Sreekanth (Sree) Chanickal Narayanapillai, Ph.D.

Sreekanth (Sree) Chanickal Narayanapillai

Research Assistant Professor

Medicinal Chemistry



PHONE: 352-273-5340



  • Ph.D in Biotechnology, University of Kerala, India (2004-2010)
  • MS in Biotechnology, Mahatma Gandhi University, India (2001-2003)
  • BS in Zoology, University of Kerala, India (1997-2000)

Biographical Sketch

Dr. Narayanapillai earned his Ph.D. in 2010 and worked as a Postdoctoral Fellow at the Department of Pharmaceutical Sciences, University of Colorado Denver for two years. In 2013, he joined the Medicinal Chemistry Department at the University of Minnesota as a Postdoctoral Research Associate in Dr. Chengguo Xing’s group. In 2016, he moved to the Dept. of Medicinal Chemistry, University of Florida as a Research Assistant Professor in Dr. Xing’s group. His research interests include cancer chemoprevention in preclinical models using natural and synthetic agents.

Representative publications

Dihydromethysticin (DHM) Blocks Tobacco Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Induced O6-Methylguanine in a Manner Independent of the Aryl Hydrocarbon Receptor (AhR) Pathway in C57BL/6 Female Mice. Narayanapillai SC, Lin S, Leitzman P, Upadhyaya P, Baglole CJ, and Xing C. Chem Res Toxicol. 2016, 29 (11), 1828-34.

Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification. Narayanapillai SC, von Weymarn LB, Carmella SG, Leitzman P, Paladino J, Upadhyaya P, Hecht SS, Murphy SE, Xing C. Drug Metab Dispos. 2016, 44(3):422-7.

4H-Chromene-based anticancer agents towards multi-drug resistant HL60/MX2 human leukemia: SAR at the 4th and 6th positions. Puppala M, Zhao X, Casemore D, Zhou B, Aridoss G, Narayanapillai S, Xing C. Bioorg Med Chem. 2016, Mar; 24(6):1292-7.

Kava as a Pharmacotherapy of Anxiety Disorders: Promises and Concerns. Rivers Z, Xing C, Narayanapillai S. Med Chem. 2016 6:081-7.Flavokawains A and B in kava, not dihydromethysticin, potentiate acetaminophen-induced hepatotoxicity in C57BL/6 mice. Narayanapillai SC, Leitzman P, O’Sullivan MG, Xing C. Chem Res Toxicol. 2014, 27(10):1871-6.

Dihydromethysticin from kava blocks tobacco carcinogen4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice. Narayanapillai SC, Balbo S, Leitzman P, Grill AE, Upadhyaya P, Shaik AA, Zhou B, O’Sullivan MG, Peterson LA, Lu J, Hecht SS, Xing C. Carcinogenesis 2014, 35(10):2365-72.

Rapid identification of Keap1-Nrf2 small-molecule inhibitors through structure-based virtual screening and hit-based substructure search. Zhuang C, Narayanapillai S, Zhang W, Sham YY, Xing C. J Med Chem. 2014, 57(3):1121-6.

Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice. Leitzman P, Narayanapillai SC, Balbo S, Zhou B, Upadhyaya P, Shaik AA, O’Sullivan MG, Hecht SS, Lu J, Xing C. Cancer Prev Res (Phila). 2014, 7(1):86-96.