Mei He

Mei He, Ph.D.

Assistant Professor

Department: Pharmaceutics
Business Phone: (352) 273-9847
Business Email: mhe@cop.ufl.edu

About Mei He

Mei He, Ph.D. is a tenure-track assistant professor in the Department of Pharmaceutics at the University of Florida in Gainesville. She received her PhD degree from the University of Alberta and postdoctoral training from the University of California, Berkeley from 2008-2012. Dr. He is also the founder of Clara Biotech Inc. and the founder committee for the MidWest 3D technology society. Dr. He received the NIH Maximizing Investigator’s Research Award (MIRA ESI), as well as the LOC Emerging Investigators in 2019, and Outstanding LOC Reviewers in 2018 by the Royal Society of Chemistry. Dr. He also serves the Editorial Board Member for journals Lab on Chip (IF 6.91) and Pharmaceutics (IF 4.8). He publications received Top 100 Read Articles in 2019 from Nature Publsihing group, as well as the SLAS Technology Readers Choice Award in 2018.

Accomplishments

NIH Maximizing Investigator's Research Award for Early Stage Investigators
2019 · National Institutes of Health
LOC Emerging Investigator
2019 · Royal Society of Chemistry
Reader Choice Award
2018 · Society for Laboratory Automation and Screening
Outstanding Reviewer for Lab on Chip
2018 · Royal Society of Chemistry
New Faculty Award
2017 · Kansas State University
Travel Award for NIH-IEEE Strategic Conference
2016 · Johnson Cancer Research Center
Ingenuity Central Kansas Innovator
2016 · Kansas State University
NSF CAREER Workshop Travel Award
2014 · National Science Foundation
Auxiliary Award
2013 · University of Kansas Medical Center
CASSS Travel Award for the 26th International Symposium on MicroScale Bioseparations
2011 · CASSS
NSF ADVANCE Future Faculty Workshop Travel Award
2011 · National Science Foundation
Final list, California Institute for Quantitative Bioscience (QB3) Distinguished Fellow The University of California, Berkeley, USA
2008 · California Institute for Quantitative Bioscience
Mary Louise Imrie Graduate Student Award
2007 · University of Alberta, Canada

Research Profile

Dr. He’s research focuses on precise definition and control of immunity at the molecular level to tissue level, via extracellular vesicles and exosomes -mediated delivery and biological programming strategies, which can be employed in advancing cancer immunotherapy, regenerative medicine, and precision therapeutics. The long-standing interest is to understand immunity communication and delivery for translating into novel therapeutics and treatments against cancers, autoimmune diseases, and infectious diseases which immune responses are the central player.

Areas of Interest
  • 3D Printing and Biomaterials
  • Cancer Immunotherapy
  • Extracellular Vesicles and Exosomes for Biological Programming and Nanodelivery
  • Microfluidic organ on chip
  • Regenerative and Precision Therapeutics

Publications

2019
3D cell culture stimulates the secretion of in vivo like extracellular vesicles
Scientific Reports. 9(1) [DOI] 10.1038/s41598-019-49671-3. [PMID] 31506601.
2019
Microfluidic On-demand Engineering of Exosomes towards Cancer Immunotherapy
Lab on a Chip. 19(10):1877-1886 [DOI] 10.1039/c8lc01279b. [PMID] 31044204.
2019
Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip
Nature biomedical engineering. 3(6):438-451 [DOI] 10.1038/s41551-019-0356-9. [PMID] 31123323.
2019
3D-printing enabled micro-assembly of microfluidic electroporation system for 3D tissue engineering
Lab on a Chip. 19(14):2362-2372 [DOI] 10.1039/c9lc00046a. [PMID] 31214669.
2018
Microfluidic Engineering of Exosomes: Editing Cellular Messages for Precision Therapeutics
Lab on a Chip. 18(12):1690-1703 [DOI] 10.1039/c8lc00246k. [PMID] 29780982.
2016
3D Printed Auto-mixing Chip Enables Rapid Smartphone Diagnosis of Anemia
Biomicrofluidics. 10(5) [DOI] 10.1063/1.4964499. [PMID] 27733894.
2016
A Microfluidic ExoSearch Chip for Multiplexed Exosome Detection Towards Blood-based Ovarian Cancer Diagnosis
Lab on a Chip. 16(3):489-496 [DOI] 10.1039/c5lc01117e. [PMID] 26645590.
2016
Microfluidic Exosome Analysis towards Liquid Biopsy for Cancer
Journal Of Laboratory Automation. 21(4):599-608 [DOI] 10.1177/2211068216651035. [PMID] 27215792.
2016
Ultrasensitive microfluidic analysis of circulating exosomes using a nanostructured graphene oxide/polydopamine coating
Lab on a Chip. 16(16):3033-3042 [DOI] 10.1039/c6lc00279j. [PMID] 27045543.
2015
Microfluidic Technology: the next-generation drug discovery tool
Drug Target Review. 2(3):18-20
2014
Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology
Lab on a Chip. 14(19):3773-3780 [DOI] 10.1039/c4lc00662c. [PMID] 25099143.
2012
Tunable thick polymer coatings for on-chip electrophoretic protein and peptide separation
Journal of chromatography. A. 1241:112-116 [DOI] 10.1016/j.chroma.2012.04.009. [PMID] 22560350.
2012
Electrostatic protein immobilization using charged polyacrylamide gels and cationic detergent microfluidic Western blotting
Analytical chemistry. 84(5):2533-2540 [DOI] 10.1021/ac3000013. [PMID] 22304398.
2011
Membrane-assisted online renaturation for automated microfluidic lectin blotting
Journal of the American Chemical Society. 133(49):19610-19613 [DOI] 10.1021/ja207963f. [PMID] 22070432.
2011
Multi-analyte on-chip native western blotting
Analytical chemistry. 83(9):3581-3588 [DOI] 10.1021/ac200322z. [PMID] 21456518.
2010
Automated microfluidic protein immunoblotting
Nature Protocols. 5(11):1844-1856 [DOI] 10.1038/nprot.2010.142. [PMID] 21030959.
2010
Parameters governing reproducibility of flow properties of porous monoliths photopatterned within microfluidic channels
Electrophoresis. 31(14):2422-2428 [DOI] 10.1002/elps.200900774. [PMID] 20568261.
2010
Polyacrylamide gel photopatterning enables automated protein immunoblotting in a twodimensional microdevice
Journal of the American Chemical Society. 132(8):2512-2513 [DOI] 10.1021/ja910164d. [PMID] 20131779.
2009
Microfluidic polyacrylamide gel electrophoresis with in-situ immunoblotting for native protein analysis
Analytical chemistry. 81(19):8177-8184 [DOI] 10.1021/ac901392u. [PMID] 19731927.
2008
Confinement effects on the morphology of photopatterned porous polymer monoliths for capillary and microchip electrophoresis of proteins
Electrophoresis. 29(14):2980-2986 [DOI] 10.1002/elps.200800040. [PMID] 18551717.
2008
Microfluidic Self-Patterning of Large-Scale Crystalline Nanoarrays for HighThroughput Continuous DNA Fractionation
Angewandte Chemie-International Edition. 47(34):6388-6391 [DOI] 10.1002/anie.200800816. [PMID] 18624306.

Grants

Aug 2020 ACTIVE
3D biomimetic lymph node engineered extracellular vesicles for understanding the heterogeneity of adaptive immunity
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS

Education

Postdoc, Bioengineering
2008-2011 · University of California-Berkeley, USA,
Ph.D., Chemistry
2004-2008 · University of Alberta, Canada,
M.S., Pharmaceutical Chemistry
2000-2003 · Chongqing University, China,
B.S., Chemical Engineering, with Honors
1996-2000 · Chongqing University, China,

Teaching Profile

Courses Taught
2020-2021
PHA5176 Drug Delivery Systems

Contact Details

Phones:
Business:
(352) 273-9847
Emails:
Business:
mhe@cop.ufl.edu