Sihong Song

Sihong Song Ph.D.

Associate Professor

Department: Pharmaceutics
Business Phone: (352) 273-7867
Business Email: shsong@ufl.edu

Research Profile

Song’s interests are in 1) improvement of safety and efficiency of rAAV vector by understanding molecular mechanisms of persistence and integration of the AAV genome in mammalian cells and 2) the use of recombinant Adeno-Associated Virus (rAAV) vectors mediated gene transfer to develop gene therapy approaches for common diseases such as diabetes and arthritis.

His research interests include: molecular and cell biology, gene expression and gene regulation, liver and muscle gene delivery, gene therapy for type 1 diabetes and alpha 1 antitrypsin deficiency, adeno-associated virus (AAV) vector biology: DNA persistence, integration and interaction with cellular factors; host immune responses to transgene products

Publications

2009 Proceedings of the National Academy of Sciences of the United States of America
2004 Proceedings of the National Academy of Sciences

Grants

March 2018 – November 2018
Testing of AAV-hAAT Vectors in Mice
APPLIED GENETICS TECH CORP · Principal Investigator
August 2016 – August 2018
Study on the inter and intra generic transmission of drug resistance determinants
EGYPTIAN CULTURAL AND EDU BUR · Principal Investigator
June 2015 – May 2018
Alpha 1 antitrypsin for the treatment of osteoporosis
UF DSR OPPORTUNITY FUND · Principal Investigator
January 2015 – January 2017
The Protective Effect of Prolostin C for the Treatment
GRIFOLS WORLDWIDE OPERATIONS LTD · Principal Investigator

Patents

Published June 2008
rAAV Vector-Based Compositions and Methods for the Prevention and Treatment of Mammalian Diseases
US 2009/0111766 A1
Published October 2007
Adeno-Associated Viral Vectors for the Treatment and Prevention of Diabetes (CON)
US-2009-0186002-A1
Published August 2005
rAAV Vector-Based Compositions and methods for the Prevention and Treatment of Mammalian Diseases
US2007/0003518A1
Published January 2003
Adeno-Associated Viral Vectors for the Treatment and Prevention of Diabetes
US-2003-0095949-A1
Issued October 2002
Materials and Methods for Gene Therapy
6,461,606
Published October 2002
rAAV Compositions for Gene Therapy
US-2003-0082162-A1

Education

1999
Post Doctoral Associate in Gene Therapy
University of Florida
1996
Ph.D.
University of Florida
1989
M.S.
Jilin Agricultural University
1982
B.S.
Jilin Agricultural University