Karen Scott

Karen Scott, Ph.D., M.S.

Research Assistant Professor

Department: Pharmacodynamics
Business Phone: (352) 294-8965
Business Email: karen.scott@cop.ufl.edu

About Karen Scott

Karen A. Scott, Ph.D., received a Bachelor’s degree in Psychology from Penn State University and a Master’s degree in Animal Sciences from Purdue University. After briefly working for the USDA, Dr. Scott joined the laboratory of Dr. Timothy H. Moran at the Johns Hopkins University School of Medicine. There, she performed research investigating how the brain controlled feeding and metabolism. Subsequently, Dr. Scott completed her doctoral training within the Department of Psychiatry and Behavioral Neuroscience in the laboratory of Dr. Randall R. Sakai. Her research focused on early life stress and its influence on stress susceptibility and social behavior in adulthood, as well as the effects of chronic social stress and early life manipulations on metabolism. Dr. Scott was awarded a competitive Ruth L. Kirchstein F31 Individual National Research Service Award from the National Institutes of Health that supported her doctoral studies. Following her Ph.D., she moved to University College Cork in Cork, Ireland, to conduct a postdoctoral fellowship in the laboratory of Dr. John F. Cryan. There, she studied the gut-brain axis, and the role that the gut microbiota plays in mediating this bi-directional communication. Dr. Scott joined University of Florida College of Pharmacy in spring 2018 as a Research Assistant Professor in the Department of Pharmacodynamics. The goal of her research at University of Florida is to continue to investigate stress vulnerability and resilience and the role of the gut-brain-microbiota axis, utilizing a multidisciplinary approach that includes behavioral, molecular, immunological, and neuroanatomical approaches.

Research Profile

Open Researcher and Contributor ID (ORCID)



An Angiotensin-responsive Connection from the Lamina Terminalis to the Paraventricular Nucleus of the Hypothalamus Evokes Vasopressin Secretion to Increase Blood Pressure in Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience. [DOI] 10.1523/JNEUROSCI.1600-20.2020. [PMID] 33328294.
Overexpression of angiotensin converting enzyme 2 reduces anxiety-like behavior in female mice.
Physiology & behavior. 224 [DOI] 10.1016/j.physbeh.2020.113002. [PMID] 32525008.
Enduring Behavioral Effects Induced by Birth by Caesarean Section in the Mouse.
Current biology : CB. 30(19):3761-3774.e6 [DOI] 10.1016/j.cub.2020.07.044. [PMID] 32822606.
Mid-life microbiota crises: middle age is associated with pervasive neuroimmune alterations that are reversed by targeting the gut microbiome.
Molecular psychiatry. 25(10):2567-2583 [DOI] 10.1038/s41380-019-0425-1. [PMID] 31092898.
An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes.
The Journal of experimental medicine. 216(11):2479-2491 [DOI] 10.1084/jem.20190430. [PMID] 31467037.
Pretreatment with a CRF antagonist amplifies feeding inhibition induced by fourth ventricular cocaine- and amphetamine-regulated transcript peptide.
BMC neuroscience. 20(1) [DOI] 10.1186/s12868-019-0494-8. [PMID] 30885137.
Fourth ventricular thyrotropin induces satiety and increases body temperature in rats.
American journal of physiology. Regulatory, integrative and comparative physiology. 314(5):R734-R740 [DOI] 10.1152/ajpregu.00107.2017. [PMID] 29351420.
A closer look at the subordinate population within the visible burrow system.
Physiology & behavior. 178:110-116 [DOI] 10.1016/j.physbeh.2017.01.039. [PMID] 28130085.
Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse.
Brain, behavior, and immunity. 65:20-32 [DOI] 10.1016/j.bbi.2017.02.004. [PMID] 28179108.
Susceptibility or resilience? Prenatal stress predisposes male rats to social subordination, but facilitates adaptation to subordinate status.
Physiology & behavior. 178:117-125 [DOI] 10.1016/j.physbeh.2017.03.006. [PMID] 28284881.
Stress coping style does not determine social status, but influences the consequences of social subordination stress.
Physiology & behavior. 178:126-133 [DOI] 10.1016/j.physbeh.2016.12.041. [PMID] 28069459.
MicroRNAs as biomarkers for major depression: a role for let-7b and let-7c.
Translational psychiatry. 6(8) [DOI] 10.1038/tp.2016.131. [PMID] 27483380.
Adipocyte glucocorticoid receptors mediate fat-to-brain signaling.
Psychoneuroendocrinology. 56:110-9 [DOI] 10.1016/j.psyneuen.2015.03.008. [PMID] 25808702.
Chronic P-glycoprotein inhibition increases the brain concentration of escitalopram: potential implications for treating depression.
Pharmacology research & perspectives. 3(6) [DOI] 10.1002/prp2.190. [PMID] 27022464.
Fourth ventricular CART peptide induces c-fos in the area postrema and nucleus of the solitary tract via a CRF-receptor dependent mechanism.
Neuroscience letters. 609:124-8 [DOI] 10.1016/j.neulet.2015.10.028. [PMID] 26475505.
Thinking small: towards microRNA-based therapeutics for anxiety disorders.
Expert opinion on investigational drugs. 24(4):529-42 [DOI] 10.1517/13543784.2014.997873. [PMID] 25566796.
Effects of Chronic Social Stress on Obesity.
Current obesity reports. 1(1):16-25 [PMID] 22943039.
View on: PubMed
Amylin blunts hyperphagia and reduces weight and fat gain during recovery in socially stressed rats.
American journal of physiology. Regulatory, integrative and comparative physiology. 303(6):R676-82 [DOI] 10.1152/ajpregu.00090.2012. [PMID] 22832535.
Blood-borne angiotensin II acts in the brain to influence behavioral and endocrine responses to psychogenic stress.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(42):15009-15 [DOI] 10.1523/JNEUROSCI.0892-11.2011. [PMID] 22016534.
Obesity/hyperleptinemic phenotype adversely affects hippocampal plasticity: effects of dietary restriction.
Physiology & behavior. 104(2):235-41 [DOI] 10.1016/j.physbeh.2010.10.020. [PMID] 21036186.
Central angiotensin II has catabolic action at white and brown adipose tissue.
American journal of physiology. Endocrinology and metabolism. 301(6):E1081-91 [DOI] 10.1152/ajpendo.00307.2011. [PMID] 21862725.
Acute exposure to a high-fat diet alters meal patterns and body composition.
Physiology & behavior. 99(1):33-9 [DOI] 10.1016/j.physbeh.2009.10.004. [PMID] 19835896.
Glucose parameters are altered in mouse offspring produced by assisted reproductive technologies and somatic cell nuclear transfer.
Biology of reproduction. 83(2):220-7 [DOI] 10.1095/biolreprod.109.082826. [PMID] 20445127.
Meal patterns and hypothalamic NPY expression during chronic social stress and recovery.
American journal of physiology. Regulatory, integrative and comparative physiology. 299(3):R813-22 [DOI] 10.1152/ajpregu.00820.2009. [PMID] 20610828.
Role of dorsomedial hypothalamic neuropeptide Y in modulating food intake and energy balance.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(1):179-90 [DOI] 10.1523/JNEUROSCI.4379-08.2009. [PMID] 19129396.
Angiotensin type 1 receptors in the subfornical organ mediate the drinking and hypothalamic-pituitary-adrenal response to systemic isoproterenol.
Endocrinology. 149(12):6416-24 [DOI] 10.1210/en.2008-0477. [PMID] 18687780.
Characterization of the feeding inhibition and neural activation produced by dorsomedial hypothalamic cholecystokinin administration.
Neuroscience. 152(1):178-88 [DOI] 10.1016/j.neuroscience.2007.12.004. [PMID] 18248910.
The GLP-1 agonist exendin-4 reduces food intake in nonhuman primates through changes in meal size.
American journal of physiology. Regulatory, integrative and comparative physiology. 293(3):R983-7 [PMID] 17581835.
View on: PubMed
Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake.
Proceedings of the National Academy of Sciences of the United States of America. 104(44):17358-63 [PMID] 17956983.
View on: PubMed
Lateral ventricular ghrelin and fourth ventricular ghrelin induce similar increases in food intake and patterns of hypothalamic gene expression.
American journal of physiology. Regulatory, integrative and comparative physiology. 290(6):R1565-9 [PMID] 16424082.
View on: PubMed
Postnatal behavioral and physiological responses of piglets from gilts housed individually or in groups during gestation.
Journal of animal science. 84(3):757-66 [PMID] 16478968.
View on: PubMed
Altered hypothalamic signaling and responses to food deprivation in rats fed a low-carbohydrate diet.
Obesity research. 13(10):1672-82 [PMID] 16286514.
View on: PubMed
Dorsomedial hypothalamic corticotropin-releasing factor mediation of exercise-induced anorexia.
American journal of physiology. Regulatory, integrative and comparative physiology. 288(6):R1800-5 [PMID] 15677523.
View on: PubMed
Peptide YY(3-36) inhibits gastric emptying and produces acute reductions in food intake in rhesus monkeys.
American journal of physiology. Regulatory, integrative and comparative physiology. 288(2):R384-8 [PMID] 15388494.
View on: PubMed
Running wheel activity prevents hyperphagia and obesity in Otsuka long-evans Tokushima Fatty rats: role of hypothalamic signaling.
Endocrinology. 146(4):1676-85 [PMID] 15625240.
View on: PubMed
Differential roles for cholecystokinin a receptors in energy balance in rats and mice.
Endocrinology. 145(8):3873-80 [PMID] 15123537.
View on: PubMed


Feb 2020 ACTIVE
Interrogating stress-relieving neural circuits to alleviate cardiovascular disease
Role: Co-Investigator


2012 · University of Cincinnati
2000 · Purdue University
1997 · The Pennsylvania State University

Contact Details

(352) 294-8965