Francine J Azeredo, B.Pharm, Ph.D.
Research Assistant Professor
About Francine J Azeredo
Francine Johansson Azeredo, Ph.D., is a research assistant professor at the Center of Pharmacometrics & Systems Pharmacology at the University of Florida College of Pharmacy. She received her B.S. in pharmacy from the Federal University of Rio Grande do Sul in Brazil in 2008 and earned her Ph.D. in Pharmaceutical Sciences in 2013 at the same university under the supervision of Prof. Teresa Dalla Costa. During her Ph.D., she was a short-term scholar at Prof. Hartmut Derendorf’s lab at UF, where she learned her skills in pharmacometrics. Dr. Azeredo had been an assistant professor at the Federal University of Bahia (UFBA) for almost six years, with Federal Grants. Her research projects include PK/PD modeling, microdialysis, pharmacokinetic evaluation of new compounds, and clinical population pharmacokinetics/pharmacodynamics of anti-infective drugs and drugs used to treat neglected diseases.
Additional Positions:
Chair of the Department of Medicine
2017 – 2021
·
Federal University of Bahia, Brazil
Teaching Profile
Courses Taught
2023-2024
PHA7979 Advanced Research
2023-2024
PHA6418 Model-Informed Drug Development
Research Profile
Dr. Azeredo’s research interests are in: i)PK-PD modeling and simulation for parasitic poverty-related diseases and anti-infective agents to optimize drug therapy, focusing on combating drug-resistant Plasmodium through better information on drug-combined therapies; ii) Use of Modeling and Simulation to optimize the pharmacological treatment in special populations.
Open Researcher and Contributor ID (ORCID)
0000-0003-3625-0186
Publications
2024
Pharmacokinetic Models of Tafenoquine: Insights for Optimal Malaria Treatment Strategies
Pharmaceutics.
16(9)
[DOI] 10.3390/pharmaceutics16091124.
2024
Preclinical Pharmacokinetic Study and Lung Penetration of a Coumarin Extracted from Zanthoxylum tingoassuiba
Pharmaceutics.
16(6)
[DOI] 10.3390/pharmaceutics16060714.
[PMID] 38931838.
2024
Validation of a bioanalytical HPLC-UV method to quantify Α-Bisabolol in rat plasma applied to pharmacokinetic pilot study with the drug nanoemulsion.
Biomedical chromatography : BMC.
38(9)
[DOI] 10.1002/bmc.5949.
2023
A cross-sectional study in critically ill patients affected by COVID-19 in an intensive care unit: would Acinetobacter baumannii resistant to carbapenems be the biggest villain?
Access Microbiology.
5(10)
[DOI] 10.1099/acmi.0.000542.v3.
[PMID] 37970088.
2023
A pilot study of chemotherapy combinations in rats: Focus on mammary cancer treatment in female dogs
Research in Veterinary Science.
156:14-21
[DOI] 10.1016/j.rvsc.2023.01.009.
[PMID] 36738520.
2023
Coumarins from Rutaceae: Chemical diversity and biological activities
Fitoterapia.
168
[DOI] 10.1016/j.fitote.2023.105489.
[PMID] 36990289.
2023
Hecogenin and its derivates: A pharmacology review
Biomedicine & Pharmacotherapy.
159
[DOI] 10.1016/j.biopha.2023.114251.
[PMID] 36641922.
2023
Requirements, expectations, challenges and opportunities associated with training the next generation of pharmacometricians
CPT: Pharmacometrics & Systems Pharmacology.
12(7):883-888
[DOI] 10.1002/psp4.12970.
[PMID] 37452453.
2022
CAT -21A>T Variant Alters Hydroxyurea Pharmacokinetic Parameters in Brazilian Children with Sickle Cell Anemia
Annals of Case Reports.
7(4)
[DOI] 10.29011/25747754.100920.
2022
Pharmacokinetic/Pharmacodynamic Modeling and Application in Antibacterial and Antifungal Pharmacotherapy: A Narrative Review
Antibiotics.
11(8)
[DOI] 10.3390/antibiotics11080986.
[PMID] 35892376.
2021
A patent review of antibiofilm fungal drugs (2002-present)
Critical Reviews in Biotechnology.
41(2):229-248
[DOI] 10.1080/07388551.2021.1874283.
2021
IAF, QGF, and QDF Peptides Exhibit Cholesterol-Lowering Activity through a Statin-like HMG-CoA Reductase Regulation Mechanism: In Silico and In Vitro Approach
International Journal of Molecular Sciences.
22(20)
[DOI] 10.3390/ijms222011067.
[PMID] 34681729.
2020
Beyond inflammation: Centrally mediated antinociceptive properties of Spirulina platensis LEB-18 biomass via the opioid system
Journal of Functional Foods.
72
[DOI] 10.1016/j.jff.2020.104083.
2020
Detection of allopurinol and oxypurinol in canine urine by HPLC/MS-MS: Focus on veterinary clinical pharmacokinetics.
Journal of pharmaceutical and biomedical analysis.
185
[DOI] 10.1016/j.jpba.2020.113204.
[PMID] 32126445.
2020
Incidence of Adverse Drug Reactions in High-Risk Pregnancy: A Prospective Cohort Study in Obstetric Intensive Care.
European journal of clinical pharmacology.
76(2):291-298
[DOI] 10.1007/s00228-019-02789-9.
[PMID] 31768575.
2020
Population Pharmacokinetics of Magnesium Sulfate in Preeclampsia and Associated Factors
Drugs in R&D.
20(3):257-266
[DOI] 10.1007/s40268-020-00315-2.
[PMID] 32642964.
2019
Pharmacogenetics-based population pharmacokinetic analysis of gabapentin in patients with chronic pain: Effect of OCT2 and OCTN1 gene polymorphisms.
Basic & clinical pharmacology & toxicology.
124(3):266-272
[DOI] 10.1111/bcpt.13126.
[PMID] 30192429.
2019
Vancomycin Therapeutic Regime Adjustment in Newborns and Infants with Bacterial Infection: Case Series.
Current pharmaceutical biotechnology.
20(4):346-351
[DOI] 10.2174/1389201020666190319161511.
[PMID] 30892160.
2018
Leishmanicidal candidate LASSBio-1736, a cysteine protease inhibitor with favorable pharmacokinetics: low clearance and good distribution.
Xenobiotica; the fate of foreign compounds in biological systems.
48(12):1258-1267
[DOI] 10.1080/00498254.2017.1405465.
[PMID] 29160126.
2015
Does the Anesthetic Urethane Influence the Pharmacokinetics of Antifungal Drugs? A Population Pharmacokinetic Investigation in Rats.
Journal of pharmaceutical sciences.
104(10):3314-8
[DOI] 10.1002/jps.24552.
[PMID] 26087701.
2014
Pre-clinical pharmacokinetics and acute toxicological evaluation of a monastrol derivative anticancer candidate LaSOM 65 in rats.
Xenobiotica; the fate of foreign compounds in biological systems.
44(3):254-63
[DOI] 10.3109/00498254.2013.822131.
[PMID] 23937080.
2014
Role of microdialysis in pharmacokinetics and pharmacodynamics: current status and future directions.
Clinical pharmacokinetics.
53(3):205-212
[DOI] 10.1007/s40262-014-0131-8.
[PMID] 24452811.
2012
Comparison of fluconazole renal penetration levels in healthy and Candida albicans-infected Wistar rats.
Antimicrobial agents and chemotherapy.
56(11):5852-7
[DOI] 10.1128/AAC.01323-12.
[PMID] 22948869.
2010
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY FOR DETERMINING A NEW ANTICONVULSANT CANDIDATE, BENZALDEHYDE SEMICARBAZONE IN RAT PLASMA
Journal of Liquid Chromatography & Related Technologies.
33(4):526-535
[DOI] 10.1080/10826070903574527.
2010
Pre-clinical pharmacokinetics evaluation of an anticonvulsant candidate benzaldehyde semicarbazone free and included in beta-cyclodextrin.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
39(5):355-62
[DOI] 10.1016/j.ejps.2010.01.003.
[PMID] 20093185.
Grants
Jul 2023
ACTIVE
Development of a semi-mechanistic disease-drug platform for hepatitis B
Role: Principal Investigator
Funding: GILEAD SCIENCES
Education
Ph.D.
2009-2013
·
Federal University of Rio Grande do Sul, Brazil
B.S.
2003-2008
·
Federal University of Rio Grande do Sul, Brazil
Contact Details
Phones:
- Business:
- (407) 313-7043
Emails:
- Business:
- francinej@ufl.edu
Addresses:
- Business Mailing:
-
6550 SANGER RD RM 476
ORLANDO FL 32827 - Business Street:
-
6550 SANGER RD RM 476
ORLANDO FL 32827