009
Diabetes induces neural degeneration in nucleus ambiguus (NA) and attenuates heart rate control in OVE26 mice.
Experimental neurology. 220(1):34-43 [DOI] 10.1016/j.expneurol.2009.07.006. [PMID] 19615367.
2009
Chronic intermittent hypoxia impairs heart rate responses to AMPA and NMDA and induces loss of glutamate receptor neurons in nucleus ambiguous of F344 rats.
American journal of physiology. Regulatory, integrative and comparative physiology. 296(2):R299-308 [DOI] 10.1152/ajpregu.90412.2008. [PMID] 19020286.

Education

Ph.D.
2016 · University of Florida College of Medicine
D.M.D.
2016 · University of Florida College of Dentistry
M.S.
2009 · University of Central Florida College of Medicine

Contact Details

Phones:
Business:
(352) 273-7704
Emails:
Business:
swharden@ufl.edu