Joanna Peris

Joanna Peris, Ph.D.

Associate Professor

Department: Pharmacodynamics
Business Phone: (352) 273-7688
Business Email: peris@cop.ufl.edu

About Joanna Peris

The Peris lab is currently studying the neurochemical mechanisms of ethanol addiction. As part of this research, we measure how dopaminergic and amino acid neurotransmission in brain reward circuitry (e.g., nucleus accumbens, ventral tegmental area) is altered in rodents exhibiting high degrees of ethanol self-administration. We have developed the “jello shot” method of ethanol self-administration with Dr. Neil Rowland of the Department of Psychology. This model results in pharmacologically relevant levels of ethanol intake in non-genetically-selected rodents, but also controls for non-ethanol reward, caloric consumption and comparable levels of operant responding by the use of non-ethanol gelatin as a control reinforcer. Utilizing a combination of behavioral and microdialysis techniques, we have demonstrated that previous binge ethanol exposures selectively increase ethanol intake, ethanol reward and glutamate levels in nucleus accumbens while not affecting plain gel intake or neurotransmission during plain gel reward. Another novel finding indicates the importance of elevations in glycine in the nucleus accumbens during anticipation of reward.

Our most recent work, in collaboration with Dr. Eric G. Krause in our department, has focused on the role of oxytocin in the regulation of reward circuitry and its impact on ethanol intake. We have found that oxytocin receptors are expressed by both dopamine and glutamate neurons in the ventral tegmental area which might mediate oxytocin inhibition of ethanol intake. We are currently developing optogenetic techniques to address how selective activation of neurons in reward centers that express oxytocin receptors is altered by excessive ethanol intake.

Research Profile

Research Group Members

Darrice Montgomery – Lab manager

Hernando Santacoloma– Pharm.D. student

Nicolette Sponer – Pharm.D. student

Hannah Lester – Undergraduate Honors student

Madelyn Steck – Undergraduate Honors student

Publications

2020
Chronic Voluntary Binge Ethanol Consumption Causes Sex-Specific Differences in Microglial Signaling Pathways and Withdrawal-associated Behaviors in Mice.
Alcoholism, clinical and experimental research. 44(9):1791-1806 [DOI] 10.1111/acer.14420. [PMID] 32767774.
2020
Oxytocin treatment for alcoholism: Potential neurocircuitry targets.
Neuropharmacology. 171 [DOI] 10.1016/j.neuropharm.2020.108091. [PMID] 32304701.
2020
Glutamatergic projections from homeostatic to hedonic brain nuclei regulate intake of highly palatable food.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-78897-9. [PMID] 33328492.
2018
Regionally Specific Effects of Oxytocin on Reinstatement of Cocaine Seeking in Male and Female Rats.
The international journal of neuropsychopharmacology. 21(7):677-686 [DOI] 10.1093/ijnp/pyy025. [PMID] 29566161.
2017
Ceftriaxone reduces alcohol intake in outbred rats while upregulating xCT in the nucleus accumbens core.
Pharmacology, biochemistry, and behavior. 159:18-23 [DOI] 10.1016/j.pbb.2017.07.001. [PMID] 28687200.
2017
Oxytocin receptors are expressed on dopamine and glutamate neurons in the mouse ventral tegmental area that project to nucleus accumbens and other mesolimbic targets.
The Journal of comparative neurology. 525(5):1094-1108 [DOI] 10.1002/cne.24116. [PMID] 27615433.
2016
Peripheral oxytocin administration reduces ethanol consumption in rats.
Pharmacology, biochemistry, and behavior. 140:27-32 [DOI] 10.1016/j.pbb.2015.10.014. [PMID] 26519603.
2015
Intermittent high-dose ethanol exposure increases ethanol preference in rats.
Journal of studies on alcohol and drugs. 76(1):165-73 [PMID] 25486406.
View on: PubMed
2015
Serotonin-2C receptor agonists decrease potassium-stimulated GABA release in the nucleus accumbens.
Synapse (New York, N.Y.). 69(2):78-85 [DOI] 10.1002/syn.21790. [PMID] 25382408.
2014
Alpha 1-antitrypsin therapy mitigated ischemic stroke damage in rats.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 23(5):e355-63 [DOI] 10.1016/j.jstrokecerebrovasdis.2013.12.029. [PMID] 24582784.
2013
The serotonin-2 receptor modulator, (-)-trans-PAT, decreases voluntary ethanol consumption in rats.
European journal of pharmacology. 718(1-3):98-104 [DOI] 10.1016/j.ejphar.2013.09.008. [PMID] 24041931.
2012
A Novelserotonin 5Ht2C Agonist/5Ht2A-2B Antagonist Selectively Decreases Ethanol Self Administration and Inhibits the Alcohol Deprivation Effect
Alcoholism-Clinical and Experimental Research. 36
2011
The protective effects of plasma gelsolin on stroke outcome in rats.
Experimental & translational stroke medicine. 3(1) [DOI] 10.1186/2040-7378-3-13. [PMID] 22047744.
2010
The novel neurotensin analog NT69L blocks phencyclidine (PCP)-induced increases in locomotor activity and PCP-induced increases in monoamine and amino acids levels in the medial prefrontal cortex.
Brain research. 1311:28-36 [DOI] 10.1016/j.brainres.2009.11.048. [PMID] 19948149.
2010
Intermittent high-dose ethanol exposures increase motivation for operant ethanol self-administration: possible neurochemical mechanism.
Brain research. 1310:142-53 [DOI] 10.1016/j.brainres.2009.11.029. [PMID] 19944084.
2009
The Novel Neurotensin Analog Nt69L Blocks Phencyclidine-Induced Increases in Locomotor Activity and Increases in Monoamine and Amino Acids Levels in the Mpfc
Biological Psychiatry. 65
2008
Effects of an enrichment device on voluntary alcohol consumption on single-housed rats.
Journal of the American Association for Laboratory Animal Science : JAALAS. 47(2):24-9 [PMID] 18351718.
View on: PubMed
2008
Effects of an enrichment device on voluntary alcohol consumption on single-housed rats.
Journal of the American Association for Laboratory Animal Science. 47(2) [PMID] 18351718.
View on: PubMed
2008
High temporal resolution of amino acid levels in rat nucleus accumbens during operant ethanol self-administration: involvement of elevated glycine in anticipation.
Journal of neurochemistry. 106(1):170-81 [DOI] 10.1111/j.1471-4159.2008.05346.x. [PMID] 18346201.
2008
Mechanism of Trh-Induced Attenuation of Ethanol Consumption On Progressive Ratio Operant Schedules in Rats
Alcoholism-Clinical and Experimental Research. 32
2008
Neuronal Mechanism of Increased Motivation for Operant Ethanol Self-Administration Caused By Intermittent Ethanol Binge Exposures
Alcoholism-Clinical and Experimental Research. 32
2006
Brain ethanol levels in rats after voluntary ethanol consumption using a sweetened gelatin vehicle.
Pharmacology, biochemistry, and behavior. 85(3):562-8 [PMID] 17140644.
View on: PubMed
2006
Microdialysis as a tool in local pharmacodynamics.
The AAPS journal. 8(2):E222-35 [PMID] 16796373.
View on: PubMed
2004
Differential increase in taurine levels by low-dose ethanol in the dorsal and ventral striatum revealed by microdialysis with on-line capillary electrophoresis.
Alcoholism, clinical and experimental research. 28(7):1028-38 [PMID] 15252289.
View on: PubMed
2004
Presynaptic dopaminergic properties of differentiated mouse embryonic stem cells.
Neurochemistry international. 45(7):1067-73 [PMID] 15337306.
View on: PubMed
2004
Taurine-induced long-lasting potentiation in the rat hippocampus shows a partial dissociation from total hippocampal taurine content and independence from activation of known taurine transporters.
Journal of neurochemistry. 89(5):1195-205 [PMID] 15147512.
View on: PubMed
2004
In vivo monitoring of amino acids by microdialysis sampling with on-line derivatization by naphthalene-2,3-dicarboxyaldehyde and rapid micellar electrokinetic capillary chromatography.
Journal of neuroscience methods. 138(1-2):189-97 [PMID] 15325127.
View on: PubMed
2003
Ethanol-induced taurine efflux: low dose effects and high temporal resolution.
Advances in experimental medicine and biology. 526:485-92 [PMID] 12908634.
View on: PubMed
2001
Lack of allosteric modulation of striatal GABA(A) receptor binding and function after cocaine sensitization.
Pharmacology, biochemistry, and behavior. 70(1):55-63 [PMID] 11566142.
View on: PubMed
1999
Chronic ethanol exposure increases 3H-GABA release in rat hippocampus by presynaptic muscarinic receptor modulation.
Alcoholism, clinical and experimental research. 23(10):1587-95 [PMID] 10549989.
View on: PubMed
1999
Endogenous GABA release is reduced in the striatum of cocaine-sensitized rats.
Synapse (New York, N.Y.). 34(2):103-10 [PMID] 10502309.
View on: PubMed
1999
Increased acute cocaine sensitivity and decreased cocaine sensitization in GABA(A) receptor beta3 subunit knockout mice.
Journal of neurochemistry. 73(4):1539-48 [PMID] 10501199.
View on: PubMed
1998
Antisense inhibition of striatal GABAA receptor proteins decreases GABA-stimulated chloride uptake and increases cocaine sensitivity in rats.
Brain research. Molecular brain research. 57(2):310-20 [PMID] 9675429.
View on: PubMed
1997
Neurochemical basis of disruption of hippocampal long term potentiation by chronic alcohol exposure.
Frontiers in bioscience : a journal and virtual library. 2:d309-16 [PMID] 9206984.
View on: PubMed
1997
Simultaneous cocaine exposure abolishes ethanol tolerance.
Behavioural pharmacology. 8(4):319-30 [PMID] 9832991.
View on: PubMed
1997
Effects of chronic ethanol exposure on GABA receptors and GABAB receptor modulation of 3H-GABA release in the hippocampus.
Alcoholism, clinical and experimental research. 21(6):1047-52 [PMID] 9309316.
View on: PubMed
1996
Repeated cocaine injections decrease the function of striatal gamma-aminobutyric acid(A) receptors.
The Journal of pharmacology and experimental therapeutics. 276(3):1002-8 [PMID] 8786528.
View on: PubMed
1995
Creatine kinase release from isolated EDL muscles in chronic ethanol-treated rats.
Alcohol (Fayetteville, N.Y.). 12(2):145-9 [PMID] 7772266.
View on: PubMed
1994
Chronic ethanol exposure enhances [3H]GABA release and does not affect GABAA receptor mediated 36Cl uptake.
Synapse (New York, N.Y.). 17(3):149-54 [PMID] 7974196.
View on: PubMed
1993
Antagonist inhibition of GABAA-mediated chloride uptake is atypical in nigrocollicular areas.
Life sciences. 53(9):707-15 [PMID] 8394972.
View on: PubMed
1993
Behavioral and neurochemical changes caused by repeated ethanol and cocaine administration.
Psychopharmacology. 110(4):443-50 [PMID] 7870915.
View on: PubMed
1993
FG7142 causes opposite changes in [3H]GABA release from nigrocollicular regions.
Pharmacology, biochemistry, and behavior. 44(2):333-8 [PMID] 8383339.
View on: PubMed
1992
Cocaine in utero enhances the behavioral response to cocaine in adult rats.
Pharmacology, biochemistry, and behavior. 42(3):509-15 [PMID] 1409782.
View on: PubMed
1992
Selective changes in GABAergic transmission in substantia nigra and superior colliculus caused by ethanol and ethanol withdrawal.
Alcoholism, clinical and experimental research. 16(2):311-9 [PMID] 1317135.
View on: PubMed
1991
Estradiol enhances behavioral sensitization to cocaine and amphetamine-stimulated striatal [3H]dopamine release.
Brain research. 566(1-2):255-64 [PMID] 1814541.
View on: PubMed
1991
Regulation of 35S-TBPS binding by bicuculline is region specific in rat brain.
Life sciences. 49(11):PL49-54 [PMID] 1875786.
View on: PubMed

Grants

Jul 2018 – Jun 2020
Ethanol dysregulation of oxytocin-mediated reward
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAAA
Jul 2015 – Jul 2016
Oxytocin Receptors in Alcoholism
Role: Principal Investigator
Funding: UF FOU

Education

Ph.D.
1984 · Oregon Health Sciences University, School of Medicine
M.S.
1982 · Oregon Health Sciences University, School of Medicine
B.S.
1980 · Bowling Green State University

Teaching Profile

Courses Taught
2006,2009-2012,2012-2021
PHA7979 Advanced Research
2006,2009-2019,2019-2021
PHA6936 Advanced Topics in Pharmaceutical Sciences
2015-2021
VME6650 Principles of Mammalian Pharmacology
2007-2021
PHA7980 Research for Doctoral Dissertation
2011-2012,2014-2020,2019-2021
PHA6521C Research Techniques in Pharmacodynamics
2006-2007,2010-2020,2019-2021
PHA7939 Journal Colloquy in Pharmacodynamics
2006,2009-2015,2015-2021
PHA6512L Experiential Research Training in Pharmacodynamics
2006-2021
PHA5515 Prin Med Chem-Pcol II
2019
PHA6935 Selected Topics in Pharmacy
2006,2010-2015,2015-2019,2019
PHA6910 Supervised Research
2019
PHA5732 Year 1 Enhancement
2018-2019
PHA5784C Pt Care 4: GI and Renal
2018-2019
PHA5789C Patient Care 7
2018
GMS7980 Research for Doctoral Dissertation
2012-2016
PHA5517 Pharmacol Bas Ther 2
2014-2016
PHA4911 Undergraduate Research in Pharmacodynamics
2016
GMS7794 Neuroscience Seminar
2006,2008-2015
PHA5902 Research Pharmacodyna
2010-2015
PHA5516 Basis of Therapeu 1
2015
PHA5561C Physiol Bas Disease 2
2013,2015
PHA6509 Systems Physiology and Pathophysiology II
2014-2015
GMS6023 Principles of Neuroscience III: Molecular Neuropharmacology and its Clinical Application
2007,2009-2014,2014
PHA6938 Research Seminar
2010-2013
PHA6971 Research for Master’s Thesis
2010-2013
PHA5560C Physiol Bas Disease 1
2010
PHA4902 Prob Pharmacodynamics
2010
PHA6540 Neurochem Founda

Contact Details

Phones:
Business:
(352) 273-7688
Emails:
Business:
peris@cop.ufl.edu