Charles Peloquin, Pharm.D.
The Jack C. Massey Endowed Professor And Associate Chair Of The Department Pharmacotherapy And Translational Research
Department:
Pharmacotherapy & Translational Research
Business Phone:
(352) 273-6266
Business Email:
peloquin@ufl.edu
About Charles Peloquin
Prior to coming to the University of Florida, Dr. Peloquin completed a hospital pharmacy residency at Duke University Medical Center, where he also served on the clinical staff. He also completed a fellowship in Infectious Diseases and Pharmacokinetics at the Clinical Pharmacokinetics Laboratory, Millard Fillmore Hospital, Buffalo, N.Y. For 20 years, Dr. Peloquin was the Director of the Infectious Disease Pharmacokinetics Laboratory (IDPL) at National Jewish Health, Denver, CO. He now serves as Professor of Pharmacy and Medicine at UF, where the IDPL now is located. Dr. Peloquin and his lab are part of the UF Emerging Pathogens Institute. He has served a consultant to the FDA, CDC and WHO, and has contributed to national guidelines on the treatment tuberculosis and the treatment of opportunistic infections in patients living with AIDS.
Accomplishments
Roger Jelliffe Individualized Therapy Award
2024
·
American College of Clinical Pharmacology
Lifetime Achievement Award
2023
·
The North American Region of the International Union against Tuberculosis and Lung Disease
Member
2004-Current
·
International Society of Antimicrobial Pharmacology
Member
1991-Current
·
Society of Infectious Disease Pharmacists
Member
1990-Current
·
American Society of Microbiology
Member
1986-Current
·
American College of Clinical Pharmacy
Teaching Profile
Courses Taught
2013-2021
PHA7979 Advanced Research
2013-2021
PHA7980 Research for Doctoral Dissertation
2012,2018
PHA6935 Selected Topics in Pharmacy
2018
PHA6971 Research for Master’s Thesis
2017-2018
PHA6910 Supervised Research
2014-2018,2021-2022
PHA6938 Research Seminar
2016-2017
PHA5878C Pt Care 3: Cv and Pulm
2012-2014
PHA5783 Pharmacotherapy 3
2014
PHA5787 Pharmacotherapy 5
2011,2013
PHA5907 Research in Phar Prac
2012
PHA5113 Personalized Medicine
2012
PHA6125 Pharmacokinetics and Biopharmaceutics
2011
PHA5113C Thera Mon/Pharmacogen
2010
PHA4907 Probs in Pharm Prac
2021-2024
PHA5876C Pt Care 8 Complex Pts
Clinical Profile
Clinical Laboratory Director, licensed in FL and NY
Research Profile
Dr. Peloquin’s laboratory serves as a national reference center for the determination of serum concentrations for the antimycobacterial, antifungal, anti-HIV drugs, and antibacterial drugs including beta-lactams and linezolid. His research efforts focus on therapeutic drug monitoring and clinical trials for patients with advanced mycobacterial diseases.
Publications
Academic Articles
2025
Efficacy and Safety of Higher Doses of Levofloxacin for MDR-TB: A Randomized Placebo-controlled Phase 2 Trial.
American journal of respiratory and critical care medicine.
[DOI] 10.1164/rccm.202407-1354OC.
[PMID] 40080768.
2025
High Time for Higher-Dose Rifampin
Clinical Infectious Diseases.
[DOI] 10.1093/cid/ciaf005.
2025
Impact of Pharmacogenetics on Pharmacokinetics of First-Line Antituberculosis Drugs in the HIRIF Trial
The Journal of Infectious Diseases.
[DOI] 10.1093/infdis/jiaf195.
2025
Impact of Timing of Beta-Lactam Therapeutic Drug Monitoring and Therapy Adjustment in Critically Ill Patients
Antibiotics.
14(5)
[DOI] 10.3390/antibiotics14050463.
[PMID] 40426530.
2025
Linezolid Dosing and Pharmacokinetics in North American Patients With Tuberculosis
Clinical Infectious Diseases.
[DOI] 10.1093/cid/ciaf027.
2025
Pharmacometabolomics in TB meningitis—Understanding the pharmacokinetic, metabolic, and immune factors associated with anti-TB drug concentrations in cerebrospinal fluid
PLOS ONE.
20(3)
[DOI] 10.1371/journal.pone.0315999.
[PMID] 40029856.
2024
A Randomized Clinical Trial of Bayesian-Guided Beta-Lactam Infusion Strategy and Associated Bacterial Resistance and Clinical Outcomes in Patients With Severe Pneumonia.
Therapeutic drug monitoring.
46(1):95-101
[DOI] 10.1097/FTD.0000000000001144.
[PMID] 38018847.
2024
Association of piperacillin and vancomycin exposure on acute kidney injury during combination therapy.
JAC-antimicrobial resistance.
6(1)
[DOI] 10.1093/jacamr/dlad157.
[PMID] 38259903.
2024
Cefepime pharmacokinetics in adult extracorporeal membrane oxygenation patients
Pulmonary Pharmacology & Therapeutics.
84
[DOI] 10.1016/j.pupt.2023.102271.
2024
Clinical considerations and pharmacokinetic interactions between HIV and tuberculosis therapeutics.
Expert review of clinical pharmacology.
17(7):537-547
[DOI] 10.1080/17512433.2024.2317954.
[PMID] 38339997.
2024
Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs
Nature Communications.
15(1)
[DOI] 10.1038/s41467-024-50989-4.
[PMID] 39143055.
2024
Dynamic PET Reveals Compartmentalized Brain and Lung Tissue Antibiotic Exposures.
Research square.
[DOI] 10.21203/rs.3.rs-4096014/v1.
[PMID] 38562706.
2024
Early vigabatrin to augment GABAergic pathways in post-anoxic status epilepticus.
Epilepsy & behavior : E&B.
160
[DOI] 10.1016/j.yebeh.2024.110082.
[PMID] 39393141.
2024
Evaluation of the predictive performance of an online voriconazole dose calculator in children.
European journal of clinical pharmacology.
80(12):1989-1993
[DOI] 10.1007/s00228-024-03762-x.
[PMID] 39327261.
2024
Isoniazid urine spectrophotometry for prediction of serum pharmacokinetics in adults with TB.
IJTLD open.
1(2):90-95
[DOI] 10.5588/ijtldopen.23.0361.
[PMID] 38655375.
2024
Linezolid does not improve bactericidal activity of rifampin-containing first-line regimens in animal models of TB meningitis
International Journal of Antimicrobial Agents.
63(1)
[DOI] 10.1016/j.ijantimicag.2023.107048.
[PMID] 38061419.
2024
Role of therapeutic drug monitoring in the treatment of multi-drug resistant tuberculosis.
Journal of clinical tuberculosis and other mycobacterial diseases.
36
[DOI] 10.1016/j.jctube.2024.100444.
[PMID] 38708036.
2024
Therapeutic drug monitoring for isoniazid and rifampicin exposure.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
28(3):168-169
[DOI] 10.5588/ijtld.23.0495.
[PMID] 38454183.
2024
Utilization of cefepime therapeutic drug monitoring in febrile neutropenia patients with hematologic malignancies.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
30(7):1207-1213
[DOI] 10.1177/10781552231213883.
[PMID] 37981806.
2023
16S rRNA gene sequencing of stool samples collected from patients with latent tuberculosis infection before, during, and two months after treatment with 3HP or 4R.
BMC research notes.
16(1)
[DOI] 10.1186/s13104-023-06370-7.
[PMID] 37308931.
2023
A Single-Run HPLC–MS Multiplex Assay for Therapeutic Drug Monitoring of Relevant First- and Second-Line Antibiotics in the Treatment of Drug-Resistant Tuberculosis
Pharmaceutics.
15(11)
[DOI] 10.3390/pharmaceutics15112543.
[PMID] 38004523.
2023
Adequacy of WHO weight-band dosing and fixed-dose combinations for the treatment of TB in children.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
27(5):401-407
[DOI] 10.5588/ijtld.22.0591.
[PMID] 37143230.
2023
Beta-lactam target attainment and associated outcomes in patients with bloodstream infections
International Journal of Antimicrobial Agents.
61(3)
[DOI] 10.1016/j.ijantimicag.2023.106727.
2023
Cefepime Daily Exposure and the Associated Impact on the Change in Sequential Organ Failure Assessment Scores and Vasopressors Requirement in Critically Ill Patients Using Repeated-Measures Mixed-Effect Modeling.
Critical care explorations.
5(11)
[DOI] 10.1097/CCE.0000000000000993.
[PMID] 38304706.
2023
Clinical standards for the management of adverse effects during treatment for TB.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
27(7):506-519
[DOI] 10.5588/ijtld.23.0078.
[PMID] 37353868.
2023
Concomitant Treatment of Tuberculosis and Hepatitis C Virus in Coinfected Patients Using Serum Drug Concentration Monitoring
Open Forum Infectious Diseases.
10(6)
[DOI] 10.1093/ofid/ofad237.
[PMID] 37383253.
2023
Effect of HIV infection on plasma exposure to first-line TB drugs and target attainment in children.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
27(12):931-937
[DOI] 10.5588/ijtld.23.0184.
[PMID] 38042977.
2023
Experience with Implementing a Beta-lactam Therapeutic Drug Monitoring Service in a Burn Intensive Care Unit: A Retrospective Chart Review.
Journal of burn care & research : official publication of the American Burn Association.
44(1):121-128
[DOI] 10.1093/jbcr/irac099.
[PMID] 35896122.
2023
Global estimates and determinants of antituberculosis drug pharmacokinetics in children and adolescents: a systematic review and individual patient data meta-analysis.
The European respiratory journal.
61(3)
[DOI] 10.1183/13993003.01596-2022.
[PMID] 36328357.
2023
Gut microbiota composition and diversity before, during, and two months after rifamycin-based tuberculosis preventive therapy.
Scientific reports.
13(1)
[DOI] 10.1038/s41598-023-44854-5.
[PMID] 37919333.
2023
Impact of Beta-Lactam Target Attainment on Resistance Development in Patients with Gram-Negative Infections
Antibiotics.
12(12)
[DOI] 10.3390/antibiotics12121696.
[PMID] 38136730.
2023
Implementation of Bedaquiline, Pretomanid, and Linezolid in the United States: Experience Using a Novel All-Oral Treatment Regimen for Treatment of Rifampin-Resistant or Rifampin-Intolerant Tuberculosis Disease.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
77(7):1053-1062
[DOI] 10.1093/cid/ciad312.
[PMID] 37249079.
2023
Making the case for precision dosing: visualizing the variability of cefepime exposures in critically ill adults.
The Journal of antimicrobial chemotherapy.
78(9):2170-2174
[DOI] 10.1093/jac/dkad211.
[PMID] 37449472.
2023
Pharmacokinetic-Pharmacodynamic Determinants of Clinical Outcomes for Rifampin-Resistant Tuberculosis: A Multisite Prospective Cohort Study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
76(3):497-505
[DOI] 10.1093/cid/ciac511.
[PMID] 35731948.
2023
Pharmacokinetics and pharmacodynamics of adult dolutegravir tablets in treatment-experienced children with HIV weighing at least 20 kg.
AIDS (London, England).
37(9):1409-1417
[DOI] 10.1097/QAD.0000000000003576.
[PMID] 37070558.
2023
Pharmacokinetics, Safety, and Tolerability of Once-Daily Darunavir With Cobicistat and Weekly Isoniazid/Rifapentine.
Journal of acquired immune deficiency syndromes (1999).
94(5):468-473
[DOI] 10.1097/QAI.0000000000003301.
[PMID] 37955446.
2023
Pharmacometabolomics in TB Meningitis – understanding the pharmacokinetic, metabolic, and immune factors associated with anti-TB drug concentrations in cerebrospinal fluid.
medRxiv : the preprint server for health sciences.
[DOI] 10.1101/2023.12.14.23299982.
[PMID] 38168338.
2023
Pretomanid-resistant tuberculosis.
The Journal of infection.
86(5):520-524
[DOI] 10.1016/j.jinf.2023.01.039.
[PMID] 36738862.
2023
Reply to Upton et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
77(1):158-159
[DOI] 10.1093/cid/ciad188.
[PMID] 36978221.
2023
Rifampin urinary excretion to predict serum targets in children with tuberculosis: a prospective diagnostic accuracy study.
Archives of disease in childhood.
108(8):616-621
[DOI] 10.1136/archdischild-2022-325250.
[PMID] 37171408.
2023
Simplified urine-based method to detect rifampin underexposure in adults with tuberculosis: a prospective diagnostic accuracy study
Antimicrobial Agents and Chemotherapy.
67(11)
[DOI] 10.1128/aac.00932-23.
[PMID] 37877727.
2023
The effect of anti-tuberculosis drug pharmacokinetics on QTc prolongation
International Journal of Antimicrobial Agents.
62(4)
[DOI] 10.1016/j.ijantimicag.2023.106939.
[PMID] 37517627.
2023
Therapeutic drug monitoring and TB treatment outcomes in patients with diabetes mellitus.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
27(2):135-139
[DOI] 10.5588/ijtld.22.0448.
[PMID] 36853114.
2023
Therapeutic drug monitoring in cystic fibrosis and associations with pulmonary exacerbations and lung function
Respiratory Medicine.
212
[DOI] 10.1016/j.rmed.2023.107237.
2023
Use of therapeutic drug monitoring to characterize cefepime-related neurotoxicity.
Pharmacotherapy.
43(1):6-14
[DOI] 10.1002/phar.2744.
[PMID] 36401796.
2022
Administration and monitoring of clofazimine for NTM infections in children with and without cystic fibrosis
Journal of Cystic Fibrosis.
21(2):348-352
[DOI] 10.1016/j.jcf.2021.08.010.
2022
Another trial for the TARGET trial.
Intensive care medicine.
48(6):774-775
[DOI] 10.1007/s00134-022-06654-9.
[PMID] 35230463.
2022
Applying Cefepime Population Pharmacokinetics to Critically Ill Patients Receiving Continuous Renal Replacement Therapy
Antimicrobial Agents and Chemotherapy.
66(1)
[DOI] 10.1128/aac.01611-21.
2022
Cefepime Precision Dosing Tool: from Standard to Precise Dose Using Nonparametric Population Pharmacokinetics
Antimicrobial Agents and Chemotherapy.
66(2)
[DOI] 10.1128/aac.02046-21.
[PMID] 34902271.
2022
Cerebrospinal fluid concentrations of fluoroquinolones and carbapenems in tuberculosis meningitis.
Frontiers in pharmacology.
13
[DOI] 10.3389/fphar.2022.1048653.
[PMID] 36578553.
2022
Clinical standards for the dosing and management of TB drugs.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
26(6):483-499
[DOI] 10.5588/ijtld.22.0188.
[PMID] 35650702.
2022
Combination Therapy to Kill Mycobacterium tuberculosis in Its Nonreplicating Persister Phenotype
Antimicrobial Agents and Chemotherapy.
66(10)
[DOI] 10.1128/aac.00695-22.
[PMID] 36165631.
2022
Cycloserine and Linezolid for Tuberculosis Meningitis: Pharmacokinetic Evidence of Potential Usefulness.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
75(4):682-689
[DOI] 10.1093/cid/ciab992.
[PMID] 34849645.
2022
Determining in vitro and ex vivo protein binding of levofloxacin and moxifloxacin in patients with TB.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
26(12):1177-1179
[DOI] 10.5588/ijtld.22.0278.
[PMID] 36447318.
2022
Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies.
Nature communications.
13(1)
[DOI] 10.1038/s41467-022-35730-3.
[PMID] 36581633.
2022
Early vigabatrin augmenting GABA-ergic pathways in post-anoxic status epilepticus (VIGAB-STAT) phase IIa clinical trial study protocol.
Neurological research and practice.
4(1)
[DOI] 10.1186/s42466-022-00168-x.
[PMID] 35067230.
2022
Effect of Rifabutin in Dolutegravir Dosing: A Case Series.
Journal of the International Association of Providers of AIDS Care.
21
[DOI] 10.1177/23259582221111077.
[PMID] 36026587.
2022
Enteropathogen spectrum and effect on antimycobacterial pharmacokinetics among children with tuberculosis in rural Tanzania: a prospective cohort study.
The Lancet. Microbe.
3(6):e408-e416
[DOI] 10.1016/S2666-5247(21)00308-6.
[PMID] 35659902.
2022
Evaluating the effect of clofazimine against Mycobacterium tuberculosis given alone or in combination with pretomanid, bedaquiline or linezolid
International Journal of Antimicrobial Agents.
59(2)
[DOI] 10.1016/j.ijantimicag.2021.106509.
2022
High-dose rifampin improves bactericidal activity without increased intracerebral inflammation in animal models of tuberculous meningitis
Journal of Clinical Investigation.
132(6)
[DOI] 10.1172/jci155851.
2022
Implementation of a β-lactam therapeutic drug monitoring program: Experience from a large academic medical center.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
79(18):1586-1591
[DOI] 10.1093/ajhp/zxac171.
[PMID] 35704702.
2022
Isoniazid and rifapentine treatment effectively reduces persistent M. tuberculosis infection in macaque lungs
Journal of Clinical Investigation.
132(18)
[DOI] 10.1172/jci161564.
2022
Linezolid Exposure Is Associated with Cytopenias in Patients Treated for Multidrug-Resistant Tuberculosis
Antimicrobial Agents and Chemotherapy.
66(9)
[DOI] 10.1128/aac.00408-22.
[PMID] 35916515.
2022
Meropenem Population Pharmacokinetics and Simulations in Plasma, Cerebrospinal Fluid, and Brain Tissue
Antimicrobial Agents and Chemotherapy.
66(8)
[DOI] 10.1128/aac.00438-22.
[PMID] 35862739.
2022
Pharmacogenetic testing for NAT2 genotypes in a Tanzanian population across the lifespan to guide future personalized isoniazid dosing.
Tuberculosis (Edinburgh, Scotland).
136
[DOI] 10.1016/j.tube.2022.102246.
[PMID] 35961094.
2022
Practices of therapeutic drug monitoring in tuberculosis: an international survey.
The European respiratory journal.
59(4)
[DOI] 10.1183/13993003.02787-2021.
[PMID] 35086830.
2022
Using Machine Learning To Define the Impact of Beta-Lactam Early and Cumulative Target Attainment on Outcomes in Intensive Care Unit Patients with Hospital-Acquired and Ventilator-Associated Pneumonia
Antimicrobial Agents and Chemotherapy.
66(7)
[DOI] 10.1128/aac.00563-22.
[PMID] 35699444.
2021
Beta-Lactams Dosing in Critically Ill Patients with Gram-Negative Bacterial Infections: A PK/PD Approach.
Antibiotics (Basel, Switzerland).
10(10)
[DOI] 10.3390/antibiotics10101154.
[PMID] 34680734.
2021
Building Optimal Three-Drug Combination Chemotherapy Regimens To Eradicate Mycobacterium tuberculosis in Its Slow-Growth Acid Phase
Antimicrobial Agents and Chemotherapy.
65(10)
[DOI] 10.1128/aac.00693-21.
2021
Cefepime Population Pharmacokinetics and Target Attainment in Critically Ill Patients on Continuous Renal Replacement Therapy
Antimicrobial Agents and Chemotherapy.
65(6)
[DOI] 10.1128/aac.00144-21.
2021
Comment on: The case for ‘conservative pharmacotherapy’.
The Journal of antimicrobial chemotherapy.
76(7):1951-1952
[DOI] 10.1093/jac/dkab087.
[PMID] 33851696.
2021
Determination of Rifampin Concentrations by Urine Colorimetry and Mobile Phone Readout for Personalized Dosing in Tuberculosis Treatment.
Journal of the Pediatric Infectious Diseases Society.
10(2):104-111
[DOI] 10.1093/jpids/piaa024.
[PMID] 32170944.
2021
Dose Fractionation of Moxifloxacin for Treatment of Tuberculosis: Impact of Dosing Interval and Elimination Half-Life on Microbial Kill and Resistance Suppression
Antimicrobial Agents and Chemotherapy.
65(4)
[DOI] 10.1128/aac.02533-20.
2021
Dynamic PET-facilitated modeling and high-dose rifampin regimens for Staphylococcus aureus orthopedic implant–associated infections
Science Translational Medicine.
13(622)
[DOI] 10.1126/scitranslmed.abl6851.
[PMID] 34851697.
2021
Effect of malnutrition on the pharmacokinetics of anti-TB drugs in Ghanaian children.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
25(1):36-42
[DOI] 10.5588/ijtld.20.0301.
[PMID] 33384043.
2021
Novel 6-Month Treatment for Drug-Resistant Tuberculosis, United States.
Emerging infectious diseases.
27(1):332-4
[DOI] 10.3201/eid2701.203766.
[PMID] 33227229.
2021
Optimising pyrazinamide for the treatment of tuberculosis.
The European respiratory journal.
58(1)
[DOI] 10.1183/13993003.02013-2020.
[PMID] 33542052.
2021
Pharmacogenetic predictors of nevirapine pharmacokinetics in Ghanaian children living with HIV with or without TB coinfection.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.
92
[DOI] 10.1016/j.meegid.2021.104856.
[PMID] 33839311.
2021
Pharmacokinetics of bedaquiline, delamanid and clofazimine in patients with multidrug-resistant tuberculosis.
The Journal of antimicrobial chemotherapy.
76(4):1019-1024
[DOI] 10.1093/jac/dkaa550.
[PMID] 33378452.
2021
Population Pharmacokinetics and Bayesian Dose Adjustment to Advance TDM of Anti-TB Drugs.
Clinical pharmacokinetics.
60(6):685-710
[DOI] 10.1007/s40262-021-00997-0.
[PMID] 33674941.
2021
Population Pharmacokinetics and Significant Under-Dosing of Anti-Tuberculosis Medications in People with HIV and Critical Illness.
Antibiotics (Basel, Switzerland).
10(6)
[DOI] 10.3390/antibiotics10060739.
[PMID] 34207312.
2021
Reply to: Observations on malnutrition and anti-TB drugs in Ghana.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
25(9):779-780
[DOI] 10.5588/ijtld.21.0357.
[PMID] 34802507.
2021
The Funnel: a Screening Technique for Identifying Optimal Two-Drug Combination Chemotherapy Regimens
Antimicrobial Agents and Chemotherapy.
65(2)
[DOI] 10.1128/aac.02172-20.
2021
The Treatment of Tuberculosis.
Clinical pharmacology and therapeutics.
110(6):1455-1466
[DOI] 10.1002/cpt.2261.
[PMID] 33837535.
2021
Therapeutic Drug Monitoring in Non-Tuberculosis Mycobacteria Infections.
Clinical pharmacokinetics.
60(6):711-725
[DOI] 10.1007/s40262-021-01000-6.
[PMID] 33751415.
2021
Therapeutic drug monitoring in patients with tuberculosis and concurrent medical problems.
Expert opinion on drug metabolism & toxicology.
17(1):23-39
[DOI] 10.1080/17425255.2021.1836158.
[PMID] 33040625.
2021
Using precision dosing to minimize cefepime-induced neurotoxicity: The challenge of targets
Journal of Infection and Chemotherapy.
27(6):929-930
[DOI] 10.1016/j.jiac.2021.02.020.
2020
A Systematic Review and Meta-analysis of Isoniazid Pharmacokinetics in Healthy Volunteers and Patients with Tuberculosis
Clinical Therapeutics.
42(11):e220-e241
[DOI] 10.1016/j.clinthera.2020.09.009.
2020
Building Optimal Three-Drug Combination Chemotherapy Regimens
Antimicrobial Agents and Chemotherapy.
64(11)
[DOI] 10.1128/aac.01610-20.
2020
Clinical Outcomes Among Patients With Drug-resistant Tuberculosis Receiving Bedaquiline- or Delamanid-Containing Regimens.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
71(9):2336-2344
[DOI] 10.1093/cid/ciz1107.
[PMID] 31712809.
2020
Comment on “Meropenem, Cefepime, and Piperacillin Protein Binding in Patient Samples”.
Therapeutic drug monitoring.
42(6)
[DOI] 10.1097/FTD.0000000000000810.
[PMID] 33197165.
2020
Correction for Kempker et al., “A Pharmacology Perspective on Simultaneous Tuberculosis and Hepatitis C Treatment”.
Antimicrobial agents and chemotherapy.
64(2)
[DOI] 10.1128/AAC.02358-19.
[PMID] 31988109.
2020
Developing New Drugs for Mycobacterium tuberculosis Therapy: What Information Do We Get from Preclinical Animal Models?
Antimicrobial Agents and Chemotherapy.
64(12)
[DOI] 10.1128/aac.01376-20.
2020
Dynamic imaging in patients with tuberculosis reveals heterogeneous drug exposures in pulmonary lesions.
Nature medicine.
26(4):529-534
[DOI] 10.1038/s41591-020-0770-2.
[PMID] 32066976.
2020
Early therapeutic monitoring of β-lactams and associated therapy outcomes in critically ill patients.
The Journal of antimicrobial chemotherapy.
75(12):3644-3651
[DOI] 10.1093/jac/dkaa359.
[PMID] 32910809.
2020
Ethionamide Population Pharmacokinetic Model and Target Attainment in Multidrug-Resistant Tuberculosis
Antimicrobial Agents and Chemotherapy.
64(9)
[DOI] 10.1128/aac.00713-20.
2020
Evaluation of super-boosted lopinavir/ritonavir in combination with rifampicin in HIV-1-infected patients with tuberculosis.
International journal of antimicrobial agents.
55(2)
[DOI] 10.1016/j.ijantimicag.2019.10.021.
[PMID] 31704214.
2020
How to design a study to evaluate therapeutic drug monitoring in infectious diseases?
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
26(8):1008-1016
[DOI] 10.1016/j.cmi.2020.03.008.
[PMID] 32205294.
2020
Integrating Pharmacokinetics and Pharmacodynamics in Operational Research to End Tuberculosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
70(8):1774-1780
[DOI] 10.1093/cid/ciz942.
[PMID] 31560376.
2020
Isoniazid and Rifapentine Treatment Eradicates Persistent Mycobacterium tuberculosis in Macaques.
American journal of respiratory and critical care medicine.
201(4):469-477
[DOI] 10.1164/rccm.201903-0646OC.
[PMID] 31647877.
2020
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Using therapeutic drug monitoring to dose the antimycobacterial drugs.
Clinics in chest medicine.
18(1):79-87
[PMID] 9098612.
1996
Adverse events associated with high-dose rifabutin in macrolide-containing regimens for the treatment of Mycobacterium avium complex lung disease.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
22(5)
[PMID] 8722972.
1996
Low antituberculosis drug concentrations in patients with AIDS.
The Annals of pharmacotherapy.
30(9):919-25
[PMID] 8876848.
1996
Pharmacokinetic evaluation of thiacetazone.
Pharmacotherapy.
16(5):735-41
[PMID] 8888068.
1996
Quinolones and tuberculosis.
The Annals of pharmacotherapy.
30(9):1034-5
[PMID] 8876870.
1996
Therapeutic drug monitoring of the antimycobacterial drugs.
Clinics in laboratory medicine.
16(3):717-29
[PMID] 8866188.
1995
Failure of drug penetration and acquisition of drug resistance in chronic tuberculous empyema.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
76(5):463-7
[PMID] 7496011.
1995
Long-term safety of ofloxacin and ciprofloxacin in the treatment of mycobacterial infections.
American journal of respiratory and critical care medicine.
151(6):2006-9
[PMID] 7767552.
1995
Recent advances: antiinfectives.
The Annals of pharmacotherapy.
29(10):1035-40
[PMID] 8845542.
1995
Tuberculosis and multi-drug resistant tuberculosis in children.
Pediatric nursing.
21(6):566-72
[PMID] 8700614.
1995
Variable disposition of ciprofloxacin in critically ill patients undergoing continuous arteriovenous hemodiafiltration.
Pharmacotherapy.
15(2):236-45
[PMID] 7624271.
1994
Clarification: controversies in the management of Mycobacterium avium complex infection in AIDS.
The Annals of pharmacotherapy.
28(6)
[PMID] 7919579.
1994
Infection caused by Mycobacterium tuberculosis.
The Annals of pharmacotherapy.
28(1):72-84
[PMID] 8123968.
1994
Pharmacokinetic evaluation of aconiazide, a potentially less toxic isoniazid prodrug.
Pharmacotherapy.
14(4):415-23
[PMID] 7937278.
1994
Pharmacokinetic evaluation of para-aminosalicylic acid granules.
Pharmacotherapy.
14(1):40-6
[PMID] 8159600.
1993
Comment: intravenous streptomycin.
The Annals of pharmacotherapy.
27(12):1546-7
[PMID] 7508298.
1993
Controversies in the management of Mycobacterium avium complex infection in AIDS patients.
The Annals of pharmacotherapy.
27(7-8):928-37
[PMID] 8364280.
1993
Low serum levels of oral antimycobacterial agents in patients with disseminated Mycobacterium avium complex disease.
The Journal of infectious diseases.
168(6):1559-62
[PMID] 8245546.
1993
Malabsorption of antimycobacterial medications.
The New England journal of medicine.
329(15):1122-3
[PMID] 8371737.
1993
Pharmacology of the antimycobacterial drugs.
The Medical clinics of North America.
77(6):1253-62
[PMID] 8231410.
1992
Malabsorption of antituberculosis medications by a patient with AIDS.
The New England journal of medicine.
327(25):1817-8
[PMID] 1435941.
1992
Shortages of antimycobacterial drugs.
The New England journal of medicine.
326(10)
[PMID] 1736124.
1991
Antibiotic tissue penetration and its relevance: impact of tissue penetration on infection response.
Antimicrobial agents and chemotherapy.
35(10):1953-9
[PMID] 1759813.
1991
Antibiotic tissue penetration and its relevance: models of tissue penetration and their meaning.
Antimicrobial agents and chemotherapy.
35(10):1947-52
[PMID] 1759812.
1991
Dosage of antimycobacterial agents.
Clinical pharmacy.
10(9):664-5
[PMID] 1914427.
1991
Improved high-performance liquid chromatographic assay for the determination of ethionamide in serum.
Journal of chromatography.
563(2):472-5
[PMID] 2056012.
1991
Kinetics and dynamics of tobramycin action in patients with bacteriuria given single doses.
Antimicrobial agents and chemotherapy.
35(6):1191-5
[PMID] 1929261.
1991
Pharmacokinetic evaluation of ethionamide suppositories.
Pharmacotherapy.
11(5):359-63
[PMID] 1745621.
1990
Fighting tuberculosis with old weapons.
DICP : the annals of pharmacotherapy.
24(9):883-4
[PMID] 2260350.
1989
Evaluation of intravenous ciprofloxacin in patients with nosocomial lower respiratory tract infections. Impact of plasma concentrations, organism, minimum inhibitory concentration, and clinical condition on bacterial eradication.
Archives of internal medicine.
149(10):2269-73
[PMID] 2508586.
1988
Storing extra calibration curves in the TDx assay system.
Clinical pharmacy.
7(11):792-3
[PMID] 3197380.
1987
Dual individualization of intravenous ciprofloxacin in patients with nosocomial lower respiratory tract infections.
The American journal of medicine.
82(4A):352-6
[PMID] 3555060.
Grants
Aug 2024
ACTIVE
Addressing Research Gaps to Optimize Dolutegravir-based ART in Children and Adolescents
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Feb 2023
ACTIVE
Cavity and Granuloma Oriented Inflammation and Tissue Pharmacokinetics in Pulmonary Tuberculosis (COOK TB)
Role: Principal Investigator
Funding: EMORY UNIV
via NATL INST OF HLTH NIAID
Sep 2021
– Feb 2023
Beta-lactam continuous vs intermittent infusion and associated bacterial resistance and therapy outcomes in critically ill patients with severe pneumonia
Role: Principal Investigator
Funding: US FOOD AND DRUG ADMN
Jul 2021
– Mar 2024
Cefepime pharmacokinetics, protein binding, and precision dosing in burn ICU patients
Role: Principal Investigator
Funding: UF HEALTH SHANDS HOSPITAL
May 2021
– Jul 2024
Prevalence of Cefazolin Inoculum Effect in Mcthicillin Susceptible Staphylococcus aureus Bacteremia
Role: Co-Investigator
Funding: UF HEALTH SHANDS HOSPITAL
Jan 2021
– Dec 2023
Early intervention augmenting GABA-ergic pathways: The VIGAB-STAT – VIGABatrin in post-anoxic STATus epilepticus
Role: Co-Investigator
Funding: AMER HEART ASSOCIATION
Dec 2020
– Nov 2024
Pharmacokinetics and Pharmacodynamics of Dolutegravir in Children Weighing =20 Kg Living with HIV with and without TB Coinfection
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Sep 2020
– Aug 2023
Urine Colorimetry for Tuberculosis Pharmacokinetics Evaluation in Children and Adults
Role: Principal Investigator
Funding: UNIV OF VIRGINIA
via NATL INST OF HLTH NIAID
Nov 2019
– Feb 2021
LegoChem Data Analysis – Task Order #1
Role: Principal Investigator
Funding: LEGOCHEM BIOSCIENCES
May 2019
– Aug 2022
Development of Gleevec for TB and TB/HIV
Role: Principal Investigator
Funding: EMORY UNIV
via NATL INST OF HLTH NIAID
Apr 2019
– Apr 2020
Urine Colorimetry for Tuberculosis Pharmacokinetics Evaluation in Children and Adults
Role: Principal Investigator
Funding: RUTGERS STATE UNIV
via NATL INST OF HLTH NIAID
Feb 2019
– Jan 2021
Diagnostics and Pharmacotherapy for Severe Forms of TB
Role: Principal Investigator
Funding: UNIV OF VIRGINIA
via NATL INST OF HLTH NIAID
Sep 2018
ACTIVE
Pharmacokinetics of Anti-tuberculosis and Antiretroviral Drugs in Children
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Jul 2018
– Jun 2021
An Exploratory Study of Anti-Tuberculosis Drug Penetration into Cerebrospinal Fluid
Role: Principal Investigator
Funding: EMORY UNIV
via NATL INST OF HLTH NIAID
Feb 2018
– Jan 2019
Diagnostics and Pharmacotherapy for Severe Forms of TB
Role: Principal Investigator
Funding: UNIV OF VIRGINIA
via NATL INST OF HLTH NIAID
Oct 2017
– Dec 2018
Screening and Treatment of Children and Adults Exposed at Home to Drug-Resistant Tuberculosis
Role: Principal Investigator
Funding: HARVARD MEDICAL SCHOOL
Aug 2017
– Jul 2024
Predictors of Resistance Emergence Evaluation in MDR-TB Patients on Treatment (PREEMPT)
Role: Principal Investigator
Funding: BOSTON UNIV
via NATL INST OF HLTH NIAID
Aug 2016
– Jul 2022
Optimizing combination therapy for accelerate clinical cure of tuberculosis
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jul 2016
– May 2017
Pharmacokinetics of second-line anti-tuberculosis drugs among patients with multidrug-resistant tuberculosis
Role: Principal Investigator
Funding: INTL SCIENCE AND TECHNOLOGY CENTER
Jun 2016
– Aug 2018
Pharmacokinetics of Anti-tuberculosis and Antiretroviral Drugs in Children
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Feb 2016
– Jan 2018
A Clinical Pharmacology Study of a Novel Drug Regimen for Pre XDR and XDR Tuberculosis
Role: Principal Investigator
Funding: EMORY UNIV
via NATL INST OF HLTH NIAID
Feb 2016
– Jan 2018
MD-INMD Diagnostics and Pharmacotherapy for Service Year 2
Role: Principal Investigator
Funding: UNIV OF VIRGINIA
via NATL INST OF HLTH NIAID
Sep 2015
– Mar 2017
task A73: Combination drug testing for new TB regimens
Role: Principal Investigator
Funding: TEXAS A&M RES FOU
via NATL INST OF HLTH
Aug 2014
– Dec 2018
Rifampin and Lopinavir Study
Role: Principal Investigator
Funding: UNIV OF MIAMI
Mar 2014
– Jun 2018
Pharmacokinetics and Pharmacodynamics of Tuberculosis Drugs in Patients with Active Disease
Role: Principal Investigator
Funding: CRITICAL PATH INSTITUTE
via BILL & MELINDA GATES FOUNDATION
Feb 2014
– Feb 2017
Advanced Neuroimaging Evaluation of the Central Nervous System Biological Changes Associated with Efavirenz Therapy
Role: Principal Investigator
Funding: BRIGHAM AND WOMENS HOSPITAL
Feb 2014
– Jul 2017
Immune Activation and Drug Absorption in HIV-Infected Patients
Role: Principal Investigator
Funding: DREXEL UNIVERSITY
via JANSSEN SCIENTIFIC AFFAIRS
Aug 2013
– Jul 2018
Phase 2 Pharmacodynamic Study of High-dose Levofloxacin in MDR-TB Treatment
Role: Principal Investigator
Funding: BOSTON UNIV
via NATL INST OF HLTH NIAID
Jul 2013
– Jun 2016
Intracavitary Drug Levels in Patients with Drug Resistant Tuberculosis
Role: Principal Investigator
Funding: EMORY UNIV
via NATL INST OF HLTH
Jun 2009
– Nov 2021
Moxifloxain PK in Bile.
Role: Principal Investigator
Funding: MULTIPLE SPONSORS
Education
Pharm.D.
1986
·
Philadelphia College of Pharmacy and Science
B.S.
1981
·
University of Connecticut
Contact Details
Phones:
- Business:
- (352) 273-6266
Emails:
- Business:
- peloquin@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100486
GAINESVILLE FL 32610 - Business Street:
-
1600 SW ARCHER RD RM P4 33
GAINESVILLE FL 32610