Bin Liu

Bin Liu, Ph.D.

Associate Professor And Graduate Coordinator

Department: Pharmacodynamics
Business Phone: (352) 273-7747
Business Email: liu@cop.ufl.edu

Teaching Profile

Courses Taught
2015-2018,2020-2021
PHA5560 Pathphys-Pt Assess I
2007,2009-2022
PHA6512L Experiential Research Training in Pharmacodynamics
2009-2013,2015-2021,2020-2021
PHA6936 Advanced Topics in Pharmaceutical Sciences
2007,2009-2022
PHA7980 Research for Doctoral Dissertation
2006-2007,2009-2015,2014-2022
PHA7979 Advanced Research
2019-2021
PHA6894 Introduction to Graduate Studies
2011-2012,2014-2021,2020-2021
PHA6521C Research Techniques in Pharmacodynamics
2016-2021
PHA6935 Selected Topics in Pharmacy
2010-2012,2015-2021,2019-2022
PHA6910 Supervised Research
2016-2018,2020
PHA5755 Micro, Immun, Virol
2010-2012,2019-2021
PHA6971 Research for Master’s Thesis
2006-2007,2009-2014,2013-2020,2018-2020,2020
PHA7939 Journal Colloquy in Pharmacodynamics
2009-2010,2014-2019,2018-2022
PHA6938 Research Seminar
2016-2019,2021-2022
PHA5561 Pathphys-Pt Assess II
2018-2019,2021-2022
PHA5789C Patient Care 7
2017
PHA5933 Select Top Pharmacy
2016
GMS6029 Brain Journal Club
2016
PHA4911 Undergraduate Research in Pharmacodynamics
2014-2015,2021
PHA6508 Systems Physiology and Pathophysiology I
2010-2015
PHA5516 Basis of Therapeu 1
2011-2015
PHA5561C Physiol Bas Disease 2
2010-2015
PHA5560C Physiol Bas Disease 1
2013-2015,2022
PHA6509 Systems Physiology and Pathophysiology II
2010,2012
PHA5902 Research Pharmacodyna
2008,2010
PHA4902 Prob Pharmacodynamics
2010
PHA6540 Neurochem Founda
2021
PHA5782C Patient Care 2: Introduction to Infectious Disease and Oncology

Research Profile

Our laboratory studies the interaction between neurons and non-neuronal glial cells in the development of disorders of the central nervus system. Microglia and astrocytes are the primary glial cells that are essential to the survival and proper function of neurons. We are particularly interested in delineating the intricate interactions between the resident immune cells in the brain, microglia and neurons in response to environmental toxicants, inflammatory agents and substances of abuse including alcohol and opioids. Microglia exhibit a wide spectrum of phenotypes from pro to anti-inflammatory status. Proinflammatory activation of microglia can lead to excessive production and accumulation of reactive oxygen and nitrogen species, proinflammatory cytokines and lipid mediators that impact on neurons to affect their functionality and survival. We are utilizing molecular, biochemical, cellular and whole animal approaches to gain insight into the relationship between microglia phenotypes and neuronal function in the development of various neurological disorders. Our ultimate goal is to identify novel molecular mediators of neurodegeneration as potential therapeutic targets and/or diagnostic biomarkers.

Publications

2021
Binge ethanol consumption-associated behavioral impairments in male mice using a gelatin-based drinking-in-the dark model
Alcohol. 95:25-36 [DOI] 10.1016/j.alcohol.2021.05.001.
2021
Organochlorine Pesticide Dieldrin Suppresses Cellular Interferon-Related Antiviral Gene Expression.
Toxicological sciences : an official journal of the Society of Toxicology. 182(2):260-274 [DOI] 10.1093/toxsci/kfab064. [PMID] 34051100.
2020
Functional Pathway Identification with CRISPR/Cas9 Genome Wide Gene Disruption in Human Dopaminergic Neuronal Cells Following Chronic Treatment with Dieldrin
Toxicological Sciences. 176(2):366-381 [DOI] 10.1093/toxsci/kfaa071. [PMID] 32421776.
2018
Role of NADPH oxidase in cooperative reactive oxygen species generation in dopaminergic neurons induced by combined treatment with dieldrin and lindane.
Toxicology letters. 299:47-55 [DOI] 10.1016/j.toxlet.2018.09.006. [PMID] 30240590.
2017
Ischemia-Responsive Protein 94 Is a Key Mediator of Ischemic Neuronal Injury-Induced Microglial Activation
Journal of Neurochemistry. 142(6):908-919 [DOI] 10.1111/jnc.14111.
2016
Characterization of a SILAC method for proteomic analysis of primary rat microglia.
Proteomics. 16(9):1341-6 [DOI] 10.1002/pmic.201500390. [PMID] 26936193.
2015
Novel Molecular Insights into Classical and Alternative Activation States of Microglia as Revealed by Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)-based Proteomics.
Molecular & cellular proteomics : MCP. 14(12):3173-84 [DOI] 10.1074/mcp.M115.053926. [PMID] 26424600.
2013
Complex II of the mitochondrial respiratory chain is the key mediator of divalent manganese-induced hydrogen peroxide production in microglia.
Toxicological sciences : an official journal of the Society of Toxicology. 132(2):298-306 [DOI] 10.1093/toxsci/kfs344. [PMID] 23315522.
2013
Quantitative proteomic characterization of ethanol-responsive pathways in rat microglial cells.
Journal of proteome research. 12(5):2067-77 [DOI] 10.1021/pr301038f. [PMID] 23495833.
2012
Involvement of dopaminergic neuronal cystatin C in neuronal injury-induced microglial activation and neurotoxicity.
Journal of neurochemistry. 122(4):752-63 [DOI] 10.1111/j.1471-4159.2012.07826.x. [PMID] 22679891.
2012
Proteomic analysis of rat microglia establishes a high-confidence reference data set of over 3000 proteins.
Proteomics. 12(2):246-50 [DOI] 10.1002/pmic.201100398. [PMID] 22121004.
2012
Stable isotope labeling with amino acids in cell culture-based proteomic analysis of ethanol-induced protein expression profiles in microglia.
Methods in molecular biology (Clifton, N.J.). 829:551-65 [DOI] 10.1007/978-1-61779-458-2_35. [PMID] 22231838.
2010
Organochlorine pesticides dieldrin and lindane induce cooperative toxicity in dopaminergic neurons: role of oxidative stress.
Neurotoxicology. 31(2):215-22 [DOI] 10.1016/j.neuro.2009.12.007. [PMID] 20036686.
2010
Synergistic dopaminergic neurotoxicity of manganese and lipopolysaccharide: differential involvement of microglia and astroglia.
Journal of neurochemistry. 112(2):434-43 [DOI] 10.1111/j.1471-4159.2009.06477.x. [PMID] 19895668.
2009
Microglia enhance manganese chloride-induced dopaminergic neurodegeneration: role of free radical generation.
Experimental neurology. 217(1):219-30 [DOI] 10.1016/j.expneurol.2009.02.013. [PMID] 19268665.
2008
Synergistic microglial reactive oxygen species generation induced by pesticides lindane and dieldrin.
Neuroreport. 19(13):1317-20 [DOI] 10.1097/WNR.0b013e32830b3677. [PMID] 18695515.
2008
The lipopolysaccharide Parkinson’s disease animal model: mechanistic studies and drug discovery.
Fundamental & clinical pharmacology. 22(5):453-64 [DOI] 10.1111/j.1472-8206.2008.00616.x. [PMID] 18710400.
2007
PKU is a reversible neurodegenerative process within the nigrostriatum that begins as early as 4 weeks of age in Pah(enu2) mice.
Brain research. 1127(1):136-50 [PMID] 17112485.
2006
Modulation of microglial pro-inflammatory and neurotoxic activity for the treatment of Parkinson’s disease.
The AAPS journal. 8(3):E606-21 [PMID] 17025278.

Grants

Sep 2020 ACTIVE
The role of histone demethylase KDM5B in ethanol-induced microglial activation
Role: Principal Investigator
Funding: UNIV OF SOUTH FLORIDA via NATL INST OF HLTH NIAAA
May 2018 – Jun 2020
Role of Methylation in Ethanol-Induced Microglial Activation
Role: Principal Investigator
Funding: ALBANY COLLEGE OF PHARMACY AND HLTH SCI via NATL INST OF HLTH NIAAA
Jan 2018 – Jun 2020
The role of histone demethylase KDM5B in ethanol-induced microglial activation
Role: Principal Investigator
Funding: ALBANY COLLEGE OF PHARMACY AND HLTH SCI via NATL INST OF HLTH NIAAA
May 2017 – Nov 2017
Role of Methylation in Ethanol-Induced Microglial Activation
Role: Principal Investigator
Funding: UNIV OF SOUTH FLORIDA via NATL INST OF HLTH NIAAA
Jul 2015 – Jun 2018
Novel Proteomic Approaches for the Study of Alcohol Neuropathology
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAAA
Aug 2013 – Jul 2016
Role of Microglia in Ethanol-induced Oxidative Stress
Role: Principal Investigator
Funding: NATL INST OF HLTH

Contact Details

Phones:
Business:
(352) 273-7747
Emails:
Business:
liu@cop.ufl.edu
Addresses:
Business Mailing:
PO Box 100487
GAINESVILLE FL 32610
Business Street:
1600 SW ARCHER DR.
MSB P2-31
GAINESVILLE FL 32610