Michael Katovich

Michael Katovich Ph.D.

Professor Emeritus

Department: Pharmacodynamics
Business Email: katovich@cop.ufl.edu

Research Profile

The Katovich Lab studies the various components of the endocrine renin-angiotensin system (RAS) and their effects on hypertension and associated cardiovascular organ damage. Over the past several years more components of the RAS have been elucidated and we have utilized gene therapy approaches to enhance and/or modify certain aspects of the RAS in order to reduce cardiovascular risks in hypertension and diabetes. We utilize in vivo animal models as well as cell culture protocols to evaluate the physiological, pharmacological and morphological effects of manipulations of the RAS. Currently we are looking at the effects of overexpressing components of the RAS such as the AT2R, ACE2 and Ang-(1-7) in models of hypertension, stroke, and coronary artery ligation to determine the “beneficial” effects of these RAS components on various end organs. Utilization of gene therapy approaches and classical physiological methods (such as vascular smooth muscle reactivity, in vitro heart perfusion, metabolic studies, etc) aid in not only the understanding of the mechanism of actions of existing therapeutic agents but also leads to new innovative therapeutic effects in treating cardiovascular and metabolic diseases.

Publications

2010 Arteriosclerosis Thrombosis and Vascular Biology
2009 American Journal of Respiratory and Critical Care Medicine
1999 American journal of physiology. Heart and circulatory physiology

Grants

January 2014 – December 2015
Modulation of the Renin-Angiotensin System for restor…
AMER HEART ASSOCIATION · Principal Investigator
March 2011 – February 2017
CVD Protection Mechanism involving ACE2/ANG-(1-7) Axis
NATL INST OF HLTH · Project Manager
May 2010 – April 2016
Angiotensin-Converting Enzyme2 in Vascular Endothelial
NATL INST OF HLTH NHLBI · Principal Investigator
November 2003 – November 2018
Katovich pharmacodynamics lab
UF FOU · Principal Investigator

Contact Details

Emails:
Addresses:
Mailing:
PO BOX 115500
GAINESVILLE, FL 326115500
Physical:
P1-33 JHMHC
1600 SW ARCHER RD
GAINESVILLE, FL 32611