Charles Peloquin, Pharm.D.
Professor
Department:
Pharmacotherapy & Translational Research
Business Phone:
(352) 273-6266
Business Email:
peloquin@cop.ufl.edu
About Charles Peloquin
Prior to coming to the University of Florida, Dr. Peloquin completed a hospital pharmacy residency at Duke University Medical Center, where he also served on the clinical staff. He also completed a fellowship in Infectious Diseases and Pharmacokinetics at the Clinical Pharmacokinetics Laboratory, Millard Fillmore Hospital, Buffalo, N.Y. For 20 years, Dr. Peloquin was the Director of the Infectious Disease Pharmacokinetics Laboratory (IDPL) at National Jewish Medical and Research Center, Denver, CO. He now serves as Professor of Pharmacy and Medicine at UF, where the IDPL is now located. Dr. Peloquin and his lab are part of the UF Emerging Pathogens Institute. He has served a consultant to the FDA, CDC and WHO, and has contributed to national guidelines on the treatment tuberculosis and the treatment of opportunistic infections in patients living with AIDS.
Accomplishments
Member
2004-Current
·
International Society of Antimicrobial Pharmacology
Member
1991-Current
·
Society of Infectious Disease Pharmacists
Member
1990-Current
·
American Society of Microbiology
Member
1986-Current
·
American College of Clinical Pharmacy
Research Profile
Dr. Peloquin’s laboratory serves as a national reference center for the determination of serum concentrations for the antimycobacterial, antifungal, anti-HIV drugs, and antibacterial drugs including beta-lactams and linezolid. His research efforts focus on therapeutic drug monitoring and clinical trials for patients with advanced mycobacterial diseases.
Publications
2021
Cefepime population pharmacokinetics and target attainment in critically ill patients on continuous renal replacement therapy.
Antimicrobial agents and chemotherapy.
[DOI] 10.1128/AAC.00144-21.
[PMID] 33722885.
2021
Comment on: The case for ‘conservative pharmacotherapy’.
The Journal of antimicrobial chemotherapy.
[DOI] 10.1093/jac/dkab087.
[PMID] 33851696.
2021
Determination of Rifampin Concentrations by Urine Colorimetry and Mobile Phone Readout for Personalized Dosing in Tuberculosis Treatment.
Journal of the Pediatric Infectious Diseases Society.
10(2):104-111
[DOI] 10.1093/jpids/piaa024.
[PMID] 32170944.
2021
Dose Fractionation of Moxifloxacin for Treatment of Tuberculosis: Impact of Dosing Interval and Elimination Half-Life on Microbial Kill and Resistance Suppression.
Antimicrobial agents and chemotherapy.
65(4)
[DOI] 10.1128/AAC.02533-20.
[PMID] 33468465.
2021
Effect of malnutrition on the pharmacokinetics of anti-TB drugs in Ghanaian children.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
25(1):36-42
[DOI] 10.5588/ijtld.20.0301.
[PMID] 33384043.
2021
Novel 6-Month Treatment for Drug-Resistant Tuberculosis, United States.
Emerging infectious diseases.
27(1)
[DOI] 10.3201/eid2701.203766.
[PMID] 33227229.
2021
Optimising pyrazinamide for the treatment of tuberculosis.
The European respiratory journal.
[DOI] 10.1183/13993003.02013-2020.
[PMID] 33542052.
2021
Pharmacogenetic predictors of nevirapine pharmacokinetics in Ghanaian children living with HIV with or without TB coinfection.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.
92
[DOI] 10.1016/j.meegid.2021.104856.
[PMID] 33839311.
2021
Pharmacokinetics of bedaquiline, delamanid and clofazimine in patients with multidrug-resistant tuberculosis.
The Journal of antimicrobial chemotherapy.
76(4):1019-1024
[DOI] 10.1093/jac/dkaa550.
[PMID] 33378452.
2021
Population Pharmacokinetics and Bayesian Dose Adjustment to Advance TDM of Anti-TB Drugs.
Clinical pharmacokinetics.
[DOI] 10.1007/s40262-021-00997-0.
[PMID] 33674941.
2021
The Funnel: a Screening Technique for Identifying Optimal Two-Drug Combination Chemotherapy Regimens.
Antimicrobial agents and chemotherapy.
65(2)
[DOI] 10.1128/AAC.02172-20.
[PMID] 33199386.
2021
Therapeutic Drug Monitoring in Non-Tuberculosis Mycobacteria Infections.
Clinical pharmacokinetics.
[DOI] 10.1007/s40262-021-01000-6.
[PMID] 33751415.
2021
Therapeutic drug monitoring in patients with tuberculosis and concurrent medical problems.
Expert opinion on drug metabolism & toxicology.
17(1):23-39
[DOI] 10.1080/17425255.2021.1836158.
[PMID] 33040625.
2021
Using precision dosing to minimize cefepime-induced neurotoxicity: The challenge of targets.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
27(6):929-930
[DOI] 10.1016/j.jiac.2021.02.020.
[PMID] 33663932.
2020
A Systematic Review and Meta-analysis of Isoniazid Pharmacokinetics in Healthy Volunteers and Patients with Tuberculosis.
Clinical therapeutics.
42(11):e220-e241
[DOI] 10.1016/j.clinthera.2020.09.009.
[PMID] 33032843.
2020
Building Optimal Three-Drug Combination Chemotherapy Regimens.
Antimicrobial agents and chemotherapy.
64(11)
[DOI] 10.1128/AAC.01610-20.
[PMID] 32900682.
2020
Clinical Outcomes Among Patients With Drug-resistant Tuberculosis Receiving Bedaquiline- or Delamanid-Containing Regimens.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
71(9):2336-2344
[DOI] 10.1093/cid/ciz1107.
[PMID] 31712809.
2020
Comment on “Meropenem, Cefepime, and Piperacillin Protein Binding in Patient Samples”.
Therapeutic drug monitoring.
42(6)
[DOI] 10.1097/FTD.0000000000000810.
[PMID] 33197165.
2020
Correction for Kempker et al., “A Pharmacology Perspective on Simultaneous Tuberculosis and Hepatitis C Treatment”.
Antimicrobial agents and chemotherapy.
64(2)
[DOI] 10.1128/AAC.02358-19.
[PMID] 31988109.
2020
Correction for Kempker et al., “A Pharmacology Perspective on Simultaneous Tuberculosis and Hepatitis C Treatment”.
Antimicrobial agents and chemotherapy.
64(2)
[DOI] 10.1128/AAC.02358-19.
[PMID] 31988109.
2020
Developing New Drugs for Mycobacterium tuberculosis Therapy: What Information Do We Get from Preclinical Animal Models?
Antimicrobial agents and chemotherapy.
64(12)
[DOI] 10.1128/AAC.01376-20.
[PMID] 32958720.
2020
Dynamic imaging in patients with tuberculosis reveals heterogeneous drug exposures in pulmonary lesions.
Nature medicine.
26(4):529-534
[DOI] 10.1038/s41591-020-0770-2.
[PMID] 32066976.
2020
Early therapeutic monitoring of β-lactams and associated therapy outcomes in critically ill patients.
The Journal of antimicrobial chemotherapy.
75(12):3644-3651
[DOI] 10.1093/jac/dkaa359.
[PMID] 32910809.
2020
Ethionamide Population Pharmacokinetic Model and Target Attainment in Multidrug-Resistant Tuberculosis.
Antimicrobial agents and chemotherapy.
64(9)
[DOI] 10.1128/AAC.00713-20.
[PMID] 32631828.
2020
Evaluation of super-boosted lopinavir/ritonavir in combination with rifampicin in HIV-1-infected patients with tuberculosis.
International journal of antimicrobial agents.
55(2)
[DOI] 10.1016/j.ijantimicag.2019.10.021.
[PMID] 31704214.
2020
How to design a study to evaluate therapeutic drug monitoring in infectious diseases?
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
26(8):1008-1016
[DOI] 10.1016/j.cmi.2020.03.008.
[PMID] 32205294.
2020
Integrating Pharmacokinetics and Pharmacodynamics in Operational Research to End Tuberculosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
70(8):1774-1780
[DOI] 10.1093/cid/ciz942.
[PMID] 31560376.
2020
Isoniazid and Rifapentine Treatment Eradicates Persistent Mycobacterium tuberculosis in Macaques.
American journal of respiratory and critical care medicine.
201(4):469-477
[DOI] 10.1164/rccm.201903-0646OC.
[PMID] 31647877.
2020
Losartan Rescues Inflammation-related Mucociliary Dysfunction in Relevant Models of Cystic Fibrosis.
American journal of respiratory and critical care medicine.
201(3):313-324
[DOI] 10.1164/rccm.201905-0990OC.
[PMID] 31613648.
2020
Pharmacokinetic Modeling, Simulation, and Development of a Limited Sampling Strategy of Cycloserine in Patients with Multidrug-/Extensively Drug-Resistant Tuberculosis.
Clinical pharmacokinetics.
59(7):899-910
[DOI] 10.1007/s40262-020-00860-8.
[PMID] 31981103.
2020
Pharmacokinetics of Efavirenz 600Â mg Once Daily During Pregnancy and Post Partum in Ghanaian Women Living With HIV.
Clinical therapeutics.
42(9):1818-1825
[DOI] 10.1016/j.clinthera.2020.07.008.
[PMID] 32811669.
2020
Pharmacokinetics of First-Line Drugs Among Children With Tuberculosis in Rural Tanzania.
Journal of the Pediatric Infectious Diseases Society.
9(1):14-20
[DOI] 10.1093/jpids/piy106.
[PMID] 30395239.
2020
Pharmacokinetics of tedizolid, sutezolid, and sutezolid-M1 in non-human primates.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
151
[DOI] 10.1016/j.ejps.2020.105421.
[PMID] 32531349.
2020
Population Pharmacokinetics and Target Attainment of Cefepime in Critically Ill Patients and Guidance for Initial Dosing.
Antimicrobial agents and chemotherapy.
64(9)
[DOI] 10.1128/AAC.00745-20.
[PMID] 32601155.
2020
Population Pharmacokinetics of Linezolid in Tuberculosis Patients: Dosing Regimen Simulation and Target Attainment Analysis.
Antimicrobial agents and chemotherapy.
64(10)
[DOI] 10.1128/AAC.01174-20.
[PMID] 32778547.
2020
Roger W. Jelliffe, M.D. (1929-2020).
Clinical pharmacokinetics.
59(9)
[DOI] 10.1007/s40262-020-00928-5.
[PMID] 32789605.
2020
The Pharmacokinetics of Moxifloxacin in Cerebrospinal Fluid Following Intravenous Administration: A Report of Successfully Treated Infant with Mycoplasma hominis Meningitis.
The Pediatric infectious disease journal.
39(8):e183-e184
[DOI] 10.1097/INF.0000000000002655.
[PMID] 32195773.
2020
Variable linezolid exposure and response and the role of therapeutic drug monitoring: Case series.
Clinical case reports.
8(7):1126-1129
[DOI] 10.1002/ccr3.2835.
[PMID] 32695341.
2019
Bacterial Factors and Relapse after Tuberculosis Therapy.
The New England journal of medicine.
380(2)
[DOI] 10.1056/NEJMc1813645.
[PMID] 30628424.
2019
Delamanid Central Nervous System Pharmacokinetics in Tuberculous Meningitis in Rabbits and Humans.
Antimicrobial agents and chemotherapy.
63(10)
[DOI] 10.1128/AAC.00913-19.
[PMID] 31383662.
2019
Dose optimization of moxifloxacin and linezolid against tuberculosis using mathematical modeling and simulation.
International journal of antimicrobial agents.
53(3):275-283
[DOI] 10.1016/j.ijantimicag.2018.10.012.
[PMID] 30385322.
2019
Effect of First-Line Antituberculosis Therapy on Nevirapine Pharmacokinetics in Children Younger than Three Years Old.
Antimicrobial agents and chemotherapy.
63(10)
[DOI] 10.1128/AAC.00839-19.
[PMID] 31332062.
2019
Effect of Rifampin-Isoniazid-Containing Antituberculosis Therapy on Efavirenz Pharmacokinetics in HIV-Infected Children 3 to 14 Years Old.
Antimicrobial agents and chemotherapy.
63(1)
[DOI] 10.1128/AAC.01657-18.
[PMID] 30397066.
2019
Fluoroquinolones in Drug-Resistant Tuberculosis: Culture Conversion and Pharmacokinetic/Pharmacodynamic Target Attainment To Guide Dose Selection.
Antimicrobial agents and chemotherapy.
63(7)
[DOI] 10.1128/AAC.00279-19.
[PMID] 31061152.
2019
Limited Sampling Strategies Using Linear Regression and the Bayesian Approach for Therapeutic Drug Monitoring of Moxifloxacin in Tuberculosis Patients.
Antimicrobial agents and chemotherapy.
63(7)
[DOI] 10.1128/AAC.00384-19.
[PMID] 31010868.
2019
Management of patients with multidrug-resistant tuberculosis
˜The œinternational journal of tuberculosis and lung disease (Online).
23(6):645-662
2019
Pharmacokinetics of Levofloxacin in Children Treated for Exposure to Drug-Resistant Tuberculosis.
Antimicrobial agents and chemotherapy.
63(5)
[DOI] 10.1128/AAC.02569-18.
[PMID] 30803975.
2019
Population pharmacokinetics of efavirenz in HIV and TB/HIV coinfected children: the significance of genotype-guided dosing.
The Journal of antimicrobial chemotherapy.
74(9):2698-2706
[DOI] 10.1093/jac/dkz238.
[PMID] 31243456.
2019
Reply to te Brake et al.: Conflicting Findings on an Intermediate Dose of Rifampicin for Pulmonary Tuberculosis.
American journal of respiratory and critical care medicine.
199(9):1167-1168
[DOI] 10.1164/rccm.201812-2281LE.
[PMID] 30645140.
2019
Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline.
American journal of respiratory and critical care medicine.
200(10):e93-e142
[DOI] 10.1164/rccm.201909-1874ST.
[PMID] 31729908.
2019
Wirelessly observed therapy compared to directly observed therapy to confirm and support tuberculosis treatment adherence: A randomized controlled trial.
PLoS medicine.
16(10)
[DOI] 10.1371/journal.pmed.1002891.
[PMID] 31584944.
2018
A comparison of linezolid lung tissue concentrations among patients with drug-resistant tuberculosis.
The European respiratory journal.
51(2)
[DOI] 10.1183/13993003.02166-2017.
[PMID] 29437945.
2018
A PRELIMINARY ANALYSIS OF PROLONGED ABSORPTION RATE OF PONAZURIL IN RED-FOOTED TORTOISES, CHELONOIDIS CARBONARIA.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
49(3):802-805
[DOI] 10.1638/2017-0178.1.
[PMID] 30212324.
2018
Digitizing Medicines for Remote Capture of Oral Medication Adherence Using Co-encapsulation.
Clinical pharmacology and therapeutics.
103(3):502-510
[DOI] 10.1002/cpt.760.
[PMID] 28597911.
2018
Effect of Genetic Variation of NAT2 on Isoniazid and SLCO1B1 and CES2 on Rifampin Pharmacokinetics in Ghanaian Children with Tuberculosis.
Antimicrobial agents and chemotherapy.
62(3)
[DOI] 10.1128/AAC.02099-17.
[PMID] 29263072.
2018
Efficacy and Safety of High-Dose Rifampin in Pulmonary Tuberculosis. A Randomized Controlled Trial.
American journal of respiratory and critical care medicine.
198(5):657-666
[DOI] 10.1164/rccm.201712-2524OC.
[PMID] 29954183.
2018
Elevated Plasma Moxifloxacin Concentrations and SLCO1B1 g.-11187G>A Polymorphism in Adults with Pulmonary Tuberculosis.
Antimicrobial agents and chemotherapy.
62(5)
[DOI] 10.1128/AAC.01802-17.
[PMID] 29463526.
2018
Evaluation of the Adequacy of the 2010 Revised World Health Organization Recommended Dosages of the First-line Antituberculosis Drugs for Children: Adequacy of Revised Dosages of TB Drugs for Children.
The Pediatric infectious disease journal.
37(1):43-51
[DOI] 10.1097/INF.0000000000001687.
[PMID] 28719501.
2018
Evaluation of the Adequacy of WHO Revised Dosages of the First-Line Antituberculosis Drugs in Children with Tuberculosis Using Population Pharmacokinetic Modeling and Simulations.
Antimicrobial agents and chemotherapy.
62(9)
[DOI] 10.1128/AAC.00008-18.
[PMID] 29914960.
2018
Increased Doses Lead to Higher Drug Exposures of Levofloxacin for Treatment of Tuberculosis.
Antimicrobial agents and chemotherapy.
62(10)
[DOI] 10.1128/AAC.00770-18.
[PMID] 30012767.
2018
Linezolid Kills Acid-Phase and Nonreplicative-Persister-Phase Mycobacterium Tuberculosis in a Hollow-Fiber Infection Model
Antimicrobial Agents and Chemotherapy.
62(8)
[DOI] 10.1128/AAC.00221-18;e00221-18.
View on:
Publisher’s Site
2018
Linezolid Kills Acid-Phase and Nonreplicative-Persister-Phase Mycobacterium tuberculosis in a Hollow-Fiber Infection Model.
Antimicrobial agents and chemotherapy.
62(8)
[DOI] 10.1128/AAC.00221-18.
[PMID] 29866864.
2018
Making optimal use of available anti-tuberculosis drugs: first steps to investigate terizidone.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
22(1)
[DOI] 10.5588/ijtld.17.0632.
[PMID] 29297417.
2018
Moxifloxacin target site concentrations in patients with pulmonary TB utilizing microdialysis: a clinical pharmacokinetic study.
The Journal of antimicrobial chemotherapy.
73(2):477-483
[DOI] 10.1093/jac/dkx421.
[PMID] 29186509.
2018
Mycobacterium tuberculosis Strains H37ra and H37rv have equivalent minimum inhibitory concentrations to most antituberculosis drugs.
International journal of mycobacteriology.
7(2):156-161
[DOI] 10.4103/ijmy.ijmy_33_18.
[PMID] 29900893.
2018
Noninvasive 11C-rifampin positron emission tomography reveals drug biodistribution in tuberculous meningitis.
Science translational medicine.
10(470)
[DOI] 10.1126/scitranslmed.aau0965.
[PMID] 30518610.
2018
Perspectives for personalized therapy for patients with multidrug-resistant tuberculosis.
Journal of internal medicine.
[DOI] 10.1111/joim.12780.
[PMID] 29806961.
2018
Pharmacokinetics of rifampicin in adult TB patients and healthy volunteers: a systematic review and meta-analysis.
The Journal of antimicrobial chemotherapy.
73(9):2305-2313
[DOI] 10.1093/jac/dky152.
[PMID] 29701775.
2018
Pharmacokinetics of tuberculosis drugs in HIV-infected patients from Irkutsk, Russian Federation: redefining drug activity.
The European respiratory journal.
51(5)
[DOI] 10.1183/13993003.00109-2018.
[PMID] 29599189.
2018
Population Pharmacokinetic Model and Limited Sampling Strategies for Personalized Dosing of Levofloxacin in Tuberculosis Patients.
Antimicrobial agents and chemotherapy.
62(12)
[DOI] 10.1128/AAC.01092-18.
[PMID] 30373800.
2018
Protein Binding of First-Line Antituberculosis Drugs.
Antimicrobial agents and chemotherapy.
62(7)
[DOI] 10.1128/AAC.00641-18.
[PMID] 29735566.
2018
Reply to Chang et al., “Pyrazinamide Is a Two-Edged Sword: Do WHO Guidelines Matter?”
Antimicrobial agents and chemotherapy.
62(1)
[DOI] 10.1128/AAC.01937-17.
[PMID] 29269429.
2018
Training a Drug to Do New Tricks: Insights on Stability of Meropenem Administered as a Continuous Infusion.
Microbiology insights.
11
[DOI] 10.1177/1178636118804549.
[PMID] 30349291.
2018
Verapamil Increases the Bioavailability and Efficacy of Bedaquiline but Not Clofazimine in a Murine Model of Tuberculosis.
Antimicrobial agents and chemotherapy.
62(1)
[DOI] 10.1128/AAC.01692-17.
[PMID] 29038265.
2017
An optimized background regimen design to evaluate the contribution of levofloxacin to multidrug-resistant tuberculosis treatment regimens: study protocol for a randomized controlled trial.
Trials.
18(1)
[DOI] 10.1186/s13063-017-2292-x.
[PMID] 29178937.
2017
Defining the optimal dose of rifapentine for pulmonary tuberculosis: Exposure-response relations from two phase II clinical trials.
Clinical pharmacology and therapeutics.
102(2):321-331
[DOI] 10.1002/cpt.634.
[PMID] 28124478.
2017
Erratum for Peloquin et al., “Pharmacokinetic Evidence from the HIRIF Trial To Support Increased Doses of Rifampin for Tuberculosis”.
Antimicrobial agents and chemotherapy.
61(9)
[DOI] 10.1128/AAC.01524-17.
[PMID] 28839086.
2017
Impact of the CYP2C19 genotype on voriconazole exposure in adults with invasive fungal infections.
Pharmacogenetics and genomics.
27(5):190-196
[DOI] 10.1097/FPC.0000000000000277.
[PMID] 28306618.
2017
Lung Tissue Concentrations of Pyrazinamide among Patients with Drug-Resistant Pulmonary Tuberculosis.
Antimicrobial agents and chemotherapy.
61(6)
[DOI] 10.1128/AAC.00226-17.
[PMID] 28373198.
2017
Mycobacterium tuberculosis Infection among Asian Elephants in Captivity.
Emerging infectious diseases.
23(3):513-516
[DOI] 10.3201/eid2303.160726.
[PMID] 28221115.
2017
Pharmacokinetics and pharmacodynamics of isoniazid in patients with intermediate resistance.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
21(1):121-123
[DOI] 10.5588/ijtld.16.0689.
[PMID] 28157477.
2017
Pharmacokinetics of Ethionamide Delivered in Spray-Dried Microparticles to the Lungs of Guinea Pigs.
Journal of pharmaceutical sciences.
106(1):331-337
[DOI] 10.1016/j.xphs.2016.09.033.
[PMID] 27842973.
2017
Pharmacokinetics of the First-Line Antituberculosis Drugs in Ghanaian Children with Tuberculosis with or without HIV Coinfection.
Antimicrobial agents and chemotherapy.
61(2)
[DOI] 10.1128/AAC.01701-16.
[PMID] 27855070.
2017
Polymyxin Combinations Combat Escherichia coli Harboring mcr-1 and blaNDM-5: Preparation for a Postantibiotic Era.
mBio.
8(4)
[DOI] 10.1128/mBio.00540-17.
[PMID] 28743810.
2017
Population Pharmacokinetics of AZD-5847 in Adults with Pulmonary Tuberculosis.
Antimicrobial agents and chemotherapy.
61(10)
[DOI] 10.1128/AAC.01066-17.
[PMID] 28739794.
2017
Population Pharmacokinetics of Pyrazinamide in Patients with Tuberculosis.
Antimicrobial agents and chemotherapy.
61(6)
[DOI] 10.1128/AAC.02625-16.
[PMID] 28289033.
2017
Population Pharmacokinetics/Pharmacodynamics of 3,4-Diaminopyridine Free Base in Patients With Lambert-Eaton Myasthenia.
CPT: pharmacometrics & systems pharmacology.
6(9):625-634
[DOI] 10.1002/psp4.12218.
[PMID] 28623849.
2017
Reply to Alffenaar et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
64(1):105-106
[PMID] 27789610.
View on:
PubMed
2017
Reply to Srivastava et al., “pH Conditions under Which Pyrazinamide Works in Humans”.
Antimicrobial agents and chemotherapy.
61(9)
[DOI] 10.1128/AAC.01120-17.
[PMID] 28839080.
2017
Rifampin vs. rifapentine: what is the preferred rifamycin for tuberculosis?
Expert review of clinical pharmacology.
10(10):1027-1036
[DOI] 10.1080/17512433.2017.1366311.
[PMID] 28803492.
2017
Stability of Second-Line Tuberculosis Medications Mixed With Milk or Yogurt.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
65(4):704-705
[DOI] 10.1093/cid/cix434.
[PMID] 28482036.
2017
The pharmacological challenges of treating tuberculosis and HIV coinfections.
Expert review of clinical pharmacology.
10(2):213-223
[DOI] 10.1080/17512433.2017.1259066.
[PMID] 27828731.
2017
The Role of Therapeutic Drug Monitoring in Mycobacterial Infections.
Microbiology spectrum.
5(1)
[DOI] 10.1128/microbiolspec.TNMI7-0029-2016.
[PMID] 28084209.
2016
Early Bactericidal Activity of AZD5847 in Patients with Pulmonary Tuberculosis.
Antimicrobial agents and chemotherapy.
60(11):6591-6599
[DOI] 10.1128/AAC.01163-16.
[PMID] 27550361.
2016
Evaluation of high-dose rifampin in patients with new, smear-positive tuberculosis (HIRIF): study protocol for a randomized controlled trial.
BMC infectious diseases.
16(1)
[DOI] 10.1186/s12879-016-1790-x.
[PMID] 27567500.
2016
ISONIAZID AND RIFAMPIN PHARMACOKINETICS IN TWO ASIAN ELEPHANTS (ELEPHAS MAXIMUS) INFECTED WITH MYCOBACTERIUM TUBERCULOSIS.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
47(3):868-871
[PMID] 27691967.
View on:
PubMed
2016
Official American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America Clinical Practice Guidelines: Treatment of Drug-Susceptible Tuberculosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
63(7):e147-e195
[DOI] 10.1093/cid/ciw376.
[PMID] 27516382.
2016
Pharmacokinetics and Dosing of Levofloxacin in Children Treated for Active or Latent Multidrug-resistant Tuberculosis, Federated States of Micronesia and Republic of the Marshall Islands.
The Pediatric infectious disease journal.
35(4):414-21
[DOI] 10.1097/INF.0000000000001022.
[PMID] 26658531.
2016
Pharmacokinetics of First-Line Antituberculosis Drugs Using WHO Revised Dosage in Children With Tuberculosis With and Without HIV Coinfection.
Journal of the Pediatric Infectious Diseases Society.
5(4):356-365
[PMID] 26407268.
View on:
PubMed
2016
Population pharmacokinetic drug-drug interaction pooled analysis of existing data for rifabutin and HIV PIs.
The Journal of antimicrobial chemotherapy.
71(5):1330-40
[DOI] 10.1093/jac/dkv470.
[PMID] 26832753.
2016
Rifapentine for the treatment of latent tuberculosis.
Expert review of clinical pharmacology.
9(10):1253-1261
[DOI] 10.1080/17512433.2016.1222270.
[PMID] 27545595.
2016
Steady-state pharmacokinetics of oral linezolid suspension in a premature infant with osteomyelitis.
The Journal of antimicrobial chemotherapy.
71(6)
[DOI] 10.1093/jac/dkv507.
[PMID] 26851607.
2016
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Incident long-term warfarin use and risk of osteoporotic fractures: propensity-score matched cohort of elders with new onset atrial fibrillation.
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PubMed
2001
Pharmacological issues in the treatment of tuberculosis.
Annals of the New York Academy of Sciences.
953:157-64
[PMID] 11795409.
View on:
PubMed
2001
Population pharmacokinetics of intravenous and intramuscular streptomycin in patients with tuberculosis.
Pharmacotherapy.
21(9):1037-45
[PMID] 11560193.
View on:
PubMed
2001
Successful treatment of vancomycin-resistant Enterococcus faecium meningitis with linezolid: case report and literature review.
Scandinavian journal of infectious diseases.
33(5):375-9
[PMID] 11440224.
View on:
PubMed
2001
Tuberculosis drug serum levels.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
33(4):584-5
[PMID] 11462203.
View on:
PubMed
2000
Comparison of the abilities of grepafloxacin and clarithromycin to eradicate potential bacterial pathogens from the sputa of patients with chronic bronchitis: influence of pharmacokinetic and pharmacodynamic variables.
The Journal of antimicrobial chemotherapy.
45:9-17
[PMID] 10719007.
View on:
PubMed
1999
AIDS and TB drug absorption.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
3(12):1143-4
[PMID] 10599022.
View on:
PubMed
1999
Clarithromycin pharmacokinetics in the desert tortoise (Gopherus agassizii).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
30(1):36-43
[PMID] 10367642.
View on:
PubMed
1999
Clofazimine crystals in the cytoplasm of pulmonary macrophages.
The Annals of pharmacotherapy.
33(2)
[PMID] 10084424.
View on:
PubMed
1999
Lack of effect of zafirlukast on the pharmacokinetics of azithromycin, clarithromycin, and 14-hydroxyclarithromycin in healthy volunteers.
Antimicrobial agents and chemotherapy.
43(5):1152-5
[PMID] 10223928.
View on:
PubMed
1999
Multidrug-resistant tuberculosis meningitis: clinical problems and concentrations of second-line antituberculous medications.
The Annals of pharmacotherapy.
33(11):1184-8
[PMID] 10573317.
View on:
PubMed
1999
Once-daily and twice-daily dosing of p-aminosalicylic acid granules.
American journal of respiratory and critical care medicine.
159(3):932-4
[PMID] 10051275.
View on:
PubMed
1999
Pharmacokinetics of ethambutol under fasting conditions, with food, and with antacids.
Antimicrobial agents and chemotherapy.
43(3):568-72
[PMID] 10049268.
View on:
PubMed
1999
Pharmacokinetics of isoniazid under fasting conditions, with food, and with antacids.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
3(8):703-10
[PMID] 10460103.
View on:
PubMed
1999
Pharmacokinetics of rifampin under fasting conditions, with food, and with antacids.
Chest.
115(1):12-8
[PMID] 9925057.
View on:
PubMed
1999
Potential interaction between itraconazole and clarithromycin.
Pharmacotherapy.
19(12):1439-44
[PMID] 10600094.
View on:
PubMed
1999
The effect of hemodialysis on cycloserine, ethionamide, para-aminosalicylate, and clofazimine.
Chest.
116(4):984-90
[PMID] 10531163.
View on:
PubMed
1999
The effect of hemodialysis on isoniazid, rifampin, pyrazinamide, and ethambutol.
American journal of respiratory and critical care medicine.
159(5 Pt 1):1580-4
[PMID] 10228130.
View on:
PubMed
1999
Therapeutic drug monitoring in antituberculosis chemotherapy.
Therapeutic drug monitoring.
21(4):426-7
[PMID] 10442697.
View on:
PubMed
1999
Therapeutic drug monitoring in patients with cystic fibrosis and mycobacterial disease.
The European respiratory journal.
14(2):347-51
[PMID] 10515412.
View on:
PubMed
1999
Therapeutic implications of drug interactions in the treatment of human immunodeficiency virus-related tuberculosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
28(3):419-29; quiz 430
[PMID] 10194057.
View on:
PubMed
1998
Effect of grapefruit juice on clarithromycin pharmacokinetics.
Antimicrobial agents and chemotherapy.
42(4):927-9
[PMID] 9559810.
View on:
PubMed
1998
Levofloxacin for drug-resistant Mycobacterium tuberculosis.
The Annals of pharmacotherapy.
32(2):268-9
[PMID] 9496417.
View on:
PubMed
1998
Oral cimetidine prolongs clarithromycin absorption.
Antimicrobial agents and chemotherapy.
42(7):1578-80
[PMID] 9660986.
View on:
PubMed
1998
Pharmacokinetics of pyrazinamide under fasting conditions, with food, and with antacids.
Pharmacotherapy.
18(6):1205-11
[PMID] 9855317.
View on:
PubMed
1998
Serum concentrations of the antimycobacterial drugs.
Chest.
113(5):1154-5
[PMID] 9596284.
View on:
PubMed
1997
Advice on treatment of drug-resistant tuberculosis.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
54(6):700-1
[PMID] 9075505.
View on:
PubMed
1997
Advice on treatment of Mycobacterium avium complex infection.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
54(10):1208-9
[PMID] 9161632.
View on:
PubMed
1997
Early bactericidal activity of isoniazid in pulmonary tuberculosis. Optimization of methodology. The DATRI 008 Study Group.
American journal of respiratory and critical care medicine.
156(3 Pt 1):918-23
[PMID] 9310014.
View on:
PubMed
1997
Mycobacterium avium complex infection. Pharmacokinetic and pharmacodynamic considerations that may improve clinical outcomes.
Clinical pharmacokinetics.
32(2):132-44
[PMID] 9068928.
View on:
PubMed
1997
Population pharmacokinetic modeling of isoniazid, rifampin, and pyrazinamide.
Antimicrobial agents and chemotherapy.
41(12):2670-9
[PMID] 9420037.
View on:
PubMed
1997
The role of advanced generation macrolides in the prophylaxis and treatment of Mycobacterium avium complex (MAC) infections.
Drugs.
54(1):69-80
[PMID] 9211081.
View on:
PubMed
1996
Adverse events associated with high-dose rifabutin in macrolide-containing regimens for the treatment of Mycobacterium avium complex lung disease.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
22(5)
[PMID] 8722972.
View on:
PubMed
1996
Low antituberculosis drug concentrations in patients with AIDS.
The Annals of pharmacotherapy.
30(9):919-25
[PMID] 8876848.
View on:
PubMed
1996
Pharmacokinetic evaluation of thiacetazone.
Pharmacotherapy.
16(5):735-41
[PMID] 8888068.
View on:
PubMed
1996
Quinolones and tuberculosis.
The Annals of pharmacotherapy.
30(9):1034-5
[PMID] 8876870.
View on:
PubMed
1996
Therapeutic drug monitoring of the antimycobacterial drugs.
Clinics in laboratory medicine.
16(3):717-29
[PMID] 8866188.
View on:
PubMed
1995
Failure of drug penetration and acquisition of drug resistance in chronic tuberculous empyema.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
76(5):463-7
[PMID] 7496011.
View on:
PubMed
1995
Long-term safety of ofloxacin and ciprofloxacin in the treatment of mycobacterial infections.
American journal of respiratory and critical care medicine.
151(6):2006-9
[PMID] 7767552.
View on:
PubMed
1995
Recent advances: antiinfectives.
The Annals of pharmacotherapy.
29(10):1035-40
[PMID] 8845542.
View on:
PubMed
1995
Tuberculosis and multi-drug resistant tuberculosis in children.
Pediatric nursing.
21(6):566-72
[PMID] 8700614.
View on:
PubMed
1995
Variable disposition of ciprofloxacin in critically ill patients undergoing continuous arteriovenous hemodiafiltration.
Pharmacotherapy.
15(2):236-45
[PMID] 7624271.
View on:
PubMed
1994
Clarification: controversies in the management of Mycobacterium avium complex infection in AIDS.
The Annals of pharmacotherapy.
28(6)
[PMID] 7919579.
View on:
PubMed
1994
Infection caused by Mycobacterium tuberculosis.
The Annals of pharmacotherapy.
28(1):72-84
[PMID] 8123968.
View on:
PubMed
1994
Pharmacokinetic evaluation of aconiazide, a potentially less toxic isoniazid prodrug.
Pharmacotherapy.
14(4):415-23
[PMID] 7937278.
View on:
PubMed
1994
Pharmacokinetic evaluation of para-aminosalicylic acid granules.
Pharmacotherapy.
14(1):40-6
[PMID] 8159600.
View on:
PubMed
1993
Comment: intravenous streptomycin.
The Annals of pharmacotherapy.
27(12):1546-7
[PMID] 7508298.
View on:
PubMed
1993
Low serum levels of oral antimycobacterial agents in patients with disseminated Mycobacterium avium complex disease.
The Journal of infectious diseases.
168(6):1559-62
[PMID] 8245546.
View on:
PubMed
1993
Malabsorption of antimycobacterial medications.
The New England journal of medicine.
329(15):1122-3
[PMID] 8371737.
View on:
PubMed
1993
Pharmacology of the antimycobacterial drugs.
The Medical clinics of North America.
77(6):1253-62
[PMID] 8231410.
View on:
PubMed
1992
Malabsorption of antituberculosis medications by a patient with AIDS.
The New England journal of medicine.
327(25):1817-8
[PMID] 1435941.
View on:
PubMed
1992
Shortages of antimycobacterial drugs.
The New England journal of medicine.
326(10)
[PMID] 1736124.
View on:
PubMed
1991
Antibiotic tissue penetration and its relevance: impact of tissue penetration on infection response.
Antimicrobial agents and chemotherapy.
35(10):1953-9
[PMID] 1759813.
View on:
PubMed
1991
Dosage of antimycobacterial agents.
Clinical pharmacy.
10(9):664-5
[PMID] 1914427.
View on:
PubMed
1991
Improved high-performance liquid chromatographic assay for the determination of ethionamide in serum.
Journal of chromatography.
563(2):472-5
[PMID] 2056012.
View on:
PubMed
1991
Kinetics and dynamics of tobramycin action in patients with bacteriuria given single doses.
Antimicrobial agents and chemotherapy.
35(6):1191-5
[PMID] 1929261.
View on:
PubMed
1991
Pharmacokinetic evaluation of ethionamide suppositories.
Pharmacotherapy.
11(5):359-63
[PMID] 1745621.
View on:
PubMed
1990
Fighting tuberculosis with old weapons.
DICP : the annals of pharmacotherapy.
24(9):883-4
[PMID] 2260350.
View on:
PubMed
1989
Evaluation of intravenous ciprofloxacin in patients with nosocomial lower respiratory tract infections. Impact of plasma concentrations, organism, minimum inhibitory concentration, and clinical condition on bacterial eradication.
Archives of internal medicine.
149(10):2269-73
[PMID] 2508586.
View on:
PubMed
1988
Storing extra calibration curves in the TDx assay system.
Clinical pharmacy.
7(11):792-3
[PMID] 3197380.
View on:
PubMed
1987
Dual individualization of intravenous ciprofloxacin in patients with nosocomial lower respiratory tract infections.
The American journal of medicine.
82(4A):352-6
[PMID] 3555060.
View on:
PubMed
Grants
Jan 2021
ACTIVE
Early intervention augmenting GABA-ergic pathways: The VIGAB-STAT – VIGABatrin in post-anoxic STATus epilepticus
Role: Co-Investigator
Funding: AMER HEART ASSOCIATION
Dec 2020
ACTIVE
Pharmacokinetics and Pharmacodynamics of Dolutegravir in Children Weighing =20 Kg Living with HIV with and without TB Coinfection
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Sep 2020
ACTIVE
Urine Colorimetry for Tuberculosis Pharmacokinetics Evaluation in Children and Adults
Role: Principal Investigator
Funding: UNIV OF VIRGINIA
via NATL INST OF HLTH NIAID
Nov 2019
– Feb 2021
LegoChem Data Analysis – Task Order #1
Role: Principal Investigator
Funding: LEGOCHEM BIOSCIENCES
May 2019
ACTIVE
Development of Gleevec for TB and TB/HIV
Role: Principal Investigator
Funding: EMORY UNIV
via NATL INST OF HLTH NIAID
Apr 2019
– Apr 2020
Urine Colorimetry for Tuberculosis Pharmacokinetics Evaluation in Children and Adults
Role: Principal Investigator
Funding: RUTGERS STATE UNIV
via NATL INST OF HLTH NIAID
Feb 2019
– Jan 2021
Diagnostics and Pharmacotherapy for Severe Forms of TB
Role: Principal Investigator
Funding: UNIV OF VIRGINIA
via NATL INST OF HLTH NIAID
Sep 2018
ACTIVE
Pharmacokinetics of Anti-tuberculosis and Antiretroviral Drugs in Children
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Jul 2018
ACTIVE
An Exploratory Study of Anti-Tuberculosis Drug Penetration into Cerebrospinal Fluid
Role: Principal Investigator
Funding: EMORY UNIV
via NATL INST OF HLTH NIAID
Feb 2018
– Jan 2019
Diagnostics and Pharmacotherapy for Severe Forms of TB
Role: Principal Investigator
Funding: UNIV OF VIRGINIA
via NATL INST OF HLTH NIAID
Oct 2017
– Dec 2018
Screening and Treatment of Children and Adults Exposed at Home to Drug-Resistant Tuberculosis
Role: Principal Investigator
Funding: HARVARD MEDICAL SCHOOL
Aug 2017
ACTIVE
Predictors of Resistance Emergence Evaluation in MDR-TB Patients on Treatment (PREEMPT)
Role: Principal Investigator
Funding: BOSTON UNIV
via NATL INST OF HLTH NIAID
Aug 2016
ACTIVE
Optimizing combination therapy for accelerate clinical cure of tuberculosis
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jul 2016
– May 2017
Pharmacokinetics of second-line anti-tuberculosis drugs among patients with multidrug-resistant tuberculosis
Role: Principal Investigator
Funding: INTL SCIENCE AND TECHNOLOGY CENTER
Jun 2016
– Aug 2018
Pharmacokinetics of Anti-tuberculosis and Antiretroviral Drugs in Children
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Feb 2016
– Jan 2018
A Clinical Pharmacology Study of a Novel Drug Regimen for Pre XDR and XDR Tuberculosis
Role: Principal Investigator
Funding: EMORY UNIV
via NATL INST OF HLTH NIAID
Feb 2016
– Jan 2018
MD-INMD Diagnostics and Pharmacotherapy for Service Year 2
Role: Principal Investigator
Funding: UNIV OF VIRGINIA
via NATL INST OF HLTH NIAID
Sep 2015
– Mar 2017
task A73: Combination drug testing for new TB regimens
Role: Principal Investigator
Funding: TEXAS A&M RES FOU
via NATL INST OF HLTH
Aug 2014
– Dec 2018
Rifampin and Lopinavir Study
Role: Principal Investigator
Funding: UNIV OF MIAMI
Mar 2014
– Jun 2018
Pharmacokinetics and Pharmacodynamics of Tuberculosis Drugs in Patients with Active Disease
Role: Principal Investigator
Funding: CRITICAL PATH INSTITUTE
via GATES FOU, BILL & MELINDA
Feb 2014
– Feb 2017
Advanced Neuroimaging Evaluation of the Central Nervous System Biological Changes Associated with Efavirenz Therapy
Role: Principal Investigator
Funding: BRIGHAM AND WOMENS HOSPITAL
Feb 2014
– Jul 2017
Immune Activation and Drug Absorption in HIV-Infected Patients
Role: Principal Investigator
Funding: DREXEL UNIVERSITY
via JANSSEN SCIENTIFIC AFFAIRS
Aug 2013
– Jul 2018
Phase 2 Pharmacodynamic Study of High-dose Levofloxacin in MDR-TB Treatment
Role: Principal Investigator
Funding: BOSTON UNIV
via NATL INST OF HLTH NIAID
Jul 2013
– Jun 2016
Intracavitary Drug Levels in Patients with Drug Resistant Tuberculosis
Role: Principal Investigator
Funding: EMORY UNIV
via NATL INST OF HLTH
Jun 2009
ACTIVE
Moxifloxain PK in Bile.
Role: Principal Investigator
Funding: MULTIPLE SPONSORS
Education
Pharm.D.
1986
·
Philadelphia College of Pharmacy and Science
B.S.
1981
·
University of Connecticut
Teaching Profile
Courses Taught
2013-2021
PHA7979 Advanced Research
2013-2021
PHA7980 Research for Doctoral Dissertation
2012,2018
PHA6935 Selected Topics in Pharmacy
2018
PHA6971 Research for Master’s Thesis
2017-2018
PHA6910 Supervised Research
2014-2018,2021
PHA6938 Research Seminar
2016-2017
PHA5878C Pt Care 3: Cv and Pulm
2012-2014
PHA5783 Pharmacotherapy 3
2014
PHA5787 Pharmacotherapy 5
2011,2013
PHA5907 Research in Phar Prac
2012
PHA5113 Personalized Medicine
2012
PHA6125 Pharmacokinetics and Biopharmaceutics
2011
PHA5113C Thera Mon/Pharmacogen
2010
PHA4907 Probs in Pharm Prac
2021
PHA5876C Pt Care 8 Complex Pts
Contact Details
Phones:
- Business:
- (352) 273-6266
Emails:
- Business:
- peloquin@cop.ufl.edu