Michael Katovich

Michael Katovich, Ph.D.

Professor Emeritus

Department: Pharmacodynamics
Business Phone: (352) 273-9537
Business Email: katovich@cop.ufl.edu

Research Profile

The Katovich Lab studies the various components of the endocrine renin-angiotensin system (RAS) and their effects on hypertension and associated cardiovascular organ damage. Over the past several years more components of the RAS have been elucidated and we have utilized gene therapy approaches to enhance and/or modify certain aspects of the RAS in order to reduce cardiovascular risks in hypertension and diabetes. We utilize in vivo animal models as well as cell culture protocols to evaluate the physiological, pharmacological and morphological effects of manipulations of the RAS. Currently we are looking at the effects of overexpressing components of the RAS such as the AT2R, ACE2 and Ang-(1-7) in models of hypertension, stroke, and coronary artery ligation to determine the “beneficial” effects of these RAS components on various end organs. Utilization of gene therapy approaches and classical physiological methods (such as vascular smooth muscle reactivity, in vitro heart perfusion, metabolic studies, etc) aid in not only the understanding of the mechanism of actions of existing therapeutic agents but also leads to new innovative therapeutic effects in treating cardiovascular and metabolic diseases.

Publications

2010 Hypertension (Dallas, Tex. : 1979)
2010 Molecular medicine (Cambridge, Mass.)
2010 Arteriosclerosis Thrombosis and Vascular Biology
2009 American Journal of Respiratory and Critical Care Medicine
2008 FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2007 American journal of physiology. Heart and circulatory physiology
2006 American journal of physiology. Heart and circulatory physiology
2006 Progress in biophysics and molecular biology
2001 American journal of pharmacogenomics : genomics-related research in drug development and clinical practice
2001 The American journal of the medical sciences
2001 Annals of the New York Academy of Sciences
2000 Journal of the renin-angiotensin-aldosterone system : JRAAS
1999 Drugs of today (Barcelona, Spain : 1998)
1998 Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology
1996 Proceedings of the National Academy of Sciences of the United States of America
1996 Clinical and experimental hypertension (New York, N.Y. : 1993)
1995 Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
1995 Clinical and experimental hypertension (New York, N.Y. : 1993)
1992 Canadian journal of physiology and pharmacology
1990 Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
1988 Clinical and experimental hypertension. Part A, Theory and practice
1986 Research communications in chemical pathology and pharmacology
1985 Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
1984 Substance and alcohol actions/misuse
1984 Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology
1983 Canadian journal of physiology and pharmacology
1983 Clinical and experimental hypertension. Part A, Theory and practice
1980 Canadian journal of physiology and pharmacology
1980 Journal of applied physiology: respiratory, environmental and exercise physiology
1979 Canadian journal of physiology and pharmacology
1979 Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
1978 Journal of applied physiology: respiratory, environmental and exercise physiology
1978 Canadian journal of physiology and pharmacology
1978 Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

Grants

Jan 2014 – Dec 2015
Modulation of the Renin-Angiotensin System for restor…
AMER HEART ASSOCIATION · Principal Investigator
Mar 2011 – Feb 2017
CVD Protection Mechanism involving ACE2/ANG-(1-7) Axis
NATL INST OF HLTH · Project Manager
May 2010 – Apr 2016
Angiotensin-Converting Enzyme2 in Vascular Endothelial
NATL INST OF HLTH NHLBI · Principal Investigator
Nov 2003 – Nov 2018
Katovich pharmacodynamics lab
UF FOU · Principal Investigator

Contact Details

Phones:
Business:
(352) 273-9537
Emails: