Wei-Hsuan " Lo-Ciganic

Wei-Hsuan " Lo-Ciganic, Ph.D., M.S., M.S.Pharm.

Associate Professor

Department: Pharmaceutical Outcomes & Policy
Business Phone: (352) 273-6255
Business Email: wlociganic@cop.ufl.edu

About Wei-Hsuan " Lo-Ciganic

Wei-Hsuan “Jenny” Lo-Ciganic, M.S.Pharm, M.S., Ph.D. is an associate professor in the University of Florida College of Pharmacy, Department of Pharmaceutical Outcomes and Policy and Center for Drug Evaluation and Safety. As a pharmacist and pharmacoepidemiologist and pharmaceutical health services researcher, she applies well-thought-out pharmacoepidemiological approaches to address relevant issues in clinical practice, to make appropriate recommendations to health care professionals, and to enhance drug safety. Her research focuses on improving drug safety, medication adherence, pain management, quality of prescribing, and treatment for substance use disorders, especially among vulnerable populations (e.g., Medicaid beneficiaries). Dr. Lo-Ciganic has extensive experience applying advanced predictive analytics including machine learning and group-based trajectory modeling with large healthcare datasets.

Lo-Ciganic was recipient of the 2020 University of Florida Excellence Awards for Assistant Professors and the 2020 University of Florida College of Pharmacy Outstanding Clinical Science Publication Award. She has served as Principal Investigator (PI) and Co-Investigator (Co-I) on multiple federally and organization funded grants. For example, she is the PI of an R21 grant, entitled “Developing a Real-Time Trajectory Tool to Identify Potentially Unsafe Concurrent Opioid and Benzodiazepine Use among Older Adults” funded by the National Institute on Aging. She is Consortium-PI on an R01 entitled “Using machine Learning to Predict Problematic Opioid Use”, which was funded by the National Institute of Drug Abuse (NIDA). Recently, she became the PI for the R01 study entitled “Developing and Evaluating a Machine-Learning Opioid Prediction & Risk-Stratification E-Platform (DEMONSTRATE)” funded by NIDA. Since 2015, she has been a member and co-chair of the Pharmacy Quality Alliance’s (PQA) workgroups and Quality Metrics Expert Panel to develop and improve quality measures of prescription medications.

Accomplishments

2020 Outstanding Reviewer
2021 · Annals of Internal Medicine
2020 University of Florida College of Pharmacy Outstanding Clinical Science Publication Award
2020 · University of Florida
2020 University of Florida Excellence Awards for Assistant Professor
2020 · University of Florida
2018 Best Reviewer
2019 · Pharmacoepidemiology and Drug Safety
2018 Outstanding Reviewer
2019 · Annals of Internal Medicine
2016 Outstanding Reviewer
2017 · Annals of Internal Medicine
2017 Best Podium Presentation Award
2017 · 2017 International Society of Pharmacoeconomics and Outcomes Research (ISPOR) 22nd Annual Meeting
Grant Mentoring and Career Development Program Awardee
2017 · U.S. Bone and Joint Initiative/Bone and Joint Canada Young Investigators Initiative (YII)

Research Profile

Pharmacoepidemiology, pharmaceutical health service research, patient safety, quality of prescribing and care, program and policy evaluation, medication adherence, prescription drug abuse and substance use disorders and advanced analytics including trajectory analysis, machine learning and spatial pattern mining

Open Researcher and Contributor ID (ORCID)

0000-0001-6590-4770

Publications

2021
Association Between Dual Trajectories of Opioid and Gabapentinoid Use and Healthcare Expenditures Among US Medicare Beneficiaries
Value in Health. 24(2):196-205 [DOI] 10.1016/j.jval.2020.12.001. [PMID] 33518026.
2021
Association of low-income subsidy, medicaid dual eligibility, and disability status with high-risk medication use among Medicare Part D beneficiaries
Research in Social & Administrative Pharmacy. [DOI] 10.1016/j.sapharm.2021.05.005. [PMID] 34006485.
2021
Changes in Schedule II oral opioid volume dispensed in a private health plan following Florida’s Acute Pain Opioid Restriction Law
Journal Of Managed Care & Specialty Pharmacy. 27(6):779-784 [DOI] 10.18553/jmcp.2021.27.6.779. [PMID] 34057389.
2021
Industry Payments to Physicians and Prescribing Branded Memantine and Donepezil Combination
Neurology-Clinical Practice. 11(3):181-187 [DOI] 10.1212/CPJ.0000000000000870. [PMID] 34484885.
2021
Integrating human services and criminal justice data with claims data to predict risk of opioid overdose among Medicaid beneficiaries: A machine-learning approach
PLoS One. 16(3) [DOI] 10.1371/journal.pone.0248360. [PMID] 33735222.
2021
Predicting Mortality Risk After a Hospital or Emergency Department Visit for Nonfatal Opioid Overdose.
Journal of general internal medicine. 36(4):908-915 [DOI] 10.1007/s11606-020-06405-w. [PMID] 33481168.
2021
The Impact of Direct-Acting Antiviral Therapy on End-Stage Liver Disease Among Individuals with Chronic Hepatitis C and Substance Use Disorders.
Hepatology (Baltimore, Md.). 74(2):566-581 [DOI] 10.1002/hep.31732. [PMID] 33544904.
2020

Extent and Factors Associated with Adherence to Antidepressant Treatment During Acute and Continuation Phase Depression Treatment Among Older Adults with Dementia and Major Depressive Disorder

Neuropsychiatric Disease and Treatment. Volume 16:1433-1450 [DOI] 10.2147/ndt.s241749.
2020
Aromatase Inhibitors and Risk of Arthritis and Carpal Tunnel Syndrome among Taiwanese Women with Breast Cancer: A Nationwide Claims Data Analysis.
Journal of clinical medicine. 9(2) [DOI] 10.3390/jcm9020566. [PMID] 32092973.
2020
Association between race/ethnicity and the risk of amputation of lower extremities among medicare beneficiaries with diabetic foot ulcers and diabetic foot infections.
BMJ open diabetes research & care. 8(1) [DOI] 10.1136/bmjdrc-2020-001328. [PMID] 32843499.
2020
Associations Between the Specialty of Opioid Prescribers and Opioid Addiction, Misuse, and Overdose Outcomes.
Pain medicine (Malden, Mass.). 21(9):1871-1890 [DOI] 10.1093/pm/pnz234. [PMID] 31626295.
2020
Comparative effectiveness and safety of apixaban versus warfarin in patients with venous thromboembolism.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 77(3):188-195 [DOI] 10.1093/ajhp/zxz307. [PMID] 31974557.
2020
Dual‐trajectories of opioid and gabapentinoid use and risk of subsequent drug overdose among Medicare beneficiaries in the United States: a retrospective cohort study
Addiction. [DOI] 10.1111/add.15189. [PMID] 32648951.
2020
Extent and Factors Associated with Adherence to Antidepressant Treatment During Acute and Continuation Phase Depression Treatment Among Older Adults with Dementia and Major Depressive Disorder.
Neuropsychiatric disease and treatment. 16:1433-1450 [DOI] 10.2147/NDT.S241749. [PMID] 32606697.
2020
Geographic Variation in the Prevalence of High-Risk Medication Use Among Medicare Part D Beneficiaries by Hospital Referral Region.
Journal of managed care & specialty pharmacy. 26(10):1309-1316 [DOI] 10.18553/jmcp.2020.26.10.1309. [PMID] 32996396.
2020
Health Outcomes Associated with Adherence to Antidepressant Use during Acute and Continuation Phases of Depression Treatment among Older Adults with Dementia and Major Depressive Disorder.
Journal of clinical medicine. 9(10) [DOI] 10.3390/jcm9103358. [PMID] 33092169.
2020
Immune Checkpoint Inhibitors and Immune-Related Adverse Events in Patients With Advanced Melanoma: A Systematic Review and Network Meta-analysis.
JAMA network open. 3(3) [DOI] 10.1001/jamanetworkopen.2020.1611. [PMID] 32211869.
2020
Lack of evidence that beta blocker use reduces knee pain, areas of joint pain, or analgesic use among individuals with symptomatic knee osteoarthritis.
Osteoarthritis and cartilage. 28(1):53-61 [DOI] 10.1016/j.joca.2019.08.008. [PMID] 31526877.
2020
Listed below are the 20 most recent articles to view the complete list click here
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2020
Occupational Patterns of Opioid-Related Overdose Deaths Among Arizona Medicaid Enrollees, 2008-2017.
Journal of general internal medicine. 35(7):2210-2213 [DOI] 10.1007/s11606-020-05684-7. [PMID] 32043261.
2020
Prevalence of substance use disorder and psychiatric comorbidity burden among pregnant women with opioid use disorder in a large administrative database, 2009-2014.
Journal of psychosomatic obstetrics and gynaecology. 1-7 [DOI] 10.1080/0167482X.2020.1727882. [PMID] 32067526.
2020
Trajectories of Short Physical Performance Battery Are Strongly Associated with Future Major Mobility Disability: Results from the LIFE Study.
Journal of clinical medicine. 9(8) [DOI] 10.3390/jcm9082332. [PMID] 32707877.
2020
Using machine learning to predict risk of incident opioid use disorder among fee-for-service Medicare beneficiaries: A prognostic study.
PloS one. 15(7) [DOI] 10.1371/journal.pone.0235981. [PMID] 32678860.
2019
Adherence trajectories of buprenorphine therapy among pregnant women in a large state Medicaid program in the United States
Pharmacoepidemiology and drug safety. 28(1):80-89 [DOI] 10.1002/pds.4647. [PMID] 30192041.
2019
Alzheimer’s disease medication and risk of all-cause mortality and all-cause hospitalization: A retrospective cohort study
Alzheimer's & dementia. Translational research & clinical interventions. [DOI] 10.1016/j.trci.2019.05.005. [PMID] 31338414.
2019
Alzheimer’s disease medication and risk of all-cause mortality and all-cause hospitalization: A retrospective cohort study.
Alzheimer's & dementia (New York, N. Y.). 5:294-302 [DOI] 10.1016/j.trci.2019.05.005. [PMID] 31338414.
2019
Alzheimer’s disease medication and risk of all-cause mortality and all-cause hospitalization: a retrospective cohort study.
. 10(5):294-302
2019
Association between physician adoption of a new oral anti-diabetic medication and Medicare and Medicaid drug spending.
BMC health services research. 19(1) [DOI] 10.1186/s12913-019-4520-4. [PMID] 31619229.
2019
Evaluation of machine-learning algorithms for predicting opioid overdose risk among Medicare beneficiaries with opioid prescription.
JAMA Network Open. 2(3)(e190968)
2019
Evaluation of Machine-Learning Algorithms for Predicting Opioid Overdose Risk Among Medicare Beneficiaries With Opioid Prescriptions
JAMA Network Open. [DOI] 10.1001/jamanetworkopen.2019.0968. [PMID] 30901048.
2019
Evaluation of Machine-Learning Algorithms for Predicting Opioid Overdose Risk Among Medicare Beneficiaries With Opioid Prescriptions.
JAMA network open. 2(3) [DOI] 10.1001/jamanetworkopen.2019.0968. [PMID] 30901048.
2019
Extent and predictors of potentially inappropriate antidepressant use among older adults with dementia and major depressive disorder
The American Journal Of Geriatric Psychiatry. 27(8):794-805
2019
Patterns of Opioid Administration Among Opioid-Naive Inpatients and Associations With Postdischarge Opioid Use: A Cohort Study.
Annals of internal medicine. 171(2):81-90 [DOI] 10.7326/M18-2864. [PMID] 31207646.
2019
Patterns of opioid administration among opioid-naïve inpatients and associations with postdischarge opioid use: A cohort study.
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2019
Patterns of opioid administration among opioid-naïve inpatients and associations with postdischarge opioid use: A cohort study.
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2019
Patterns of opioid administration among opioid-naïve inpatients and associations with postdischarge opioid use: A cohort study.
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2019
Trends, Patient and Prescriber Characteristics in Gabapentinoid Use in a Sample of United States Ambulatory Care Visits from 2003 to 2016.
Journal of clinical medicine. 9(1) [DOI] 10.3390/jcm9010083. [PMID] 31905718.
2018
Adherence trajectories of buprenorphine therapy among pregnant women in a large state Medicaid program in the United States.
Pharmacoepidemiology and Drug Safety. [DOI] 10.1002/pds.4647. [PMID] 30192041.
2018
Influence of peer networks on physician adoption of new drugs.
PLoS One. 13(10)
2018
Influence of peer networks on physician adoption of new drugs.
PLoS One. 13(10)
2018
Influence of peer networks on physician adoption of new drugs.
PLoS One. 13(10)
2018
Misoprostol in addition to a double balloon catheter for induction: A double-blind randomized controlled trial.
American Journal of Perinatology. 35(3):225-232
2018
Misoprostol in addition to a double balloon catheter for induction: A double-blind randomized controlled trial.
American Journal of Perinatology. 35(3):225-232
2018
Misoprostol in addition to a double balloon catheter for induction: A double-blind randomized controlled trial.
American Journal of Perinatology. 35(3):225-232
2018
Patterns and predictors of physician adoption of new cardiovascular drugs
. 6(1):33-40
2018
Prescription opioid quality measures applied among Pennsylvania Medicaid enrollees.
Journal Of Managed Care & Specialty Pharmacy. 24(9):875-885
2017
An examination of claims-based predictors of overdose from a large Medicaid program.
. 55(3):291-298
2017
Analgesic use and risk of recurrent falls in participants with or at risk of knee osteoarthritis: data from the Osteoarthritis Initiative
Osteoarthritis and Cartilage. 25(9):1390-1398 [DOI] 10.1016/j.joca.2017.03.017. [PMID] 28385483.
2017
Effectiveness and safety of non-Vitamin K antiagonist oral anticoagulants for atrial fibrillation and venous thromboembolism: a systematic review and meta-analyses.
Clinical Therapeutics. 39(7):1456-1478
2017
Medicaid prior authorization and opioid medication abuse and overdose.
American Journal of Managed Care. 23(5):e164-e171
2017
Medication-assisted treatment and opioid use before and after overdose in Pennsylvania Medicaid.
Jama-Journal of the American Medical Association. 318(8):750-752
2016
Association between trajectories of buprenorphine treatment and emergency department and in-patient utilization
Addiction. 111(5):892-902 [DOI] 10.1111/add.13270. [PMID] 26662858.
2016
Partnership building and implementation of an integrated healthy-aging program.
Progress in Community Health Partnerships-Research Education and Action. 10(1):123-132
2016
Pilot enhancement of the Arthritis Foundation exercise program with a healthy aging program
Research in Gerontological Nursing. 9(3):123-132 [DOI] 10.3928/19404921-20151019-04. [PMID] 26501346.
2016
Pilot enhancement of the Arthritis Foundation exercise program with a healthy aging program.
Research in Gerontological Nursing. 9(3):123-132
2016
The preventive services use self-efficacy (PRESS) scale in older women: development and psychometric properties.
Bmc Health Services Research. 16(1)
2016
The preventive services use self-efficacy (PRESS) scale in older women: development and psychometric properties.
Bmc Health Services Research. 16(1)
2016
The preventive services use self-efficacy (PRESS) scale in older women: development and psychometric properties.
Bmc Health Services Research. 16(1)
2016
Trajectories of diabetes medication adherence and hospitalization risk: A retrospective cohort study in a large state Medicaid program
Journal of General Internal Medicine. 31(9):1052-1060
2016
Treatment quality for buprenorphine care: The pot at the end of the rainbow. [In Reply to “Measurement Quality of Buprenorphine Care”].
Journal of Addiction Medicine. 10(3):210-211
2016
Who were the early adopters of dabigatran? An application of group-based trajectory models.
. 54(7):725-732
2015
Defining Nonmedical Use of Prescription Opioids Within Health Care Claims: A Systematic Review.
Substance abuse. 36(2):192-202 [DOI] 10.1080/08897077.2014.993491. [PMID] 25671499.
2015
Patterns and quality of buprenorphine opioid agonist treatment in a large Medicaid program
Journal of Addiction Medicine. 9(6):470-477 [DOI] 10.1097/ADM.0000000000000164. [PMID] 26517324.
2015
Statin Use and Decline in Gait Speed in Community-Dwelling Older Adults
Journal of the American Geriatrics Society. 63(1):124-9 [DOI] 10.1111/jgs.13134. [PMID] 25537649.
2015
Use of common analgesics is not associated with ovarian cancer survival.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 24(8):1291-4 [DOI] 10.1158/1055-9965.EPI-15-0508. [PMID] 26063476.
2015
Using machine learning to examine medication adherence thresholds and risk of hospitalization
Medical care. 53(8):720-728 [DOI] 10.1097/MLR.0000000000000394. [PMID] 26147866.
2014
Aspirin, non-aspirin nonsteroidal anti-inflammatory drug, and acetaminophen use and risk of invasive epithelial ovarian cancer: a pooled analysis in the Ovarian Cancer Association Consortium
Journal of the National Cancer Institute. 106(2) [DOI] 10.1093/jnci/djt431. [PMID] 24503200.
2013
Changes in cholesterol-lowering medications use over a decade in community-dwelling older adults
The Annals of pharmacotherapy. 47(7-8):984-992 [DOI] 10.1345/aph.1S050. [PMID] 23780807.
2013
Genital powder use and risk of ovarian cancer: a pooled analysis of 8,525 cases and 9,859 controls.
Cancer prevention research (Philadelphia, Pa.). 6(8):811-21 [DOI] 10.1158/1940-6207.CAPR-13-0037. [PMID] 23761272.
2012
Aspirin, nonaspirin nonsteroidal anti-inflammatory drugs, or acetaminophen and risk of ovarian cancer.
Epidemiology (Cambridge, Mass.). 23(2):311-9 [DOI] 10.1097/EDE.0b013e3182456ad3. [PMID] 22252409.
2011
Identifying type 1 and type 2 diabetic cases using administrative data: a tree-structured model.
Journal of diabetes science and technology. 5(3):486-93 [PMID] 21722564.
View on: PubMed
2004
Antihypertensive agents and new-onset diabetes
. 16:225-240
2004
Selective serotonin reuptake inhibitors (SSRI)
. 14(6)

Grants

Jul 2021 ACTIVE
Developing and Evaluating a Machine-Learning Opioid Prediction & Risk-Stratification E-Platform (DEMONSTRATE)
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDA
Jul 2021 ACTIVE
Predicting Risky Opioid Therapy e-Care Tool (PROTeCT): Prototype Development and Pilot Testing
Role: Principal Investigator
Funding: UF HEALTH SHANDS HOSPITAL
May 2021 ACTIVE
Utilization patterns of cough medications in the United States
Role: Principal Investigator
Funding: MERCK AND COMPANY INC
Mar 2021 ACTIVE
VA IPA – Nursing Unit Design and Hospital Falls 2021-2022
Role: Principal Investigator
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Sep 2020 ACTIVE
Linking VA and non-VA data to study the risk of suicide in chronic pain patients
Role: Co-Investigator
Funding: WEILL MED COLLEGE OF CORNELL UNIV NY via NATL INST OF HLTH NIMH
Jul 2020 ACTIVE
Implementing Opioid Risk Prediction Models
Role: Principal Investigator
Funding: UNIV OF PITTSBURGH via RICHARD KING MELLON FOU
Jan 2020 – Feb 2021
Leveraging social media data for evaluation of drug use trends after opioid policies
Role: Co-Investigator
Funding: AMER ASSO OF COL OF PHARMACY
May 2019 ACTIVE
Developing a Real-Time Trajectory Tool to Identify Potentially Unsafe Concurrent Opioid and Benzodiazepine Use among Older Adults
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Jul 2018 – Jun 2021
Using Machine Learning to Predict Problematic Opioid Use and Opioid Overdoses
Role: Principal Investigator
Funding: UNIV OF PITTSBURGH via NATL INST OF HLTH NIDA
Jul 2018 – Jun 2020
Machine Learning and Opioid Overdoses
Role: Principal Investigator
Funding: UNIV OF PITTSBURGH via RICHARD KING MELLON FOU

Education

Ph.D.
2013 · University of Pittsburgh
M.S.
2010 · University of Pittsburgh
M.S.Pharm.
2005 · National Cheng Kung University
B.S.
2003 · National Taiwan University

Teaching Profile

Courses Taught
2020-2021
PHA6268 Pharmacoepidemiology and Patient Safety
2020-2021
PHA7980 Research for Doctoral Dissertation
2020-2021
PHA6910 Supervised Research
2020-2021
PHA7979 Advanced Research
2019-2021
PHA5244 Prin Evid Based Prac
2020-2021
PHA6971 Research for Master’s Thesis
2020-2021
PHA6935 Selected Topics in Pharmacy
2021
PHA6937 Topics in Pharmaceutical Administration
2021
PHA6936 Advanced Topics in Pharmaceutical Sciences
2021
PHA6265 Introduction to Pharmaceutical Outcomes and Policy I
2021
PHA6940 Supervised Teaching

Contact Details

Phones:
Business:
(352) 273-6255
Emails:

Recent news

Machine-learning algorithm led by UF researcher improves the prediction of opioid overdose by integrating health claims data with public human services data

The study led by Dr. Weihsuan “Jenny” Lo-Ciganic was published by PLOS One.

Drs. Lo-Ciganic and Hincapie-Castillo appointed as section co-editors for Pain Medicine journal

Pain Medicine is a multidisciplinary journal dedicated to pain clinicians, educators and researchers with an interest in pain from various medical specialties.

Dr. Weihsuan “Jenny” Lo-Ciganic to lead virtual ISPOR workshop on machine learning

Weihsuan “Jenny” Lo-Ciganic, Ph.D., M.S., M.S.Pharm., will lead a short course workshop on machine learning as part of the International Society for Pharmacoeconomics and Outcomes Research’s Virtual ISPOR 2020 Conference from 10 a.m.…

Dr. Weihsuan “Jenny” Lo-Ciganic wins UF Excellence Award for Assistant Professors

The UF Excellence Award for Assistant Professors is one of the university’s top awards for a junior faculty member.