Jenny Wilkerson,
Research Assistant Professor
Teaching Profile
Courses Taught
2022-2023
PHA7980 Research for Doctoral Dissertation
2021
PHA7979 Advanced Research
2019-2020
PHA5560 Pathphys-Pt Assess I
2020
PHA4911 Undergraduate Research in Pharmacodynamics
Publications
2023
Cannabidiol and mitragynine exhibit differential interactive effects in the attenuation of paclitaxel-induced mechanical allodynia, acute antinociception, and schedule-controlled responding in mice.
Pharmacological reports : PR.
75(4):937-950
[DOI] 10.1007/s43440-023-00498-w.
[PMID] 37243887.
2023
Pharmacokinetic and Pharmacodynamic Consequences of Cytochrome P450 3A Inhibition on Mitragynine Metabolism in Rats.
The Journal of pharmacology and experimental therapeutics.
385(3):180-192
[DOI] 10.1124/jpet.122.001525.
[PMID] 37019472.
2022
Evaluation of the terpenes β-caryophyllene, α-terpineol, and γ-terpinene in the mouse chronic constriction injury model of neuropathic pain: possible cannabinoid receptor involvement.
Psychopharmacology.
239(5):1475-1486
[DOI] 10.1007/s00213-021-06031-2.
[PMID] 34846548.
2022
In vitro and in vivo pharmacology of kratom.
Advances in pharmacology (San Diego, Calif.).
93:35-76
[DOI] 10.1016/bs.apha.2021.10.001.
[PMID] 35341571.
2022
Interactive Effects of µ-Opioid and Adrenergic-α 2 Receptor Agonists in Rats: Pharmacological Investigation of the Primary Kratom Alkaloid Mitragynine and Its Metabolite 7-Hydroxymitragynine.
The Journal of pharmacology and experimental therapeutics.
383(3):182-198
[DOI] 10.1124/jpet.122.001192.
[PMID] 36153006.
2022
Medicinal Cannabis and Central Nervous System Disorders.
Frontiers in pharmacology.
13
[DOI] 10.3389/fphar.2022.881810.
[PMID] 35529444.
2022
Novel roles of phentolamine in protecting axon myelination, muscle atrophy, and functional recovery following nerve injury.
Scientific reports.
12(1)
[DOI] 10.1038/s41598-022-07253-w.
[PMID] 35228612.
2022
Peripherally administered cannabinoid receptor 2 (CB2R) agonists lose anti-allodynic effects in TRPV1 knockout mice, while intrathecal administration leads to anti-allodynia and reduced GFAP, CCL2 and TRPV1 expression in the dorsal spinal cord and DRG.
Brain research.
1774
[DOI] 10.1016/j.brainres.2021.147721.
[PMID] 34774500.
2022
The discriminative stimulus effects of baclofen and gamma hydroxybutyrate in C57BL/6J mice.
Behavioural pharmacology.
33(6):427-434
[DOI] 10.1097/FBP.0000000000000691.
[PMID] 35947069.
2021
Characterization of a mouse neuropathic pain model caused by the highly active antiviral therapy (HAART) Stavudine.
Pharmacological reports : PR.
73(5):1457-1464
[DOI] 10.1007/s43440-021-00262-y.
[PMID] 33860918.
2021
Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for μ-Opioid Receptor and Opioid-Like Behavioral Effects in Rats.
The Journal of pharmacology and experimental therapeutics.
376(3):410-427
[DOI] 10.1124/jpet.120.000189.
[PMID] 33384303.
2021
Sex differences and the endocannabinoid system in pain.
Pharmacology, biochemistry, and behavior.
202
[DOI] 10.1016/j.pbb.2021.173107.
[PMID] 33444598.
2021
Untapped endocannabinoid pharmacological targets: Pipe dream or pipeline?
Pharmacology, biochemistry, and behavior.
206
[DOI] 10.1016/j.pbb.2021.173192.
[PMID] 33932409.
2020
Advances in the In vitro and In vivo pharmacology of Alpha4beta2 nicotinic receptor positive allosteric modulators.
Neuropharmacology.
168
[DOI] 10.1016/j.neuropharm.2020.108008.
[PMID] 32113032.
2020
Alterations in mouse spinal cord and sciatic nerve microRNAs after the chronic constriction injury (CCI) model of neuropathic pain.
Neuroscience letters.
731
[DOI] 10.1016/j.neulet.2020.135029.
[PMID] 32380144.
2020
Axially Chiral Cannabinols: A New Platform for Cannabinoid-Inspired Drug Discovery.
ChemMedChem.
15(9):728-732
[DOI] 10.1002/cmdc.202000025.
[PMID] 32061146.
2020
More than Smoke and Patches: The Quest for Pharmacotherapies to Treat Tobacco Use Disorder.
Pharmacological reviews.
72(2):527-557
[DOI] 10.1124/pr.119.018028.
[PMID] 32205338.
2020
Nicotinic Acetylcholine Receptor Accessory Subunits Determine the Activity Profile of Epibatidine Derivatives.
Molecular pharmacology.
98(4):328-342
[DOI] 10.1124/molpharm.120.000037.
[PMID] 32690626.
2020
Peripheral versus central mechanisms of the cannabinoid type 2 receptor agonist AM1710 in a mouse model of neuropathic pain.
Brain and behavior.
10(12)
[DOI] 10.1002/brb3.1850.
[PMID] 32977358.
2020
Unexpected loss of sensitivity to the nicotinic acetylcholine receptor antagonist activity of mecamylamine and dihydro-β-erythroidine in nicotine-tolerant mice.
Brain and behavior.
10(4)
[DOI] 10.1002/brb3.1581.
[PMID] 32092237.
2019
The effects of mitragynine and morphine on schedule-controlled responding and antinociception in rats.
Psychopharmacology.
236(9):2725-2734
[DOI] 10.1007/s00213-019-05247-7.
[PMID] 31098655.
2019
The Effects of Morphine, Baclofen, and Buspirone Alone and in Combination on Schedule-Controlled Responding and Hot Plate Antinociception in Rats.
The Journal of pharmacology and experimental therapeutics.
370(3):380-389
[DOI] 10.1124/jpet.118.255844.
[PMID] 31235534.
2019
Tolerance and dependence to Δ9-tetrahydrocannabinol in rhesus monkeys: Activity assessments.
PloS one.
14(3)
[DOI] 10.1371/journal.pone.0209947.
[PMID] 30861005.
2018
Differential Tolerance to FTY720-Induced Antinociception in Acute Thermal and Nerve Injury Mouse Pain Models: Role of Sphingosine-1-Phosphate Receptor Adaptation.
The Journal of pharmacology and experimental therapeutics.
366(3):509-518
[DOI] 10.1124/jpet.118.248260.
[PMID] 29945931.
2018
Evaluation of different drug classes on transient sciatic nerve injury-depressed marble burying in mice.
Pain.
159(6):1155-1165
[DOI] 10.1097/j.pain.0000000000001199.
[PMID] 29528965.
2018
Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy.
The Journal of pharmacology and experimental therapeutics.
366(1):169-183
[DOI] 10.1124/jpet.117.245704.
[PMID] 29540562.
2018
The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
43(1):52-79
[DOI] 10.1038/npp.2017.204.
[PMID] 28857069.
2017
Investigation of Diacylglycerol Lipase Alpha Inhibition in the Mouse Lipopolysaccharide Inflammatory Pain Model.
The Journal of pharmacology and experimental therapeutics.
363(3):394-401
[DOI] 10.1124/jpet.117.243808.
[PMID] 28970359.
2017
The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice.
Neuropharmacology.
114:156-167
[DOI] 10.1016/j.neuropharm.2016.11.015.
[PMID] 27890602.
2016
Diacylglycerol lipase β inhibition reverses nociceptive behaviour in mouse models of inflammatory and neuropathic pain.
British journal of pharmacology.
173(10):1678-92
[DOI] 10.1111/bph.13469.
[PMID] 26915789.
2016
Palmitoylethanolamide Reverses Paclitaxel-Induced Allodynia in Mice.
The Journal of pharmacology and experimental therapeutics.
359(2):310-318
[PMID] 27608657.
2016
The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity.
British journal of pharmacology.
173(3):446-58
[DOI] 10.1111/bph.13338.
[PMID] 26398481.
2016
The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.
The Journal of pharmacology and experimental therapeutics.
357(1):145-56
[DOI] 10.1124/jpet.115.229971.
[PMID] 26791602.
2016
The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain.
British journal of pharmacology.
173(16):2506-20
[DOI] 10.1111/bph.13528.
[PMID] 27243753.
2015
Selective monoacylglycerol lipase inhibitors: antinociceptive versus cannabimimetic effects in mice.
The Journal of pharmacology and experimental therapeutics.
353(2):424-32
[DOI] 10.1124/jpet.114.222315.
[PMID] 25762694.
2014
Improvement of spinal non-viral IL-10 gene delivery by D-mannose as a transgene adjuvant to control chronic neuropathic pain.
Journal of neuroinflammation.
11
[DOI] 10.1186/1742-2094-11-92.
[PMID] 24884664.
2013
Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord.
Journal of controlled release : official journal of the Controlled Release Society.
168(2):209-24
[DOI] 10.1016/j.jconrel.2013.03.009.
[PMID] 23517784.
2012
Immunofluorescent spectral analysis reveals the intrathecal cannabinoid agonist, AM1241, produces spinal anti-inflammatory cytokine responses in neuropathic rats exhibiting relief from allodynia.
Brain and behavior.
2(2):155-77
[DOI] 10.1002/brb3.44.
[PMID] 22574283.
2012
Intrathecal cannabilactone CB(2)R agonist, AM1710, controls pathological pain and restores basal cytokine levels.
Pain.
153(5):1091-1106
[DOI] 10.1016/j.pain.2012.02.015.
[PMID] 22425445.
2011
The Central Role of Glia in Pathological Pain and the Potential of Targeting the Cannabinoid 2 Receptor for Pain Relief.
ISRN anesthesiology.
2011(2011)
[PMID] 22442754.
Grants
Jul 2019
– Dec 2020
Consortium for Medical Marijuana Clinical Outcomes Research
Role: Project Manager
Funding: STATE UNIVERSITY SYSTEM OF FLORIDA
via FL LEGISLATURE
Contact Details
Phones:
- Business:
- (352) 294-8908
Emails:
- Business:
- jenny.wilkerson@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100487
GAINESVILLE FL 32610 - Business Street:
-
1345 CENTER DR
MSB P1-20
GAINESVILLE FL 32610