Lina Cui

Lina Cui, Ph.D.

Assistant Professor

Department: Medicinal Chemistry
Business Phone: (352) 273-7090
Business Email: linacui@cop.ufl.edu

About Lina Cui

Lina Cui, Ph.D., obtained her B.Sc. in chemistry from Nankai University (China) in 2003. She continued her study in the University of Alberta (Canada) and obtained her Ph.D. degree in Organic Chemistry and Glycobiology in 2009 under the direction of Prof. David R. Bundle, the founding Director of the Alberta Glycomics Centre. Following graduate school, Dr. Cui spent two years (2009-2010) as a postdoctoral fellow with Prof. Jean M.J. Fréchet at UC Berkeley. Her postdoctoral training continued at Stanford University School of Medicine (2011-2014), where she worked with Prof. Jianghong Rao in the Molecular Imaging Program at Stanford (MIPS) directed by Prof. Sanjiv Sam Gambhir. In 2015, Dr. Cui joined the faculty of the Department of Chemistry and Chemical Biology as a tenure-track Assistant Professor at the University of New Mexico and UNM Comprehensive Cancer Center. In August 2018, she was recruited to the University of Florida and was appointed as a tenure-track assistant professor in the College of Pharmacy.

Research Profile

The Cui lab explores the biochemical activities of glycan processing enzymes and develops therapeutic and diagnostic molecules or tools for various types of cancer and age-related diseases (e.g. diabetes, neurodegeneration, etc). The interdisciplinary program integrates organic chemistry, molecular and cellular biology, and molecular imaging. Our current research explores the biochemistry of heparanase, a key enzyme involved in the remodeling of extracellular matrix. We are developing molecular probes to study the precise modes of heparanase activity using molecular imaging, as well as diagnostic tools and drug molecules targeting heparanase and related enzymes. Our lab also develops molecular tools to detect senescence and DNA damage, and we have applied these molecules in various collaborative projects to explore the progression of diabetes, neurodegeneration and other age-related diseases.

Publications

2020
Responsive Fluorophore Aggregation Provides Spectral Contrast for Fluorescence Lifetime Imaging.
Chembiochem : a European journal of chemical biology. 21(15):2196-2204 [DOI] 10.1002/cbic.202000056. [PMID] 32180309.
2020
Reduction Triggered In Situ Polymerization in Living Mice.
Journal of the American Chemical Society. 142(36):15575-15584 [DOI] 10.1021/jacs.0c07594. [PMID] 32804495.
2020
Dual-Mechanism Quenched Fluorogenic Probe Provides Selective and Rapid Detection of Cathepsin L Activity*.
ChemMedChem. [DOI] 10.1002/cmdc.202000823. [PMID] 33295147.
2019
Real-time imaging of senescence in tumors with DNA damage.
Scientific reports. 9(1) [DOI] 10.1038/s41598-019-38511-z. [PMID] 30765819.

Grants

May 2019 ACTIVE
Development of Diagnostic Tools for Metastatic Melanoma via Imaging of Heparanase Activity
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION
Aug 2018 ACTIVE
Probing the role of heparanase via in situ labeling
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS

Education

Postdoctoral Fellow
2011-2014 · Stanford University School of Medicine
Postdoctoral Fellow
2009-2010 · University of California at Berkeley
Ph.D.
2008 · University of Alberta
B.Sc.
2003 · Nankai University

Teaching Profile

Courses Taught
2018,2020-2021
PHA5878C Pt Care 3: Cv and Pulm
2020-2021
PHA7939 Journal Colloquy in Pharmacodynamics
2019-2021
PHA7979 Advanced Research
2019-2021
PHA6934 Seminar in Medicinal Chemistry
2020-2021
PHA6971 Research for Master’s Thesis
2019-2021
PHA7980 Research for Doctoral Dissertation
2020-2021
PHA6910 Supervised Research
2020-2021
PHA6935 Selected Topics in Pharmacy
2018,2020-2021
PHA5439 Prin Med Chem-Pcol I

Contact Details

Phones:
Business:
(352) 273-7090
Emails: