Yan Gong, Ph.D.
Associate Professor
Department:
Pharmacotherapy & Translational Research
Business Phone:
(352) 273-6297
Business Email:
gong@cop.ufl.edu
About Yan Gong
Yan Gong, Ph.D., is an Associate Professor in the Department of Pharmacotherapy and Translational Research at the University of Florida (UF) College of Pharmacy and the UF Center for Pharmacogenomics and Precision Medicine. Dr. Gong received a Ph.D. in Pharmaceutics in 2004 from Department of Pharmaceutics, College of Pharmacy at UF. She also obtained a Master’s Degree in Statistics in 2003 from UF Department of Statistics. Before joining the UF faculty in 2005, she completed one year of post-doctoral Fellowship in Cardiovascular Pharmacogenomics at the UF Center for Pharmacogenomics.
Dr. Gong’s research focuses on pharmacogenomics of efficacy and adverse response of antihypertensives medications, and pharmacogenomics of serious adverse drug events such as medication-related osteonecrosis of the jaw (MRONJ) and cardiotoxicities related to cancer therapies (Cardio-Oncology). Dr. Gong has authored over 170 peer-reviewed publications.
In addition to research, Dr. Gong has been involved in teaching multiple graduate level and professional level courses at the UF College of Pharmacy and College of Medicine. She is currently the course co-coordinator for Pharmacogenomic and Genomic Data Analysis (PHA6449), a required graduate level course for the Department of Pharmacotherapy and Translational Research at the UF College of Pharmacy.
Teaching Profile
Courses Taught
2019-2020,2022-2024
PHA7979 Advanced Research
2020
PHA7980 Research for Doctoral Dissertation
2020-2021
PHA7939 Journal Colloquy in Pharmacodynamics
2020-2024
PHA6910 Supervised Research
2012,2014-2016,2016-2020,2018-2024,2020-2024,2022-2024,2024
PHA6449 Pharmacogenomic and Genomic Data Analysis
2010-2015
PHA5719 Intro Quant Methods
2014
PHA5907 Research in Phar Prac
2021
PHA6935 Selected Topics in Pharmacy
2021-2022
PHA7900 Journal Club in Pharmaceutical Research
2022
PHA6971 Research for Master’s Thesis
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-8218-1620
Publications
2024
CYP2C19 Genotype Is Associated With Adverse Cardiovascular Outcomes in Black Patients Treated With Clopidogrel Undergoing Percutaneous Coronary Intervention
Journal of the American Heart Association.
13(12)
[DOI] 10.1161/jaha.123.033791.
2024
Differential Expression of Circulating miRNAs and Carfilzomib-Related Cardiovascular Adverse Events in Patients with Multiple Myeloma
International Journal of Molecular Sciences.
25(14)
[DOI] 10.3390/ijms25147795.
[PMID] 39063038.
2024
Effectiveness of Clopidogrel vs Alternative P2Y12 Inhibitors Based on the ABCD-GENE Score
Journal of the American College of Cardiology.
83(15):1370-1381
[DOI] 10.1016/j.jacc.2024.02.015.
[PMID] 38599713.
2024
Evaluating the Effect of Estimating Renal Function With the CKD‐EPI 2021 Equation on the ABCD‐GENE Score for Clopidogrel Response Prediction
Clinical Pharmacology & Therapeutics.
[DOI] 10.1002/cpt.3385.
2024
Implementation of a pharmacogenetic panel‐based test for pharmacotherapy‐based supportive care in an adult oncology clinic
Clinical and Translational Science.
17(7)
[DOI] 10.1111/cts.13890.
[PMID] 39046302.
2024
Integrated metabolomics analysis reveals mechanistic insights into variability in blood pressure response to thiazide diuretics and beta blockers
Clinical and Translational Science.
17(5)
[DOI] 10.1111/cts.13816.
[PMID] 38747311.
2024
Metabolomic signatures of carfilzomib‐related cardiotoxicity in patients with multiple myeloma
Clinical and Translational Science.
17(5)
[DOI] 10.1111/cts.13828.
[PMID] 38783568.
2024
Pharmacogenetic determinants of tenofovir diphosphate and lamivudine triphosphate concentrations in people with HIV/HBV coinfection.
Antimicrobial agents and chemotherapy.
68(9)
[DOI] 10.1128/aac.00549-24.
[PMID] 39078131.
2024
Precision Antiplatelet Therapy after Percutaneous Coronary Intervention (Precision PCI) Registry – Informing optimal antiplatelet strategies
Clinical and Translational Science.
17(8)
[DOI] 10.1111/cts.70004.
[PMID] 39150361.
2024
Research summary of poster presentations at the 2023 Florida cardio-oncology symposium.
American heart journal plus : cardiology research and practice.
37
[DOI] 10.1016/j.ahjo.2023.100348.
[PMID] 38510509.
2024
Use of CYP2D6 Inhibitors with CYP2D6 Opioids: Association with Emergency Department Visits for Pain
Clinical Pharmacology & Therapeutics.
[DOI] 10.1002/cpt.3314.
2023
Adverse Cardiovascular Events Associated With Cyclin‐Dependent Kinase 4/6 Inhibitors in Patients With Metastatic Breast Cancer
Journal of the American Heart Association.
12(12)
[DOI] 10.1161/jaha.123.029361.
2023
CYP2D6-guided opioid therapy for adults with cancer pain: A randomized implementation clinical trial.
Pharmacotherapy.
43(12):1286-1296
[DOI] 10.1002/phar.2875.
[PMID] 37698371.
2023
Evaluation of Potential Racial Disparities in CYP2C19‐Guided P2Y12 Inhibitor Prescribing After Percutaneous Coronary Intervention
Clinical Pharmacology & Therapeutics.
113(3):615-623
[DOI] 10.1002/cpt.2776.
[PMID] 36306392.
2023
Racial and Ethnic Differences in Cardiac Surveillance Evaluation of Patients Treated With Anthracycline‐Based Chemotherapy
Journal of the American Heart Association.
12(10)
[DOI] 10.1161/jaha.122.027981.
2023
Whole-Exome sequencing analysis identified TMSB10/TRABD2A locus to be associated with carfilzomib-related cardiotoxicity among patients with multiple myeloma.
Frontiers in cardiovascular medicine.
10
[DOI] 10.3389/fcvm.2023.1181806.
[PMID] 37408649.
2022
A randomized, cross‐over trial of metoprolol succinate formulations to evaluate PK and PD end points for therapeutic equivalence
Clinical and Translational Science.
15(7):1764-1775
[DOI] 10.1111/cts.13294.
[PMID] 35488487.
2022
Analysis of Biological Aging and Risks of All-Cause and Cardiovascular Disease-Specific Death in Cancer Survivors.
JAMA network open.
5(6)
[DOI] 10.1001/jamanetworkopen.2022.18183.
[PMID] 35731518.
2022
Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease: An Individual-Level Meta-Analysis.
Frontiers in physiology.
13
[DOI] 10.3389/fphys.2022.909870.
[PMID] 35812313.
2022
Cardiometabolic Consequences of Targeted Anticancer Therapies.
Journal of cardiovascular pharmacology.
80(4):515-521
[DOI] 10.1097/FJC.0000000000001149.
[PMID] 34654781.
2022
Cardiotoxicity as an adverse effect of immunomodulatory drugs and proteasome inhibitors in multiple myeloma: A network meta-analysis of randomized clinical trials.
Hematological oncology.
40(2):233-242
[DOI] 10.1002/hon.2959.
[PMID] 34940983.
2022
Genetic Contributors of Efficacy and Adverse Metabolic Effects of Chlorthalidone in African Americans from the Genetics of Hypertension Associated Treatments (GenHAT) Study.
Genes.
13(7)
[DOI] 10.3390/genes13071260.
[PMID] 35886043.
2022
Impact of the ABCD-GENE Score on Clopidogrel Clinical Effectiveness after PCI: A Multi-Site, Real-World Investigation.
Clinical pharmacology and therapeutics.
112(1):146-155
[DOI] 10.1002/cpt.2612.
[PMID] 35429163.
2022
Implementing a pragmatic clinical trial to tailor opioids for acute pain on behalf of the IGNITE ADOPT PGx investigators
Clinical and Translational Science.
15(10):2479-2492
[DOI] 10.1111/cts.13376.
[PMID] 35899435.
2022
Influence of Genetic West African Ancestry on Metabolomics among Hypertensive Patients
Metabolites.
12(9)
[DOI] 10.3390/metabo12090783.
[PMID] 36144188.
2021
A hybrid implementation-effectiveness randomized trial of CYP2D6-guided postoperative pain management.
Genetics in medicine : official journal of the American College of Medical Genetics.
23(4):621-628
[DOI] 10.1038/s41436-020-01050-4.
[PMID] 33420349.
2021
Adverse Cardiovascular Outcomes and Antihypertensive treatment: A Genome-Wide Interaction Meta-Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies (ICAPS).
Clinical pharmacology and therapeutics.
[DOI] 10.1002/cpt.2355.
[PMID] 34231218.
2021
Association of 1-Year Blood Pressure Variability With Long-term Mortality Among Adults With Coronary Artery Disease: A Post Hoc Analysis of a Randomized Clinical Trial.
JAMA network open.
4(4)
[DOI] 10.1001/jamanetworkopen.2021.8418.
[PMID] 33914047.
2021
Epigenetic Changes Associated With Anthracycline‐Induced Cardiotoxicity
Clinical and Translational Science.
14(1):36-46
[DOI] 10.1111/cts.12857.
[PMID] 32770710.
2021
Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality.
European heart journal.
42(18):1742-1756
[DOI] 10.1093/eurheartj/ehab107.
[PMID] 33748830.
2021
Genome-wide Association Study Identified Chromosome 8 Locus Associated with Medication-Related Osteonecrosis of the Jaw.
Clinical pharmacology and therapeutics.
110(6):1558-1569
[DOI] 10.1002/cpt.2397.
[PMID] 34390503.
2021
Implications of Polymorphisms in the BCKDK and GATA-4 Gene Regions on Stable Warfarin Dose in African Americans.
Clinical and translational science.
14(2):492-496
[DOI] 10.1111/cts.12939.
[PMID] 33278335.
2021
Lactate Dehydrogenase B and Pyruvate Oxidation Pathway Associated With Carfilzomib-Related Cardiotoxicity in Multiple Myeloma Patients: Result of a Multi-Omics Integrative Analysis.
Frontiers in cardiovascular medicine.
8
[DOI] 10.3389/fcvm.2021.645122.
[PMID] 33996940.
2021
Metabolomics Signature of Plasma Renin Activity and Linkage with Blood Pressure Response to Beta Blockers and Thiazide Diuretics in Hypertensive European American Patients.
Metabolites.
11(9)
[DOI] 10.3390/metabo11090645.
[PMID] 34564461.
2021
Newly diagnosed cardiovascular disease in patients treated with immune checkpoint inhibitors: a retrospective analysis of patients at an academic tertiary care center.
Cardio-oncology (London, England).
7(1)
[DOI] 10.1186/s40959-021-00097-9.
[PMID] 33736707.
2021
Optimizing Precision of Hypertension Care to Maximize Blood Pressure Control: A Pilot Study Utilizing a Smartphone App to Incorporate Plasma Renin Activity Testing.
Clinical and translational science.
14(2):617-624
[DOI] 10.1111/cts.12922.
[PMID] 33142006.
2021
Pharmacogenetic predictors of nevirapine pharmacokinetics in Ghanaian children living with HIV with or without TB coinfection.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.
92
[DOI] 10.1016/j.meegid.2021.104856.
[PMID] 33839311.
2020
Impact of the CYP2C19*17 allele on outcomes in patients receiving genotype-guided antiplatelet therapy after percutaneous coronary intervention.
Clinical Pharmacology & Therapeutics.
2020
Systolic blood pressure, heart rate, and outcomes in patients with coronary disease and heart failure.
.
7(1):123-129
2020
Association of Factor V Leiden with Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data.
Circulation.
July(13)
2020
Association of P2RX7 functional variants with localized aggressive periodontitis.
Journal of periodontal research.
55(1):32-40
[DOI] 10.1111/jre.12682.
[PMID] 31292966.
2020
Attended vs unattended systolic blood pressure measurement: A randomized comparison in patients with cardiovascular disease
The Journal of Clinical Hypertension.
22(11):1987-1992
[DOI] 10.1111/jch.14037.
[PMID] 32951360.
2020
Combination Antihypertensive Therapy Prescribing and Blood Pressure Control in a Real-World Setting.
American journal of hypertension.
33(4):316-324
[DOI] 10.1093/ajh/hpz196.
[PMID] 31853537.
2020
Cost-effectiveness of CYP2C19-guided antiplatelet therapy in patients with acute coronary syndrome and percutaneous coronary intervention informed by real-world data
The Pharmacogenomics Journal.
20(5):724-735
[DOI] 10.1038/s41397-020-0162-5.
[PMID] 32042096.
2020
Examination of Metoprolol Pharmacokinetics and Pharmacodynamics Across CYP2D6 Genotype-Derived Activity Scores.
CPT: pharmacometrics & systems pharmacology.
9(12):678-685
[DOI] 10.1002/psp4.12563.
[PMID] 33067866.
2020
Medication-Related Osteonecrosis of the Jaw in Cancer Patients: Result from the OneFlorida Clinical Research Consortium
Journal of Bone and Mineral Research.
37(12):2466-2471
[DOI] 10.1002/jbmr.4708.
[PMID] 36151778.
2020
Optimal systolic blood pressure and reduced long-term mortality in older hypertensive women with prior coronary events – An analysis from INVEST☆.
International Journal of Cardiology. Hypertension.
7
[DOI] 10.1016/j.ijchy.2020.100052.
[PMID] 33817619.
2020
Response to: Heterogeneous Treatment Response by Race Cannot Be Claimed in the Absence of Evidence.
American journal of hypertension.
33(2)
[DOI] 10.1093/ajh/hpz168.
[PMID] 31891170.
2020
Risk and Blood Pressure Control Rates Across the Spectrum of Coronary Artery Disease in Hypertensive Women: An Analysis from The INternational VErapamil SR-Trandolapril STudy (INVEST)
Journal of Womens Health.
29(2):158-166
2020
Risk and Blood Pressure Control Rates Across the Spectrum of Coronary Artery Disease in Hypertensive Women: An Analysis from The INternational VErapamil SR-Trandolapril STudy (INVEST).
Journal of women's health (2002).
29(2):158-166
[DOI] 10.1089/jwh.2018.7235.
[PMID] 31403360.
2020
SIRT1 Gene SNP rs932658 Is Associated With Medication-Related Osteonecrosis of the Jaw
Journal of Bone and Mineral Research.
36(2):347-356
[DOI] 10.1002/jbmr.4185.
[PMID] 32967053.
2020
Systolic blood pressure, heart rate, and outcomes in patients with coronary disease and heart failure.
ESC heart failure.
7(1):123-129
[DOI] 10.1002/ehf2.12534.
[PMID] 31840441.
2020
Systolic blood pressure, heart rate, and outcomes in patients with coronary disease and heart failure.
.
7(1):123-129
2019
Antihypertensive therapy prescribing patterns and correlates of blood pressure control among hypertensive patients with chronic kidney disease
The Journal of Clinical Hypertension.
21(1):91-101
[DOI] 10.1111/jch.13429.
[PMID] 30427124.
2019
Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events.
Circulation-Genomic and Precision Medicine.
12(4)
[DOI] 10.1161/CIRCGEN.119.002471.
[PMID] 30897348.
2019
CYP2D6-guided opioid therapy improves pain control in CYP2D6 intermediate and poor metabolizers: a pragmatic clinical trial.
Genetics in medicine : official journal of the American College of Medical Genetics.
21(8):1842-1850
[DOI] 10.1038/s41436-018-0431-8.
[PMID] 30670877.
2019
Effect of plasma MicroRNA on antihypertensive response to beta blockers in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) studies.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
131:93-98
[DOI] 10.1016/j.ejps.2019.02.013.
[PMID] 30753892.
2019
Genome Wide Analysis Approach Suggests Chromosome 2 Locus to be Associated with Thiazide and Thiazide Like-Diuretics Blood Pressure Response.
Scientific reports.
9(1)
[DOI] 10.1038/s41598-019-53345-5.
[PMID] 31754133.
2019
Genome-wide association analysis of common genetic variants of resistant hypertension.
The pharmacogenomics journal.
19(3):295-304
[DOI] 10.1038/s41397-018-0049-x.
[PMID] 30237584.
2019
Genome-Wide Meta-Analysis of Blood Pressure Response to β1-Blockers: Results From ICAPS (International Consortium of Antihypertensive Pharmacogenomics Studies).
Journal of the American Heart Association.
8(16)
[DOI] 10.1161/JAHA.119.013115.
[PMID] 31423876.
2019
Genomic Association Analysis Reveals Variants Associated With Blood Pressure Response to Beta-Blockers in European Americans.
Clinical and translational science.
12(5):497-504
[DOI] 10.1111/cts.12643.
[PMID] 31033190.
2019
Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers.
PloS one.
14(9)
[DOI] 10.1371/journal.pone.0221957.
[PMID] 31532792.
2019
Identifying Cancer Patients at Risk for Heart Failure Using Machine Learning Methods.
AMIA … Annual Symposium proceedings / AMIA Symposium. AMIA Symposium.
933-941
2019
MADEx: A System for Detecting Medications, Adverse Drug Events, and Their Relations from Clinical Notes.
Drug safety.
42(1):123-133
[DOI] 10.1007/s40264-018-0761-0.
[PMID] 30600484.
2019
Novel Implementation of Genotype-Guided Proton Pump Inhibitor Medication Therapy in Children: A Pilot, Randomized, Multisite Pragmatic Trial.
Clinical and translational science.
12(2):172-179
[DOI] 10.1111/cts.12589.
[PMID] 30341969.
2019
PCSK9 Inhibitor Use in the Real World: Data From the National Patient-Centered Research Network
Journal of the American Heart Association.
8(9)
[DOI] 10.1161/JAHA.118.011246.
[PMID] 31020929.
2019
Pharmacogenomics of osteonecrosis of the jaw.
Bone.
124:75-82
[DOI] 10.1016/j.bone.2019.04.010.
[PMID] 31022475.
2019
Plasma Renin Activity Is a Predictive Biomarker of Blood Pressure Response in European but not in African Americans With Uncomplicated Hypertension.
American journal of hypertension.
32(7):668-675
[DOI] 10.1093/ajh/hpz022.
[PMID] 30753254.
2019
Relationship Between ABCC4 SNPs and Hepatitis B Virus Suppression During Tenofovir-Containing Antiretroviral Therapy in Patients With HIV/HBV Coinfection.
Journal of acquired immune deficiency syndromes (1999. Online).
82(4):421-425
2019
Subsequent Event Risk in Individuals With Established Coronary Heart Disease.
Circulation-Genomic and Precision Medicine.
12(4)
[DOI] 10.1161/CIRCGEN.119.002470.
[PMID] 30896328.
2019
β2 -Adrenergic Receptor Gene Affects the Heart Rate Response of β-Blockers: Evidence From 3 Clinical Studies.
Journal of clinical pharmacology.
59(11):1462-1470
[DOI] 10.1002/jcph.1443.
[PMID] 31090079.
2018
A Genetic Score Associates With Pioglitazone Response in Patients With Non-alcoholic Steatohepatitis.
Frontiers in pharmacology.
9
[DOI] 10.3389/fphar.2018.00752.
[PMID] 30065651.
2018
Blood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies.
BMC medical genomics.
11(1)
[DOI] 10.1186/s12920-018-0370-x.
[PMID] 29925376.
2018
Clinical implementation of rapid CYP2C19 genotyping to guide antiplatelet therapy after percutaneous coronary intervention.
Journal of translational medicine.
16(1)
[DOI] 10.1186/s12967-018-1469-8.
[PMID] 29642909.
2018
Conflicting Meal Recommendations for Oral Oncology Drugs: Pose Risks to Patient Care?
European Journal of Clinical Pharmacology.
74(6):833-842
[DOI] 10.1007/s00228-018-2439-z.
2018
Design and rational for the precision medicine guided treatment for cancer pain pragmatic clinical trial.
Contemporary clinical trials.
68:7-13
[DOI] 10.1016/j.cct.2018.03.001.
[PMID] 29535047.
2018
Factors Affecting the Association of Proton Pump Inhibitors and Capecitabine Efficacy in Advanced Gastroesophageal Cancer.
JAMA oncology.
4(2)
[DOI] 10.1001/jamaoncol.2017.3407.
[PMID] 29098270.
2018
Genetic Variants Influencing Plasma Renin Activity in Hypertensive Patients From the PEAR Study (Pharmacogenomic Evaluation of Antihypertensive Responses).
Circulation. Genomic and precision medicine.
11(4)
[DOI] 10.1161/CIRCGEN.117.001854.
[PMID] 29650764.
2018
Genome Wide Association Study Identifies the HMGCS2 Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients.
Journal of the American Heart Association.
7(6)
[DOI] 10.1161/JAHA.117.007339.
[PMID] 29523524.
2018
Genome-Wide Association Approach Identified Novel Genetic Predictors of Heart Rate Response to β-Blockers.
Journal of the American Heart Association.
7(5)
[DOI] 10.1161/JAHA.117.006463.
[PMID] 29478026.
2018
Genome-wide association study identifies pharmacogenomic loci linked with specific antihypertensive drug treatment and new-onset diabetes.
The pharmacogenomics journal.
18(1):106-112
[DOI] 10.1038/tpj.2016.67.
[PMID] 27670767.
2018
Implementation of Standardized Clinical Processes for TPMT Testing in a Diverse Multidisciplinary Population: Challenges and Lessons Learned.
Clinical and translational science.
11(2):175-181
[DOI] 10.1111/cts.12533.
[PMID] 29351371.
2018
Implementation of Standardized Clinical Processes for TPMT Testing in a Diverse Multidisciplinary Population: Challenges and Lessons Learned.
.
11(2):175-181
2018
Intensive blood pressure lowering reduces adverse cardiovascular outcomes among patients with high‐normal glucose: An analysis from the Systolic Blood Pressure Intervention Trial database
The Journal of Clinical Hypertension.
20(4):620-624
[DOI] 10.1111/jch.13247.
[PMID] 29532983.
2018
Mortality implications of lower DBP with lower achieved systolic pressures in coronary artery disease: long-term mortality results from the INternational VErapamil-trandolapril STudy US cohort.
.
36(2):419-427
2018
Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.
JACC. Cardiovascular interventions.
11(2):181-191
[DOI] 10.1016/j.jcin.2017.07.022.
[PMID] 29102571.
2018
Optimal Systolic Blood Pressure Target in Resistant and Non-Resistant Hypertension: A Pooled Analysis of Patient-Level Data from SPRINT and ACCORD.
The American journal of medicine.
131(12):1463-1472.e7
[DOI] 10.1016/j.amjmed.2018.08.005.
[PMID] 30142317.
2018
Radiographic bone loss and the risk of medication-related osteonecrosis of the jaw (MRONJ) in multiple myeloma patients-A retrospective case control study.
Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry.
38(6):356-361
[DOI] 10.1111/scd.12318.
[PMID] 30194738.
2018
SIRT1/HERC4 Locus Associated With Bisphosphonate-Induced Osteonecrosis of the Jaw: An Exome-Wide Association Analysis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
33(1):91-98
[DOI] 10.1002/jbmr.3285.
[PMID] 28856724.
2018
Targeted sequencing identifies a missense variant in the BEST3 gene associated with antihypertensive response to hydrochlorothiazide.
Pharmacogenetics and Genomics.
28(11):251-255
[DOI] 10.1097/FPC.0000000000000353.
[PMID] 30289819.
2018
Unanticipated Cardiotoxicity Associated with Targeted Anticancer Therapy in Patients with Hematologic Malignancies Patients: Natural History and Risk Factors.
Cardiovascular toxicology.
18(2):184-191
[DOI] 10.1007/s12012-017-9429-8.
[PMID] 29022233.
2017
Blood pressure response to metoprolol and chlorthalidone in European and African Americans with hypertension.
Journal of clinical hypertension (Greenwich, Conn.).
19(12):1301-1308
[DOI] 10.1111/jch.13094.
[PMID] 28940643.
2017
Blood pressure response to metoprolol and chlorthalidone in European and African Americans with hypertension.
Journal of Clinical Hypertension.
19(12):1301-1308
2017
Colorectal cancer stages transcriptome analysis
PLOS ONE.
12(11)
[DOI] 10.1371/journal.pone.0188697.
[PMID] 29182684.
2017
Genetic Variants Associated With Uncontrolled Blood Pressure on Thiazide Diuretic/β-Blocker Combination Therapy in the PEAR (Pharmacogenomic Evaluation of Antihypertensive Responses) and INVEST (International Verapamil-SR Trandolapril Study) Trials.
Journal of the American Heart Association.
6(11)
[DOI] 10.1161/JAHA.117.006522.
[PMID] 29097388.
2017
Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide.
Hypertension (Dallas, Tex. : 1979).
69(1):51-59
[PMID] 27802415.
2017
Genome-Wide Prioritization and Transcriptomics Reveal Novel Signatures Associated With Thiazide Diuretics Blood Pressure Response
Circulation-Cardiovascular Genetics.
10(1)
[DOI] 10.1161/CIRCGENETICS.116.001404.
2017
Long-term clinical response to treatment and maintenance of localized aggressive periodontitis: a cohort study.
Journal of clinical periodontology.
44(2):158-168
[DOI] 10.1111/jcpe.12640.
[PMID] 27767222.
2017
Pharmacogenetic Associations of β1-Adrenergic Receptor Polymorphisms With Cardiovascular Outcomes in the SPS3 Trial (Secondary Prevention of Small Subcortical Strokes).
Stroke.
48(5):1337-1343
[DOI] 10.1161/STROKEAHA.116.015936.
[PMID] 28351962.
2017
Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics.
Journal of the American Heart Association.
7(1)
[DOI] 10.1161/JAHA.117.006656.
[PMID] 29288159.
2017
Whole Transcriptome Sequencing Analyses Reveal Molecular Markers of Blood Pressure Response to Thiazide Diuretics.
Scientific reports.
7(1)
[DOI] 10.1038/s41598-017-16343-z.
[PMID] 29167564.
2016
A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration.
Hypertension (Dallas, Tex. : 1979).
68(3):621-9
[DOI] 10.1161/HYPERTENSIONAHA.116.07328.
[PMID] 27381900.
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Long-Term Mortality in Hypertensive Patients With Coronary Artery Disease: Results From the US Cohort of the International Verapamil (SR)/Trandolapril Study.
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Pharmacogenomics of Hypertension: a Genome-Wide, Placebo-Controlled Cross-Over Study, Using Four Classes of Antihypertensive Drugs
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2014 Eighth Joint National Committee Panel Recommendation for Blood Pressure Targets Revisited Results From the Invest Study
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A Pharmacogenomic Genome-Wide Association Study (Gwas) for New Onset Diabetes (Nod) in the International Verapamil Sr-Trandolapril Study (Invest)
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A Pharmacogenomic Genome-Wide Association Study for Adverse Cardiovascular Outcomes in the International Verapamil Sr-Trandolapril Study (Invest)
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Gene-Centric Meta-Analyses for Central Adiposity Traits in Up To 57 412 Individuals of European Descent Confirm Known Loci and Reveal Several Novel Associations
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Is Diabetes Mellitus-Linked Amino Acid Signature Associated With Beta-Blocker-Induced Impaired Fasting Glucose?
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Clinical Pharmacology & Therapeutics.
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Antihypertensive Medication Exposure and Adverse Glycemic Effects: An Evaluation of Fasting and Stimulated Glucose
Clinical Pharmacology & Therapeutics.
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Association of Fto With Hydrochlorothiazide (Hctz)-Induced Elevation in Uric Acid (Ua) in African American (Aa) Hypertensives in the Pharmacogenomic Evaluation of Antihypertensive Response (Pear) Study.
Clinical Pharmacology & Therapeutics.
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Cholesteryl Ester Transfer Protein (Cetp) Polymorphisms Affect Mrna Splicing, Hdl Levels, and Sex-Dependent Cardiovascular Risk
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Cyp2C9 Promoter Variable Number Tandem Repeat Polymorphism Regulates Mrna Expression in Human Livers
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G protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertension.
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Simple Prediction of Long-Term Mortality Among Hypertensive Patients With Coronary Artery Disease: New Data From An Extended Follow-Up of the International Verapamil-Sr/Trandolapril Study (Invest)
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Treatment-Resistant Blood Pressure Among Patients With Coronary Artery Disease – Cause for Concern: New Data From the Extended Follow-Up of the International Verapamail Sr-Trandolapril Study (Invest)
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Genetic Variation in the Calcium Signaling Pathway and Association With Outcomes in Hypertensive Coronary Artery Disease Patients
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Kcnj1 Snps Are Associated With Increased Fasting Glucose and Risk of New Onset Diabetes During Hctz Therapy
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Clinical Association of Variation in the Beta 2 Regulatory Subunit of the Voltage- Gated Calcium Channel (Cacnb2) With Outcomes in Hypertensive Coronary Artery Disease (Cad) Patients.
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Outcomes Among hypertensive patients with concomitant peripheral and coronary artery disease: findings from the INternational VErapamil-SR/Trandolapril STudy.
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Novel Promoter Polymorphisms in Angiotensin-I Converting Enzyme (Ace) Associated With Clinical Outcomes in Hypertensive Coronary Artery Disease (Cad) Patients.
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Jul 2024
ACTIVE
Cardiovascular Adverse Events Related to Aromatase Inhibitors in Breast Cancer
Role: Co-Investigator
Funding: FL BREAST CANCER FOU
Mar 2024
– Aug 2024
Cardiovascular Adverse Events Related to Aromatase Inhibitors in Female Breast Cancer
Role: Consultant
Funding: ARIZONA STATE UNIVERSITY
via NATL INST OF HLTH
Sep 2021
– Sep 2023
Toward a Precision Medicine Approach to Medication-Related Osteonecrosis of the Jaw
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Aug 2021
ACTIVE
A Multi-omics evaluation of Carfilzomib-related Cardiotoxicity
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Jun 2021
– Aug 2021
Replication of GenHAT GWAS signals in Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) and Genetic Epidemiology of Responses to Antihypertensives (GERA)
Role: Co-Investigator
Funding: UNIV OF ALABAMA BIRMINGHAM
via NATL INST OF HLTH
Jul 2020
ACTIVE
Precision antiplatelet therapy after percutaneous coronary intervention
Role: Other
Funding: NATL INST OF HLTH NHLBI
Sep 2018
ACTIVE
Pharmacokinetics of Anti-tuberculosis and Antiretroviral Drugs in Children
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Aug 2018
ACTIVE
Carboxylesterase 1 Genetic Variation and Methylphenidate in ADHD
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Apr 2017
– Jun 2024
HSC COM Matching Commitment
Role: Project Manager
Funding: UNIV OF FLORIDA
Apr 2017
– Jun 2021
OoR CTSI Institutional Matching Support
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Jul 2016
– Sep 2020
A stem cell tactic to promote personalized medicine
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
Jun 2016
– Aug 2018
Pharmacokinetics of Anti-tuberculosis and Antiretroviral Drugs in Children
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Oct 2015
– Mar 2019
OneFlorida Clinical Research Consortium Phase II
Role: Other
Funding: PATIENT-CENTERED OUTCOMES RES INST
Apr 2015
– Jun 2021
Clinical and Translational Science Institute (CTSI)
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Jun 2014
– Nov 2021
Mechanisms and Treatment Response of Aggressive Periodontitis in Children
Role: Project Manager
Funding: NATL INST OF HLTH NIDCR
Education
Ph.D.
2004
·
University of Florida
M.S.
2003
·
University of Florida
M.S.
1999
·
West China University of Medical Sciences
Contact Details
Phones:
- Business:
- (352) 273-6297
Emails:
- Business:
- gong@cop.ufl.edu
Addresses:
- Business Mailing:
-
UNIVERSITY OF FLORIDA HEALTH SCIENCE CENTER
PO BOX 100486
1600 SW ARCHER ROAD
GAINESVILLE FL 326100486 - Business Street:
-
MSB PG-27
1345 CENTER DR
GAINESVILLE FL 32610