About Rodrigo Cristofoletti
Rodrigo Cristofoletti, Ph.D., joined the University of Florida in 2019 as research assistant professor in the Center for Pharmacometrics and Systems Pharmacology (Orlando) in the Department of Pharmaceutics. He received his B.S. in Pharmaceutical Sciences from the University of Sao Paulo, Brazil in 2004. Dr. Cristofoletti received his Ph.D. summa cum laude from the Johann Wolfgang Goethe University (Frankfurt am Main, Germany) under the supervision of Dr. Jennifer Dressman in 2017. The Clinical Pharmacology & Biopharmaceutics Office of the Brazilian Drug Regulatory Agency (ANVISA) has been Dr. Cristofoletti’s place of employment for the last 15 years. While there, his research on oral drug absorption has helped in building scientific foundations for generic policies within Brazilian jurisdiction.
Dr. Cristofoletti received the Simcyp Academic Most Informative and Scientific Report 2017 and 2020 Award for his research on translational modeling strategies to establishing an in vitro-in vivo link. He serves as a member of the Special Interest Group on BCS and Biowaiver of the International Pharmaceutical Federation (FIP) and a member of the Brazilian Pharmacopoeia.
Dr. Cristofoletti’s research focuses on integrating in vitro systems and quantitative methods and modeling to inform drug discovery and drug product development with focus on: a) Mechanistic absorption models for IVIVC, IVIVE and virtual bioequivalence trials; b) Metabolic- and transport-mediated drug-drug interaction and c) Disease-based models. Dr. Cristofoletti’s lab has been applying stem cell technology, co-culture techniques and microfluidics to develop microphysiological systems to investigate drug- and disease-related mechanisms affecting membrane integrity and predict drug absorption/tissue disposition. A major emphasis has been on developing a segment-specific intestine-on-a-chip to investigate drug- and disease-related mechanism affecting intestinal membrane integrity (leaky gut) as well as transport-mediated kinetics and drug-drug interactions. He is also interested in applying organ-on-a-chip technology to study drug penetration in brain parenchyma and cerebrospinal fluid. Dr. Cristofoletti published more than 50 peer-reviewed articles in highly respected journals in the pharmaceutics field as well as 5 book chapters.