Aurore Valfort

Aurore Valfort, M.Sc.

Research Assistant Scientist

Department: Pharmacodynamics
Business Email: a.valfort@ufl.edu

About Aurore Valfort

Aurore-Cecile Valfort is a Research Assistant Scientist in the Department of Pharmacodynamics. She graduated a B.Sc. in biochemistry from University Claude Bernard (Lyon, France) in 2007, then a M.Sc. in Biotechnology from University Louis Pasteur (Strasbourg, France) in 2009.

During her M.Sc., she did an internship at the Biotechnology Research Institute in Montreal (Quebec, Canada) where she worked on engineering lentiviral vector with different envelop proteins. After graduating she studied retrotransposon biology as a Research Engineer at the French National Institute for health and Medical Research (INSERM). From 2010 to 2017 she worked at the French National Center of Scientific Research (CNRS). She studied the 1st mitotic spindle division among 42 nematode species and the identification of new genes involved in the synaptic assembly and scaffold at the Neuro-Muscular Junction (NMJ) in C. elegans. For both project, she worked on the development of new genome engineering methods and successfully used CRISPR/Cas-9 technology for the modification of genes of interest and site-directed mutagenesis. She then joined Dr. Flaveny’s team at Saint Louis University School of Medicine in 2017, where she began to study nuclear receptor. She then joined Dr. Burris at Washington University in Saint Louis, whose lab moved to University of Florida (Genetics Institute) in 2021. Aurore-Cecile Valfort focuses on the development of new cell-based assay for drug discovery purpose. Her goal is to screen new small molecules targeting nuclear receptors for the treatment of several metabolic diseases such as diabetes, obesity Alzheimer disease. Her work was published in multiple scientific articles and presented during several scientific meetings.

Publications

Academic Articles
2024
The Estrogen Receptor-Related Orphan Receptors Regulate Autophagy through TFEB.
Molecular pharmacology. 106(4):164-172 [DOI] 10.1124/molpharm.124.000889. [PMID] 39168657.
2022
Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB.
Nature communications. 13(1) [DOI] 10.1038/s41467-022-34892-4. [PMID] 36414641.
2021
A two-hit model of alcoholic liver disease that exhibits rapid, severe fibrosis.
PloS one. 16(3) [DOI] 10.1371/journal.pone.0249316. [PMID] 33770118.
2020
The netrin receptor UNC-40/DCC assembles a postsynaptic scaffold and sets the synaptic content of GABAA receptors.
Nature communications. 11(1) [DOI] 10.1038/s41467-020-16473-5. [PMID] 32471987.
2019
LXR-inverse agonism stimulates immune-mediated tumor destruction by enhancing CD8 T-cell activity in triple negative breast cancer.
Scientific reports. 9(1) [DOI] 10.1038/s41598-019-56038-1. [PMID] 31863071.
2018
Evolution of mitotic spindle behavior during the first asymmetric embryonic division of nematodes.
PLoS biology. 16(1) [DOI] 10.1371/journal.pbio.2005099. [PMID] 29357348.
2017
Biallelic mutation of UNC50, encoding a protein involved in AChR trafficking, is responsible for arthrogryposis.
Human molecular genetics. 26(20):3989-3994 [DOI] 10.1093/hmg/ddx288. [PMID] 29016857.
2017
Pharmacological inhibition of REV-ERB stimulates differentiation, inhibits turnover and reduces fibrosis in dystrophic muscle.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-17496-7. [PMID] 29215066.
2015
Scaling, selection, and evolutionary dynamics of the mitotic spindle.
Current biology : CB. 25(6):732-740 [DOI] 10.1016/j.cub.2014.12.060. [PMID] 25683802.

Education

MS Biotechnology
2007 · Universite de Strasbourg, France
BS Biochemistry
2004 · Universite Claude Bernard Lyon1, France

Contact Details

Emails:
Business:
a.valfort@ufl.edu
Addresses:
Business Mailing:
PO Box 103610
GAINESVILLE FL 32611
Business Street:
UFGI – Burris Lab
2033 Mowry Road
Gainesville FL 32608