Yaxia Yuan

Yaxia Yuan, Ph.D.

Research Assistant Professor

Department: Pharmacodynamics
Business Email: yaxia.yuan@cop.ufl.edu

About Yaxia Yuan

Yaxia Yuan, Ph.D., joined University of Florida as a research assistant professor in department of pharmacodynamics in June 2018. Yuan received his B.S. degree in Chemistry and Ph.D. in Physical Chemistry from Peking University. Following his Ph.D. program, Yuan completed a postdoctoral fellowship at College of Pharmacy in University of Kentucky. His research focused on methodology development and application of computer-aided drug discovery, data mining, and molecular dynamic simulation.

Research Profile

Drug Discovery: De novo drug design; Multi-target drug design; Protein-ligand binding affinity estimation; Virtual screening; ADME/T prediction; Synthesis-accessibility analysis

Machine learning: Supporting vector machine; Artificial neural network; Deep-learning; Data assimilation

Biomolecular Mechanism: Protein-Protein interaction; Inflammation network; Monoamine transporting mechanism; Synthetic HDL nano-particle

Publications

2020
Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity.
European journal of medicinal chemistry. 192 [DOI] 10.1016/j.ejmech.2020.112186. [PMID] 32145645.

Grants

Sep 2020 ACTIVE
Identifying Novel Senolytic Agents and Molecular Targets
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Apr 2020 ACTIVE
Inhibition of Bcl-xL by Targeted Degradation
Role: Faculty
Funding: NATL INST OF HLTH NCI
Sep 2019 ACTIVE
Use of BCL-xL Proteolysis targeting chimeras to treat pancreatic cancer
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Aug 2019 ACTIVE
Develop BCL-xL proteolysis targeting chimeras as safer and better senolytics
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA

Education

Ph.D.
2012 · Peking University
B.S.
2006 · Peking University

Contact Details

Emails: