Maureen Keller-Wood

Maureen Keller-Wood Ph.D.

Associate Dean for Research and Graduate Education, CVS/Pharmacy, Inc. Professorship

Department: Dean's Office
Business Phone: (352) 273-7687
Business Email: kellerwd@cop.ufl.edu

About Maureen Keller-Wood

Maureen Keller-Wood, Ph.D., is the associate dean for research and graduate education and professor of pharmacodynamics. She holds the CVS/Pharmacy, Inc. professorship. Dr. Keller-Wood’s overall research interest is the physiologic adaptations to pregnancy and effects of maternal physiology on fetal maturation and growth. Her current research focuses on understanding the mechanism for increased stillbirth and neonatal mortality in pregnancies complicated by maternal hypercortisolemia and altered maternal and fetal glucose metabolism. She received her Ph.D. in endocrinology from the University of California, San Francisco, in 1982 and her Bachelor of Arts in biochemistry from Vassar College in 1977.

Honors & Awards

Liley Lectureship
2017 · Perinatal Research Society
CV Professorship
2013-current · University of Florida, College of Pharmacy
UFRF Professorship
2012-2015 · University of Florida
UFRF Professorship
2000-2003 · University of Florida

Research Profile

Dr. Keller-Wood’s overall research interest is the physiologic adaptations to pregnancy and effects of maternal physiology on fetal maturation and growth. Her areas of current interest are:

The laboratory has a long standing interest in the effects of the adrenal hormone cortisol. Secretion of cortisol is increased in pregnancy, and this hormone mediates important adaptive physiologic effects necessary for regulating blood glucose, blood pressure, fluid and electrolyte excretion, appetite, and mood. The research team is interested in the role of the normal increase in cortisol and its action in both the mother and in the fetus, as well as the adverse effects that occur when there are excess increases in maternal cortisol in pregnancy, as occurs with maternal stress.

A major current focus of the laboratory is the adverse effects of maternal cortisol on fetal and neonatal cardiac health and metabolism. Excess maternal cortisol secretion in late gestation is associated with an increased risk of stillbirth. Researchers are using a combination of techniques to determine the effects of cortisol on fetal cardiac maturation and on function during labor and delivery. These include in vivo techniques such as telemetry to continuously monitor fetal ECG and arterial pressure during labor and delivery, transcriptomic methods to determine altered expression of genes as a result of pre-term cortisol exposure, biochemical techniques to assess mitochondrial function, and metabolomic techniques to assess shifts in metabolism. These studies include collaborations with Drs. Matthew Merritt, Jennifer Co-Vu, and Stephanie Wohlgemuth at UF, as well as Dr. Art Edison at UGa. In collaboration with Dr. Peter Stacpoole, the research is also testing the efficacy of treatment with dicholoracetate in ameliorating adverse events during labor and delivery.

Her research team recently has collaborated with Drs. Charles Wood, Eric Triplett and Kelly RIce to examine the effects of maternal stress on the maternal microbiome, and effects of altered maternal bacterial populations on fetal and neonatal health.

She has also collaborated with Dr. Kirk Conrad and others on a grant to investigate the cardiorenal adaptions to pregnancy in women who become pregnant through assisted reproductive technologies (ART). ART has been associated with increases in maternal cardiorenal disease and in the incidence of small for gestation infants. She served as PI of the analytic core for this P01 which performed analysis of plasma, serum and urine to determine endocrine, electrolyte and other endpoints.

Publications

2019 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
2018 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
2018 American journal of physiology. Endocrinology and metabolism
2014 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
2009 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
2009 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
2008 American Journal of Physiology-Endocrinology and Metabolism
2007 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
2005 Journal of the Society for Gynecologic Investigation
2005 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
2005 Journal of the Society for Gynecologic Investigation
2005 Proceedings of the Society for Experimental Biology and medicine
2001 American Journal of Physiology-Regulatory Integrative and Comparative Physiology

Grants

May 2019ACTIVE
Biocultural investigation of maternal adversity on gene expression and DNA methylation in the placenta
NATL INST OF HLTH NICHD ·
April 2017ACTIVE
Therapeutic use of dichloroacetate in treatment of perinatal mitochondrial deficiency and cardiac dysfunction
NATL INST OF HLTH NICHD · Principal Investigator
December 2016ACTIVE
Effects of maternal cortisol on perinatal cardiac metabolism and function
NATL INST OF HLTH NICHD · Principal Investigator
February 2016 – January 2019
Modeling the Fetal Microbiome
NATL INST OF HLTH NIAID ·
August 2011ACTIVE
Corpus Luteal Contribution to Maternal Pregnancy Physiology and Outcomes in ART
NATL INST OF HLTH NICHD · Project Manager

Education

1983-1985
postdoctoral scholar, Physiology
University of Florida
1983
postdoctoral scholar, Physiology
University of California, San Francisco
1977-1982
Ph.D. Endocrinology
University of California, San Francisco
1973-1977
A.B. Biochemistry
Vassar College