Scott W Harden

Scott W Harden, D.M.D., Ph.D.

Research Scientist

Department: Pharmacodynamics
Business Phone: (352) 273-7704
Business Email:

About Scott W Harden

Scott W Harden, D.M.D., Ph.D., originally studied biology at the University of Central Florida in Orlando, where he received a Master of Science in molecular biology and microbiology. After moving to Gainesville for dental school, Scott entered the DMD/PhD program and completed a dental degree while also earning a PhD in the field of Neuroscience. As a scientist with academic and clinical training, Scott now uses advanced optical and electrophysiological techniques (such as whole-cell patch-clamp, optogenetics, and multi-photon calcium imaging) to pursue his core research goals involving identification and characterization of novel neurohormonal signaling pathways in the brain. Scott’s interest in cellular neurophysiology and affinity for technology lead him to adapt new and emerging electrophysiological, optical, and computational techniques to pursue answers for biological questions which lie at the intersection of science, medicine, and technology.

Research Profile

Open Researcher and Contributor ID (ORCID)



Region-specific effects of HIV-1 Tat on intrinsic electrophysiological properties of pyramidal neurons in mouse prefrontal cortex and hippocampus.
Journal of neurophysiology. 123(4):1332-1341 [DOI] 10.1152/jn.00029.2020. [PMID] 32101482.
Endogenous oxytocin inhibits hypothalamic corticotrophin-releasing hormone neurones following acute hypernatraemia.
Journal of neuroendocrinology. 32(3) [DOI] 10.1111/jne.12839. [PMID] 32133707.
An Angiotensin-responsive Connection from the Lamina Terminalis to the Paraventricular Nucleus of the Hypothalamus Evokes Vasopressin Secretion to Increase Blood Pressure in Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience. [DOI] 10.1523/JNEUROSCI.1600-20.2020. [PMID] 33328294.
Oxytocin Receptors Are Expressed by Glutamatergic Prefrontal Cortical Neurons That Selectively Modulate Social Recognition.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(17):3249-3263 [DOI] 10.1523/JNEUROSCI.2944-18.2019. [PMID] 30804095.
Optogenetic dissection of basolateral amygdala contributions to intertemporal choice in young and aged rats.
eLife. 8 [DOI] 10.7554/eLife.46174. [PMID] 31017572.
Oxytocin depolarizes fast-spiking hilar interneurons and induces GABA release onto mossy cells of the rat dentate gyrus.
Hippocampus. 26(9):1124-39 [DOI] 10.1002/hipo.22595. [PMID] 27068005.
A method for high purity intestinal epithelial cell culture from adult human and murine tissues for the investigation of innate immune function.
Journal of immunological methods. 414:20-31 [DOI] 10.1016/j.jim.2014.08.002. [PMID] 25193428.
Augmented LPS responsiveness in type 1 diabetes-derived osteoclasts.
Journal of cellular physiology. 228(2):349-61 [DOI] 10.1002/jcp.24138. [PMID] 22718269.
Structural remodeling of vagal afferent innervation of aortic arch and nucleus ambiguus (NA) projections to cardiac ganglia in a transgenic mouse model of type 1 diabetes (OVE26).
The Journal of comparative neurology. 518(14):2771-93 [DOI] 10.1002/cne.22363. [PMID] 20506475.
Maternal diabetes increases small conductance Ca2+-activated K+ (SK) currents that alter action potential properties and excitability of cardiac motoneurons in the nucleus ambiguus.
Journal of neurophysiology. 104(4):2125-38 [DOI] 10.1152/jn.00671.2009. [PMID] 20668269.
Impairment of baroreflex control of heart rate in conscious transgenic mice of type 1 diabetes (OVE26).
Autonomic neuroscience : basic & clinical. 152(1-2):67-74 [DOI] 10.1016/j.autneu.2009.09.020. [PMID] 19910264.
Impairment of baroreflex control of heart rate and structural changes of cardiac ganglia in conscious streptozotocin (STZ)-induced diabetic mice.
Autonomic neuroscience : basic & clinical. 155(1-2):39-48 [DOI] 10.1016/j.autneu.2010.01.004. [PMID] 20171940.
Vagal afferent innervation and remodeling in the aortic arch of young-adult fischer 344 rats following chronic intermittent hypoxia.
Neuroscience. 164(2):658-66 [DOI] 10.1016/j.neuroscience.2009.06.066. [PMID] 19580847.
Impaired baroreflex control of renal sympathetic nerve activity in type 1 diabetic mice (OVE26).
Neuroscience. 161(1):78-85 [DOI] 10.1016/j.neuroscience.2009.02.083. [PMID] 19303918.
Diabetes induces neural degeneration in nucleus ambiguus (NA) and attenuates heart rate control in OVE26 mice.
Experimental neurology. 220(1):34-43 [DOI] 10.1016/j.expneurol.2009.07.006. [PMID] 19615367.
Chronic intermittent hypoxia impairs heart rate responses to AMPA and NMDA and induces loss of glutamate receptor neurons in nucleus ambiguous of F344 rats.
American journal of physiology. Regulatory, integrative and comparative physiology. 296(2):R299-308 [DOI] 10.1152/ajpregu.90412.2008. [PMID] 19020286.


2016 · University of Florida College of Medicine
2016 · University of Florida College of Dentistry
2009 · University of Central Florida College of Medicine

Contact Details

(352) 273-7704