Lance McMahon, Jr

Lance McMahon, Jr Ph.D., M.S.

Chair and Professor

Department: Pharmacodynamics
Business Phone: (352) 294-8878
Business Email: lance.mcmahon@cop.ufl.edu

Research Profile

Research in my laboratory integrates principles of behavior and receptor theory to identify central nervous system mechanisms responsible for drug dependence. We also investigate novel pharmacological strategies that maximize therapeutic potential and minimize abuse and dependence liability. We combine behavioral and physiological approaches, receptor-selective ligands, and quantitative analyses of drug interactions. We are interested in several pharmacological classes of abused drugs.

Cannabinoids, for example, include cannabis-derived tetrahydrocannabinols, numerous synthetic cannabinoids, and endogenous cannabinoid neurotransmitters. We systematically compare the effects of cannabinoids and evaluate underlying receptor mechanisms to better understand dependence and therapeutic potential.

Cholinergic drugs of interest include FDA-approved smoking cessation aids such as nicotine, varenicline, and bupropion. We compare the effects of smoking cessation aids and investigational nicotinic acetylcholine receptor drugs to better understand relationships between nicotinic acetylcholine receptor subtypes, intrinsic activity (i.e., efficacy), and behavioral effects. Most recently, we are joining investigators in the Departments of Medicinal Chemistry (McCurdy), Pharmaceutics (Avery), and Pharmacodynamics (McLaughlin, Peris) to evaluate the in vitro and in vivo pharmacology of kratom and its derivatives which have proven therapeutic utility in the reduction of opioid dependence.

Grants

June 2019ACTIVE
Opioid and cannabinoid interactions in pain and reward
UF OFFICE OF RESEARCH ·
April 2019ACTIVE
Kratom alkaloids: in vitro and in vivo pharmacological mechanisms
NATL INST OF HLTH NIDA · Principal Investigator
December 2018ACTIVE
Opioid use disorders: UF Pharmacy medications discovery and development
NATL INST OF HLTH NIDA · Principal Investigator
October 2017 – June 2019
Nicotine dependence: neuropharmacology in monkeys
NATL INST OF HLTH NIDA · Principal Investigator

Education

1997
Ph.D.
Texas A&M University
1994
M.S.
Texas A&M University
1992
B.A.
Texas A&M University