Satyamaheshwar Peddibhotla

Satyamaheshwar Peddibhotla, Ph.D.

Research Assistant Professor

Department: Pharmacodynamics
Business Phone: (352) 294-8940
Business Email: speddibhotla@cop.ufl.edu

Research Profile

Areas of Interest
  • Chemical biology
  • Medicinal chemistry
  • Small molecule drug discovery

Publications

2020
Discovery of small molecule antagonists of chemokine receptor CXCR6 that arrest tumor growth in SK-HEP-1 mouse xenografts as a model of hepatocellular carcinoma.
Bioorganic & medicinal chemistry letters. 30(4) [DOI] 10.1016/j.bmcl.2019.126899. [PMID] 31882297.
2020
β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.
Cell. 181(6):1364-1379.e14 [DOI] 10.1016/j.cell.2020.04.053. [PMID] 32470395.
2019
Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.
Journal of medicinal chemistry. 62(17):8357-8363 [DOI] 10.1021/acs.jmedchem.9b00340. [PMID] 31390201.
2018
Repurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularization.
PloS one. 13(9) [DOI] 10.1371/journal.pone.0202436. [PMID] 30208056.
2016
ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse.
ACS chemical biology. 11(7):1880-90 [DOI] 10.1021/acschembio.6b00291. [PMID] 27119457.
2016
MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling.
The Journal of clinical investigation. 126(9):3567-79 [DOI] 10.1172/JCI87382. [PMID] 27500491.
2015
Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes.
ACS chemical biology. 10(8):1871-9 [DOI] 10.1021/acschembio.5b00304. [PMID] 25946346.
2014
Imidazole-derived agonists for the neurotensin 1 receptor.
Bioorganic & medicinal chemistry letters. 24(1):262-7 [DOI] 10.1016/j.bmcl.2013.11.026. [PMID] 24332089.
2013
Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.
ACS medicinal chemistry letters. 4(9):846-851 [PMID] 24611085.
View on: PubMed
2013
Synthesis and physicochemical characterization of novel phenotypic probes targeting the nuclear factor-kappa B signaling pathway.
Beilstein journal of organic chemistry. 9:900-7 [DOI] 10.3762/bjoc.9.103. [PMID] 23766805.
2012
Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro.
Journal of medicinal chemistry. 55(16):7262-72 [DOI] 10.1021/jm300833h. [PMID] 22813531.
2011
Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation.
ACS medicinal chemistry letters. 2(10):780-785 [PMID] 22003428.
View on: PubMed
2010
Chemical biology strategy reveals pathway-selective inhibitor of NF-kappaB activation induced by protein kinase C.
ACS chemical biology. 5(3):287-99 [DOI] 10.1021/cb9003089. [PMID] 20141195.
2010
Inhibition of protein kinase C-driven nuclear factor-kappaB activation: synthesis, structure-activity relationship, and pharmacological profiling of pathway specific benzimidazole probe molecules.
Journal of medicinal chemistry. 53(12):4793-7 [DOI] 10.1021/jm1000248. [PMID] 20481485.
2010
Mild arming and derivatization of natural products via an In(OTf)3-catalyzed arene iodination.
Organic letters. 12(9):2104-7 [DOI] 10.1021/ol100587j. [PMID] 20387852.
2008
Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors.
The Journal of biological chemistry. 283(43):29461-72 [DOI] 10.1074/jbc.M804103200. [PMID] 18728010.
2007
Simultaneous arming and structure/activity studies of natural products employing O-H insertions: an expedient and versatile strategy for natural products-based chemical genetics.
Journal of the American Chemical Society. 129(40):12222-31 [PMID] 17880073.
View on: PubMed
2006
Sensitization of cancer cells to DNA damaging agents by imidazolines.
Journal of the American Chemical Society. 128(28):9137-43 [PMID] 16834387.
View on: PubMed
2004
Sensitization of tumor cells toward chemotherapy: enhancing the efficacy of camptothecin with imidazolines.
Chemistry & biology. 11(12):1689-99 [PMID] 15610853.
View on: PubMed
2004
Stereoselective synthesis of highly substituted Delta1-pyrrolines: exo-selective 1,3-dipolar cycloaddition reactions with azlactones.
Journal of the American Chemical Society. 126(40):12776-7 [PMID] 15469263.
View on: PubMed

Education

Ph.D.
2004 · Michigan State University

Contact Details

Phones:
Business:
(352) 294-8940
Emails: