Jane V Aldrich, V

Jane V Aldrich, V, Ph.D.

Professor

Department: Medicinal Chemistry
Business Phone: (352) 273-8708
Business Email: jaldrich@cop.ufl.edu

About Jane V Aldrich, V

Jane V. Aldrich, Ph.D., joined the University of Florida as professor of medicinal chemistry in 2015 under UF’s preeminence initiative in drug discovery and development. Dr. Aldrich’s research on analogs of opioid peptides has been continuously funded by the National Institute on Drug Abuse for over 25 years, and she has been the principal investigator of over $14 million in research grants. Following receiving her Ph.D. in medicinal chemistry, Dr. Aldrich was an NIH postdoctoral fellow at the University of Minnesota where she began her research on opioid peptides. She subsequently rose through the ranks at Oregon State University and the University of Maryland Baltimore prior to moving to the University of Kansas as professor of medicinal chemistry in 2001. Dr. Aldrich has served the scientific community in multiple capacities. She is currently chair of the NIH Drug Discovery for the Nervous System Study Section and also a Councilor for the Medicinal Chemistry Division of the American Chemical Society. She has also served as chair of the Medicinal Chemistry Division, president of the American Peptide Society, and co-chair of the Gordon Research Conference on the Chemistry and Biology of Peptides. She is currently on the editorial board of the Journal of Medicinal Chemistry and previously was an editor of the journal Letters in Peptide Science.

Accomplishments

Distinguished Alumni Award
2013 · Michigan State University
Leroy B. Townsend Lecturer
2012 · University of Michigan
Independent Scientist Award
1998-2009 · National Institute on Drug Abuse
Postdoctoral Fellowship
1984-1986 · NIH

Research Profile

Dr. Aldrich’s research focuses on the design and synthesis of peptide and peptidomimetic analogs of opioid peptides, along with the development of synthetic methods to prepare these compounds. A major emphasis has been peptide ligands for kappa opioid receptors as potential treatments for pain and drug abuse. These have included novel cyclic peptides that are active after oral administration, in addition to analogs of the endogenous dynorphin opioid peptides. These peptides are studied both in vitro for opioid activity and in vivo in collaboration with Dr. Jay McLaughlin in the Department of Pharmacodynamics. Dr. Aldrich’s laboratory is also studying the anticancer activity of novel cyclic peptides and has designed and synthesized labeled opioid peptides as tools to study opioid receptors.

Areas of Interest
  • Drug abuse
  • Drug discovery
  • Medicinal chemistry
  • Peptides

Publications

2012 Drug discovery today. Technologies
2012 Annual review of analytical chemistry (Palo Alto, Calif.)
2009 Proceedings of the National Academy of Sciences of the United States of America
2005 The journal of peptide research : official journal of the American Peptide Society
2004 The journal of peptide research : official journal of the American Peptide Society
2003 The journal of peptide research : official journal of the American Peptide Society
2003 The journal of peptide research : official journal of the American Peptide Society
1992 International journal of peptide and protein research

Grants

Jul 2020 ACTIVE
OR-DRPD-ROF2020: Exploration of the SIM2 class as potential novel peptide anticancer therapeutics
UF RESEARCH · Principal Investigator
Jun 2018 ACTIVE
A Novel Strategy for Prostate Cancer Therapy Targeting the c-Myc Oncoprotein
US ARMY MED RES ACQUISITION · Principal Investigator
Sep 2015 – Aug 2020
Novel peptide antagonists as treatments for
US ARMY MED RES ACQUISITION · Principal Investigator
Apr 2015 ACTIVE
Peptidic Kappa Opioid Receptor Ligands as Potential Treatments for Drug Addiction
NATL INST OF HLTH NIDA · Principal Investigator
Mar 2015 – Feb 2018
Peptidic Ligands for Kappa Opioid Receptors
NATL INST OF HLTH NIDA · Principal Investigator

Education

Postdoc – Medicinal Chemistry
1986 · University of Minnesota
Ph.D. – Medicinal Chemistry
1983 · University of Michigan
B.S. – Biochemistry
1976 · Michigan State University

Contact Details

Phones:
Business:
(352) 273-8708
Emails:

ALDRICH LAB