Maureen Keller-Wood

Maureen Keller-Wood, Ph.D.

Professor Emeritus

Department: Pharmacodynamics
Business Phone: (352) 273-7687
Business Email: mkeller@ufl.edu

About Maureen Keller-Wood

Maureen Keller-Wood, Ph.D., is a professor emeritus in pharmacodynamics. She formerly served the UF College of Pharmacy as the associate dean for research and graduate education from 2015-2023. Dr. Keller-Wood’s overall research interest is the physiologic adaptations to pregnancy and effects of maternal physiology on fetal maturation and growth. Her current research focuses on understanding the mechanism for increased stillbirth and neonatal mortality in pregnancies complicated by maternal hypercortisolemia and altered maternal and fetal glucose metabolism. She received her Ph.D. in endocrinology from the University of California, San Francisco, in 1982 and her Bachelor of Arts in biochemistry from Vassar College in 1977.

Accomplishments

Liley Lectureship
2017 · Perinatal Research Society
CV Professorship
2013-current · University of Florida, College of Pharmacy
UFRF Professorship
2012-2015 · University of Florida
UFRF Professorship
2000-2003 · University of Florida

Teaching Profile

Courses Taught
2016,2018-2020,2020-2021
PHA5878C Pt Care 3: Cv and Pulm
2015-2018,2020-2021
PHA5560 Pathphys-Pt Assess I
2007,2009-2015,2015-2023,2020-2023
PHA6512L Experiential Research Training in Pharmacodynamics
2011-2012,2014-2021,2020-2021
PHA6521C Research Techniques in Pharmacodynamics
2006,2009-2012,2012-2020
PHA7979 Advanced Research
2009-2013,2015-2021,2020-2021
PHA6936 Advanced Topics in Pharmaceutical Sciences
2007,2009-2020
PHA7980 Research for Doctoral Dissertation
2019-2024
PHA6935 Selected Topics in Pharmacy
2009-2012,2015-2019,2019
PHA6910 Supervised Research
2016,2019-2021,2021
PHA5561 Pathphys-Pt Assess II
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2018
VME7980 Research for Doctoral Dissertation
2017-2018,2021
PHA5787C Pt Care 5: Endo
2017,2021-2022
PHA6894 Introduction to Graduate Studies
2016
PHA4911 Undergraduate Research in Pharmacodynamics
2012-2016
PHA5517 Pharmacol Bas Ther 2
2010,2012-2015,2015
PHA5902 Research Pharmacodyna
2012-2015
PHA5561C Physiol Bas Disease 2
2013-2015
PHA6509 Systems Physiology and Pathophysiology II
2010-2014
PHA5560C Physiol Bas Disease 1
2014,2022-2023
PHA6508 Systems Physiology and Pathophysiology I
2010-2011,2013
PHA7939 Journal Colloquy in Pharmacodynamics
2010-2012
PHA6971 Masters Research
2009-2011
PHA4902 Prob Pharmacodynamics
2009-2010
PHA6938 Research Seminar
2010
PHA6540 Neurochem Founda
2009
IDH4917 Undergrad Research
2021
PHA5787 Pharmacotherapy 5
2022
PHA6946 Practicum in the Pharmaceutical Sciences
2022-2024
PHA6740 Fundamentals of Grant Writing in the Pharmaceutical Sciences

Research Profile

Dr. Keller-Wood’s overall research interest is the physiologic adaptations to pregnancy and effects of maternal physiology on fetal maturation and growth. Her areas of current interest are:

The laboratory has a long standing interest in the effects of the adrenal hormone cortisol. Secretion of cortisol is increased in pregnancy, and this hormone mediates important adaptive physiologic effects necessary for regulating blood glucose, blood pressure, fluid and electrolyte excretion, appetite, and mood. The research team is interested in the role of the normal increase in cortisol and its action in both the mother and in the fetus, as well as the adverse effects that occur when there are excess increases in maternal cortisol in pregnancy, as occurs with maternal stress.

A major current focus of the laboratory is the adverse effects of maternal cortisol on fetal and neonatal cardiac health and metabolism. Excess maternal cortisol secretion in late gestation is associated with an increased risk of stillbirth. Researchers are using a combination of techniques to determine the effects of cortisol on fetal cardiac maturation and on function during labor and delivery. These include in vivo techniques such as telemetry to continuously monitor fetal ECG and arterial pressure during labor and delivery, transcriptomic methods to determine altered expression of genes as a result of pre-term cortisol exposure, biochemical techniques to assess mitochondrial function, and metabolomic techniques to assess shifts in metabolism. These studies include collaborations with Drs. Matthew Merritt, Jennifer Co-Vu, and Stephanie Wohlgemuth at UF, as well as Dr. Art Edison at UGa. In collaboration with Dr. Peter Stacpoole, the research is also testing the efficacy of treatment with dicholoracetate in ameliorating adverse events during labor and delivery.

Her research team recently has collaborated with Drs. Charles Wood, Eric Triplett and Kelly RIce to examine the effects of maternal stress on the maternal microbiome, and effects of altered maternal bacterial populations on fetal and neonatal health.

She has also collaborated with Dr. Kirk Conrad and others on a grant to investigate the cardiorenal adaptions to pregnancy in women who become pregnant through assisted reproductive technologies (ART). ART has been associated with increases in maternal cardiorenal disease and in the incidence of small for gestation infants. She served as PI of the analytic core for this P01 which performed analysis of plasma, serum and urine to determine endocrine, electrolyte and other endpoints.

Publications

Academic Articles
2022
Chronic maternal hypercortisolemia models stress-induced adverse birth outcome and altered cardiac function in newborn lambs.
American journal of physiology. Regulatory, integrative and comparative physiology. 323(2):R193-R203 [DOI] 10.1152/ajpregu.00041.2022. [PMID] 35670476.
2022
Sodium dichloroacetate stimulates cardiac mitochondrial metabolism and improves cardiac conduction in the ovine fetus during labor.
American journal of physiology. Regulatory, integrative and comparative physiology. 322(1):R83-R98 [DOI] 10.1152/ajpregu.00185.2021. [PMID] 34851727.
2021
Application of Carbon-13 Isotopomer Analysis to Assess Perinatal Myocardial Glucose Metabolism in Sheep.
Metabolites. 11(1) [DOI] 10.3390/metabo11010033. [PMID] 33466367.
2021
Relationships between reproductive hormones and maternal pregnancy physiology in women conceiving with or without in vitro fertilization.
American journal of physiology. Regulatory, integrative and comparative physiology. 321(3):R454-R468 [DOI] 10.1152/ajpregu.00174.2020. [PMID] 34346723.
2021
Transfer of oral bacteria to the fetus during late gestation.
Scientific reports. 11(1) [DOI] 10.1038/s41598-020-80653-y. [PMID] 33436911.
2020
Diabetes Leads to Alterations in Normal Metabolic Transitions of Pregnancy as Revealed by Time-Course Metabolomics.
Metabolites. 10(9) [DOI] 10.3390/metabo10090350. [PMID] 32867274.
2020
Differential gene responses 3 days following infarction in the fetal and adolescent sheep heart.
Physiological genomics. 52(3):143-159 [DOI] 10.1152/physiolgenomics.00092.2019. [PMID] 31961761.
2020
Fetal ovine skeletal and cardiac muscle transcriptomics are differentially altered by increased maternal cortisol during gestation.
Physiological genomics. 52(4):178-190 [DOI] 10.1152/physiolgenomics.00096.2019. [PMID] 32116114.
2020
Maternal hypercortisolemia alters placental metabolism: a multiomics view.
American journal of physiology. Endocrinology and metabolism. 319(5):E950-E960 [DOI] 10.1152/ajpendo.00190.2020. [PMID] 32954824.
2020
Pharmacokinetic and Biochemical Profiling of Sodium Dichloroacetate in Pregnant Ewes and Fetuses.
Drug metabolism and disposition: the biological fate of chemicals. 49(6):451-458 [DOI] 10.1124/dmd.120.000330. [PMID] 33811107.
2019
A Transcriptomic Model of Postnatal Cardiac Effects of Prenatal Maternal Cortisol Excess in Sheep.
Frontiers in physiology. 10 [DOI] 10.3389/fphys.2019.00816. [PMID] 31333485.
2019
Chronic maternal cortisol excess during late gestation leads to metabolic alterations in the newborn heart.
American journal of physiology. Endocrinology and metabolism. 316(3):E546-E556 [DOI] 10.1152/ajpendo.00386.2018. [PMID] 30620638.
2019
Contamination Is Not Linked to the Gestational Microbiome.
Applied and environmental microbiology. 85(19) [DOI] 10.1128/AEM.01127-19. [PMID] 31350318.
2019
Current paradigms and new perspectives on fetal hypoxia: implications for fetal brain development in late gestation.
American journal of physiology. Regulatory, integrative and comparative physiology. 317(1):R1-R13 [DOI] 10.1152/ajpregu.00008.2019. [PMID] 31017808.
2019
Effect of Mode of Conception on Maternal Serum Relaxin, Creatinine, and Sodium Concentrations in an Infertile Population.
Reproductive sciences (Thousand Oaks, Calif.). 26(3):412-419 [DOI] 10.1177/1933719118776792. [PMID] 29862889.
2019
Mechanisms of in utero cortisol effects on the newborn heart revealed by transcriptomic modeling.
American journal of physiology. Regulatory, integrative and comparative physiology. 316(4):R323-R337 [DOI] 10.1152/ajpregu.00322.2018. [PMID] 30624972.
2019
Potential influence of the corpus luteum on circulating reproductive and volume regulatory hormones, angiogenic and immunoregulatory factors in pregnant women.
American journal of physiology. Endocrinology and metabolism. 317(4):E677-E685 [DOI] 10.1152/ajpendo.00225.2019. [PMID] 31408378.
2019
Proof of principle: Physiological transfer of small numbers of bacteria from mother to fetus in late-gestation pregnant sheep.
PloS one. 14(6) [DOI] 10.1371/journal.pone.0217211. [PMID] 31170184.
2019
Transcriptomic evidence that cortisol alters perinatal epicardial adipose tissue maturation.
American journal of physiology. Endocrinology and metabolism. 317(4):E573-E585 [DOI] 10.1152/ajpendo.00007.2019. [PMID] 31322429.
2018
A transcriptomics model of estrogen action in the ovine fetal hypothalamus: evidence for estrogenic effects of ICI 182,780.
Physiological reports. 6(18) [DOI] 10.14814/phy2.13871. [PMID] 30221477.
2018
Chronic maternal hypercortisolemia in late gestation alters fetal cardiac function at birth.
American journal of physiology. Regulatory, integrative and comparative physiology. 314(3):R342-R352 [DOI] 10.1152/ajpregu.00296.2017. [PMID] 29092858.
2018
Global Metabolomics of the Placenta Reveals Distinct Metabolic Profiles between Maternal and Fetal Placental Tissues Following Delivery in Non-Labored Women.
Metabolites. 8(1) [DOI] 10.3390/metabo8010010. [PMID] 29360753.
2018
Ketamine Reduces Inflammation Pathways in the Hypothalamus and Hippocampus Following Transient Hypoxia in the Late-Gestation Fetal Sheep.
Frontiers in physiology. 9 [DOI] 10.3389/fphys.2018.01858. [PMID] 30666211.
2018
Multiomics approach reveals metabolic changes in the heart at birth.
American journal of physiology. Endocrinology and metabolism. 315(6):E1212-E1223 [DOI] 10.1152/ajpendo.00297.2018. [PMID] 30300011.
2017
Post-hypoxia Invasion of the fetal brain by multidrug resistant Staphylococcus.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-06789-6. [PMID] 28743956.
2017
Use of radiotelemetry to assess perinatal cardiac function in the ovine fetus and newborn.
American journal of physiology. Regulatory, integrative and comparative physiology. 313(6):R660-R668 [DOI] 10.1152/ajpregu.00078.2017. [PMID] 28855176.
2016
Genomic Effect of Triclosan on the Fetal Hypothalamus: Evidence for Altered Neuropeptide Regulation.
Endocrinology. 157(7):2686-97 [DOI] 10.1210/en.2016-1080. [PMID] 27145008.
2016
Ketamine decreases inflammatory and immune pathways after transient hypoxia in late gestation fetal cerebral cortex.
Physiological reports. 4(6) [DOI] 10.14814/phy2.12741. [PMID] 27033443.
2016
Ketamine suppresses hypoxia-induced inflammatory responses in the late-gestation ovine fetal kidney cortex.
The Journal of physiology. 594(5):1295-310 [DOI] 10.1113/JP271066. [PMID] 26497972.
2016
The critical importance of the fetal hypothalamus-pituitary-adrenal axis.
F1000Research. 5 [DOI] 10.12688/f1000research.7224.1. [PMID] 26918188.
2016
Transcriptomics Modeling of the Late-Gestation Fetal Pituitary Response to Transient Hypoxia.
PloS one. 11(2) [DOI] 10.1371/journal.pone.0148465. [PMID] 26859870.
2015
Altered Biological Processes in the Late Gestation Ovine Fetal Hypothalamus After Fetal Or Maternal Parenteral Exposure To Triclosan
Reproductive Sciences. 22(1)
2015
Blockade of Steroid Sulfatase Augments Fetal Hypothalamus-Pitutiary-Adrenal Axis Activity in Late Gestation Fetal Sheep
Reproductive Sciences. 22(1)
2015
Chronic Maternal Hypercortisolemia Impairs Fetal Cardiac Function.
Reproductive Sciences. 22(1):268A-269A
2015
Early Pregnancy Relaxin Levels After Infertility
Reproductive Sciences. 22(1)
2015
Hypothalamic-Pituitary–Adrenal Axis-Feedback Control.
Comprehensive Physiology. 5(3):1161-82 [DOI] 10.1002/cphy.c140065. [PMID] 26140713.
2015
Increased maternal nighttime cortisol concentrations in late gestation alter glucose and insulin in the neonatal lamb.
Physiological reports. 3(9) [DOI] 10.14814/phy2.12548. [PMID] 26371232.
2015
Patterns of gene expression in the sheep heart during the perinatal period revealed by transcriptomic modeling.
Physiological genomics. 47(9):407-19 [DOI] 10.1152/physiolgenomics.00027.2015. [PMID] 26126790.
2014
Elevated maternal cortisol leads to relative maternal hyperglycemia and increased stillbirth in ovine pregnancy.
American journal of physiology. Regulatory, integrative and comparative physiology. 307(4):R405-13 [DOI] 10.1152/ajpregu.00530.2013. [PMID] 24920731.
2014
Evidence for Impaired Maternal Circulatory Adaptations in Pregnancies Conceived Using Donor Eggs
Reproductive Sciences. 21(3, S)
2014
Late Gestational Increases in Maternal Cortisol in Ewes Results in Changes in Gene Expression Pathways Regulating Responses To Nutrients and Decreases the Content of Mitochondrial Dna in the Septa of Ovine Fetal Hearts
Reproductive Sciences. 21(3, S)
2014
Mechanisms for the adverse effects of late gestational increases in maternal cortisol on the heart revealed by transcriptomic analyses of the fetal septum.
Physiological genomics. 46(15):547-59 [DOI] 10.1152/physiolgenomics.00009.2014. [PMID] 24867915.
2014
Mechanisms of the adverse effects of late gestational increases in maternal cortisol on the fetal heart revealed by transcriptomic analysis of the fetal septum
Physiological Reports. 46(15):547-559
2014
Mineralocorticoid effects in the late gestation ovine fetal lung
. 2(7)
2014
Mineralocorticoid effects in the late gestation ovine fetal lung.
Physiological reports. 2(7) [DOI] 10.14814/phy2.12066. [PMID] 25347852.
2014
Transcriptomics of the fetal hypothalamic response to brachiocephalic occlusion and estradiol treatment.
Physiological genomics. 46(14):523-32 [DOI] 10.1152/physiolgenomics.00186.2013. [PMID] 24824211.
2014
Transcriptomics of the late gestation ovine fetal brain: modeling the co-expression of immune marker genes.
BMC genomics. 15(1) [DOI] 10.1186/1471-2164-15-1001. [PMID] 25409740.
2013
Cortisol stimulates proliferation and apoptosis in the late gestation fetal heart: differential effects of mineralocorticoid and glucocorticoid receptors.
American journal of physiology. Regulatory, integrative and comparative physiology. 305(4):R343-50 [DOI] 10.1152/ajpregu.00112.2013. [PMID] 23785077.
2013
Genomics of the fetal hypothalamic cellular response to transient hypoxia: endocrine, immune, and metabolic responses.
Physiological genomics. 45(13):521-7 [DOI] 10.1152/physiolgenomics.00005.2013. [PMID] 23653468.
2012
Effect of Increased Cortisol On Heart Rate in Pregnant Ewes
The FASEB's Journal. 26
2012
Genomics of estradiol-3-sulfate action in the ovine fetal hypothalamus.
Physiological genomics. 44(13):669-77 [DOI] 10.1152/physiolgenomics.00127.2011. [PMID] 22570439.
2012
Glutamatergic Receptors Are Expressed At Pronounced Higher Rate in the Ovine Fetal Hypothalamus Than Pituitary During the Late Gestation Period
Reproduction in Domestic Animals. 47
2012
Serotonergic effects on feeding, but not hypothalamus-pituitary-adrenal secretion, are altered in ovine pregnancy.
American journal of physiology. Endocrinology and metabolism. 302(10):E1231-8 [DOI] 10.1152/ajpendo.00582.2011. [PMID] 22374755.
2011
A role for mineralocorticoid receptors in the physiology of the ovine fetus: effects on ACTH and lung liquid composition.
Pediatric research. 69(6):491-6 [DOI] 10.1203/PDR.0b013e318217f4cf. [PMID] 21378597.
2011
Differential effects of mineralocorticoid blockade on the hypothalamo-pituitary-adrenal axis in pregnant and nonpregnant ewes.
American journal of physiology. Endocrinology and metabolism. 300(3):E592-9 [DOI] 10.1152/ajpendo.00560.2010. [PMID] 21205934.
2011
Gene Expression in the Hypothalamus of Ovine Fetuses Treated With Estradiol-3-Sulfate in Late Gestation
Reproductive Sciences. 18
2011
Influence of estradiol and fetal stress on luteinizing hormone, follicle-stimulating hormone, and prolactin in late-gestation fetal sheep.
Neonatology. 100(2):155-61 [DOI] 10.1159/000324431. [PMID] 21430392.
2011
Loss of the pregnancy-induced rise in cortisol concentrations in the ewe impairs the fetal insulin-like growth factor axis.
Reproduction, fertility, and development. 23(5):665-72 [DOI] 10.1071/RD10317. [PMID] 21635815.
2011
Mineralocorticoid Receptor (Mr)-Induced Gene Expression Pathways Implicated in Fetal Heart Growth Resulting From Increased Maternal Cortisol Levels
Journal of Developmental Origins of Health and Disease. 2
2011
Ontogeny of Global Gene Expression in the Ovine Fetal Hypothalamus in Late Gestation
Reproductive Sciences. 18
2011
Role of Mr and Gr in Cortisol-Mediated Apoptosis in Fetal Heart
Reproductive Sciences. 18
2010
Effects of Glucocorticoid and Mineralocorticoid Agonists On Gene Expression and Compliance in the Preterm Fetal Lung.
Reproductive Sciences. 17
2010
Physiological changes in maternal cortisol do not alter expression of growth-related genes in the ovine placenta.
Placenta. 31(12):1064-9 [DOI] 10.1016/j.placenta.2010.09.010. [PMID] 20951429.
2009
Aldosterone Infusion Increases Lung Compliance in the Late Gestation Fetal Sheep
Reproductive Sciences. 16
2009
Blockade of PGHS-2 inhibits the hypothalamus-pituitary-adrenal axis response to cerebral hypoperfusion in the sheep fetus.
American journal of physiology. Regulatory, integrative and comparative physiology. 296(6):R1813-9 [DOI] 10.1152/ajpregu.90917.2008. [PMID] 19297537.
2009
Expression of ENaC subunits, chloride channels, and aquaporins in ovine fetal lung: ontogeny of expression and effects of altered fetal cortisol concentrations.
American journal of physiology. Regulatory, integrative and comparative physiology. 297(2):R453-61 [DOI] 10.1152/ajpregu.00127.2009. [PMID] 19515987.
2009
Is the fetal lung a mineralocorticoid receptor target organ? Induction of cortisol-regulated genes in the ovine fetal lung, kidney and small intestine.
Neonatology. 95(1):47-60 [DOI] 10.1159/000151755. [PMID] 18787337.
2009
The ontogeny of genes related to ovine fetal cardiac growth.
Gene expression patterns : GEP. 9(2):122-8 [DOI] 10.1016/j.gep.2008.09.003. [PMID] 18835462.
2008
Blockade of estrogen receptors decreases CNS and pituitary prostaglandin synthase expression in fetal sheep.
Neuroendocrinology. 87(2):121-8 [PMID] 17934250.
2008
Cardiac corticosteroid receptors mediate the enlargement of the ovine fetal heart induced by chronic increases in maternal cortisol.
The Journal of endocrinology. 198(2):419-27 [DOI] 10.1677/JOE-08-0022. [PMID] 18495945.
2008
Development of ER-alpha and ER-beta expression in the developing ovine brain and pituitary.
Gene expression patterns : GEP. 8(6):457-463 [DOI] 10.1016/j.gep.2008.03.001. [PMID] 18424193.
2008
Fetal Heart Enlargement Caused By Chronically Elevated Maternal Cortisol Is Mediated By Mineralocorticoid Receptors in the Fetal Sheep Heart
Reproductive Sciences. 15:68A-69A
2008
Inhibition of Brain PGHS-2 Prevents the Preparturient Increase in Fetal ACTH Secretion in the Sheep Fetus
Endocrinology. 149:4128-4136
2008
Inhibition of brain prostaglandin endoperoxide synthase-2 prevents the preparturient increase in fetal adrenocorticotropin secretion in the sheep fetus.
Endocrinology. 149(8):4128-36 [DOI] 10.1210/en.2008-0123. [PMID] 18450957.
2008
Ontogeny of androgen receptor expression in the ovine fetal central nervous system and pituitary.
Neuroscience letters. 439(2):153-6 [DOI] 10.1016/j.neulet.2008.05.008. [PMID] 18514409.
2008
Regulation of maternal ACTH in ovine pregnancy: does progesterone play a role?
American journal of physiology. Endocrinology and metabolism. 295(4):E913-20 [DOI] 10.1152/ajpendo.90399.2008. [PMID] 18697912.
2008
Role of Mineralocorticoid Receptors in Control of Acth and Lung Liquid Composition in the Preterm Fetal Sheep
Reproductive Sciences. 15
2007
Adrenalectomy alters regulation of blood pressure and endothelial nitric oxide synthase in sheep: modulation by estradiol.
American journal of physiology. Regulatory, integrative and comparative physiology. 293(1):R257-66 [PMID] 17459913.
2007
Reduction of maternal adrenal steroids results in increased VEGF protein without increased eNOS in the ovine placenta.
Placenta. 28(7):658-67 [PMID] 17113146.
2006
Genomic analysis of neuroendocrine development of fetal brain-pituitary-adrenal axis in late gestation.
Physiological genomics. 24(3):218-24 [PMID] 16352695.
2006
Increased maternal cortisol in late-gestation ewes decreases fetal cardiac expression of 11beta-HSD2 mRNA and the ratio of AT1 to AT2 receptor mRNA.
American journal of physiology. Regulatory, integrative and comparative physiology. 291(6):R1708-16 [PMID] 16902187.
2005
Chronic alterations in ovine maternal corticosteroid levels influence uterine blood flow and placental and fetal growth.
American journal of physiology. Regulatory, integrative and comparative physiology. 288(1):R54-61 [PMID] 15231491.
2005
Expression of nitric oxide synthase isoforms is reduced in late-gestation ovine fetal brainstem.
American journal of physiology. Regulatory, integrative and comparative physiology. 289(2):R613-R619 [PMID] 16014452.
2005
Mineralocorticoid receptor expression in late-gestation ovine fetal lung.
Journal of the Society for Gynecologic Investigation. 12(2):84-91 [PMID] 15695102.
2005
Ontogenetic changes in the extra-pituitary expression of pro-opiomelanocortin in the developing ovine fetus.
Peptides. 26(2):301-6 [PMID] 15629542.
2005
Ontogeny of expression of organic anion transporters 1 and 3 in ovine fetal and neonatal kidney.
Experimental biology and medicine (Maywood, N.J.). 230(9):668-73 [PMID] 16179735.
2003
Alterations in maternal corticosteroid levels influence fetal urine and lung liquid production.
Journal of the Society for Gynecologic Investigation. 10(8):480-9 [PMID] 14662161.
2003
Biological activity of 17beta-estradiol-3-sulfate in ovine fetal plasma and uptake in fetal brain.
Endocrinology. 144(2):599-604 [PMID] 12538622.
2003
Pharmacology and physiology of ovine corticosteroid receptors.
Neuroendocrinology. 77(1):2-14 [PMID] 12624536.
2002
The normal increase in adrenal secretion during pregnancy contributes to maternal volume expansion and fetal homeostasis.
Journal of the Society for Gynecologic Investigation. 9(6):362-71 [PMID] 12445601.
2001
Estrogen and androgen influence hypothalamic AVP and CRF concentrations in fetal and adult sheep.
Regulatory peptides. 98(1-2):63-8 [PMID] 11179780.
2001
Pregnancy alters cortisol feedback inhibition of stimulated ACTH: studies in adrenalectomized ewes.
American journal of physiology. Regulatory, integrative and comparative physiology. 280(6):R1790-8 [PMID] 11353684.
2000
Effects of a simulated estrous cycle on sodium, volume, ACTH, and AVP in sheep.
Domestic animal endocrinology. 18(1):31-40 [PMID] 10701762.
1999
Differential effects of pregnancy on mineralocorticoid and glucocorticoid receptor availability and immunoreactivity in cortisol feedback sites.
Neuroendocrinology. 70(1):55-62 [PMID] 10420093.
1998
ACTH responses to CRF and AVP in pregnant and nonpregnant ewes.
The American journal of physiology. 274(6):R1762-8 [DOI] 10.1152/ajpregu.1998.274.6.R1762. [PMID] 9841549.
1998
ACTH responses to hypotension and feedback inhibition of ACTH increased by chronic progesterone treatment.
The American journal of physiology. 274(1):R81-7 [DOI] 10.1152/ajpregu.1998.274.1.R81. [PMID] 9458902.
1998
Evidence for reset of regulated cortisol in pregnancy: studies in adrenalectomized ewes.
The American journal of physiology. 274(1):R145-51 [DOI] 10.1152/ajpregu.1998.274.1.R145. [PMID] 9458911.
1998
Sheep model for study of maternal adrenal gland function during pregnancy.
Laboratory animal science. 48(5):507-12 [PMID] 10090066.
1997
Effects of progesterone on blood pressure, plasma volume, and responses to hypotension.
The American journal of physiology. 272(1 Pt 2):R377-85 [PMID] 9039032.
1997
Progesterone rapidly reduces arterial pressure in ewes.
The American journal of physiology. 272(1 Pt 2):H386-91 [PMID] 9038960.
1996
Inhibition of stimulated and basal ACTH by cortisol during ovine pregnancy.
The American journal of physiology. 271(1 Pt 2):R130-6 [PMID] 8760213.
1995
Characterization of 11 beta-hydroxysteroid dehydrogenase activity in fetal and adult ovine tissues.
Reproduction, fertility, and development. 7(3):377-83 [PMID] 8606946.
1995
Ontogeny and ultradian rhythms of adrenocorticotropin and cortisol in the late-gestation fetal horse.
The Journal of endocrinology. 144(2):271-83 [PMID] 7706980.
1995
Reflex regulation of hormonal responses during pregnancy.
Clinical and experimental pharmacology & physiology. 22(2):143-51 [PMID] 7621608.
1994
Corticotropin responses to hypoglycemia and hypotension during ovine pregnancy.
The American journal of physiology. 266(1 Pt 2):R180-7 [PMID] 8304539.
1994
Prolonged absence of ovarian hormones in the ewe reduces the adrenocorticotropin response to hypotension, but not to hypoglycemia or corticotropin-releasing factors.
Endocrinology. 134(2):678-84 [PMID] 8299564.
1994
Vasopressin response to hyperosmolality and hypotension during ovine pregnancy.
The American journal of physiology. 266(1 Pt 2):R188-93 [PMID] 8304540.
1991
Corticotropin-releasing factor in the ovine fetus and pregnant ewe: role of placenta.
The American journal of physiology. 261(4 Pt 2):R995-1002 [PMID] 1928447.
1991
Does the ovine placenta secrete ACTH under normoxic or hypoxic conditions?
The American journal of physiology. 260(2 Pt 2):R389-95 [PMID] 1847602.
1991
Effect of ovariectomy on vasopressin, ACTH, and renin activity responses to hypotension.
The American journal of physiology. 261(1 Pt 2):R223-30 [PMID] 1650146.
1991
Induction of parturition by cortisol: effects on negative feedback sensitivity and plasma CRF.
Journal of developmental physiology. 16(5):287-92 [PMID] 1668556.
1991
Influence of reproductive state on pituitary-adrenal activity in the ewe.
Domestic animal endocrinology. 8(2):245-54 [PMID] 1649030.
1990
Fast feedback control of canine corticotropin by cortisol.
Endocrinology. 126(4):1959-66 [PMID] 2156673.
1990
Progesterone-cortisol interaction in control of renin activity but not aldosterone.
The American journal of physiology. 259(2 Pt 2):R350-6 [PMID] 2201219.
1989
Control of canine ACTH by corticosteroids: an integral feedback effect of steroids.
The American journal of physiology. 257(2 Pt 2):R427-30 [PMID] 2548411.
1988
Control of canine ACTH by corticosteroids: interaction between dose and time.
The American journal of physiology. 254(1 Pt 2):R23-6 [PMID] 2827528.
1988
Evidence for rapid inhibition of ACTH by corticosteroids in dogs.
The American journal of physiology. 255(2 Pt 2):R344-9 [PMID] 2841878.
1988
Progesterone attenuates the inhibition of adrenocorticotropin responses by cortisol in nonpregnant ewes.
Endocrinology. 123(1):647-51 [PMID] 2838268.
1984
Corticosteroid inhibition of ACTH secretion.
Endocrine reviews. 5(1):1-24 [PMID] 6323158.
1983
Feedback inhibition of adrenocorticotropic hormone by physiological increases in plasma corticosteroids in conscious dogs.
The Journal of clinical investigation. 71(4):859-66 [PMID] 6300189.
1983
Inhibition of the adrenocorticotropin and corticosteroid responses to hypoglycemia after prior stress.
Endocrinology. 113(2):491-6 [PMID] 6307641.
1983
Insulin-induced hypoglycemia in conscious dogs: effect of maintaining carotid arterial glucose levels on the adrenocorticotropin, epinephrine, and vasopressin responses.
Endocrinology. 112(2):624-32 [PMID] 6293805.
1983
Integral as well as proportional adrenal responses to ACTH.
The American journal of physiology. 245(1):R53-9 [PMID] 6307068.
1981
Insulin-induced hypoglycemia in conscious dogs. I. Dose-related pituitary and adrenal responses.
Endocrinology. 109(3):818-24 [PMID] 6266809.

Grants

Apr 2017 – Mar 2020
Therapeutic use of dichloroacetate in treatment of perinatal mitochondrial deficiency and cardiac dysfunction
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Dec 2016 – Nov 2022
Effects of maternal cortisol on perinatal cardiac metabolism and function
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Feb 2016 – Jan 2019
Modeling the Fetal Microbiome
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jul 2014 – Dec 2016
Increases in Maternal Cortisol Alter the Metabolism and Function of the Fetal Heart at Term
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION
Aug 2011 – Feb 2020
Corpus Luteal Contribution to Maternal Pregnancy Physiology and Outcomes in ART
Role: Project Manager
Funding: NATL INST OF HLTH NICHD
Jul 2011 – Jun 2017
Glucocorticoids, Stress and Blood Pressure Regulation
Role: Project Manager
Funding: NATL INST OF HLTH
Dec 2008 – Dec 2015
Effects of Maternal Cortisol on Fetal and Neonatal Growth and Metabolism.
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD

Education

postdoctoral scholar, Physiology
1983-1985 · University of Florida
postdoctoral scholar, Physiology
1983 · University of California, San Francisco
Ph.D. Endocrinology
1977-1982 · University of California, San Francisco
A.B. Biochemistry
1973-1977 · Vassar College

Contact Details

Phones:
Business:
(352) 273-7687
Emails:
Business:
mkeller@ufl.edu
Addresses:
Business Mailing:
PO Box 100487
GAINESVILLE FL 32610
Business Street:
1225 CENTER DR
HPNP 4332A
GAINESVILLE FL 326103007