William C Mobley

William C Mobley, Ph.D.

Clinical Associate Professor

Department: Pharmaceutics
Business Phone: (352) 273-6282
Business Email: mobley@cop.ufl.edu

About William C Mobley

Dr. Mobley is a Clinical Associate Professor in the Department of Pharmaceutics and teaches Drug Delivery and Dosage Forms, Problem Solving, Integrated Case Studies and Pharmaceutical Compounding. Prior to his faculty appointment with the UF College of Pharmacy, Mobley held academic appointments at Idaho State University College of Pharmacy and Nova Southeastern University College of Pharmacy. Prior to embarking on a career as an educator, he was a retail pharmacist, an experience for which he is grateful for enabling him to bring practical insight to basic science knowledge.

A core element of Mobley’s teaching philosophy is to motivate students to engage in effortful and meaningful learning. Learning must be effortful in the sense that it takes significant and sustained personal cognitive effort to develop the knowledge and skills required to become a competent pharmacist. Motivating students to engage in this relatively difficult process of pharmacy education can be accomplished by first striving to continuously show respect and concern for students during all interactions. This is critical in order to build a trust in his efforts to help them achieve their educational goals. Other ways he uses to motivate students are to stimulate curiosity and sustain their engagement by trying making the lectures and other learning activities interesting and relevant to real world practice, so that they are in full accordance with their ultimate goals of becoming a self-confident and competent pharmacist. Elements of these motivational principles, including emphasizing the relevance of what they are learning to real-world practice, are also important for meaningful learning, which is learning-with-understanding that is seen as a process where the student constructs meaning or understanding of new knowledge based on how it integrates with his or her existing knowledge. The better the integration, the deeper and more durable the acquired knowledge can become and be made retrievable from long term memory for acquiring further knowledge and for understanding and resolving patient problems.

Research Profile

· Application of instructional design principles to optimize student pharmacist learning.

· Application of critical thinking and reasoning skills to help develop student pharmacists’ problem-solving abilities.

Publications

2021
Minocycline Topical Foam: A New Drug for the Treatment of Acne.
The Annals of pharmacotherapy. 55(1):105-110 [DOI] 10.1177/1060028020939926. [PMID] 32618475.
2018
Trends in Readmission Rates, Hospital Charges, and Mortality for Patients With Chronic Obstructive Pulmonary Disease (COPD) in Florida From 2009 to 2014.
Clinical therapeutics. 40(4):613-626.e1 [DOI] 10.1016/j.clinthera.2018.03.006. [PMID] 29609879.
2016
Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration.
The Journal of clinical investigation. 126(5):1815-33 [DOI] 10.1172/JCI82409. [PMID] 27064279.
2014
Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits.
Human molecular genetics. 23(3):578-89 [DOI] 10.1093/hmg/ddt446. [PMID] 24041763.
2014
Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.
Biochemistry. 53(4):702-13 [DOI] 10.1021/bi401537v. [PMID] 24401146.
2013
Aging and intellectual disability: insights from mouse models of Down syndrome.
Developmental disabilities research reviews. 18(1):43-50 [DOI] 10.1002/ddrr.1127. [PMID] 23949828.
2013
Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies.
Chemistry (Weinheim an der Bergstrasse, Germany). 19(20):6398-408 [DOI] 10.1002/chem.201300198. [PMID] 23526661.
2013
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down’s syndrome.
Nature medicine. 19(4):473-80 [DOI] 10.1038/nm.3117. [PMID] 23524343.
2013
Rita Levi-Montalcini: the story of an uncommon intellect and spirit.
Neuroscience. 252:431-7 [PMID] 24288807.
View on: PubMed
2013
The challenge of connecting the dots in the B.R.A.I.N.
Neuron. 80(2):270-4 [DOI] 10.1016/j.neuron.2013.09.008. [PMID] 24139032.
2012
Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome.
Current opinion in neurobiology. 22(5):880-6 [DOI] 10.1016/j.conb.2012.05.002. [PMID] 22658745.
2012
Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(27):9217-27 [DOI] 10.1523/JNEUROSCI.1673-12.2012. [PMID] 22764230.
2012
Genetic analysis of Down syndrome facilitated by mouse chromosome engineering.
Bioengineered bugs. 3(1):8-12 [DOI] 10.4161/bbug.3.1.17696. [PMID] 22126738.
2012
Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome.
Neurobiology of disease. 45(2):683-91 [DOI] 10.1016/j.nbd.2011.10.009. [PMID] 22062771.
2012
Potential use of γ-secretase modulators in the treatment of Alzheimer disease.
Archives of neurology. 69(10):1255-8 [PMID] 22801784.
View on: PubMed
2011
Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer.
Neurobiology of disease. 43(2):397-413 [DOI] 10.1016/j.nbd.2011.04.011. [PMID] 21527343.
2011
Enantioselective synthesis of (-)-jiadifenin, a potent neurotrophic modulator.
Organic letters. 13(17):4554-7 [DOI] 10.1021/ol201742j. [PMID] 21812392.
2011
Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer’s disease.
Journal of neurochemistry. 117(4):613-22 [DOI] 10.1111/j.1471-4159.2011.07237.x. [PMID] 21388375.
2011
Mouse models for Down syndrome-associated developmental cognitive disabilities.
Developmental neuroscience. 33(5):404-13 [DOI] 10.1159/000329422. [PMID] 21865664.
2010
Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice.
Mammalian genome : official journal of the International Mammalian Genome Society. 21(5-6):258-67 [DOI] 10.1007/s00335-010-9262-x. [PMID] 20512340.
2010
Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice.
Brain research. 1366:162-71 [DOI] 10.1016/j.brainres.2010.09.107. [PMID] 20932954.
2010
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer’s disease.
Neuron. 67(5):769-80 [DOI] 10.1016/j.neuron.2010.08.018. [PMID] 20826309.
2009
Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation.
Neurobiology of disease. 34(1):71-7 [DOI] 10.1016/j.nbd.2008.12.016. [PMID] 19167498.
2009
Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome.
The Journal of comparative neurology. 512(4):453-66 [DOI] 10.1002/cne.21895. [PMID] 19034952.
2009
Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis.
Cell stem cell. 5(3):310-9 [DOI] 10.1016/j.stem.2009.05.022. [PMID] 19733542.
2009
Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome.
Science translational medicine. 1(7) [DOI] 10.1126/scitranslmed.3000258. [PMID] 20368182.
2009
The “Down syndrome critical region” is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(18):5938-48 [DOI] 10.1523/JNEUROSCI.1547-09.2009. [PMID] 19420260.
2009
The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome.
Genetics in medicine : official journal of the American College of Medical Genetics. 11(9):611-6 [DOI] 10.1097/GIM.0b013e3181b2e34c. [PMID] 19636252.
2009
The coming of age of axonal neurotrophin signaling endosomes.
Journal of proteomics. 72(1):46-55 [DOI] 10.1016/j.jprot.2008.10.007. [PMID] 19028611.
2009
Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks.
The Journal of comparative neurology. 514(3):240-58 [DOI] 10.1002/cne.22009. [PMID] 19296534.
2008
Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome.
The Journal of comparative neurology. 508(1):184-95 [DOI] 10.1002/cne.21673. [PMID] 18306326.
2008
Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(36):9002-12 [DOI] 10.1523/JNEUROSCI.0767-08.2008. [PMID] 18768694.
2008
Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides.
Traffic (Copenhagen, Denmark). 9(2):215-29 [PMID] 18034774.
View on: PubMed
2008
Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment.
Critical reviews in toxicology. 38 Suppl 2:1-125 [DOI] 10.1080/10408440802272158 . [PMID] 18726789.
2008
Sleep and EEG features in genetic models of Down syndrome.
Neurobiology of disease. 30(1):1-7 [DOI] 10.1016/j.nbd.2007.07.014. [PMID] 18282758.
2007
A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathway.
Traffic (Copenhagen, Denmark). 8(11):1503-20 [PMID] 17822405.
View on: PubMed
2007
One at a time, live tracking of NGF axonal transport using quantum dots.
Proceedings of the National Academy of Sciences of the United States of America. 104(34):13666-71 [PMID] 17698956.
View on: PubMed
2007
Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport.
Proceedings of the National Academy of Sciences of the United States of America. 104(7):2223-8 [PMID] 17287360.
View on: PubMed
2007
Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships.
The Journal of comparative neurology. 504(4):329-45 [PMID] 17663443.
View on: PubMed
2007
Using mouse models to explore genotype-phenotype relationship in Down syndrome.
Mental retardation and developmental disabilities research reviews. 13(3):207-14 [PMID] 17910089.
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2006
Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport.
Human molecular genetics. 15(9):1451-63 [PMID] 16565160.
View on: PubMed
2006
Increased App expression in a mouse model of Down’s syndrome disrupts NGF transport and causes cholinergic neuron degeneration.
Neuron. 51(1):29-42 [PMID] 16815330.
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2006
Intrathecal administration of AAV vectors for the treatment of lysosomal storage in the brains of MPS I mice.
Gene therapy. 13(11):917-25 [PMID] 16482204.
View on: PubMed
2005
Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12.
Mammalian genome : official journal of the International Mammalian Genome Society. 16(2):79-90 [PMID] 15859352.
View on: PubMed
2005
Long-distance retrograde neurotrophic signaling.
Current opinion in neurobiology. 15(1):40-8 [PMID] 15721743.
View on: PubMed
2005
Penetration, diffusion, and uptake of recombinant human alpha-L-iduronidase after intraventricular injection into the rat brain.
Molecular genetics and metabolism. 86(1-2):141-9 [PMID] 16006167.
View on: PubMed
2005
Report on the ‘Expert Workshop on the Biology of Chromosome 21: towards gene-phenotype correlations in Down syndrome’, held June 11-14, 2004, Washington D.C.
Cytogenetic and genome research. 108(4):269-77 [PMID] 15627744.
View on: PubMed
2004
An AUPN/ANA survey of department leader opinions on the health of US academic neurology.
Neurology. 63(8):1354-6 [PMID] 15505148.
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2004
Going the distance, or not, with neurotrophin signals.
Cell. 118(2):141-3 [PMID] 15260984.
View on: PubMed
2004
Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(37):8153-60 [PMID] 15371516.
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2004
Intrathecal enzyme replacement therapy reduces lysosomal storage in the brain and meninges of the canine model of MPS I.
Molecular genetics and metabolism. 83(1-2):163-74 [PMID] 15464431.
View on: PubMed
2004
Late onset neurodegeneration in the Cln3-/- mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation.
Brain research. 1023(2):231-42 [PMID] 15374749.
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2004
Signaling endosome hypothesis: A cellular mechanism for long distance communication.
Journal of neurobiology. 58(2):207-16 [PMID] 14704953.
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2004
Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome.
The Journal of comparative neurology. 480(3):281-98 [PMID] 15515178.
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2004
Trafficking the NGF signal: implications for normal and degenerating neurons.
Progress in brain research. 146:3-23 [PMID] 14699953.
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2003
BPAG1n4 is essential for retrograde axonal transport in sensory neurons.
The Journal of cell biology. 163(2):223-9 [PMID] 14581450.
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2003
NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals.
Neuron. 39(1):69-84 [PMID] 12848933.
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2003
Traffic at the intersection of neurotrophic factor signaling and neurodegeneration.
Trends in neurosciences. 26(2):73-80 [PMID] 12536130.
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2002
Ethics and the practice of brain science.
Cerebrum : the Dana forum on brain science. 4(3):64-6 [PMID] 16619416.
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2001
Failed retrograde transport of NGF in a mouse model of Down’s syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion.
Proceedings of the National Academy of Sciences of the United States of America. 98(18):10439-44 [PMID] 11504920.
View on: PubMed
2001
Nerve growth factor activates persistent Rap1 signaling in endosomes.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 21(15):5406-16 [PMID] 11466412.
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2001
Nerve growth factor signaling, neuroprotection, and neural repair.
Annual review of neuroscience. 24:1217-81 [PMID] 11520933.
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2001
Neurotrophic factors as potential therapeutic agents in neuronal ceroid lipofuscinosis.
Advances in genetics. 45:169-82 [PMID] 11332772.
View on: PubMed
2001
NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway.
Neuron. 32(5):801-14 [PMID] 11738027.
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2001
The extracellular domain of p75NTR is necessary to inhibit neurotrophin-3 signaling through TrkA.
The Journal of biological chemistry. 276(14):11294-301 [PMID] 11150291.
View on: PubMed
2000
Comprehensive theory of Alzheimer’s disease. The effects of cholesterol on membrane receptor trafficking.
Annals of the New York Academy of Sciences. 924:104-11 [PMID] 11193786.
View on: PubMed
2000
Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system.
The Journal of experimental medicine. 191(10):1799-806 [PMID] 10811872.
View on: PubMed
2000
NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 20(19):7325-33 [PMID] 11007890.
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1999
Apparent loss and hypertrophy of interneurons in a mouse model of neuronal ceroid lipofuscinosis: evidence for partial response to insulin-like growth factor-1 treatment.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 19(7):2556-67 [PMID] 10087069.
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1999
Early BDNF, NT-3, and NT-4 signaling events.
Experimental neurology. 159(1):297-308 [PMID] 10486198.
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1999
EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake.
Cell. 96(5):677-87 [PMID] 10089883.
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1999
Nerve growth factor signaling in caveolae-like domains at the plasma membrane.
The Journal of biological chemistry. 274(51):36707-14 [PMID] 10593976.
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1999
Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten Mouse Model Consortium [corrected].
Neurobiology of disease. 6(5):321-34 [PMID] 10527801.
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1998
Changes in the localization of brain prion proteins during scrapie infection.
Neurology. 50(1):1271-80; discussion 2 [PMID] 9443448.
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1998
Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors.
Biochemistry. 37(48):16846-52 [PMID] 9836577.
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1998
Doxycycline control of prion protein transgene expression modulates prion disease in mice.
Proceedings of the National Academy of Sciences of the United States of America. 95(21):12580-5 [PMID] 9770528.
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1998
Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury.
Experimental neurology. 151(2):314-25 [PMID] 9628766.
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1998
The effect of jet-milling on lyophilized liposomes.
Pharmaceutical research. 15(1):149-52 [PMID] 9487563.
View on: PubMed
1998
Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities.
Proceedings of the National Academy of Sciences of the United States of America. 95(11):6256-61 [PMID] 9600952.
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1997
A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis.
Journal of virology. 71(11):8821-31 [PMID] 9343242.
View on: PubMed
1997
A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA.
Proceedings of the National Academy of Sciences of the United States of America. 94(18):9909-14 [PMID] 9275225.
View on: PubMed
1997
Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 17(20):7594-605 [PMID] 9315882.
View on: PubMed
1996
A comprehensive study of the spatiotemporal pattern of beta-amyloid precursor protein mRNA and protein in the rat brain: lack of modulation by exogenously applied nerve growth factor.
Brain research. Molecular brain research. 39(1-2):185-97 [PMID] 8804727.
View on: PubMed
1996
A signaling endosome hypothesis to explain NGF actions: potential implications for neurodegeneration.
Cold Spring Harbor symposia on quantitative biology. 61:389-406 [PMID] 9246468.
View on: PubMed
1996
Abnormal plasma membrane properties and functions in prion-infected cell lines.
Cold Spring Harbor symposia on quantitative biology. 61:531-40 [PMID] 9246479.
View on: PubMed
1996
Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome.
Proceedings of the National Academy of Sciences of the United States of America. 93(23):13333-8 [PMID] 8917591.
View on: PubMed
1996
Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 16(24):7950-64 [PMID] 8987823.
View on: PubMed
1996
Expression of neuronal-NOS in developing basal forebrain cholinergic neurons: regulation by NGF.
Neurochemical research. 21(7):861-8 [PMID] 8873091.
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1996
Minimized hormones grow in stature.
Nature biotechnology. 14(9) [PMID] 9631056.
View on: PubMed
1996
Nerve growth factor and the neurotrophic factor hypothesis.
Brain & development. 18(5):362-8 [PMID] 8891230.
View on: PubMed
1996
Recent progress in developmental neurology: exploring the bench to bedside interface.
Current opinion in neurology. 9(2):107-112 [PMID] 8782977.
View on: PubMed
1996
Therapeutic potential of neurotrophic factors for neurological disorders.
Annals of neurology. 40(3):346-54 [PMID] 8797524.
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1995
Multiple levels for regulation of TrkA in PC12 cells by nerve growth factor.
Journal of neurochemistry. 65(3):1146-56 [PMID] 7543930.
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1995
Preliminary characterization of the central nervous system in partial trisomy 16 mice.
Progress in clinical and biological research. 393:227-40 [PMID] 8545453.
View on: PubMed
1995
Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 15(4):2888-905 [PMID] 7536822.
View on: PubMed
1995
Therapeutic applications of neurotrophic factors in disorders of motor neurons and peripheral nerves.
Molecular medicine today. 1(6):278-86 [PMID] 9415162.
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1995
TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 15(2):1567-76 [PMID] 7869118.
View on: PubMed
1994
A reverse transcription-polymerase chain reaction study of p75 nerve growth factor receptor gene expression in developing rat cerebellum.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 12(4):255-62 [PMID] 7976482.
View on: PubMed
1994
Expression of TrkA confers neuron-like responsiveness to nerve growth factor on an immortalized hypothalamic cell line.
Proceedings of the National Academy of Sciences of the United States of America. 91(9):3824-8 [PMID] 8170995.
View on: PubMed
1994
Isolation and characterization of a nerve growth factor-regulated Fos kinase from PC12 cells.
The Journal of biological chemistry. 269(1):308-18 [PMID] 8276812.
View on: PubMed
1994
Loss of developing cholinergic basal forebrain neurons following excitotoxic lesions of the hippocampus: rescue by neurotrophins.
Experimental neurology. 130(2):178-95 [PMID] 7867749.
View on: PubMed
1994
Neurotrophic factors and neurologic disease.
The Western journal of medicine. 161(3):246-54 [PMID] 7975562.
View on: PubMed
1994
NOS induction by NGF in basal forebrain cholinergic neurones: evidence for regulation of brain NOS by a neurotrophin.
Neurobiology of disease. 1(1-2):51-60 [PMID] 9216986.
View on: PubMed
1994
Transgenic mouse brain histopathology resembles early Alzheimer’s disease.
Annals of neurology. 35(5):598-607 [PMID] 7513982.
View on: PubMed
1993
Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration.
Neurology. 43(12):2668-73 [PMID] 8255474.
View on: PubMed
1992
Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome.
The EMBO journal. 11(2):619-27 [PMID] 1371464.
View on: PubMed
1992
Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants.
Proceedings of the National Academy of Sciences of the United States of America. 89(4):1383-7 [PMID] 1741393.
View on: PubMed
1992
Neurodegeneration and gene dysregulation: studies utilizing the mouse trisomy 16 model of Down syndrome.
Progress in clinical and biological research. 379:227-44 [PMID] 1409747.
View on: PubMed
1992
p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF.
Neuron. 9(3):465-78 [PMID] 1524827.
View on: PubMed
1991
A novel group of nerve growth factor receptor-immunoreactive neurons in the ventral horn of the lumbar spinal cord.
Brain research. 541(1):121-8 [PMID] 1851446.
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1991
beta-NGF-endopeptidase: structure and activity of a kallikrein encoded by the gene mGK-22.
Biochemistry. 30(14):3443-50 [PMID] 2012805.
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1991
Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates.
Annals of neurology. 30(6):831-40 [PMID] 1789695.
View on: PubMed
1991
Hyperalgesia induced in the rat by the amino-terminal octapeptide of nerve growth factor.
Proceedings of the National Academy of Sciences of the United States of America. 88(12):5144-8 [PMID] 1647026.
View on: PubMed
1991
Modeling cholinergic abnormalities in Down syndrome and Alzheimer’s disease.
Progress in clinical and biological research. 373:189-202 [PMID] 1838184.
View on: PubMed
1991
Molecular studies in Alzheimer’s disease.
Trends in biochemical sciences. 16(4):140-4 [PMID] 1877089.
View on: PubMed
1991
Recombinant human nerve growth factor prevents retrograde degeneration of axotomized basal forebrain cholinergic neurons in the rat.
Experimental neurology. 112(2):161-73 [PMID] 2037030.
View on: PubMed
1991
Regulation of axonal caliber, neurofilament content, and nuclear localization in mature sensory neurons by nerve growth factor.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 11(4):943-55 [PMID] 2010817.
View on: PubMed
1990
In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 10(6):1788-98 [PMID] 2162385.
View on: PubMed
1990
Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 10(12):3801-13 [PMID] 2269884.
View on: PubMed
1990
Nerve growth factor induces gene expression of the prion protein and beta-amyloid protein precursor in the developing hamster central nervous system.
Progress in brain research. 86:227-38 [PMID] 1982367.
View on: PubMed
1990
The in vitro biological effect of nerve growth factor is inhibited by synthetic peptides.
Cell regulation. 1(2):189-95 [PMID] 2100197.
View on: PubMed
1990
The protease inhibitory properties of the Alzheimer’s beta-amyloid precursor protein.
The Journal of biological chemistry. 265(16):8983-5 [PMID] 2111813.
View on: PubMed
1990
Trophic actions of recombinant human nerve growth factor on cultured rat embryonic CNS cells.
Experimental neurology. 110(3):274-83 [PMID] 2249737.
View on: PubMed
1989
Acceleration of scrapie in neonatal Syrian hamsters.
Neurology. 39(10):1319-24 [PMID] 2507957.
View on: PubMed
1989
Developmental regulation of nerve growth factor and its receptor in the rat caudate-putamen.
Neuron. 3(5):655-64 [PMID] 2561975.
View on: PubMed
1989
Induction of the c-fos gene product in rat forebrain following cortical lesions and NGF injections.
Neuroscience letters. 100(1-3):117-22 [PMID] 2503789.
View on: PubMed
1989
Intraventricular NGF infusion in the mature rat brain enhances sympathetic innervation of cerebrovascular targets but fails to elicit sympathetic ingrowth.
Brain research. 492(1-2):245-54 [PMID] 2752299.
View on: PubMed
1989
Nerve growth factor in Alzheimer’s disease: to treat or not to treat?
Neurobiology of aging. 10(5):578-80; discussion 588 [PMID] 2812231.
View on: PubMed
1989
Potential use of nerve growth factor to treat Alzheimer’s disease.
Neurobiology of aging. 10(2):205-7 [PMID] 2657468.
View on: PubMed
1989
PrPSc in scrapie-infected hamster brain is spatially and temporally related to histopathology and infectivity titer.
Progress in clinical and biological research. 317:601-18 [PMID] 2574872.
View on: PubMed
1989
The effects of nerve growth factor on the development of septal cholinergic neurons in reaggregate cell cultures.
Neuroscience. 29(1):209-23 [PMID] 2710345.
View on: PubMed
1988
Infertility, chemical exposure, and farming in Iowa: absence of an association.
Urology. 31(1):46-50 [PMID] 3336927.
View on: PubMed
1988
Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain.
Proceedings of the National Academy of Sciences of the United States of America. 85(24):9811-5 [PMID] 2904679.
View on: PubMed
1988
Neurological dysfunction after intrathecal injection of dynorphin A (1-13) in the rat. I. Injection procedures modify pharmacological responses.
The Journal of pharmacology and experimental therapeutics. 246(3):1158-66 [PMID] 2901486.
View on: PubMed
1988
Neurological dysfunction after intrathecal injection of dynorphin A (1-13) in the rat. II. Nonopioid mechanisms mediate loss of motor, sensory and autonomic function.
The Journal of pharmacology and experimental therapeutics. 246(3):1167-74 [PMID] 2901487.
View on: PubMed
1988
Processing and secretion of nerve growth factor: expression in mammalian cells with a vaccinia virus vector.
Molecular and cellular biology. 8(6):2456-64 [PMID] 3405211.
View on: PubMed
1987
Changes in the localization of brain prion proteins during scrapie infection.
Neurology. 37(8):1271-80 [PMID] 3112607.
View on: PubMed
1987
NGF effects on developing forebrain cholinergic neurons are regionally specific.
Neurochemical research. 12(11):985-94 [PMID] 3683745.
View on: PubMed
1986
Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons.
Brain research. 387(1):53-62 [PMID] 3742234.
View on: PubMed
1986
Use of intravesical cisplatin and mitomycin-C for recurrent transitional cell carcinoma of bladder refractory to thiotepa.
Urology. 27(4):335-9 [PMID] 3083555.
View on: PubMed
1985
Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates.
Neuroscience. 16(3):691-9 [PMID] 2869445.
View on: PubMed
1985
Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor.
Science (New York, N.Y.). 229(4710):284-7 [PMID] 2861660.
View on: PubMed
1984
Combination perineal cryosurgery and external radiation therapy for adenocarcinoma of prostate.
Urology. 24(1):11-4 [PMID] 6539996.
View on: PubMed
1984
Evidence for cholinergic neurites in senile plaques.
Science (New York, N.Y.). 226(4681):1443-5 [PMID] 6505701.
View on: PubMed
1982
Scientific overview of inflammatory demyelinating polyneuropathy and design of the North American collaborative study of plasma exchange in Guillain-Barre syndrome.
Progress in clinical and biological research. 106:159-87 [PMID] 6757937.
View on: PubMed
1980
Guillain-Barré syndrome: is there a role for plasmapheresis?
Neurology. 30(10) [PMID] 7191502.
View on: PubMed
1978
Localization of 2′,3′-cyclic nucleotide-3′-phosphohydrolase of rabbit brain by sedimentation in a continuous sucrose gradient.
Journal of neurochemistry. 30(4):735-44 [PMID] 206668.
View on: PubMed
1977
Nerve growth factor (first of three parts).
The New England journal of medicine. 297(20):1096-104 [PMID] 333290.
View on: PubMed
1977
Nerve growth factor (second of three parts).
The New England journal of medicine. 297(21):1149-58 [PMID] 72356.
View on: PubMed
1977
Nerve growth factor (third of three parts).
The New England journal of medicine. 297(22):1211-8 [PMID] 411033.
View on: PubMed
1976
Characterization and isolation of proteolytically modified nerve growth factor.
Biochemistry. 15(25):5543-52 [PMID] 999827.
View on: PubMed
1975
Short- and long-term effects of nerve growth factor on the sympathetic nervous system in the adult mouse.
Brain research. 94(2):263-77 [PMID] 1148872.
View on: PubMed
1974
Effects of localized intracerebral injections of nerve growth factor on the regenerative growth of lesioned central noradrenergic neurones.
Brain research. 69(2):217-34 [PMID] 4406332.
View on: PubMed
1974
Proteolytic modification of the beta nerve growth factor protein.
Biochemistry. 13(4):833-40 [PMID] 4811070.
View on: PubMed
1973
A stimulatory effect by nerve growth factor on the regrowth of adrenergic nerve fibres in the mouse peripheral tissues after chemical sympathectomy with 6-hydroxydopamine.
Zeitschrift fur Zellforschung und mikroskopische Anatomie (Vienna, Austria : 1948). 146(1):15-43 [PMID] 4777497.
View on: PubMed

Education

Ph.D.
1994 · University of Florida
B.S.
1985 · University of Florida
B.S.
1980 · University of Miami

Teaching Profile

Courses Taught
2016-2021
PHA5177C Adv Nonsterile Cpding
2017-2018,2020-2021
PHA5788C Patient Care 6
2015-2021
PHA5176 Drug Delivery Systems
2018,2020-2021
PHA5165L Prof Skills Lab V
2016-2021
PHA6935 Selected Topics in Pharmacy
2015-2016,2018-2021
PHA5104 Sterile Compounding
2018-2019,2021
PHA5732 Year 1 Enhancement
2018-2019
PHA5733 Year 2 Enhancement
2015,2018
PHA5161L Pract Skills Lab I
2014-2015,2018-2021,2021
PHA5781 Patient Care I
2006,2008-2010,2010-2014,2012-2018,2014-2018,2018
PHA6116 In Vivo and In Vitro Stability of Drugs
2014,2017
PHA5933 Select Top Pharmacy
2006-2017
PHA5109L Pharmaceu Skls Lab 2
2015
PHA5700C Personal and Prof Dev I
2015
PHA5007 Pharm and Pop Health
2006-2015
PHA5100 Dosage Forms 1
2006-2015
PHA5101 Dosage Forms 2
2006-2009,2011-2014
PHA5943C Intr Pha Prac Exp 3
2006-2009,2011-2014
PHA5941C Intr Pha Prac Exp 1
2007,2009-2012,2012-2014
PHA5944C Intr Pha Prac Exp 4
2007,2009-2013,2013-2014
PHA5942C Intr Pha Prac Exp 2
2008-2009
PHA5108L Pharmaceu Skls Lab 1
2021
PHA5787 Pharmacotherapy 5
2021
PHA5162L Prac Skills Lab II
2021
PHA5787C Pt Care 5: Endo

Contact Details

Phones:
Business:
(352) 273-6282
Emails:
Business:
mobley@cop.ufl.edu