Lawrence Lesko

Lawrence Lesko, Ph.D.

Professor Emeritus

Department: Pharmaceutics
Business Email: llesko@cop.ufl.edu

About Lawrence Lesko

Lawrence J. Lesko, Ph.D., F.C.P. joined the UF Research and Academic Center in Lake Nona (Orlando) in July 2011.

Before joining UF, Dr. Lesko worked nearly 20 years in the Food and Drug Administration’s Center for Drug Evaluation and Research as the Director of the Office of Clinical Pharmacology. He was also Chair of the Clinical Pharmacology Coordinating Subcommittee of the FDA’s Medical Policy Coordinating Committee and authored or co-authored numerous Guidance for Industry, and started the FDA’s Voluntary Genomics Data Submission Program and Mechanistic Drug Safety Program.

Lesko has published more than 200 peer-reviewed scientific publications and is a frequent invited national and international speaker in clinical pharmacology, personalized medicine, pharmacometrics and systems pharmacology. His research interests include drug development and regulatory science, quantitative clinical pharmacology and pharmacogenomics.

In 2011, Lesko received the Gary Neil Prize for Innovation in Drug Development from the American Society of Clinical Pharmacology and Therapeutics (ASCPT). He also received the Coriell Scientific Leadership Award for Personalized Medicine (2010), the Rawls-Palmer Progress in Medicine award from ASCPT (2007), the University of North Carolina Institute for Pharmacogenomics and Individualized Therapy Award for Clinical Service (2007), and the Nathanial B. Kwit Distinguished Service Award for Clinical Pharmacology from the American College of Clinical Pharmacology (2007). Lesko served as President of the American College of Clinical Pharmacology in 2004-2006. He is a Fellow in the Japanese Society for the Study of Xenobiotics, American College of Clinical Pharmacology and the American Association of Pharmaceutical Scientists. He is Board Certified in Clinical Pharmacology and a registered pharmacist.

Publications

2018 Clinical pharmacology and therapeutics
2017 Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
2017 Journal of cardiovascular pharmacology and therapeutics
2016 Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
2016 European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
2016 European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
2016 Clinical pharmacology and therapeutics
2013 Clinical pharmacology and therapeutics
2012 Clinical pharmacology and therapeutics
2012 Clinical pharmacology and therapeutics
2012 Clinical pharmacology and therapeutics
2011 Clinical pharmacology and therapeutics
2010 Clinical pharmacology and therapeutics
2010 Clinical cancer research : an official journal of the American Association for Cancer Research
2010 Medical decision making : an international journal of the Society for Medical Decision Making
2009 The New England journal of medicine
2009 Annual review of pharmacology and toxicology
2008 American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
2007 Clinical pharmacology and therapeutics
2007 Journal of clinical oncology : official journal of the American Society of Clinical Oncology
2006 Toxicology mechanisms and methods
2002 European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
2002 Clinical pharmacology and therapeutics
2001 International journal of clinical pharmacology and therapeutics
2001 Clinical pharmacokinetics
2000 Xenobiotica; the fate of foreign compounds in biological systems
2000 European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
1996 European journal of drug metabolism and pharmacokinetics
1989 The Journal of investigative dermatology
1989 Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
1984 Clinical pharmacology and therapeutics
1981 Clinical pharmacology and therapeutics

Grants

Oct 2015 – Oct 2018
Translational Research Institute for Metabolism and Diab
TRANSLATIONAL RES INST METABOLISM & DIAB · Project Manager
Apr 2015 – Aug 2017
Pharmacogenomics of Oxydocone in Chronic Pain Management
RAJ ENTERPRISES OF CENTRAL FLORIDA LLC · Principal Investigator
Sep 2014 – Aug 2018
A Model- and Systems-based Approach to Efficacy and Safety Questions Related to Generic Substitution
US FOOD AND DRUG ADMN · Project Manager
Jun 2014 – Apr 2016
Vertex – Cystic Fibrosis Research
VERTEX PHARMACEUTICALS · Principal Investigator
Mar 2014 – Mar 2016
Application of Population Pharmacokinetic/Pharmacodynami
TAKEDA PHARMACEUTICALS INTERNATIONAL · Principal Investigator
Apr 2013 – Apr 2016
Educational Grant Agreement
DAIICHI PHARMACEUTICAL PHARM CORP · Principal Investigator

Education

Ph.D.
1971 · Temple University Health Science Center
B.S.
1967 · Temple University Health Science Center

Contact Details

Emails:
Business:
llesko@cop.ufl.edu