Lina Cui

Lina Cui, Ph.D.

Assistant Professor

Department: Medicinal Chemistry
Business Phone: (352) 273-7090
Business Email:

About Lina Cui

Lina Cui, Ph.D., obtained her B.Sc. in chemistry from Nankai University (China) in 2003. She continued her study in the University of Alberta (Canada) and obtained her Ph.D. degree in Organic Chemistry and Glycobiology in 2009 under the direction of Prof. David R. Bundle, the founding Director of the Alberta Glycomics Centre. Following graduate school, Dr. Cui spent two years (2009-2010) as a postdoctoral fellow with Prof. Jean M.J. Fréchet at UC Berkeley. Her postdoctoral training continued at Stanford University School of Medicine (2011-2014), where she worked with Prof. Jianghong Rao in the Molecular Imaging Program at Stanford (MIPS) directed by Prof. Sanjiv Sam Gambhir. In 2015, Dr. Cui joined the faculty of the Department of Chemistry and Chemical Biology as a tenure-track Assistant Professor at the University of New Mexico and UNM Comprehensive Cancer Center. In August 2018, she was recruited to the University of Florida and was appointed as a tenure-track assistant professor in the College of Pharmacy.

Research Profile

The Cui lab explores the biochemical activities of glycan processing enzymes and develops therapeutic and diagnostic molecules or tools for various types of cancer and age-related diseases (e.g. diabetes, neurodegeneration, etc). The interdisciplinary program integrates organic chemistry, molecular and cellular biology, and molecular imaging. Our current research explores the biochemistry of heparanase, a key enzyme involved in the remodeling of extracellular matrix. We are developing molecular probes to study the precise modes of heparanase activity using molecular imaging, as well as diagnostic tools and drug molecules targeting heparanase and related enzymes. Our lab also develops molecular tools to detect senescence and DNA damage, and we have applied these molecules in various collaborative projects to explore the progression of diabetes, neurodegeneration and other age-related diseases.


May 2019 ACTIVE
Development of Diagnostic Tools for Metastatic Melanoma via Imaging of Heparanase Activity
US ARMY MED RES ACQUISITION · Principal Investigator
Aug 2018 ACTIVE
Probing the role of heparanase via in situ labeling
NATL INST OF HLTH NIGMS · Principal Investigator


Postdoctoral Fellow
2011-2014 · Stanford University School of Medicine
Postdoctoral Fellow
2009-2010 · University of California at Berkeley
2008 · University of Alberta
2003 · Nankai University

Contact Details

(352) 273-7090