Jane V Aldrich, Ph.D.
Professor
On This Page
About Jane V Aldrich
Jane V. Aldrich, Ph.D., joined the University of Florida as professor of medicinal chemistry in 2015 under UF’s preeminence initiative in drug discovery and development. Dr. Aldrich’s research on analogs of opioid peptides has been continuously funded by the National Institute on Drug Abuse for over 25 years, and she has been the principal investigator of over $14 million in research grants. Following receiving her Ph.D. in medicinal chemistry, Dr. Aldrich was an NIH postdoctoral fellow at the University of Minnesota where she began her research on opioid peptides. She subsequently rose through the ranks at Oregon State University and the University of Maryland Baltimore prior to moving to the University of Kansas as professor of medicinal chemistry in 2001. Dr. Aldrich has served the scientific community in multiple capacities. She is currently chair of the NIH Drug Discovery for the Nervous System Study Section and also a Councilor for the Medicinal Chemistry Division of the American Chemical Society. She has also served as chair of the Medicinal Chemistry Division, president of the American Peptide Society, and co-chair of the Gordon Research Conference on the Chemistry and Biology of Peptides. She is currently on the editorial board of the Journal of Medicinal Chemistry and previously was an editor of the journal Letters in Peptide Science.
Accomplishments
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Distinguished Alumni Award
Michigan State University
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Leroy B. Townsend Lecturer
University of Michigan
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Independent Scientist Award
National Institute on Drug Abuse
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Postdoctoral Fellowship
NIH
Teaching Profile
Courses Taught
Research Profile
Dr. Aldrich’s research focuses on the design and synthesis of peptide and peptidomimetic analogs of opioid peptides, along with the development of synthetic methods to prepare these compounds. A major emphasis has been peptide ligands for kappa opioid receptors as potential treatments for pain and drug abuse. These have included novel cyclic peptides that are active after oral administration, in addition to analogs of the endogenous dynorphin opioid peptides. These peptides are studied both in vitro for opioid activity and in vivo in collaboration with Dr. Jay McLaughlin in the Department of Pharmacodynamics. Dr. Aldrich’s laboratory is also studying the anticancer activity of novel cyclic peptides and has designed and synthesized labeled opioid peptides as tools to study opioid receptors.
Areas of Interest
- Drug abuse
- Drug discovery
- Medicinal chemistry
- Peptides
Publications
Academic Articles
Grants
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Cyclic Peptides to Treat Cocaine Use Disorder
Active
- Role:
- Principal Investigator
- Funding:
- NATL INST OF HLTH NINDS
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Exploration of compounds that target alpha-synuclein phosphorylation
- Role:
- Principal Investigator
- Funding:
- PARKINSONS FOU
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Cyclic Peptides to Treat Cocaine Use Disorder
- Role:
- Principal Investigator
- Funding:
- NATL INST OF HLTH NINDS
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Targeting CIP2A for the Potential Treatment of Ovarian Cancer
- Role:
- Principal Investigator
- Funding:
- US ARMY MED RES ACQUISITION
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OR-DRPD-ROF2020: Exploration of the SIM2 class as potential novel peptide anticancer therapeutics
- Role:
- Principal Investigator
- Funding:
- UF RESEARCH
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A Novel Strategy for Prostate Cancer Therapy Targeting the c-Myc Oncoprotein
- Role:
- Principal Investigator
- Funding:
- US ARMY MED RES ACQUISITION
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Novel peptide antagonists as treatments for substance abuse
- Role:
- Principal Investigator
- Funding:
- US ARMY MED RES ACQUISITION
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Peptidic Kappa Opioid Receptor Ligands as Potential Treatments for Drug Addiction
- Role:
- Principal Investigator
- Funding:
- NATL INST OF HLTH NIDA
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Peptidic Ligands for Kappa Opioid Receptors
- Role:
- Principal Investigator
- Funding:
- NATL INST OF HLTH NIDA
Education
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Postdoc – Medicinal Chemistry
University of Minnesota
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Ph.D. – Medicinal Chemistry
University of Michigan
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B.S. – Biochemistry
Michigan State University
Contact Details
- Business:
- (352) 273-8708
- Business:
- janealdrich@ufl.edu
- Business Mailing:
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PO Box 100485
GAINESVILLE FL 32610 - Business Street:
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MSB P4-27
1345 Center Drive
GAINESVILLE FL 326103003