Search results for natural product

For selected compounds (by ourselves or in collaboration), we are devising synthetic methods to probe structure–activity relationships (SAR) and to obtain larger quantities of material for biological evaluation, including toxicity, pharmacokinetic and efficacy studies in animal models, which we will carry out in due course. Molecules of interest include largazoles and apratoxins, which we discovered and...

Research Assistant Professors           Qi-Yin Chen, Ph.D. (Total Synthesis) Research Assistant Professor Ph.D. Organic Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China M.S. Applied Chemistry, Central South University, Changsha, China B.S. Chemistry, Henan Normal University, Xinxiang, China chenqyufl@ufl.edu Ranjala Ratnayake, Ph.D. (Natural Products Chemistry) Research Assistant Professor & Assistant...

In parallel efforts, we are carrying out studies to reveal the function and action of genes/proteins that are putatively involved in cancer, aging and neurodegeneration. Candidate genes identified by high-throughput genome-wide cDNA and RNAi screening are subjected to molecular and biological characterization including structure-function studies in cell- and animal-based models. The ultimate goal is to...

Drug target identification and mode of action studies for molecules discovered through phenotypic screens usually represent a bottleneck in drug discovery. The limited abundance of compound available for characterization studies is an additional fundamental concern in natural products drug discovery, particularly if the structural complexity precludes chemical synthesis in a timely manner. Genomic and proteomic...

A chemical compound made from a type of bacteria discovered in the Florida Keys by a University of Florida pharmacy researcher has shown effectiveness in fighting colon cancer in preclinical experiments. Writing online in the Journal of Pharmacology and Experimental Therapeutics, scientists say the compound — known as largazole because it was first found near...

1923 The first entering class of 43 students registered for classes in Science Hall, now Flint Hall and Peabody Hall. Townes R. Leigh, Head of the Department of Chemistry, was appointed Director of the School of Pharmacy by President Murphree. The School of Pharmacy offered the Graduate of Pharmacy degree (Ph.G.), the Pharmaceutical Chemist degree...

Center for Drug Evaluation and Safety The University of Florida Center for Drug Evaluation and Safety, or CoDES, unites researchers interested in using big data to evaluate drugs and the safety of medications in real-world populations. More than 20 drug safety researchers representing four of the six academic colleges at UF Health are members of...

The college has five academic departments that have a unique research focus, are highly successful in attracting extramural research support, and are an integral part of the University of Florida Health Science Center. Faculty in the departments lead the training and education of students in the UF College of Pharmacy and maintain robust research activities that position the...

Research activities in the UF College of Pharmacy span the entire life cycle of a drug and include broad interest areas such as medicinal chemistry, pharmaceutics, pharmacology, clinical and translational research, and pharmaceutical outcomes and policy. Led by award-winning faculty, whose discoveries are significantly impacting the lives of patients around the world, the college achieved...

Ranked by U.S. News & World Report as the No. 1 pharmacy college in Florida and in the Top 5 nationally, the University of Florida College of Pharmacy has been developing future leaders in pharmacy practice and science for nearly a century. At campuses in Gainesville, Jacksonville and Orlando, award-winning faculty aim to improve the...