Bin Liu

Bin Liu, Ph.D.

Associate Professor and Graduate Coordinator

Department: Pharmacodynamics
Business Phone: (352) 273-7747
Business Email: liu@cop.ufl.edu

Research Profile

Our laboratory has been studying the role of environmental agents that include pesticides, heavy metals and infectious agents in the development of neurological disorders including Parkinson’s disease, a degenerative movement disorder resulted from a progressive destruction of the nigrostriatal dopamine-releasing neurons in the midbrain. We are particularly interested in delineating the intricate interactions between the immune cells in the brain (microglia and astrocytes) and the affected neurons in response to environmental agents. Aberrant activation of glial cells, induced through interactions with environmental agents or in response to neuronal injuries can lead to the excessive production and accumulation of reactive oxygen and nitrogen species, proinflammatory cytokines and lipid mediators that contribute to the progressive neurodegenerative process. We are utilizing molecular, biochemical, cellular and whole animal approaches to decipher the various aspects of the neuroinflammation-mediated neurodegeneration. Our ultimate goal is to identify highly specific molecular mediators of neurodegeneration as potential therapeutic targets and/or diagnostic biomarkers.

Publications

2018
Role of NADPH Oxidase in Cooperative Reactive Oxygen Species Generation in Dopaminergic Neurons Induced by Combined Treatment with Dieldrin and Lindane.
Toxicology letters. 299:47-55 [DOI] 10.1016/j.toxlet.2018.09.006. [PMID] 30240590.
2017
Ischemia-Responsive Protein 94 Is a Key Mediator of Ischemic Neuronal Injury-Induced Microglial Activation
Journal of Neurochemistry. 142(6):908-919 [DOI] 10.1111/jnc.14111.
2016
Characterization of a Silac Method for Proteomic Analysis of Primary Rat Microglia
Proteomics. 16(9):1341-1346 [DOI] 10.1002/pmic.201500390. [PMID] 26936193.
2015
Bed bugs bite the hospitality industry? A framing analysis of bed bug news coverage.
Tourism management. 48:33-42 [DOI] 10.1016/j.tourman.2014.10.020. [PMID] 32287744.
2015
Novel Molecular Insights Into Classical and Alternative Activation States of Microglia As Revealed By Stable Isotope Labeling By Amino Acids in Cell Culture (Silac)-Based Proteomics
Molecular & Cellular Proteomics. 14(12):3173-3184 [DOI] 10.1074/mcp.M115.053926. [PMID] 26424600.
2014
A Unifying Gene Signature for Adenoid Cystic Cancer Identifies Parallel Myb-Dependent and Myb-Independent Therapeutic Targets
Oncotarget. 5(24):12528-12542
2013
Complex II of the Mitochondrial Respiratory Chain Is the Key Mediator of Divalent Manganese-Induced Hydrogen Peroxide Production in Microglia
Toxicological Sciences. 132(2):298-306 [DOI] 10.1093/toxsci/kfs344. [PMID] 23315522.
2013
Quantitative Proteomic Characterization of Ethanol-Responsive Pathways in Rat Microglial Cells
Journal of Proteome Research. 12(5):2067-2077 [DOI] 10.1021/pr301038f. [PMID] 23495833.
2012
Involvement of dopaminergic neuronal cystatin C in neuronal injury-induced microglial activation and neurotoxicity.
Journal of neurochemistry. 122(4):752-63 [DOI] 10.1111/j.1471-4159.2012.07826.x. [PMID] 22679891.
2012
Proteomic Analysis of Rat Microglia Establishes a High-Confidence Reference Data Set of Over 3000 Proteins
Proteomics. 12(2):246-250 [DOI] 10.1002/pmic.201100398. [PMID] 22121004.
2012
Stable isotope labeling with amino acids in cell culture-based proteomic analysis of ethanol-induced protein expression profiles in microglia
Methods in Molecular Biology. 829:551-65 [DOI] 10.1007/978-1-61779-458-2_35. [PMID] 22231838.
2011
Dissecting Quantitative Resistance Against Blast Disease Using Heterogeneous Inbred Family Lines in Rice
Theoretical and Applied Genetics. 122(2):341-353 [DOI] 10.1007/s00122-010-1450-2. [PMID] 20872132.
2010
Organochlorine pesticides dieldrin and lindane induce cooperative toxicity in dopaminergic neurons: role of oxidative stress.
Neurotoxicology. 31(2):215-22 [DOI] 10.1016/j.neuro.2009.12.007. [PMID] 20036686.
2010
Synergistic Dopaminergic Neurotoxicity of Manganese and Lipopolysaccharide: Differential Involvement of Microglia and Astroglia
Journal of Neurochemistry. 112(2):434-443 [DOI] 10.1111/j.1471-4159.2009.06477.x. [PMID] 19895668.
2009
Microglia enhance manganese chloride-induced dopaminergic neurodegeneration: role of free radical generation.
Experimental neurology. 217(1):219-30 [DOI] 10.1016/j.expneurol.2009.02.013. [PMID] 19268665.
2008
Development and Evaluation of a High-Throughput, Low-Cost Genotyping Platform Based On Oligonucleotide Microarrays in Rice
Plant Methods. 4 [DOI] 10.1186/1746-4811-4-13. [PMID] 18510771.
2008
Synergistic microglial reactive oxygen species generation induced by pesticides lindane and dieldrin.
Neuroreport. 19(13):1317-20 [DOI] 10.1097/WNR.0b013e32830b3677. [PMID] 18695515.
2008
The lipopolysaccharide Parkinson’s disease animal model: mechanistic studies and drug discovery.
Fundamental & clinical pharmacology. 22(5):453-64 [DOI] 10.1111/j.1472-8206.2008.00616.x. [PMID] 18710400.
2007
PKU is a reversible neurodegenerative process within the nigrostriatum that begins as early as 4 weeks of age in Pah(enu2) mice.
Brain Research. 1127(1):136-50 [DOI] 10.1016/j.brainres.2006.09.101. [PMID] 17112485.
2006
Modulation of microglial pro-inflammatory and neurotoxic activity for the treatment of Parkinson’s disease.
Aaps Journal. 8(3):E606-21 [DOI] 10.1208/aapsj080369. [PMID] 17025278.

Grants

May 2018 – Jun 2020
Role of Methylation in Ethanol-Induced Microglial Activation
Role: Principal Investigator
Funding: ALBANY COLLEGE OF PHARMACY AND HLTH SCI via NATL INST OF HLTH NIAAA
Jan 2018 ACTIVE
The role of histone demethylase KDM5B in ethanol-induced microglial activation
Role: Principal Investigator
Funding: ALBANY COLLEGE OF PHARMACY AND HLTH SCI via NATL INST OF HLTH NIAAA
May 2017 – Nov 2017
Role of Methylation in Ethanol-Induced Microglial Activation
Role: Principal Investigator
Funding: UNIV OF SOUTH FLORIDA via NATL INST OF HLTH NIAAA
Jul 2015 – Jun 2018
Novel Proteomic Approaches for the Study of Alcohol Neuropathology
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAAA
Aug 2013 – Jul 2016
Role of Microglia in Ethanol-induced Oxidative Stress
Role: Principal Investigator
Funding: NATL INST OF HLTH

Teaching Profile

Courses Taught
2015-2018,2020-2021
PHA5560 Pathphys-Pt Assess I
2007,2009-2021
PHA6512L Experiential Research Training in Pharmacodynamics
2009-2013,2015-2021,2020-2021
PHA6936 Advanced Topics in Pharmaceutical Sciences
2007,2009-2021
PHA7980 Research for Doctoral Dissertation
2006-2007,2009-2015,2014-2021
PHA7979 Advanced Research
2019-2021
PHA6894 Introduction to Graduate Studies
2011-2012,2014-2021,2020-2021
PHA6521C Research Techniques in Pharmacodynamics
2016-2021
PHA6935 Selected Topics in Pharmacy
2010-2012,2015-2021,2019-2021
PHA6910 Supervised Research
2016-2018,2020-2021
PHA5755 Micro, Immun, Virol
2010-2012,2019-2020
PHA6971 Research for Master’s Thesis
2006-2007,2009-2014,2013-2020,2018-2020,2020
PHA7939 Journal Colloquy in Pharmacodynamics
2009-2010,2014-2019,2018-2021
PHA6938 Research Seminar
2016-2019
PHA5561 Pathphys-Pt Assess II
2018-2019
PHA5789C Patient Care 7
2017
PHA5933 Select Top Pharmacy
2016
GMS6029 Brain Journal Club
2016
PHA4911 Undergraduate Research in Pharmacodynamics
2014-2015
PHA6508 Systems Physiology and Pathophysiology I
2010-2015
PHA5516 Basis of Therapeu 1
2011-2015
PHA5561C Physiol Bas Disease 2
2010-2015
PHA5560C Physiol Bas Disease 1
2013-2015
PHA6509 Systems Physiology and Pathophysiology II
2010,2012
PHA5902 Research Pharmacodyna
2008,2010
PHA4902 Prob Pharmacodynamics
2010
PHA6540 Neurochem Founda

Contact Details

Phones:
Business:
(352) 273-7747
Emails:
Business:
liu@cop.ufl.edu