Search results for natural product

Showing 71 - 80 of 92 results

Medicinal Chemistry

http://mc.pharmacy.ufl.edu/

The department of medicinal chemistry is located in the University of Florida College of Pharmacy and is an integral part of UF Health. The department has excellent research facilities dedicated to major areas of medicinal chemistry research, and faculty in the department have been highly successful in attracting extramural research support. UF’s Preeminence initiative in...

Chemical Synthesis and Drug (or Probe) Development

https://mc.pharmacy.ufl.edu/research/faculty-research-areas/marine-natural-products-drug-discovery-and-development/chemical-synthesis-and-drug-or-probe-development/

For selected compounds (by ourselves or in collaboration), we are devising synthetic methods to probe structure–activity relationships (SAR) and to obtain larger quantities of material for biological evaluation, including toxicity, pharmacokinetic and efficacy studies in animal models, which we will carry out in due course. Molecules of interest include largazoles and apratoxins, which we discovered and...

Luesch Lab Members

https://mc.pharmacy.ufl.edu/research/faculty-research-areas/marine-natural-products-drug-discovery-and-development/luesch-lab-members/

Research Assistant Professors           Qi-Yin Chen, Ph.D. (Total Synthesis) Research Assistant Professor Ph.D. Organic Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China M.S. Applied Chemistry, Central South University, Changsha, China B.S. Chemistry, Henan Normal University, Xinxiang, China chenqyufl@ufl.edu Ranjala Ratnayake, Ph.D. (Natural Products Chemistry) Research Assistant Professor & Assistant...

Functional Genomics and High-Throughput Screening

https://mc.pharmacy.ufl.edu/research/faculty-research-areas/marine-natural-products-drug-discovery-and-development/functional-genomics-and-high-throughput-screening/

In parallel efforts, we are carrying out studies to reveal the function and action of genes/proteins that are putatively involved in cancer, aging and neurodegeneration. Candidate genes identified by high-throughput genome-wide cDNA and RNAi screening are subjected to molecular and biological characterization including structure-function studies in cell- and animal-based models. The ultimate goal is to...

Target Identification and Mode of Action Studies

https://mc.pharmacy.ufl.edu/research/faculty-research-areas/marine-natural-products-drug-discovery-and-development/target-identification-and-mode-of-action-studies/

Drug target identification and mode of action studies for molecules discovered through phenotypic screens usually represent a bottleneck in drug discovery. The limited abundance of compound available for characterization studies is an additional fundamental concern in natural products drug discovery, particularly if the structural complexity precludes chemical synthesis in a timely manner. Genomic and proteomic...

Compound discovered in Florida Keys shows early promise as colon cancer treatment

A chemical compound made from a type of bacteria discovered in the Florida Keys by a University of Florida pharmacy researcher has shown effectiveness in fighting colon cancer in preclinical experiments. Writing online in the Journal of Pharmacology and Experimental Therapeutics, scientists say the compound — known as largazole because it was first found near...

College History

1923 The first entering class of 43 students registered for classes in Science Hall, now Flint Hall and Peabody Hall. Townes R. Leigh, Head of the Department of Chemistry, was appointed Director of the School of Pharmacy by President Murphree. The School of Pharmacy offered the Graduate of Pharmacy degree (Ph.G.), the Pharmaceutical Chemist degree...

Centers

Center for Drug Evaluation and Safety The University of Florida Center for Drug Evaluation and Safety, or CoDES, unites researchers interested in using big data to evaluate drugs and the safety of medications in real-world populations. More than 20 drug safety researchers representing four of the six academic colleges at UF Health are members of...

Departments

The college has five academic departments that have a unique research focus, are highly successful in attracting extramural research support, and are an integral part of the University of Florida Academic Health Center. A sixth department, pharmacy education and practice, is dedicated to enhancing clinical education and practice. Faculty in the departments lead the training and education of...

Research

Research activities in the UF College of Pharmacy span the entire life cycle of a drug and include broad interest areas such as medicinal chemistry, pharmaceutics, pharmacology, clinical and translational research, and pharmaceutical outcomes and policy. Led by award-winning faculty, whose discoveries are significantly impacting the lives of patients around the world, the college achieved...