Mohamed O A Radwan, Ph.D.
Research Assistant Professor
Teaching Profile
Courses Taught
2024
PHA5878C Pt Care 3: Cv and Pulm
2024
PHA5439 Prin Med Chem-Pcol I
Publications
Academic Articles
2024
Beyond Psychotropic: Potential Repurposing of Fluoxetine toward Cancer Therapy.
International journal of molecular sciences.
25(12)
[DOI] 10.3390/ijms25126314.
[PMID] 38928021.
2024
HIV-1 Gag MA domain binds to cardiolipin in a binding mode distinct from virus assemble mediator PI(4,5)P2.
Chemical biology & drug design.
103(1)
[DOI] 10.1111/cbdd.14401.
[PMID] 37985015.
2024
Ligand-based design and synthesis of new trityl histamine and trityl cysteamine derivatives as SIRT2 inhibitors for cancer therapy.
European journal of medicinal chemistry.
269
[DOI] 10.1016/j.ejmech.2024.116302.
[PMID] 38484678.
2023
Gypsogenin Battling for a Front Position in the Pentacyclic Triterpenes Game of Thrones on Anti-Cancer Therapy: A Critical Review-Dedicated to the Memory of Professor Hanaa M. Rady.
Molecules (Basel, Switzerland).
28(15)
[DOI] 10.3390/molecules28155677.
[PMID] 37570648.
2023
Harnessing Oleanolic Acid and Its Derivatives as Modulators of Metabolic Nuclear Receptors.
Biomolecules.
13(10)
[DOI] 10.3390/biom13101465.
[PMID] 37892147.
2023
In vitro acetylcholinesterase, tyrosinase inhibitory potentials of secondary metabolites from Euphorbia schimperiana and Euphorbia balsamifera.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
78(5-6):209-216
[DOI] 10.1515/znc-2021-0178.
[PMID] 36321624.
2023
New insight into the bioactivity of substituted benzimidazole derivatives: Repurposing from anti-HIV activity to cell migration inhibition targeting hnRNP M.
Bioorganic & medicinal chemistry.
86
[DOI] 10.1016/j.bmc.2023.117294.
[PMID] 37141680.
2023
Overview of Ursolic Acid Potential for the Treatment of Metabolic Disorders, Autoimmune Diseases, and Cancers via Nuclear Receptor Pathways.
Biomedicines.
11(10)
[DOI] 10.3390/biomedicines11102845.
[PMID] 37893218.
2023
Structural Characterization of TRAF6 N-Terminal for Therapeutic Uses and Computational Studies on New Derivatives.
Pharmaceuticals (Basel, Switzerland).
16(11)
[DOI] 10.3390/ph16111608.
[PMID] 38004473.
2022
A New 1,2-Naphthoquinone Derivative with Anti-lung Cancer Activity.
Chemical & pharmaceutical bulletin.
70(7):477-482
[DOI] 10.1248/cpb.c21-01087.
[PMID] 35786566.
2022
Design, semi-synthesis and examination of new gypsogenin derivatives against leukemia via Abl tyrosine kinase inhibition and apoptosis induction.
International journal of biological macromolecules.
222(Pt A):1487-1499
[DOI] 10.1016/j.ijbiomac.2022.09.257.
[PMID] 36195231.
2022
Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity.
Pharmaceuticals (Basel, Switzerland).
15(4)
[DOI] 10.3390/ph15040426.
[PMID] 35455423.
2022
In Vitro and In Silico Study to Assess Toxic Mechanisms of Hybrid Molecules of Quinone-Benzocaine as Plastoquinone Analogues in Breast Cancer Cells.
ACS omega.
7(34):30250-30264
[DOI] 10.1021/acsomega.2c03428.
[PMID] 36061710.
2022
Natural-product-inspired design and synthesis of thiolated coenzyme Q analogs as promising agents against Gram-positive bacterial strains: insights into structure-activity relationship, activity profile, mode of action, and molecular docking.
RSC advances.
12(32):20507-20518
[DOI] 10.1039/d2ra02136f.
[PMID] 35919160.
2022
New Insights into the Structural Requirements of Isatin-Derived Pro-Apoptotic Agents against Acute Myeloid Leukemia.
Pharmaceuticals (Basel, Switzerland).
15(12)
[DOI] 10.3390/ph15121579.
[PMID] 36559030.
2022
Promising Antibacterial and Antifungal Agents Based on Thiolated Vitamin K3 Analogs: Synthesis, Bioevaluation, Molecular Docking.
Pharmaceuticals (Basel, Switzerland).
15(5)
[DOI] 10.3390/ph15050586.
[PMID] 35631412.
2021
A New Inhibitor of ADAM17 Composed of a Zinc-Binding Dithiol Moiety and a Specificity Pocket-Binding Appendage.
Chemical & pharmaceutical bulletin.
69(11):1123-1130
[DOI] 10.1248/cpb.c21-00701.
[PMID] 34719595.
2021
A New Series of Antileukemic Agents: Design, Synthesis, In Vitro and In Silico Evaluation of Thiazole-Based ABL1 Kinase Inhibitors.
Anti-cancer agents in medicinal chemistry.
21(9):1099-1109
[DOI] 10.2174/1871520620666200824100408.
[PMID] 32838725.
2021
EGFR-Targeted Pentacyclic Triterpene Analogues for Glioma Therapy.
International journal of molecular sciences.
22(20)
[DOI] 10.3390/ijms222010945.
[PMID] 34681605.
2021
First In Class (S,E)-11-[2-(Arylmethylene)Hydrazono]-PBD Analogs As Selective CB2 Modulators Targeting Neurodegenerative Disorders.
Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents.
30(1):98-108
[DOI] 10.1007/s00044-020-02640-2.
[PMID] 33776384.
2021
Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives.
Archives of pharmacal research.
44(11):903-986
[DOI] 10.1007/s12272-021-01354-2.
[PMID] 34907492.
2021
Selective SIRT2 inhibitors as promising anticancer therapeutics: An update from 2016 to 2020.
European journal of medicinal chemistry.
224
[DOI] 10.1016/j.ejmech.2021.113709.
[PMID] 34303869.
2020
A novel series of chlorinated plastoquinone analogs: Design, synthesis, and evaluation of anticancer activity.
Chemical biology & drug design.
95(3):343-354
[DOI] 10.1111/cbdd.13651.
[PMID] 31785034.
2020
Anticancer activity of Turkish marine extracts: a purple sponge extract induces apoptosis with multitarget kinase inhibition activity.
Investigational new drugs.
38(5):1326-1333
[DOI] 10.1007/s10637-020-00911-8.
[PMID] 32062733.
2020
HSP70 induction by bleomycin metal core analogs.
Bioorganic & medicinal chemistry letters.
30(7)
[DOI] 10.1016/j.bmcl.2020.127002.
[PMID] 32044184.
2020
In Vitro and In Silico Evaluation of Anticancer Activity of New Indole-Based 1,3,4-Oxadiazoles as EGFR and COX-2 Inhibitors.
Molecules (Basel, Switzerland).
25(21)
[DOI] 10.3390/molecules25215190.
[PMID] 33171861.
2020
Interruption of Vif/Elongin C interaction: In silico and experimental elucidation of the underlying molecular mechanism of benzimidazole-based APOBEC3G stabilizers.
Bioorganic & medicinal chemistry.
28(8)
[DOI] 10.1016/j.bmc.2020.115409.
[PMID] 32169404.
2020
Pentabromobenzyl-RP versus triazole-HILIC columns for separation of the polar basic analytes famotidine and famotidone: LC method development combined with in silico tools to follow the potential consequences of famotidine gastric instability.
Journal of pharmaceutical and biomedical analysis.
186
[DOI] 10.1016/j.jpba.2020.113305.
[PMID] 32353682.
2020
Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition.
Bioorganic & medicinal chemistry letters.
30(19)
[DOI] 10.1016/j.bmcl.2020.127458.
[PMID] 32755678.
2019
Antileukemic Activity of Twig Components of Caucasian Beech in Turkey.
Molecules (Basel, Switzerland).
24(21)
[DOI] 10.3390/molecules24213850.
[PMID] 31731511.
2019
Antiproliferative S-Trityl-l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement.
Molecules (Basel, Switzerland).
24(18)
[DOI] 10.3390/molecules24183295.
[PMID] 31510043.
2019
Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors.
European journal of medicinal chemistry.
182
[DOI] 10.1016/j.ejmech.2019.111648.
[PMID] 31493743.
2019
Design, synthesis, and biological activity of Plastoquinone analogs as a new class of anticancer agents.
Bioorganic chemistry.
92
[DOI] 10.1016/j.bioorg.2019.103255.
[PMID] 31542717.
2019
Discovery and structure-activity relationship of plastoquinone analogs as anticancer agents against chronic myelogenous leukemia cells.
Archiv der Pharmazie.
352(12)
[DOI] 10.1002/ardp.201900170.
[PMID] 31602720.
2019
Estimation of nizatidine gastric nitrosatability and product toxicity via an integrated approach combining HILIC, in silico toxicology, and molecular docking.
Journal of food and drug analysis.
27(4):915-925
[DOI] 10.1016/j.jfda.2019.08.001.
[PMID] 31590763.
2019
Minimum structural requirements for inhibitors of the zinc finger protein TRAF6.
Bioorganic & medicinal chemistry letters.
29(16):2162-2167
[DOI] 10.1016/j.bmcl.2019.06.050.
[PMID] 31272791.
2019
New SIRT2 inhibitors: Histidine-based bleomycin spin-off.
Bioorganic & medicinal chemistry.
27(9):1767-1775
[DOI] 10.1016/j.bmc.2019.03.003.
[PMID] 30885568.
2019
Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib-sensitive and -resistant multiple myeloma cells.
Cancer science.
110(10):3275-3287
[DOI] 10.1111/cas.14154.
[PMID] 31368616.
2018
Bioactive products from singlet oxygen photooxygenation of cannabinoids.
European journal of medicinal chemistry.
143:983-996
[DOI] 10.1016/j.ejmech.2017.11.043.
[PMID] 29232588.
2018
The First Pentacyclic Triterpenoid Gypsogenin Derivative Exhibiting Anti-ABL1 Kinase and Anti-chronic Myelogenous Leukemia Activities.
Biological & pharmaceutical bulletin.
41(4):570-574
[DOI] 10.1248/bpb.b17-00902.
[PMID] 29386476.
2017
A Dithiol Compound Binds to the Zinc Finger Protein TRAF6 and Suppresses Its Ubiquitination.
ChemMedChem.
12(23):1935-1941
[DOI] 10.1002/cmdc.201700399.
[PMID] 28884970.
2017
A novel inhibitor of farnesyltransferase with a zinc site recognition moiety and a farnesyl group.
Bioorganic & medicinal chemistry letters.
27(16):3862-3866
[DOI] 10.1016/j.bmcl.2017.06.047.
[PMID] 28666734.
2017
Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Thiadiazole Derivatives as Potential Antitumor Agents against Chronic Myelogenous Leukemia: Striking Effect of Nitrothiazole Moiety.
Molecules (Basel, Switzerland).
23(1)
[DOI] 10.3390/molecules23010059.
[PMID] 29280989.
2017
Marine Inspired 2-(5-Halo-1H-indol-3-yl)-N,N-dimethylethanamines as Modulators of Serotonin Receptors: An Example Illustrating the Power of Bromine as Part of the Uniquely Marine Chemical Space.
Marine drugs.
15(8)
[DOI] 10.3390/md15080248.
[PMID] 28792478.
2016
Zinc-mediated binding of a low-molecular-weight stabilizer of the host anti-viral factor apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G.
Bioorganic & medicinal chemistry.
24(18):4398-4405
[DOI] 10.1016/j.bmc.2016.07.030.
[PMID] 27475536.
2015
Clinical and prognostic features of erionite-induced malignant mesothelioma.
Yonsei medical journal.
56(2):311-23
[DOI] 10.3349/ymj.2015.56.2.311.
[PMID] 25683976.
2010
Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.
Pharmacology, biochemistry, and behavior.
95(4):434-42
[DOI] 10.1016/j.pbb.2010.03.004.
[PMID] 20332000.
2010
Protective effect of trapidil and l-arginine against renal and hepatic toxicity induced by cyclosporine in rats.
Renal failure.
32(8):959-68
[DOI] 10.3109/0886022X.2010.501933.
[PMID] 20722564.
Contact Details
Phones:
- Business:
- (352) 273-7700
Emails:
- Business:
- radwanm@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 103610
2033 MOWRY RD
GAINESVILLE FL 32610 - Business Street:
-
CGRC 103
2033 Mowry Road
GAINESVILLE FL 32610