Taimour Langaee

Taimour Langaee, MSPH, Ph.D.

Research Professor

Department: Pharmacotherapy & Translational Research
Business Phone: (352) 273-6357
Business Email: langaee@cop.ufl.edu

About Taimour Langaee

Dr. Langaee is a Research Professor in the Department of Pharmacotherapy and Translational Research at the University of Florida (UF) College of Pharmacy and Director of the UF Center for Pharmacogenomics Genotyping Core Laboratory. Before joining the UF faculty in 2002, he completed three years of post-doctoral fellowship in Immunology and Molecular Biology, and Microbiology and Molecular Genetics working on developing HIV vaccine at the College of Medicine University of Montreal and High Density DNA chips for Pseudomonas aeruginosa at the College of Medicine University of Florida.

Dr. Langaee’s research interests are focused on pharmacogenetics (genetic-based variability in drug response) in cardiovascular and auto-immune diseases and developing microarray-based technology methods to facilitate disease diagnosis, genotyping of patients and discovering disease-gene associations.

Research Profile

Dr. Langaee’s research interests are focused on Pharmacogenomics and Personalized Medicine, Development and application of Clinical Diagnostic Genetic Biomarkers, Pharmacogenetics of Dichloroacetate (DCA), Infectious Disease and Microbial Resistance to Beta-lactam antibiotics.

Publications

2021
Implications of Polymorphisms in the BCKDK and GATA-4 Gene Regions on Stable Warfarin Dose in African Americans.
Clinical and translational science. 14(2):492-496 [DOI] 10.1111/cts.12939. [PMID] 33278335.
2021
Newly diagnosed cardiovascular disease in patients treated with immune checkpoint inhibitors: a retrospective analysis of patients at an academic tertiary care center.
Cardio-oncology (London, England). 7(1) [DOI] 10.1186/s40959-021-00097-9. [PMID] 33736707.
2021
Pharmacokinetic and biochemical profiling of Sodium Dichloroacetate in pregnant ewes and fetuses.
Drug metabolism and disposition: the biological fate of chemicals. [DOI] 10.1124/dmd.120.000330. [PMID] 33811107.
2021
SIRT1 Gene SNP rs932658 Is Associated With Medication-Related Osteonecrosis of the Jaw.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 36(2):347-356 [DOI] 10.1002/jbmr.4185. [PMID] 32967053.
2020
A single variant sequencing method for sensitive and quantitative detection of HIV-1 minority variants.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-65085-y. [PMID] 32424187.
2020
Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes.
Drug metabolism and disposition: the biological fate of chemicals. 48(7):563-569 [DOI] 10.1124/dmd.120.090639. [PMID] 32357971.
2020
Clinical Utility of Pharmacogene Panel-Based Testing in Patients Undergoing Percutaneous Coronary Intervention.
Clinical and translational science. 13(3):473-481 [DOI] 10.1111/cts.12729. [PMID] 31758664.
2020
Effect of Genetic and Nongenetic Factors on the Clinical Response to Mineralocorticoid Receptor Antagonist Therapy in Egyptians with Heart Failure.
Clinical and translational science. 13(1):195-203 [DOI] 10.1111/cts.12702. [PMID] 31560448.
2020
Examination of Metoprolol Pharmacokinetics and Pharmacodynamics Across CYP2D6 Genotype-Derived Activity Scores.
CPT: pharmacometrics & systems pharmacology. 9(12):678-685 [DOI] 10.1002/psp4.12563. [PMID] 33067866.
2020
How to Transition from Single-Gene Pharmacogenetic Testing to Preemptive Panel-Based Testing: A Tutorial.
Clinical pharmacology and therapeutics. 108(3):557-565 [DOI] 10.1002/cpt.1912. [PMID] 32460360.
2019
Brief Report: Relationship Between ABCC4 SNPs and Hepatitis B Virus Suppression During Tenofovir-Containing Antiretroviral Therapy in Patients With HIV/HBV Coinfection.
Journal of acquired immune deficiency syndromes (1999). 82(4):421-425 [DOI] 10.1097/QAI.0000000000002136. [PMID] 31335591.
2019
CYP2D6-guided opioid therapy improves pain control in CYP2D6 intermediate and poor metabolizers: a pragmatic clinical trial.
Genetics in medicine : official journal of the American College of Medical Genetics. 21(8):1842-1850 [DOI] 10.1038/s41436-018-0431-8. [PMID] 30670877.
2019
Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals.
Clinical pharmacology and therapeutics. 105(6):1477-1491 [DOI] 10.1002/cpt.1323. [PMID] 30506689.
2019
Effect of First-Line Antituberculosis Therapy on Nevirapine Pharmacokinetics in Children Younger than Three Years Old.
Antimicrobial agents and chemotherapy. 63(10) [DOI] 10.1128/AAC.00839-19. [PMID] 31332062.
2019
Effect of plasma MicroRNA on antihypertensive response to beta blockers in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) studies.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 131:93-98 [DOI] 10.1016/j.ejps.2019.02.013. [PMID] 30753892.
2019
Effect of Rifampin-Isoniazid-Containing Antituberculosis Therapy on Efavirenz Pharmacokinetics in HIV-Infected Children 3 to 14 Years Old.
Antimicrobial agents and chemotherapy. 63(1) [DOI] 10.1128/AAC.01657-18. [PMID] 30397066.
2019
Pharmacogenomics of osteonecrosis of the jaw.
Bone. 124:75-82 [DOI] 10.1016/j.bone.2019.04.010. [PMID] 31022475.
2019
Population pharmacokinetics of efavirenz in HIV and TB/HIV coinfected children: the significance of genotype-guided dosing.
The Journal of antimicrobial chemotherapy. 74(9):2698-2706 [DOI] 10.1093/jac/dkz238. [PMID] 31243456.
2019
The association of an alpha2C adrenoreceptor gene polymorphism with vasomotor symptoms in African American women.
Menopause (New York, N.Y.). 26(3):300-305 [DOI] 10.1097/GME.0000000000001218. [PMID] 30277919.
2018
A Genetic Score Associates With Pioglitazone Response in Patients With Non-alcoholic Steatohepatitis.
Frontiers in pharmacology. 9 [DOI] 10.3389/fphar.2018.00752. [PMID] 30065651.
2018
A Rapid Phenotypic Whole-Cell Screening Approach for the Identification of Small-Molecule Inhibitors That Counter β-Lactamase Resistance in Pseudomonas aeruginosa.
SLAS discovery : advancing life sciences R & D. 23(1):55-64 [DOI] 10.1177/2472555217728489. [PMID] 28850797.
2018
Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1.
Drug metabolism and disposition: the biological fate of chemicals. 46(8):1118-1128 [DOI] 10.1124/dmd.118.081810. [PMID] 29853471.
2018
Blood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies.
BMC medical genomics. 11(1) [DOI] 10.1186/s12920-018-0370-x. [PMID] 29925376.
2018
Design and rational for the precision medicine guided treatment for cancer pain pragmatic clinical trial.
Contemporary clinical trials. 68:7-13 [DOI] 10.1016/j.cct.2018.03.001. [PMID] 29535047.
2018
Effect of Genetic Variation of NAT2 on Isoniazid and SLCO1B1 and CES2 on Rifampin Pharmacokinetics in Ghanaian Children with Tuberculosis.
Antimicrobial agents and chemotherapy. 62(3) [DOI] 10.1128/AAC.02099-17. [PMID] 29263072.
2018
Implementation of Standardized Clinical Processes for TPMT Testing in a Diverse Multidisciplinary Population: Challenges and Lessons Learned.
Clinical and translational science. 11(2):175-181 [DOI] 10.1111/cts.12533. [PMID] 29351371.
2018
Influence of Vitamin K Epoxide Reductase Complex 1 Polymorphism on Warfarin Therapy in a Cohort Study of Saudi Patients
International Journal of Pharmacology. 14(3):415-420 [DOI] 10.3923/ijp.2018.415.420.
2018
Personalized Dosing of Dichloroacetate Using GSTZ1 Clinical Genotyping Assay.
Genetic testing and molecular biomarkers. 22(4):266-269 [DOI] 10.1089/gtmb.2017.0261. [PMID] 29641284.
2018
Pharmacogenetic and clinical predictors of response to clopidogrel plus aspirin after acute coronary syndrome in Egyptians.
Pharmacogenetics and genomics. 28(9):207-213 [DOI] 10.1097/FPC.0000000000000349. [PMID] 30188374.
2018
SIRT1/HERC4 Locus Associated With Bisphosphonate-Induced Osteonecrosis of the Jaw: An Exome-Wide Association Analysis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 33(1):91-98 [DOI] 10.1002/jbmr.3285. [PMID] 28856724.
2018
Targeted sequencing identifies a missense variant in the BEST3 gene associated with antihypertensive response to hydrochlorothiazide.
Pharmacogenetics and Genomics. 28(11):251-255 [DOI] 10.1097/FPC.0000000000000353. [PMID] 30289819.
2018
Unanticipated Cardiotoxicity Associated with Targeted Anticancer Therapy in Patients with Hematologic Malignancies Patients: Natural History and Risk Factors.
Cardiovascular toxicology. 18(2):184-191 [DOI] 10.1007/s12012-017-9429-8. [PMID] 29022233.
2017
Cross-Validation of High-Resolution Melting Analysis-Based Genotyping Platform.
Genetic testing and molecular biomarkers. 21(4):259-264 [DOI] 10.1089/gtmb.2016.0317. [PMID] 28384046.
2017
Epigenetic regulation of inflammation in localized aggressive periodontitis.
Clinical epigenetics. 9 [DOI] 10.1186/s13148-017-0385-8. [PMID] 28883894.
2017
Genome-Wide Prioritization and Transcriptomics Reveal Novel Signatures Associated With Thiazide Diuretics Blood Pressure Response.
Circulation. Cardiovascular genetics. 10(1) [DOI] 10.1161/CIRCGENETICS.116.001404. [PMID] 28115488.
2017
Impact of the CYP2C19 genotype on voriconazole exposure in adults with invasive fungal infections.
Pharmacogenetics and genomics. 27(5):190-196 [DOI] 10.1097/FPC.0000000000000277. [PMID] 28306618.
2017
Matrix Metalloproteinase Polymorphisms in Patients with Floppy Mitral Valve/Mitral Valve Prolapse (FMV/MVP) and FMV/MVP Syndrome.
Cardiology. 138(3):179-185 [DOI] 10.1159/000477656. [PMID] 28750369.
2017
Whole Transcriptome Sequencing Analyses Reveal Molecular Markers of Blood Pressure Response to Thiazide Diuretics.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-16343-z. [PMID] 29167564.
2016
CES1P1 variant -816A>C is not associated with hepatic carboxylesterase 1 expression and activity or antihypertensive effect of trandolapril.
European journal of clinical pharmacology. 72(6):681-7 [DOI] 10.1007/s00228-016-2029-x. [PMID] 26915813.
2016
Clinical Features and Treatment Outcomes of Primary Immune Thrombocytopenic Purpura in Hospitalized Children Under 2-Years Old.
Iranian journal of pediatric hematology and oncology. 6(1):24-31 [PMID] 27222699.
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2016
CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease.
Journal of neurosurgery. 124(6):1746-51 [DOI] 10.3171/2015.6.JNS15795. [PMID] 26587656.
2016
Genetic and Nongenetic Factors Affecting Clopidogrel Response in the Egyptian Population.
Clinical and translational science. 9(1):23-8 [DOI] 10.1111/cts.12383. [PMID] 26757134.
2016
Genetic Moderators of the Impact of Physical Activity on Depressive Symptoms.
The Journal of frailty & aging. 5(1):6-14 [DOI] 10.14283/jfa.2016.76. [PMID] 26980363.
2016
GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate.
Biochimica et biophysica acta. 1860(6):1202-10 [DOI] 10.1016/j.bbagen.2016.01.024. [PMID] 26850694.
2016
Identification of Suitable Endogenous Normalizers for qRT-PCR Analysis of Plasma microRNA Expression in Essential Hypertension.
Molecular biotechnology. 58(3):179-87 [DOI] 10.1007/s12033-015-9912-z. [PMID] 26798072.
2016
Impact of GGCX, STX1B and FPGS Polymorphisms on Warfarin Dose Requirements in European-Americans and Egyptians.
Clinical and translational science. 9(1):36-42 [DOI] 10.1111/cts.12385. [PMID] 26751406.
2016
Melatonin Pathway and Atenolol-Related Glucose Dysregulation: Is There a Correlation?
Clinical and translational science. 9(2):114-22 [DOI] 10.1111/cts.12389. [PMID] 26946962.
2016
Osteonecrosis of the Jaw in the United States Food and Drug Administration’s Adverse Event Reporting System (FAERS).
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 31(2):336-40 [DOI] 10.1002/jbmr.2693. [PMID] 26288087.
2016
Pharmacogenomic Genome-Wide Meta-Analysis of Blood Pressure Response to β-Blockers in Hypertensive African Americans.
Hypertension (Dallas, Tex. : 1979). 67(3):556-63 [DOI] 10.1161/HYPERTENSIONAHA.115.06345. [PMID] 26729753.
2016
The role of the COMT val158met polymorphism in mediating aversive learning in visual cortex.
NeuroImage. 125:633-642 [DOI] 10.1016/j.neuroimage.2015.11.003. [PMID] 26549298.
2015
A novel simple method for determining CYP2D6 gene copy number and identifying allele(s) with duplication/multiplication.
PloS one. 10(1) [DOI] 10.1371/journal.pone.0113808. [PMID] 25625348.
2015
Characterization of Multidrug Resistant Extended-Spectrum Beta-Lactamase-Producing Escherichia coli among Uropathogens of Pediatrics in North of Iran.
BioMed research international. 2015 [DOI] 10.1155/2015/309478. [PMID] 26064896.
2015
Chloral hydrate, through biotransformation to dichloroacetate, inhibits maleylacetoacetate isomerase and tyrosine catabolism in humans.
Drug metabolism and personalized therapy. 30(1):49-55 [DOI] 10.1515/dmdi-2014-0015. [PMID] 25283137.
2015
Correlating the Melatonin (Mt) Pathway With Atenolol Associated Glucose Dysregulation in the Pharmacogenomic Evaluation of Antihypertensive Responses (Pear) Study.
Clinical Pharmacology & Therapeutics. 97(1)
2015
Floppy mitral valve/mitral valve prolapse syndrome: Beta-adrenergic receptor polymorphism may contribute to the pathogenesis of symptoms.
Journal of cardiology. 65(5):434-8 [DOI] 10.1016/j.jjcc.2014.07.020. [PMID] 25172623.
2015
Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children.
Journal of clinical pharmacology. 55(1):50-5 [DOI] 10.1002/jcph.371. [PMID] 25079374.
2015
Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for tamoxifen pharmacogenetic studies.
Journal of the National Cancer Institute. 107(2) [DOI] 10.1093/jnci/dju437. [PMID] 25638249.
2015
PTPRD gene associated with blood pressure response to atenolol and resistant hypertension.
Journal of hypertension. 33(11):2278-85 [DOI] 10.1097/HJH.0000000000000714. [PMID] 26425837.
2015
Rapid Detection of Viable Bacillus Cereus Emetic and Enterotoxic Strains in Food By Coupling Propidium Monoazide and Multiplex Pcr (Pma-Mpcr)
Food Control. 55:151-157 [DOI] 10.1016/j.foodcont.2015.02.049.
2015
The influence of human GSTZ1 gene haplotype variations on GSTZ1 expression.
Pharmacogenetics and genomics. 25(5):239-45 [DOI] 10.1097/FPC.0000000000000129. [PMID] 25738370.
2014
A Cyp2C19 Genotype Guided Dosing Approach for Optimizing Voriconazole in Patients With Ifis.
Pharmacotherapy. 34(10)
2014
A Novel Simple Method for Determining Cyp2D6 Gene Copy Number and Identifying Allele(S) With Duplication/Multiplication.
Clinical Pharmacology & Therapeutics. 95(1)
2014
A Pharmacogenomic Genome-Wide Association Study for Adverse Cardiovascular Outcomes in the International Verapamil Sr-Trandolapril Study (Invest)
Clinical Pharmacology & Therapeutics. 95(1)
2014
Chloride and other anions inhibit dichloroacetate-induced inactivation of human liver GSTZ1 in a haplotype-dependent manner.
Chemico-biological interactions. 215:33-9 [DOI] 10.1016/j.cbi.2014.02.015. [PMID] 24632415.
2014
Clinical pharmacogenetics implementation: approaches, successes, and challenges.
American journal of medical genetics. Part C, Seminars in medical genetics. 166C(1):56-67 [DOI] 10.1002/ajmg.c.31390. [PMID] 24616371.
2014
Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations.
Human molecular genetics. 23(9):2498-510 [DOI] 10.1093/hmg/ddt626. [PMID] 24345515.
2014
Genetic variant in folate homeostasis is associated with lower warfarin dose in African Americans.
Blood. 124(14):2298-305 [DOI] 10.1182/blood-2014-04-568436. [PMID] 25079360.
2014
Genome-Wide Association Analysis (Gwas) of Blood Pressure Response To Atenolol-Results From the Pharmacogenomic Evaluation of Antihypertensive Responses (Pear) Study
Clinical Pharmacology & Therapeutics. 95(1):S16-S17
2014
Hydrochlorothiazide-induced hyperuricaemia in the pharmacogenomic evaluation of antihypertensive responses study.
Journal of internal medicine. 276(5):486-97 [DOI] 10.1111/joim.12215. [PMID] 24612202.
2014
Impact of CYP2D6 polymorphisms on clinical efficacy and tolerability of metoprolol tartrate.
Clinical pharmacology and therapeutics. 96(2):175-81 [DOI] 10.1038/clpt.2014.62. [PMID] 24637943.
2014
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
Investigational new drugs. 32(3):452-64 [DOI] 10.1007/s10637-013-0047-4. [PMID] 24297161.
2014
Pyrosequencing of the CYP2C9 -1766T>C polymorphism as a means of detecting the CYP2C9*8 allele.
Pharmacogenomics. 15(13):1717-22 [DOI] 10.2217/pgs.14.130. [PMID] 25410896.
2014
The influence of the CYP2C19*10 allele on clopidogrel activation and CYP2C19*2 genotyping.
Pharmacogenetics and genomics. 24(8):381-6 [DOI] 10.1097/FPC.0000000000000068. [PMID] 24945780.
2013
Association of chromosome 12 locus with antihypertensive response to hydrochlorothiazide may involve differential YEATS4 expression.
The pharmacogenomics journal. 13(3):257-63 [DOI] 10.1038/tpj.2012.4. [PMID] 22350108.
2013
Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment.
The pharmacogenomics journal. 13(5):430-6 [DOI] 10.1038/tpj.2012.34. [PMID] 22907731.
2013
Association of variants in NEDD4L with blood pressure response and adverse cardiovascular outcomes in hypertensive patients treated with thiazide diuretics.
Journal of hypertension. 31(4):698-704 [DOI] 10.1097/HJH.0b013e32835e2a71. [PMID] 23353631.
2013
Atenolol induced HDL-C change in the pharmacogenomic evaluation of antihypertensive responses (PEAR) study.
PloS one. 8(10) [DOI] 10.1371/journal.pone.0076984. [PMID] 24116192.
2013
Fasting Glucose Loci Associated With Glucose Response To Antihypertensives- Results From the Pharmacogenomic Evaluation of Antihypertensive Responses (Pear) Study
Clinical Pharmacology & Therapeutics. 93
2013
Fasting Glucose Loci Associated With Glucose Response To Antihypertensives- Results From the Pharmacogenomic Evaluation of Antihypertensive Responses (Pear) Study
Clinical Pharmacology & Therapeutics. 93
2013
Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.
Lancet (London, England). 382(9894):790-6 [DOI] 10.1016/S0140-6736(13)60681-9. [PMID] 23755828.
2013
Impact of Cyp2D6 Polymorphisms On the Clinical Response and Tolerability of Immediate Release Metoprolol.
Pharmacotherapy. 33
2013
Impact of TCF7L2 single nucleotide polymorphisms on hydrochlorothiazide-induced diabetes.
Pharmacogenetics and genomics. 23(12):697-705 [DOI] 10.1097/FPC.0000000000000012. [PMID] 24128935.
2013
Lack of association of the HMGA1 IVS5-13insC variant with type 2 diabetes in an ethnically diverse hypertensive case control cohort.
Journal of translational medicine. 11 [DOI] 10.1186/1479-5876-11-12. [PMID] 23302499.
2013
Loci influencing blood pressure identified using a cardiovascular gene-centric array.
Human molecular genetics. 22(8):1663-78 [DOI] 10.1093/hmg/dds555. [PMID] 23303523.
2013
Long-term safety of dichloroacetate in congenital lactic acidosis.
Molecular genetics and metabolism. 109(2):139-43 [DOI] 10.1016/j.ymgme.2013.03.019. [PMID] 23611579.
2013
Pharmacogenomic association of nonsynonymous SNPs in SIGLEC12, A1BG, and the selectin region and cardiovascular outcomes.
Hypertension (Dallas, Tex. : 1979). 62(1):48-54 [DOI] 10.1161/HYPERTENSIONAHA.111.00823. [PMID] 23690342.
2013
The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation.
Clinical pharmacology and therapeutics. 94(2):207-10 [DOI] 10.1038/clpt.2013.59. [PMID] 23588301.
2013
Vkorc1 Asp36Tyr Geographic Distribution and Its Impact On Warfarin Dose Requirements in Egyptians
Clinical Pharmacology & Therapeutics. 93
2013
VKORC1 Asp36Tyr geographic distribution and its impact on warfarin dose requirements in Egyptians.
Thrombosis and haemostasis. 109(6):1045-50 [DOI] 10.1160/TH12-10-0789. [PMID] 23571513.
2012
Alpha Adducin-1 (Add1)Singlenucleotide Polymorphism (Snp) Associated With New Onset Diabetes Risk With Hydrochlorothiazide (Hctz) Therapy in the International Verapamil Sr Trandolapril Genetic Substudy (Invest-Genes)
Clinical Pharmacology & Therapeutics. 91
2012
Antihypertensive Medication Exposure and Adverse Glycemic Effects: An Evaluation of Fasting and Stimulated Glucose
Clinical Pharmacology & Therapeutics. 91
2012
Association of Fto With Hydrochlorothiazide (Hctz)-Induced Elevation in Uric Acid (Ua) in African American (Aa) Hypertensives in the Pharmacogenomic Evaluation of Antihypertensive Response (Pear) Study.
Clinical Pharmacology & Therapeutics. 91:S59-S60
2012
Chronic pain, perceived stress, and cellular aging: an exploratory study.
Molecular pain. 8 [DOI] 10.1186/1744-8069-8-12. [PMID] 22325162.
2012
Clinical Predictors of Dysglycemic Effects Associated With Use of Beta Blockers and Thiazide Diuretics
Clinical Pharmacology & Therapeutics. 91:S24-S25
2012
CXCL5 polymorphisms are associated with variable blood pressure in cardiovascular disease-free adults.
Human genomics. 6 [DOI] 10.1186/1479-7364-6-9. [PMID] 23245743.
2012
CYP2C9 promoter variable number tandem repeat polymorphism regulates mRNA expression in human livers.
Drug metabolism and disposition: the biological fate of chemicals. 40(5):884-91 [DOI] 10.1124/dmd.111.044255. [PMID] 22289258.
2012
Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide.
Journal of translational medicine. 10 [DOI] 10.1186/1479-5876-10-56. [PMID] 22440088.
2012
G protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertension.
Hypertension (Dallas, Tex. : 1979). 60(4):957-64 [DOI] 10.1161/HYPERTENSIONAHA.112.198721. [PMID] 22949529.
2012
Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate.
Journal of clinical pharmacology. 52(6):837-49 [DOI] 10.1177/0091270011405664. [PMID] 21642471.
2012
Hypertension susceptibility loci and blood pressure response to antihypertensives: results from the pharmacogenomic evaluation of antihypertensive responses study.
Circulation. Cardiovascular genetics. 5(6):686-91 [DOI] 10.1161/CIRCGENETICS.112.964080. [PMID] 23087401.
2012
Impact of the CYP4F2 p.V433M polymorphism on coumarin dose requirement: systematic review and meta-analysis.
Clinical pharmacology and therapeutics. 92(6):746-56 [DOI] 10.1038/clpt.2012.184. [PMID] 23132553.
2012
Implementing personalized medicine: development of a cost-effective customized pharmacogenetics genotyping array.
Clinical pharmacology and therapeutics. 92(4):437-9 [DOI] 10.1038/clpt.2012.125. [PMID] 22910441.
2012
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
American journal of human genetics. 91(5):823-38 [DOI] 10.1016/j.ajhg.2012.08.032. [PMID] 23063622.
2012
Non-Synonymous Snps in Sele, Selp, and Siglec12 Associate With Cardiovascular (Cv) Outcomes in the International Verapamil Sr-Trandol-April Study Genetic Substudy (Invest-Genes)
Clinical Pharmacology & Therapeutics. 91:S20-S21
2012
Prenatal and postnatal expression of glutathione transferase ζ 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate.
Drug metabolism and disposition: the biological fate of chemicals. 40(2):232-9 [DOI] 10.1124/dmd.111.041533. [PMID] 22028318.
2012
Urate transporter gene SLC22A12 polymorphisms associated with obesity and metabolic syndrome in Caucasians with hypertension.
Kidney & blood pressure research. 35(6):477-82 [DOI] 10.1159/000337370. [PMID] 22688828.
2011
Association of apolipoprotein E genotype with duration of time to achieve a stable warfarin dose in African-American patients.
Pharmacotherapy. 31(8):785-92 [DOI] 10.1592/phco.31.8.785. [PMID] 21923605.
2011
Chromosome 9p21 haplotypes and prognosis in white and black patients with coronary artery disease.
Circulation. Cardiovascular genetics. 4(2):169-78 [DOI] 10.1161/CIRCGENETICS.110.959296. [PMID] 21372283.
2011
Dichloroacetate-Dependent Inactivation of Gstz1 in Human Liver Cytosol Is Modulated By Physiologically Important Anions in a Gstz1 Haplotype-Dependent Manner
Drug Metabolism Reviews. 43
2011
Effect of cytochrome P450 3A5 genotype on atorvastatin pharmacokinetics and its interaction with clarithromycin.
Pharmacotherapy. 31(10):942-50 [DOI] 10.1592/phco.31.10.942. [PMID] 21950641.
2011
Genetic and nongenetic factors associated with warfarin dose requirements in Egyptian patients.
Pharmacogenetics and genomics. 21(3):130-5 [DOI] 10.1097/FPC.0b013e3283436b86. [PMID] 21228733.
2011
Genetic polymorphisms and other risk factors associated with bisphosphonate induced osteonecrosis of the jaw.
International journal of oral and maxillofacial surgery. 40(6):605-11 [DOI] 10.1016/j.ijom.2011.02.002. [PMID] 21396799.
2011
Influence of G Protein Receptor Kinase 4 (Grk4) Polymorphisms On Blood Pressure Response To the Beta-Blocker Atenolol.
Clinical Pharmacology & Therapeutics. 89
2011
Kcnj1 Snps Are Associated With Increased Fasting Glucose and Risk of New Onset Diabetes During Hctz Therapy
Clinical Pharmacology & Therapeutics. 89
2011
Predictability of Glutathione Transferase Zeta 1 Haplotype On Kinetics of Dichloroacetate in Human Trials
Drug Metabolism Reviews. 43:181-182
2011
Response To Letter Regarding Article “Chromosome 9P21 Haplotypes and Prognosis in White and Black Patients With Coronary Artery Disease”
Circulation-Cardiovascular Genetics. 4 [DOI] 10.1161/CIRCGENETICS.111.960807.
2010
Association Between Melatonin Receptor 1B Single Nucleotide Polymorphisms (Snps) and Response To Antihypertensive Drugs.
Clinical Pharmacology & Therapeutics. 87
2010
Genetic and clinical predictors of warfarin dose requirements in African Americans.
Clinical pharmacology and therapeutics. 87(4):459-64 [DOI] 10.1038/clpt.2009.223. [PMID] 20072124.
2010
Genetic variation in the beta2 subunit of the voltage-gated calcium channel and pharmacogenetic association with adverse cardiovascular outcomes in the INternational VErapamil SR-Trandolapril STudy GENEtic Substudy (INVEST-GENES).
Circulation. Cardiovascular genetics. 3(6):548-55 [DOI] 10.1161/CIRCGENETICS.110.957654. [PMID] 21156931.
2010
Lack of association between polymorphisms in STK39, a putative thiazide response gene, and blood pressure response to hydrochlorothiazide.
Pharmacogenetics and genomics. 20(8):516-9 [DOI] 10.1097/FPC.0b013e32833b5958. [PMID] 20555294.
2010
New-Onset Diabetes Risk Associated With Antihypertensive Therapy in Hypertensive Coronary Artery Disease Patients Is Modified By a Single Nucleotide Polymorphism (Snp) in the L-Type Calcium Channel (Ltcc)
Clinical Pharmacology & Therapeutics. 87
2010
Study of Vkorc1, Cyp2C9, and Cyp4F2 Polymorphisms and Their Association With Warfarin Dose Requirements in Egyptian Patients.
. 50
2010
Yeats4 Gene Region Polymorphisms Associate With Antihypertensive Response To Hydrochlorothiazide in African Americans.
Clinical Pharmacology & Therapeutics. 87
2009
Altered beta-2 adrenergic receptor gene expression in human clinical hypertension.
Biological research for nursing. 11(1):17-26 [DOI] 10.1177/1099800409332538. [PMID] 19254913.
2009
Association between CARD15/NOD2 gene polymorphisms and paratuberculosis infection in cattle.
Veterinary microbiology. 134(3-4):346-52 [DOI] 10.1016/j.vetmic.2008.09.052. [PMID] 18926647.
2009
CACNA1C gene polymorphisms, cardiovascular disease outcomes, and treatment response.
Circulation. Cardiovascular genetics. 2(4):362-70 [DOI] 10.1161/CIRCGENETICS.109.857839. [PMID] 20031608.
2009
Candidate gene polymorphisms (BoIFNG, TLR4, SLC11A1) as risk factors for paratuberculosis infection in cattle.
Preventive veterinary medicine. 91(2-4):189-96 [DOI] 10.1016/j.prevetmed.2009.05.020. [PMID] 19525022.
2009
Estimation of the Warfarin Dose With Clinical and Pharmacogenetic Data
New England Journal of Medicine. 360:753-764
2009
Genotyping the GGGCGG tandem repeat promoter polymorphism in the 5-lipoxygenase enzyme gene (ALOX5) by pyrosequencing assay.
Genetic testing and molecular biomarkers. 13(3):361-5 [DOI] 10.1089/gtmb.2008.0103. [PMID] 19473080.
2009
Pharmacogenetics: from discovery to patient care.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 66(7):625-37 [DOI] 10.2146/ajhp080170. [PMID] 19299369.
2009
Promoter polymorphisms in ACE (angiotensin I-converting enzyme) associated with clinical outcomes in hypertension.
Clinical pharmacology and therapeutics. 85(1):36-44 [DOI] 10.1038/clpt.2008.194. [PMID] 18946466.
2008
A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.
Blood. 112(4):1022-7 [DOI] 10.1182/blood-2008-01-134247. [PMID] 18535201.
2008
Alpha-adducin polymorphism associated with increased risk of adverse cardiovascular outcomes: results from GENEtic Substudy of the INternational VErapamil SR-trandolapril STudy (INVEST-GENES).
American heart journal. 156(2):397-404 [DOI] 10.1016/j.ahj.2008.03.007. [PMID] 18657677.
2008
Association of beta1-adrenergic receptor genetic polymorphism with mental stress-induced myocardial ischemia in patients with coronary artery disease.
Archives of internal medicine. 168(7):763-70 [DOI] 10.1001/archinte.168.7.763. [PMID] 18413560.
2008
B1-Adrenergic Receptor Polymorphism Predicts Mental Stress-Induced Myocardial Ischemia in Patients With Coronary Artery Disease
Journal of the American College of Cardiology. 51
2008
beta-adrenergic receptor gene polymorphisms and beta-blocker treatment outcomes in hypertension.
Clinical pharmacology and therapeutics. 84(6):715-21 [DOI] 10.1038/clpt.2008.139. [PMID] 18615004.
2008
Cacnaic Polymorphisms and Cardiovascular Outcomes in the International Verapamil Sr/Trandolapril Study-Genetic Substudy (Invest-Genes).
Clinical Pharmacology & Therapeutics. 83
2008
CXCL5 gene polymorphism association with diabetes mellitus.
Molecular diagnosis & therapy. 12(6):391-4 [DOI] 10.2165/1250444-200812060-00005. [PMID] 19035625.
2008
CYP4F2 genetic variant alters required warfarin dose.
Blood. 111(8):4106-12 [DOI] 10.1182/blood-2007-11-122010. [PMID] 18250228.
2008
Interpopulation variation frequency of human inosine 5′-monophosphate dehydrogenase type II (IMPDH2) genetic polymorphisms.
Genetic testing. 12(4):513-6 [DOI] 10.1089/gte.2008.0049. [PMID] 18976158.
2008
Novel Promoter Polymorphisms in Angiotensin-I Converting Enzyme (Ace) Associated With Clinical Outcomes in Hypertensive Coronary Artery Disease (Cad) Patients.
Clinical Pharmacology & Therapeutics. 83
2008
Persistence of restricted CD4 T cell expansions in SIV-infected macaques resistant to SHIV89.6P superinfection.
Virology. 377(2):239-47 [DOI] 10.1016/j.virol.2008.04.031. [PMID] 18570962.
2008
Role of dichloroacetate in the treatment of genetic mitochondrial diseases.
Advanced drug delivery reviews. 60(13-14):1478-87 [DOI] 10.1016/j.addr.2008.02.014. [PMID] 18647626.
2008
Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis.
American journal of human genetics. 82(6):1241-8 [DOI] 10.1016/j.ajhg.2008.04.015. [PMID] 18485328.
2008
Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin.
Clinical pharmacology and therapeutics. 84(3):326-31 [DOI] 10.1038/clpt.2008.10. [PMID] 18305455.
2008
VKORC1 and CYP2C9 polymorphisms are associated with warfarin dose requirements in Turkish patients.
European journal of clinical pharmacology. 64(9):889-94 [DOI] 10.1007/s00228-008-0507-5. [PMID] 18542936.
2007
Assessment of human serotonin 1A receptor polymorphisms and SSRI responsiveness.
Molecular diagnosis & therapy. 11(3):155-60 [PMID] 17570737.
View on: PubMed
2007
Association of CYP3A5 polymorphisms with hypertension and antihypertensive response to verapamil.
Clinical pharmacology and therapeutics. 81(3):386-91 [PMID] 17339868.
View on: PubMed
2007
Factors influencing blood pressure response to trandolapril add-on therapy in patients taking verapamil SR (from the International Verapamil SR/Trandolapril [INVEST] Study).
The American journal of cardiology. 99(11):1549-54 [PMID] 17531579.
View on: PubMed
2007
KCNMB1 genotype influences response to verapamil SR and adverse outcomes in the INternational VErapamil SR/Trandolapril STudy (INVEST).
Pharmacogenetics and genomics. 17(9):719-29 [PMID] 17700361.
View on: PubMed
2007
Relation of beta(2)-adrenoceptor haplotype to risk of death and heart transplantation in patients with heart failure.
The American journal of cardiology. 99(2):250-5 [PMID] 17223428.
View on: PubMed
2007
Single nucleotide polymorphism discovery and haplotype analysis of Ca2+-dependent K+ channel beta-1 subunit.
Pharmacogenetics and genomics. 17(4):267-75 [PMID] 17496725.
View on: PubMed
2007
Synergistic polymorphisms of beta1 and alpha2C-adrenergic receptors and the influence on left ventricular ejection fraction response to beta-blocker therapy in heart failure.
Pharmacogenetics and genomics. 17(4):277-82 [PMID] 17496726.
View on: PubMed
2006
Common laboratory methods in pharmacogenomics studies.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 63(21):2101-10 [PMID] 17057047.
View on: PubMed
2006
CXCL5 gene polymorphisms are related to systemic concentrations and leukocyte production of epithelial neutrophil-activating peptide (ENA-78).
Cytokine. 33(5):258-63 [PMID] 16567110.
View on: PubMed
2006
Development and cross-validation of sequencing-based assays for genotyping common polymorphisms of the CXCL5 gene.
Clinica chimica acta; international journal of clinical chemistry. 370(1-2):72-5 [PMID] 16574090.
View on: PubMed
2006
Influence of coagulation factor, vitamin K epoxide reductase complex subunit 1, and cytochrome P450 2C9 gene polymorphisms on warfarin dose requirements.
Clinical pharmacology and therapeutics. 79(4):291-302 [PMID] 16580898.
View on: PubMed
2006
Multiplex PCR-pyrosequencing assay for genotyping CYP3A5 polymorphisms.
Clinica chimica acta; international journal of clinical chemistry. 372(1-2):195-8 [PMID] 16701601.
View on: PubMed
2005
Genetic variation analyses by Pyrosequencing.
Mutation research. 573(1-2):96-102 [PMID] 15829240.
View on: PubMed
2005
Single nucleotide polymorphisms: discovery, detection and analysis.
Personalized medicine. 2(2):111-125 [DOI] 10.1517/17410541.2.2.111. [PMID] 29788584.
2005
The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects.
British journal of clinical pharmacology. 59(1):70-9 [PMID] 15606443.
View on: PubMed
2004
Comparison of cytochrome P450 2C9 genotyping methods and implications for the clinical laboratory.
Pharmacotherapy. 24(6):720-6 [PMID] 15222661.
View on: PubMed
2004
Pyrosequencing method for genotyping cytochrome P450 CYP2C8 and CYP2C9 enzymes.
Clinical chemistry. 50(12):2392-5 [PMID] 15563491.
View on: PubMed
2000
Inactivation of the ampD gene in Pseudomonas aeruginosa leads to moderate-basal-level and hyperinducible AmpC beta-lactamase expression.
Antimicrobial agents and chemotherapy. 44(3):583-9 [PMID] 10681322.
View on: PubMed
1998
An ampD gene in Pseudomonas aeruginosa encodes a negative regulator of AmpC beta-lactamase expression.
Antimicrobial agents and chemotherapy. 42(12):3296-300 [PMID] 9835532.
View on: PubMed

Grants

Dec 2020 ACTIVE
Pharmacokinetics and Pharmacodynamics of Dolutegravir in Children Weighing =20 Kg Living with HIV with and without TB Coinfection
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jul 2020 ACTIVE
Precision antiplatelet therapy after percutaneous coronary intervention
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Apr 2020 ACTIVE
Adherence and Intracellular Pharmacology of Tenofovir and HBV Suppression in People with HBV/HIV Coinfection
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Sep 2018 ACTIVE
Pharmacokinetics of Anti-tuberculosis and Antiretroviral Drugs in Children
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Jul 2017 ACTIVE
Countering beta-lactam resistance in Pseudomonas aeruginosa
Role: Faculty
Funding: NATL INST OF HLTH NIAID
Nov 2016 – Nov 2017
Genotyping for the Alpha 2C adrenoreceptor del 322-325 polymorphism.
Role: Principal Investigator
Funding: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Jun 2016 – Aug 2018
Pharmacokinetics of Anti-tuberculosis and Antiretroviral Drugs in Children
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Sep 2015 – Mar 2016
RAPID HAPLOTYPING PROCEDURE FOR DETERMINING THE RESPONSE OFPATIENTS TO DCA
Role: Project Manager
Funding: MEDOSOME BIOTEC via US FOOD AND DRUG ADMN
Jul 2015 – Jun 2017
Countering beta-lactam resistance in Pseudomonas aeruginosa
Role: Project Manager
Funding: NATL INST OF HLTH NIAID
Sep 2012 – Aug 2016
Developmental Pharmacology of Cytosolic and Mitochondrials GSTZ1-1/MAAI
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS

Patents

Issued September 2017
Methods and Kits For Predicting Dosing and Improving Safety of Dichloroacetate (DCA)
#9,765,393
Published October 2010
Pharmacogenetics for the Identification of Risk Factors for Development of Jaw Osteonrcrosis in Patients on Biphosphonates
#US-2011-0166107

Education

Ph.D.
1999 · Laval University
M.Sc.
1987 · Tehran University of Medical Sciences
B.Sc.
1979 · University of Texas at Arlington

Teaching Profile

Courses Taught
2012,2018-2020,2020
PHA6427 Pharmacogenetics of Drug Metabolism
2015-2017
PHA7980 Research for Doctoral Dissertation
2015-2017
PHA7979 Advanced Research
2016
PHA6971 Research for Master’s Thesis
2015-2016
PHA6938 Research Seminar
2009-2010,2013-2014
PHA5907 Research in Phar Prac
2014
DEN6678 Advanced Oral Medicine and Drug Interactions in Dentistry
2012-2013
PHA5113 Personalized Medicine
2012
PHA6449 Pharmacogenomics
2011
PHA5113C Thera Mon/Pharmacogen
2009
PHA4907 Probs in Pharm Prac

Contact Details

Phones:
Business:
(352) 273-6357
Emails: