Maddalena Parafati

Maddalena Parafati, Ph.D.

Research Assistant Professor

Department: Pharmacodynamics
Business Phone: (352) 294-8940
Business Email: mparafati@cop.ufl.edu

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-7627-2729

Areas of Interest
  • Biochemistry and Cell Biology
  • Disease Modeling
  • Phenotype-based drug discovery

Publications

2021
Apigenin and Luteolin Regulate Autophagy by Targeting NRH-Quinone Oxidoreductase 2 in Liver Cells
Antioxidant. 10(5) [DOI] 10.3390/antiox10050776.
2020
Pluripotent Stem Cell-Derived Hepatocytes Phenotypic Screening Reveals Small Molecules Targeting the CDK2/4-C/EBPα/DGAT2 Pathway Preventing ER-Stress Induced Lipid Accumulation
International Journal of Molecular Sciences. 21(24) [DOI] 10.3390/ijms21249557. [PMID] 33334026.
2019
Atherogenic Index Reduction and Weight Loss in Metabolic Syndrome Patients Treated with A Novel Pectin-Enriched Formulation of Bergamot Polyphenols
Nutrients. 11(6) [DOI] 10.3390/nu11061271. [PMID] 31167512.
2019
Oxidative Imbalance and Kidney Damage in Cafeteria Diet-Induced Rat Model of Metabolic Syndrome: Effect of Bergamot Polyphenolic Fraction.
Antioxidants (Basel, Switzerland). 8(3) [DOI] 10.3390/antiox8030066. [PMID] 30884780.
2018
A nonalcoholic fatty liver disease model in human induced pluripotent stem cell-derived hepatocytes, created by endoplasmic reticulum stress-induced steatosis.
Disease models & mechanisms. 11(9) [DOI] 10.1242/dmm.033530. [PMID] 30254132.
2018
Analysis of proautophagic activities of Citrus flavonoids in liver cells reveals the superiority of a natural polyphenol mixture over pure flavones.
The Journal of nutritional biochemistry. 58:119-130 [DOI] 10.1016/j.jnutbio.2018.04.005. [PMID] 29890411.
2018
Bergamot Polyphenols Boost Therapeutic Effects of the Diet on Non-Alcoholic Steatohepatitis (NASH) Induced by “Junk Food”: Evidence for Anti-Inflammatory Activity.
Nutrients. 10(11) [DOI] 10.3390/nu10111604. [PMID] 30388763.
2018
Dibutyryl cAMP- or Interleukin-6-induced astrocytic differentiation enhances mannose binding lectin (MBL)-associated serine protease (MASP)-1/3 expression in C6 glioma cells
Archives of Biochemistry and Biophysics. 653:39-49 [DOI] 10.1016/j.abb.2018.06.016.
2015
Bergamot polyphenol fraction prevents nonalcoholic fatty liver disease via stimulation of lipophagy in cafeteria diet-induced rat model of metabolic syndrome.
The Journal of nutritional biochemistry. 26(9):938-48 [DOI] 10.1016/j.jnutbio.2015.03.008. [PMID] 26025327.
2015
Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2/quinone oxidoreductase 2: Implications for neuroprotection.
Autophagy. 11(7):1063-80 [DOI] 10.1080/15548627.2015.1058683. [PMID] 26046590.
2013
The antidote effect of quinone oxidoreductase 2 inhibitor against paraquat-induced toxicity in vitro and in vivo.
British journal of pharmacology. 168(1):46-59 [DOI] 10.1111/j.1476-5381.2012.01870.x. [PMID] 22289031.
2009
Conformational and biochemical characterization of a biologically active rat recombinant Protease Nexin-1 expressed in E. coli.
Biochimica et biophysica acta. 1794(4):602-14 [DOI] 10.1016/j.bbapap.2008.12.006. [PMID] 19167525.
2009
Localization of tyrosine hydroxylase immunoreactive neurons in the forebrain of the guppyPoecilia reticulata
Journal of Fish Biology. 75(6):1194-1205 [DOI] 10.1111/j.1095-8649.2009.02339.x.

Contact Details

Phones:
Business:
(352) 294-8940
Emails: