Brandon Warren

Brandon Warren, Ph.D.

Assistant Professor

Department: Pharmacodynamics
Business Phone: (352) 273-7010
Business Email: brandon.warren@cop.ufl.edu

About Brandon Warren

Brandon Warren, Ph.D., received his B.S., M.S., and Ph.D. from Florida State University. He then completed a postdoctoral fellowship at the National Institute on Drug Abuse in Baltimore, Maryland. Warren’s lab integrates behavioral, biochemical, and microscopic approaches to probe the role of neuronal ensembles (patterns of neurons activated during behavior) in animal models of drug addiction.

Research Profile

Drug addiction appears to involve abnormally strong learned associations, typified by intrusive memories that often induce drug craving and relapse. Our research endeavors to decode how these drug memories are stored in the brain. We hypothesize that learned associations are encoded by patterns of sparsely distributed neurons, called neuronal ensembles, which are selected by cues and their reinforcers. Since strong neuronal activity drives expression of the immediate early gene Fos, we use Fos expression to identify neuronal ensembles activated during behavior. The relationship between neuronal activity and Fos expression permits us to use the Fos promoter to drive expression of transgenes in rats. Transgenic rat lines now allow us to characterize and manipulate neuronal ensembles with unmatched specificity. Understanding how these memories are encoded may one day enable us to treat drug addiction by strengthening or weakening specific drug or memories.

For more details and information about joining the lab, please visit our website: http://www.warren-lab.com

Publications

2020
Can I Get a Witness? Using Vicarious Defeat Stress to Study Mood-Related Illnesses in Traditionally Understudied Populations.
Biological psychiatry. 88(5):381-391 [DOI] 10.1016/j.biopsych.2020.02.004. [PMID] 32228871.
2020
Nicotine treatment buffers negative behavioral consequences induced by exposure to physical and emotional stress in adolescent male mice.
Psychopharmacology. 237(10):3125-3137 [DOI] 10.1007/s00213-020-05598-6. [PMID] 32594187.
2019
Separate vmPFC Ensembles Control Cocaine Self-Administration Versus Extinction in Rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(37):7394-7407 [DOI] 10.1523/JNEUROSCI.0918-19.2019. [PMID] 31331999.
2019
Upregulation of hippocampal extracellular signal-regulated kinase (ERK)-2 induces antidepressant-like behavior in the rat forced swim test.
Behavioral neuroscience. 133(2):225-231 [DOI] 10.1037/bne0000303. [PMID] 30907619.
2018
Prelimbic cortex is a common brain area activated during cue-induced reinstatement of cocaine and heroin seeking in a polydrug self-administration model
European Journal of Neuroscience. 49(2):165-178 [DOI] 10.1111/ejn.14203. [PMID] 30307667.
2018
Parvalbumin-Expressing Neurons in the Nucleus Accumbens: A New Player in Amphetamine Sensitization and Reward.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 43(5):929-930 [DOI] 10.1038/npp.2017.256. [PMID] 29162905.
2017
Bidirectional Modulation of Intrinsic Excitability in Rat Prelimbic Cortex Neuronal Ensembles and Non-Ensembles after Operant Learning.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(36):8845-8856 [DOI] 10.1523/JNEUROSCI.3761-16.2017. [PMID] 28779019.
2017
Mechanistic Resolution Required to Mediate Operant Learned Behaviors: Insights from Neuronal Ensemble-Specific Inactivation.
Frontiers in neural circuits. 11 [DOI] 10.3389/fncir.2017.00028. [PMID] 28484375.
2017
Neurons Internalize Functionalized Micron-Sized Silicon Dioxide Microspheres.
Cellular and molecular neurobiology. 37(8):1487-1499 [DOI] 10.1007/s10571-017-0479-z. [PMID] 28260198.
2017
Role of Dorsomedial Striatum Neuronal Ensembles in Incubation of Methamphetamine Craving after Voluntary Abstinence.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(4):1014-1027 [DOI] 10.1523/JNEUROSCI.3091-16.2016. [PMID] 28123032.
2017
The Anterior Insular Cortex→Central Amygdala Glutamatergic Pathway Is Critical to Relapse after Contingency Management.
Neuron. 96(2):414-427.e8 [DOI] 10.1016/j.neuron.2017.09.024. [PMID] 29024664.
2016
Distinct Fos-Expressing Neuronal Ensembles in the Ventromedial Prefrontal Cortex Mediate Food Reward and Extinction Memories.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(25):6691-703 [DOI] 10.1523/JNEUROSCI.0140-16.2016. [PMID] 27335401.
2016
Vicarious social defeat stress: Bridging the gap between physical and emotional stress.
Journal of neuroscience methods. 258:94-103 [DOI] 10.1016/j.jneumeth.2015.10.012. [PMID] 26545443.
2015
Context-induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(14):5625-39 [DOI] 10.1523/JNEUROSCI.4997-14.2015. [PMID] 25855177.
2014
Altered gene expression and spine density in nucleus accumbens of adolescent and adult male mice exposed to emotional and physical stress.
Developmental neuroscience. 36(3-4):250-60 [DOI] 10.1159/000362875. [PMID] 24943326.
2014
Effects of psychotropic drugs on second messenger signaling and preference for nicotine in juvenile male mice.
Psychopharmacology. 231(8):1479-92 [DOI] 10.1007/s00213-014-3434-4. [PMID] 24452697.
2014
Fluoxetine exposure during adolescence alters responses to aversive stimuli in adulthood.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(3):1007-21 [DOI] 10.1523/JNEUROSCI.5725-12.2014. [PMID] 24431458.
2014
Life-long consequences of juvenile exposure to psychotropic drugs on brain and behavior.
Progress in brain research. 211:13-30 [DOI] 10.1016/B978-0-444-63425-2.00002-7. [PMID] 24968775.
2014
Social defeat stress induces a depression-like phenotype in adolescent male c57BL/6 mice.
Stress (Amsterdam, Netherlands). 17(3):247-55 [DOI] 10.3109/10253890.2014.910650. [PMID] 24689732.
2014
Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress
Proceedings of the National Academy of Sciences of the United States of America. 111(45):16136-16141 [DOI] 10.1073/pnas.1415191111. [PMID] 25331895.
2013
Neurobiological sequelae of witnessing stressful events in adult mice.
Biological psychiatry. 73(1):7-14 [DOI] 10.1016/j.biopsych.2012.06.006. [PMID] 22795644.
2013
Repeated ketamine exposure induces an enduring resilient phenotype in adolescent and adult rats.
Biological psychiatry. 74(10):750-9 [DOI] 10.1016/j.biopsych.2013.04.027. [PMID] 23790225.
2011
Juvenile administration of concomitant methylphenidate and fluoxetine alters behavioral reactivity to reward- and mood-related stimuli and disrupts ventral tegmental area gene expression in adulthood.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(28):10347-58 [DOI] 10.1523/JNEUROSCI.1470-11.2011. [PMID] 21753012.
2010
DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses.
Nature neuroscience. 13(6):745-52 [DOI] 10.1038/nn.2551. [PMID] 20473292.
2010
Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
Nature Neuroscience. 13(9):1137-1143 [PMID] 2072844.
View on: PubMed
2010
Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens.
Nature neuroscience. 13(9):1137-43 [DOI] 10.1038/nn.2619. [PMID] 20729844.
2010
Extracellular signal-regulated kinase-2 within the ventral tegmental area regulates responses to stress.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(22):7652-63 [DOI] 10.1523/JNEUROSCI.0951-10.2010. [PMID] 20519540.
2010
Short- and long-term functional consequences of fluoxetine exposure during adolescence in male rats.
Biological psychiatry. 67(11):1057-66 [DOI] 10.1016/j.biopsych.2009.12.033. [PMID] 20172503.
2010
Viral-mediated expression of extracellular signal-regulated kinase-2 in the ventral tegmental area modulates behavioral responses to cocaine.
Behavioural brain research. 214(2):460-4 [DOI] 10.1016/j.bbr.2010.05.040. [PMID] 20561901.
2009
Nicotine exposure during adolescence induces a depression-like state in adulthood.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 34(6):1609-24 [DOI] 10.1038/npp.2008.220. [PMID] 19092782.
2008
Insulin receptor substrate-2 in ventral tegmental area regulates cocaine-induced behavioral adaptations
Biological psychiatry. 122(5):1172-1177 [DOI] 10.1016/j.biopsych.2008.06.003. [PMID] 18639865.
2008
Insulin receptor substrate-2 in the ventral tegmental area regulates behavioral responses to cocaine.
Behavioral neuroscience. 122(5):1172-7 [DOI] 10.1037/a0012893. [PMID] 18823173.

Grants

Feb 2019 ACTIVE
Neuronal ensembles in extinction of cocaine seeking
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDA
Jan 2019 – Jan 2021
The Role of Neuronal Ensembles in Food Versus Cocaine Self-administration.
Role: Principal Investigator
Funding: BRAIN & BEHAVIOR RESEARCH FOUNDATION

Education

Ph.D.
2013 · Florida State University
M.S.
2010 · Florida State University
B.Sc.
2008 · Florida State University

Teaching Profile

Courses Taught
2020-2021
PHA7979 Advanced Research
2020-2021
PHA6512L Experiential Research Training in Pharmacodynamics
2020-2021
PHA6521C Research Techniques in Pharmacodynamics
2020-2021
PHA6936 Advanced Topics in Pharmaceutical Sciences
2020-2021
PHA7980 Research for Doctoral Dissertation
2020
PHA6910 Supervised Research

Contact Details

Phones:
Business:
(352) 273-7010
Emails: