Bin Liu

Bin Liu Ph.D.

Associate Professor

Department: Pharmacodynamics
Business Phone: (352) 273-7747
Business Email: liu@cop.ufl.edu

Research Profile

Our laboratory has been studying the role of environmental agents that include pesticides, heavy metals and infectious agents in the development of neurological disorders including Parkinson’s disease, a degenerative movement disorder resulted from a progressive destruction of the nigrostriatal dopamine-releasing neurons in the midbrain. We are particularly interested in delineating the intricate interactions between the immune cells in the brain (microglia and astrocytes) and the affected neurons in response to environmental agents. Aberrant activation of glial cells, induced through interactions with environmental agents or in response to neuronal injuries can lead to the excessive production and accumulation of reactive oxygen and nitrogen species, proinflammatory cytokines and lipid mediators that contribute to the progressive neurodegenerative process. We are utilizing molecular, biochemical, cellular and whole animal approaches to decipher the various aspects of the neuroinflammation-mediated neurodegeneration. Our ultimate goal is to identify highly specific molecular mediators of neurodegeneration as potential therapeutic targets and/or diagnostic biomarkers.

Publications

Grants

May 2018ACTIVE
Role of Methylation in Ethanol-Induced Microglial Activation
ALBANY COLLEGE OF PHARMACY AND HLTH SCI · Principal Investigator
January 2018ACTIVE
The role of histone demethylase KDM5B in ethanol-induced microglial activation
ALBANY COLLEGE OF PHARMACY AND HLTH SCI · Principal Investigator
May 2017 – November 2017
Role of Methylation in Ethanol-Induced Microglial Activation
UNIV OF SOUTH FLORIDA · Principal Investigator
July 2015 – June 2018
Novel Proteomic Approaches for the Study of Alcohol Neuropathology
NATL INST OF HLTH NIAAA · Principal Investigator