William Millard

William Millard, Ph.D.

Professor Emeritus

Department: MD-PHARMACOLOGY / THERAPEUTICS
Business Phone: (352) 338-0110
Business Email: millard@cop.ufl.edu

Publications

2011
Implication of the melanocortin-3 receptor in the regulation of food intake.
European journal of pharmacology. 660(1):80-7 [DOI] 10.1016/j.ejphar.2010.10.101. [PMID] 21199647.
2009
Discovery of a ligand that compensates for decreased endogenous agonist potency of melanocortin-4 receptor polymorphisms identified in obese humans.
Advances in experimental medicine and biology. 611:509-10 [PMID] 19400288.
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2009
Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin-4 receptor knockout mouse.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 23(2):642-55 [DOI] 10.1096/fj.08-109686. [PMID] 18971258.
2007
Assessment of human serotonin 1A receptor polymorphisms and SSRI responsiveness.
Molecular diagnosis & therapy. 11(3):155-60 [PMID] 17570737.
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2007
Peptide and small molecules rescue the functional activity and agonist potency of dysfunctional human melanocortin-4 receptor polymorphisms.
Biochemistry. 46(28):8273-87 [PMID] 17590021.
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2006
Molecular mechanism of the constitutive activation of the L250Q human melanocortin-4 receptor polymorphism.
Chemical biology & drug design. 67(3):215-29 [PMID] 16611215.
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2006
Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist.
Biochemistry. 45(23):7277-88 [PMID] 16752916.
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2005
Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice.
Peptides. 26(10):1720-7 [PMID] 16005545.
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2004
Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands.
Journal of medicinal chemistry. 47(9):2194-207 [PMID] 15084118.
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2004
Structural characterization and pharmacology of a potent (Cys101-Cys119, Cys110-Cys117) bicyclic agouti-related protein (AGRP) melanocortin receptor antagonist.
Journal of medicinal chemistry. 47(23):5662-73 [PMID] 15509165.
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2003
Elongation studies of the human agouti-related protein (AGRP) core decapeptide (Yc[CRFFNAFC]Y) results in antagonism at the mouse melanocortin-3 receptor.
Peptides. 24(2):263-70 [PMID] 12668211.
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2003
Long-term neuronal effects and disposition of ectopic preproNGF gene transfer into the rat septum.
Human gene therapy. 14(15):1463-72 [PMID] 14577926.
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2002
Alpha7 nicotinic receptor activation inhibits ethanol-induced mitochondrial dysfunction, cytochrome c release and neurotoxicity in primary rat hippocampal neuronal cultures.
Journal of neurochemistry. 81(4):853-8 [PMID] 12065644.
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2002
Measurements of vector-derived neurotrophic factor and green fluorescent protein levels in the brain.
Methods (San Diego, Calif.). 28(2):286-92 [PMID] 12413428.
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2001
17-beta estradiol can reduce secondary ischemic damage and mortality of subarachnoid hemorrhage.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 21(2):174-81 [PMID] 11176283.
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2000
Leptin resistance is associated with hypothalamic leptin receptor mRNA and protein downregulation.
Metabolism: clinical and experimental. 49(11):1479-84 [PMID] 11092515.
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1999
Altered IGF-I and IGFBPs in senescent male and female rats.
The journals of gerontology. Series A, Biological sciences and medical sciences. 54(3):B111-5 [PMID] 10191834.
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1999
Characterization of the neuroprotective and toxic effects of alpha7 nicotinic receptor activation in PC12 cells.
Brain research. 830(2):218-25 [PMID] 10366678.
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1999
Kainic acid (KA)-induced seizures in Sprague-Dawley rats and the effect of dietary taurine (TAU) supplementation or deficiency.
Amino acids. 16(2):133-47 [PMID] 10319185.
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1998
Neurochemical and neurobehavioral effects of neonatal administration of beta-N-methylamino-L-alanine and 3,3′-iminodipropionitrile.
Neurotoxicology and teratology. 20(2):181-92 [PMID] 9536463.
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1998
NGF gene expression in dividing and non-dividing cells from AAV-derived constructs.
Neurochemical research. 23(5):779-86 [PMID] 9566618.
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1997
An HPLC/RIA method for dynorphin A1-13 and its main metabolites in human blood.
Journal of pharmaceutical and biomedical analysis. 16(1):101-9 [PMID] 9447557.
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1997
Attenuation of leptin-mediated effects by monosodium glutamate-induced arcuate nucleus damage.
The American journal of physiology. 273(1 Pt 1):E202-6 [PMID] 9252497.
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1996
An AAV promoter-driven neuropeptide Y gene delivery system using Sendai virosomes for neurons and rat brain.
Gene therapy. 3(3):246-53 [PMID] 8646556.
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1996
Evaluation of immune parameters and lymphocyte production of prolactin-immunoreactive proteins after chronic administration of cocaine to pregnant rats.
The Journal of pharmacology and experimental therapeutics. 277(2):1090-6 [PMID] 8627520.
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1995
Measurement of growth hormone-binding protein in the rat by a ligand immunofunctional assay.
Endocrinology. 136(2):379-85 [PMID] 7835268.
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1995
Sendai virosomal infusion of an adeno-associated virus-derived construct containing neuropeptide Y into primary rat brain cultures.
Neuroscience letters. 190(2):73-6 [PMID] 7543991.
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1994
Differential adenoassociated virus vector-driven expression of a neuropeptide Y gene in primary rat brain astroglial cultures after transfection with Sendai virosomes versus Lipofectin.
Neurochemical research. 19(6):643-8 [PMID] 8065520.
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1994
Differential neuropeptide Y gene expression in post-mitotic versus dividing neuroblastoma cells driven by an adeno-associated virus vector.
Brain research. Molecular brain research. 24(1-4):27-33 [PMID] 7968366.
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1994
Effect of growth hormone administration and treadmill exercise on serum and skeletal IGF-I in rats.
The American journal of physiology. 266(1 Pt 1):E129-35 [PMID] 7508193.
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1994
Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats.
Brain research. 644(2):305-12 [PMID] 8050041.
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1993
Developmental and sex-related changes of the growth hormone axis in lean and obese Zucker rats.
Neuroendocrinology. 57(2):213-23 [PMID] 8099719.
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1993
Effects of chronic stimulation or antagonism of opiate receptors on GH secretion in male and female rats.
Life sciences. 52(17):1443-50 [PMID] 8385257.
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1993
Influence of in vivo reproductive endocrine state on growth hormone-releasing factor stimulated adenylate cyclase activity in anterior pituitary fragments.
Neuroendocrinology. 57(1):63-9 [PMID] 8479617.
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1993
Inhibition of IGF-I and b-FGF stimulated growth of human retinal endothelial cells by the somatostatin analogue, octreotide: a potential treatment for ocular neovascularization.
Regulatory peptides. 48(1-2):267-78 [PMID] 7505469.
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1993
Modulation of neuropeptide Y expression in rat brain neuronal cultures.
Brain research. Developmental brain research. 74(1):25-9 [PMID] 8403372.
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1992
Cocaine in utero enhances the behavioral response to cocaine in adult rats.
Pharmacology, biochemistry, and behavior. 42(3):509-15 [PMID] 1409782.
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1992
Opiate modulation of growth hormone secretion is compromised during the steroid-induced luteinizing hormone surge.
Neuroendocrinology. 55(2):214-20 [PMID] 1620289.
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1992
Opiate stimulation of prolactin secretion is reversed by ovarian hormone treatment.
Neuroendocrinology. 56(2):195-203 [PMID] 1407373.
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1991
Comparison of efficacy of cysteamine in depleting prolactin immunoreactivity in different hyperprolactinemic animal models.
Life sciences. 49(22):1635-42 [PMID] 1943468.
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1991
Effects of gonadal steroids on clearance of growth hormone at steady state in the rat.
Endocrinology. 128(2):1065-72 [PMID] 1989846.
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1991
Evaluation of the sites of opioid influence on anterior pituitary hormone secretion using a quaternary opiate antagonist.
Neuroendocrinology. 54(4):384-90 [PMID] 1661859.
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1991
Growth hormone secretion in the obese male rat: modulation by the gonadal and thyroid axes.
Growth, development, and aging : GDA. 55(2):91-103 [PMID] 1682282.
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1991
Hormonal regulation of rat hypothalamic neuropeptide mRNAs: effect of hypophysectomy and hormone replacement on growth-hormone-releasing factor, somatostatin and the insulin-like growth factors.
Neuroendocrinology. 53(3):298-305 [PMID] 1674982.
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1991
Signal transduction systems in growth hormone-releasing hormone and somatostatin release from perifused rat hypothalamic fragments.
Endocrinology. 129(3):1355-62 [PMID] 1678698.
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1990
Absence of ultradian rhythm or diurnal variation in insulin-like growth factor-I in rats.
Neuroendocrinology. 52(1):1-8 [PMID] 2118602.
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1990
Effects of nucleus basalis lesions on cerebral cortical concentrations of corticotropin-releasing hormone (CRH)-like immunoreactivity in the rat.
Neuroscience letters. 113(2):233-9 [PMID] 2377321.
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1990
Glucose modulation of skin temperature responses during morphine withdrawal in the rat.
Psychopharmacology. 102(2):213-20 [PMID] 2274603.
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1990
Growth hormone (GH) secretory dynamics in animals administered estradiol utilizing a chemical delivery system.
Pharmaceutical research. 7(10):1011-8 [PMID] 2281029.
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1990
Growth hormone and thyrotropin secretory profiles and provocative testing in aged rats.
Neurobiology of aging. 11(3):229-35 [PMID] 2113997.
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1990
Neuropeptide Y-cholinergic interactions in neocortical tissue.
Annals of the New York Academy of Sciences. 611:219-25 [PMID] 2248476.
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1990
Opiate-thyroid hormone interactions in the regulation of thyrotropin secretion in the rat.
Neuroendocrinology. 52(3):303-8 [PMID] 2120610.
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1990
Preproneuropeptide Y mRNA expression in glial cell cultures of the neonate but not 21-day-old rat brain
Annals of the New York Academy of Sciences. 611(1 Central and P):522-524 [DOI] 10.1111/j.1749-6632.1990.tb49005.x.
1990
The effect of cellular glucoprivation on skin temperature regulation in the rat.
Life sciences. 47(2):107-15 [PMID] 2388522.
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1989
Different long-term effects of bilateral and unilateral nucleus basalis lesions on rat cerebral cortical neurotransmitter content.
Neurochemical research. 14(11):1113-8 [PMID] 2574419.
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1989
Sexual and developmental differences in peptides regulating growth hormone secretion in the rat.
Neuroendocrinology. 50(3):299-307 [PMID] 2571953.
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1988
Growth hormone is secreted by ectopic pituitary grafts and stimulates maternal behavior in rats.
Hormones and behavior. 22(2):194-206 [PMID] 3397052.
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1987
Effect of cysteamine on suckling-induced prolactin secretion in the rat.
Life sciences. 41(20):2255-60 [PMID] 3683075.
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1987
Influence of age on neurotransmitter function.
Endocrinology and metabolism clinics of North America. 16(4):893-917 [PMID] 2892672.
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1987
Long-term neuropathological and neurochemical effects of nucleus basalis lesions in the rat.
Science (New York, N.Y.). 238(4829):952-6 [PMID] 2890210.
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1986
Early exposure to delta 9-tetrahydrocannabinol influences neuroendocrine and reproductive functions in female rats.
Neuroendocrinology. 44(2):260-4 [PMID] 2432439.
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1986
Growth hormone secretion in genetic large (LL) and small (SS) rats.
Endocrinology. 119(5):1948-53 [PMID] 3769860.
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1986
Growth hormone-secretory patterns in androgen-resistant (testicular feminized) rats.
Endocrinology. 119(6):2655-60 [PMID] 3780546.
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1985
Changes in anterior pituitary hormone secretion and hypothalamic catecholamine metabolism during morphine withdrawal in the female rat.
Brain research. 346(1):15-21 [PMID] 4052762.
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1985
Cysteamine-induced depletion of somatostatin and prolactin.
Federation proceedings. 44(9):2546-50 [PMID] 2860016.
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1985
Dose-response characteristics of various peptides with growth hormone-releasing activity in the unanesthetized male rat.
Endocrinology. 117(1):97-105 [PMID] 2861083.
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1985
The mechanism of action of cysteamine in depleting prolactin immunoreactivity.
Endocrinology. 117(2):591-600 [PMID] 3926458.
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1984
Cysteamine depletes prolactin (PRL) but does not alter the structure of PRL-containing granules in the anterior pituitary.
Endocrinology. 115(4):1543-50 [PMID] 6479101.
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1984
Effect of short photoperiod on hypothalamic methionine-enkephalin and LHRH content and serum beta-endorphin-like immunoreactivity (beta-end LI) levels in golden hamsters.
Journal of pineal research. 1(2):197-205 [PMID] 6100720.
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1984
Evidence that chronic hyperprolactinemia effects skin temperature regulation through an opioid mechanism.
Neuroendocrinology. 39(4):321-9 [PMID] 6092986.
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1984
Evidence that thyrotropin-releasing hormone is not a major prolactin-releasing factor during suckling in the rat.
Endocrinology. 115(1):312-6 [PMID] 6329654.
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1984
Opiate modulation of the anterior pituitary hormone response during suckling in the rat.
Endocrinology. 114(4):1232-7 [PMID] 6323136.
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1984
The effects of chronic naloxone on pituitary hormone secretion in female rats.
Brain research bulletin. 12(4):359-62 [PMID] 6329481.
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1984
The effects of growth hormone (GH)-releasing peptides on GH secretion in perifused pituitary cells of adult male rats.
Endocrinology. 115(4):1432-8 [PMID] 6148232.
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1983
Cysteamine depletes prolactin in young and old hyperprolactinemic rats.
Endocrinology. 112(5):1889-91 [PMID] 6832077.
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1983
Cysteamine effects on growth hormone secretion in the male rat.
Endocrinology. 112(2):509-17 [PMID] 6129131.
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1983
Cysteamine induces depletion of both immunological and biological prolactin activity in the anterior pituitary and blood of the rat.
Endocrinology. 113(6):2161-7 [PMID] 6641630.
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1983
Intake of water and ethanol by C57BL mice: effect of an altered light-dark schedule.
Pharmacology, biochemistry, and behavior. 18(2):281-4 [PMID] 6835984.
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1983
The effects of cysteamine on thyrotropin and immunoreactive beta-endorphin secretion in the rat.
Endocrinology. 112(2):518-25 [PMID] 6184215.
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1982
Cysteamine reduces serum gonadotropin concentrations in adult male rats.
Life sciences. 30(3):245-52 [PMID] 6803092.
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1982
Cysteamine: a potent and specific depletor of pituitary prolactin.
Science (New York, N.Y.). 217(4558):452-4 [PMID] 7089575.
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1982
Depletion of somatostatin-like immunoreactivity in the rat central nervous system by cysteamine.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 2(2):225-31 [PMID] 6121016.
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1982
Evidence that reduced growth hormone secretion observed in monosodium glutamate-treated rats is the result of a deficiency in growth hormone-releasing factor.
Endocrinology. 110(2):540-50 [PMID] 6120072.
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1982
Hypothalamic-pituitary function in adult rats treated neonatally with monosodium glutamate.
Endocrinology. 111(6):2031-8 [PMID] 6754352.
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1981
Light-dark entrainment of the growth hormone ultradian rhythm in the rat is mediated by the arcuate nucleus.
Endocrinology. 108(6):2394-6 [PMID] 7194776.
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1974
Short-term influence of intra-ventromedial hypothalamic administration of insulin on feeding in normal and diabetic rats.
Pharmacology, biochemistry, and behavior. 2(2):223-6 [PMID] 4829598.
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Patents

Issued August 2007
Human High Affinity Choline Transporter (DIV)
#7,256,268
Issued December 2002
Human High Affinity Choline Transporter
#6,500,643

Education

Research Fellow in Neurology
1979-1981 · Massachusetts General Hospital
Ph.D.
1979 · University of Toledo
B.S.
1971 · Mount Union College

Teaching Profile

Courses Taught
2012-2015
PHA5517 Pharmacol Bas Ther 2
2012-2015
PHA5561C Physiol Bas Disease 2
2011,2014
PHA6521C Research Techniques in Pharmacodynamics
2013-2014
PHA5902 Research Pharmacodyna
2014
PHA6509 Systems Physiology and Pathophysiology II
2009,2013
PHA5907 Research in Phar Prac
2011
PHA6910 Supervised Research
2010-2011
PHA6936 Adv Topics Pharm Sci
2010
PHA6540 Neurochem Founda
2009
PHA4907 Probs in Pharm Prac

Contact Details

Phones:
Business:
(352) 338-0110
Emails: