Julie A Johnson, Pharm.D.
Distinguished Professor
Department:
Pharmacotherapy & Translational Research
Business Phone:
(352) 273-6309
Business Email:
julie.johnson@ufl.edu
About Julie A Johnson
Julie Johnson is a Distinguished Professor of Pharmacy and Medicine at the University of Florida. She recently completed a term as Dean of the UF College of Pharmacy, having served in that role from 2013 to 2022. She received her B.S. in Pharmacy from the Ohio State University and her Pharm.D. from the University of Texas at Austin and the UT Health Science Center at San Antonio. She completed a post-doctoral fellowship in cardiovascular pharmacology/ pharmacokinetics at Ohio State.
Dr. Johnson’s research focuses on cardiovascular pharmacogenomics and implementation of precision medicine approaches into clinical practice. She is an internationally recognized leader in clinical pharmacology, pharmacogenomics and genomic medicine, with over 330 peer reviewed original publications and over $50M in research funding as principal investigator. In 2015, 2016, 2017 and 2018 she was named a Clarivate Analytics Highly Cited Researcher, indicating she was in the top 1% most highly cited scientists globally in the discipline in previous decade (pharmacology and toxicology 2015-2017 and across disciplines in 2018).
Under her leadership as dean, the UF College of Pharmacy implemented a new Pharm.D. curriculum, its faculty grew by 90%, the U.S. News & World Report ranking rose from #14 to #5, research funding grew 3.8-fold and research funding rankings rose from the high teens to #3, and it had the highest percentage of under-represented minority students among professional degree programs at UF and the top 40 colleges of pharmacy, with the percentage or URM Pharm.D. students doubling in her time as dean.
Dr. Johnson has had numerous service roles, including with the NIH, FDA, CDC, American Heart Association, American College of Clinical Pharmacy (ACCP) and American Society for Clinical Pharmacology and Therapeutics (ASCPT), for which she served as President in 2016-17. She is currently serving as President-Elect of the Pharmacogenomics Global Research Network, and President of the Academy for Science, Engineering and Medicine – Florida (ASEM-FL). Dr. Johnson has received numerous awards and honors. She was elected to the National Academy of Medicine, and has been the recipient of the Leon I Goldberg Young Investigator Award, Rawls Palmer Progress in Medicine Award and Mentoring Award from the ASCPT, Volwiler Research Achievement Award from the American Association of Colleges of Pharmacy (AACP) (2007), the Therapeutic Frontiers Award, and Paul Parker Medal from ACCP, the ACCP-Pharmacology Distinguished Scientist Award, the Luminary Award from the Precision Medicine World Conference, among others. She has also received teaching awards from both the University of Tennessee and the University of Florida.
Accomplishments
Luminary Award
2021
·
Precision Medicine World Conference
Rawls Palmer Progress in Medicine Award
2021
·
American Society for Clinical Pharmacology and Therapeutics
Elected Fellow
2020
·
American Association for the Advancement of Science
Distinguished Investigator Award
2019
·
American College of Clinical Pharmacology
Paul Parker Medal
2019
·
American College of Clinical Pharmacy
Volwiler Research Achievement Award
2016
·
American Association of Colleges of Pharmacy
Highly Cited Scientist
2015-2018
·
Clarivate Analytics
Distinguished Scientist Award
2015
·
Southeastern Universities Research Associate
Elected Member
2014
·
National Academy of Medicine
Honorary Fellow Award
2014
·
American College of Clinical Pharmacology
Russell Miller Award for Contribution to the Literature
2010
·
American College of Clinical Pharmacy
Fellow
2009
·
American Heart Association; Functional Genomics and Translational Biology Council
Therapeutic Frontiers Award
2009
·
American College of Clinical Pharmacy
Paul Dawson Biotechnology Research Award
2007
·
American Association of Colleges of Pharmacy
Leon I. Goldberg Young Investigator Award
2004
·
American Society for Clinical Pharmacology and Therapeutics
William Oxley Thompson Alumni Award
1997
·
The Ohio State University
Fellow
1996
·
American College of Clinical Pharmacy
Teaching Profile
Courses Taught
2013-2021
PHA7979 Advanced Research
2020
PHA6910 Supervised Research
2013-2023
PHA7980 Research for Doctoral Dissertation
2014-2018,2021-2022
PHA6938 Research Seminar
2016
PHA6971 Research for Master’s Thesis
2015
GMS7794 Neuroscience Seminar
2009-2011,2013
PHA5907 Research in Phar Prac
2013
PHA5933 Select Top Pharmacy
2012-2013
PHA5787 Pharmacotherapy 5
2011-2012
PHA5782 Pharmacotherapy 2
2012
PHA5113 Personalized Medicine
2011-2012
PHA5784 Pharmacotherapy 4
2008,2010-2012,2012
PHA6449 Pharmacogenomics
2011
PHA5113C Thera Mon/Pharmacogen
2009-2010
PHA4907 Probs in Pharm Prac
2010
IDH4917 Undergrad Research
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0001-9847-1932
Publications
2023
A Pharmacogenetics-Based Approach to Managing Gastroesophageal Reflux Disease: Current Perspectives and Future Steps
Pharmacogenomics and Personalized Medicine.
Volume 16:645-664
[DOI] 10.2147/pgpm.s371994.
2023
Evaluation of Potential Racial Disparities in CYP2C19-Guided P2Y12 Inhibitor Prescribing After Percutaneous Coronary Intervention.
Clinical pharmacology and therapeutics.
113(3):615-623
[DOI] 10.1002/cpt.2776.
[PMID] 36306392.
2023
Use of a multi-gene pharmacogenetic panel reduces adverse drug effects.
Cell reports. Medicine.
4(5)
[DOI] 10.1016/j.xcrm.2023.101021.
[PMID] 37084734.
2022
A randomized, cross-over trial of metoprolol succinate formulations to evaluate PK and PD end points for therapeutic equivalence.
Clinical and translational science.
15(7):1764-1775
[DOI] 10.1111/cts.13294.
[PMID] 35488487.
2022
Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease: An Individual-Level Meta-Analysis.
Frontiers in physiology.
13
[DOI] 10.3389/fphys.2022.909870.
[PMID] 35812313.
2022
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update.
Clinical pharmacology and therapeutics.
112(5):959-967
[DOI] 10.1002/cpt.2526.
[PMID] 35034351.
2022
Comparison of Data Normalization Strategies for Array-Based MicroRNA Profiling Experiments and Identification and Validation of Circulating MicroRNAs as Endogenous Controls in Hypertension.
Frontiers in genetics.
13
[DOI] 10.3389/fgene.2022.836636.
[PMID] 35432462.
2022
Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke
Neurology.
99(16):e1738-e1754
[DOI] 10.1212/wnl.0000000000201006.
2022
CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention in Diverse Clinical Settings.
Journal of the American Heart Association.
11(4)
[DOI] 10.1161/JAHA.121.024159.
[PMID] 35156424.
2022
CYP2D6 pharmacogenetics and phenoconversion in personalized medicine.
Expert opinion on drug metabolism & toxicology.
18(11):769-785
[DOI] 10.1080/17425255.2022.2160317.
[PMID] 36597259.
2022
Design and rationale of GUARDD-US: A pragmatic, randomized trial of genetic testing for APOL1 and pharmacogenomic predictors of antihypertensive efficacy in patients with hypertension.
Contemporary clinical trials.
119
[DOI] 10.1016/j.cct.2022.106813.
[PMID] 35660539.
2022
Genetic Contributors of Efficacy and Adverse Metabolic Effects of Chlorthalidone in African Americans from the Genetics of Hypertension Associated Treatments (GenHAT) Study.
Genes.
13(7)
[DOI] 10.3390/genes13071260.
[PMID] 35886043.
2022
Impact of the ABCD-GENE Score on Clopidogrel Clinical Effectiveness after PCI: A Multi-Site, Real-World Investigation.
Clinical pharmacology and therapeutics.
112(1):146-155
[DOI] 10.1002/cpt.2612.
[PMID] 35429163.
2022
Implementing a pragmatic clinical trial to tailor opioids for acute pain on behalf of the IGNITE ADOPT PGx investigators.
Clinical and translational science.
15(10):2479-2492
[DOI] 10.1111/cts.13376.
[PMID] 35899435.
2022
Influence of Genetic West African Ancestry on Metabolomics among Hypertensive Patients
Metabolites.
12(9)
[DOI] 10.3390/metabo12090783.
[PMID] 36144188.
2022
Pairwise comparison of hydrochlorothiazide and chlorthalidone responses among hypertensive patients.
Clinical and translational science.
15(12):2858-2867
[DOI] 10.1111/cts.13396.
[PMID] 36271676.
2022
Warfarin Dosing in Patients With CYP2C9*5 Variant Alleles.
Clinical pharmacology and therapeutics.
111(4):950-955
[DOI] 10.1002/cpt.2549.
[PMID] 35108398.
2022
β1-receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery.
Clinical and translational science.
15(3):619-625
[DOI] 10.1111/cts.13178.
[PMID] 34713976.
2021
A hybrid implementation-effectiveness randomized trial of CYP2D6-guided postoperative pain management.
Genetics in medicine : official journal of the American College of Medical Genetics.
23(4):621-628
[DOI] 10.1038/s41436-020-01050-4.
[PMID] 33420349.
2021
Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome-Wide Interaction Meta-Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies.
Clinical pharmacology and therapeutics.
110(3):723-732
[DOI] 10.1002/cpt.2355.
[PMID] 34231218.
2021
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing.
Clinical pharmacology and therapeutics.
109(6):1417-1423
[DOI] 10.1002/cpt.2015.
[PMID] 32770672.
2021
Determining the potential clinical value of panel-based pharmacogenetic testing in patients with chronic pain or gastroesophageal reflux disease.
The pharmacogenomics journal.
21(6):657-663
[DOI] 10.1038/s41397-021-00244-6.
[PMID] 34075203.
2021
Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network.
Genetics in medicine : official journal of the American College of Medical Genetics.
23(7):1185-1191
[DOI] 10.1038/s41436-021-01118-9.
[PMID] 33782552.
2021
Evaluating an interactive teaching approach with personal genotyping to provide pharmacy students with a knowledge base for clinical pharmacogenetics
JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY.
4(3):343-351
[DOI] 10.1002/jac5.1335.
2021
Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality.
European heart journal.
42(18):1742-1756
[DOI] 10.1093/eurheartj/ehab107.
[PMID] 33748830.
2021
How to Integrate CYP2D6 Phenoconversion Into Clinical Pharmacogenetics: A Tutorial.
Clinical pharmacology and therapeutics.
110(3):677-687
[DOI] 10.1002/cpt.2354.
[PMID] 34231197.
2021
Impact of the CYP2C19*17 Allele on Outcomes in Patients Receiving Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.
Clinical pharmacology and therapeutics.
109(3):705-715
[DOI] 10.1002/cpt.2039.
[PMID] 32897581.
2021
Metabolomics Signature of Plasma Renin Activity and Linkage with Blood Pressure Response to Beta Blockers and Thiazide Diuretics in Hypertensive European American Patients.
Metabolites.
11(9)
[DOI] 10.3390/metabo11090645.
[PMID] 34564461.
2021
Multisite investigation of strategies for the clinical implementation of pre-emptive pharmacogenetic testing.
Genetics in medicine : official journal of the American College of Medical Genetics.
23(12):2335-2341
[DOI] 10.1038/s41436-021-01269-9.
[PMID] 34282303.
2021
Race-Specific Comparisons of Antihypertensive and Metabolic Effects of Hydrochlorothiazide and Chlorthalidone.
The American journal of medicine.
134(7):918-925.e2
[DOI] 10.1016/j.amjmed.2020.12.015.
[PMID] 33434556.
2021
Racial disparities in survival outcomes among breast cancer patients by molecular subtypes.
Breast cancer research and treatment.
185(3):841-849
[DOI] 10.1007/s10549-020-05984-w.
[PMID] 33111220.
2021
Strategies to Integrate Genomic Medicine into Clinical Care: Evidence from the IGNITE Network.
Journal of personalized medicine.
11(7)
[DOI] 10.3390/jpm11070647.
[PMID] 34357114.
2021
Tribute to Professor Hartmut Derendorf – 1953 to 2020: Driving force in Clinical Pharmacology and Mentor Extraordinaire.
Clinical pharmacology and therapeutics.
109(4):805-809
[DOI] 10.1002/cpt.2193.
[PMID] 33667324.
2020
A Scoping Review of the Evidence Behind Cytochrome P450 2D6 Isoenzyme Inhibitor Classifications.
Clinical pharmacology and therapeutics.
108(1):116-125
[DOI] 10.1002/cpt.1768.
[PMID] 31910286.
2020
Association of Factor V Leiden With Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data.
Circulation.
142(6):546-555
[DOI] 10.1161/CIRCULATIONAHA.119.045526.
[PMID] 32654539.
2020
Blending Traditional Vocational Services and Individualized Placement and Support for Formerly Incarcerated Veterans.
Psychiatric services (Washington, D.C.).
71(8):816-823
[DOI] 10.1176/appi.ps.201900421.
[PMID] 32393158.
2020
Clinical Pharmacology Education – The Decade Ahead.
Clinical pharmacology and therapeutics.
107(1):37-39
[DOI] 10.1002/cpt.1652.
[PMID] 31709518.
2020
Clinical Utility of Pharmacogene Panel-Based Testing in Patients Undergoing Percutaneous Coronary Intervention.
Clinical and translational science.
13(3):473-481
[DOI] 10.1111/cts.12729.
[PMID] 31758664.
2020
Combination Antihypertensive Therapy Prescribing and Blood Pressure Control in a Real-World Setting.
American journal of hypertension.
33(4):316-324
[DOI] 10.1093/ajh/hpz196.
[PMID] 31853537.
2020
Correction: Evaluating the extent of reusability of CYP2C19 genotype data among patients genotyped for antiplatelet therapy selection.
Genetics in medicine : official journal of the American College of Medical Genetics.
22(11)
[DOI] 10.1038/s41436-020-0931-1.
[PMID] 32747766.
2020
Cost-effectiveness of CYP2C19-guided antiplatelet therapy in patients with acute coronary syndrome and percutaneous coronary intervention informed by real-world data.
The pharmacogenomics journal.
20(5):724-735
[DOI] 10.1038/s41397-020-0162-5.
[PMID] 32042096.
2020
Design and Early Implementation Successes and Challenges of a Pharmacogenetics Consult Clinic.
Journal of clinical medicine.
9(7)
[DOI] 10.3390/jcm9072274.
[PMID] 32708920.
2020
Evaluating the extent of reusability of CYP2C19 genotype data among patients genotyped for antiplatelet therapy selection.
Genetics in medicine : official journal of the American College of Medical Genetics.
22(11):1898-1902
[DOI] 10.1038/s41436-020-0894-2.
[PMID] 32678355.
2020
Examination of Metoprolol Pharmacokinetics and Pharmacodynamics Across CYP2D6 Genotype-Derived Activity Scores.
CPT: pharmacometrics & systems pharmacology.
9(12):678-685
[DOI] 10.1002/psp4.12563.
[PMID] 33067866.
2020
How to Transition from Single-Gene Pharmacogenetic Testing to Preemptive Panel-Based Testing: A Tutorial.
Clinical pharmacology and therapeutics.
108(3):557-565
[DOI] 10.1002/cpt.1912.
[PMID] 32460360.
2020
Pharmacogenetic factors affecting β-blocker metabolism and response
Expert Opinion on Drug Metabolism & Toxicology.
16(10):953-964
[DOI] 10.1080/17425255.2020.1803279.
[PMID] 32726152.
2020
Response to: Heterogeneous Treatment Response by Race Cannot Be Claimed in the Absence of Evidence.
American journal of hypertension.
33(2)
[DOI] 10.1093/ajh/hpz168.
[PMID] 31891170.
2020
Sorting nexin 1 loss results in increased oxidative stress and hypertension.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
34(6):7941-7957
[DOI] 10.1096/fj.201902448R.
[PMID] 32293069.
2020
The Patient-Centered Future of Clinical Pharmacology.
Clinical pharmacology and therapeutics.
107(1):72-75
[DOI] 10.1002/cpt.1681.
[PMID] 31751490.
2020
What will be your legacy in pharmacy? How will you be a Paul Parker?
JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY.
3(1):6-7
[DOI] 10.1002/jac5.1195.
2019
A case for genotype-guided pain management.
Pharmacogenomics.
20(10):705-708
[DOI] 10.2217/pgs-2019-0068.
[PMID] 31368851.
2019
Antihypertensive therapy prescribing patterns and correlates of blood pressure control among hypertensive patients with chronic kidney disease.
Journal of clinical hypertension (Greenwich, Conn.).
21(1):91-101
[DOI] 10.1111/jch.13429.
[PMID] 30427124.
2019
Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events.
Circulation. Genomic and precision medicine.
12(4)
[DOI] 10.1161/CIRCGEN.119.002471.
[PMID] 30897348.
2019
Challenges and lessons learned from clinical pharmacogenetic implementation of multiple gene-drug pairs across ambulatory care settings.
Genetics in medicine : official journal of the American College of Medical Genetics.
21(10):2264-2274
[DOI] 10.1038/s41436-019-0500-7.
[PMID] 30926959.
2019
CYP2D6-guided opioid therapy improves pain control in CYP2D6 intermediate and poor metabolizers: a pragmatic clinical trial.
Genetics in medicine : official journal of the American College of Medical Genetics.
21(8):1842-1850
[DOI] 10.1038/s41436-018-0431-8.
[PMID] 30670877.
2019
Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals.
Clinical pharmacology and therapeutics.
105(6):1477-1491
[DOI] 10.1002/cpt.1323.
[PMID] 30506689.
2019
Effect of plasma MicroRNA on antihypertensive response to beta blockers in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) studies.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
131:93-98
[DOI] 10.1016/j.ejps.2019.02.013.
[PMID] 30753892.
2019
Essential Characteristics of Pharmacogenomics Study Publications.
Clinical pharmacology and therapeutics.
105(1):86-91
[DOI] 10.1002/cpt.1279.
[PMID] 30406943.
2019
Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals.
Hypertension (Dallas, Tex. : 1979).
74(3):614-622
[DOI] 10.1161/HYPERTENSIONAHA.118.12177.
[PMID] 31327267.
2019
Genome Wide Analysis Approach Suggests Chromosome 2 Locus to be Associated with Thiazide and Thiazide Like-Diuretics Blood Pressure Response
Scientific Reports.
9(1)
[DOI] 10.1038/s41598-019-53345-5.
[PMID] 31754133.
2019
Genome-wide association analysis of common genetic variants of resistant hypertension.
The pharmacogenomics journal.
19(3):295-304
[DOI] 10.1038/s41397-018-0049-x.
[PMID] 30237584.
2019
Genome-Wide Meta-Analysis of Blood Pressure Response to β1-Blockers: Results From ICAPS (International Consortium of Antihypertensive Pharmacogenomics Studies).
Journal of the American Heart Association.
8(16)
[DOI] 10.1161/JAHA.119.013115.
[PMID] 31423876.
2019
Genomic Association Analysis Reveals Variants Associated With Blood Pressure Response to Beta-Blockers in European Americans.
Clinical and translational science.
12(5):497-504
[DOI] 10.1111/cts.12643.
[PMID] 31033190.
2019
Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers.
PloS one.
14(9)
[DOI] 10.1371/journal.pone.0221957.
[PMID] 31532792.
2019
Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing.
Genetics in medicine : official journal of the American College of Medical Genetics.
21(10):2255-2263
[DOI] 10.1038/s41436-019-0484-3.
[PMID] 30894703.
2019
Novel Implementation of Genotype-Guided Proton Pump Inhibitor Medication Therapy in Children: A Pilot, Randomized, Multisite Pragmatic Trial.
Clinical and translational science.
12(2):172-179
[DOI] 10.1111/cts.12589.
[PMID] 30341969.
2019
Plasma Renin Activity Is a Predictive Biomarker of Blood Pressure Response in European but not in African Americans With Uncomplicated Hypertension.
American journal of hypertension.
32(7):668-675
[DOI] 10.1093/ajh/hpz022.
[PMID] 30753254.
2019
Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Nature genetics.
51(7):1192-1193
[DOI] 10.1038/s41588-019-0449-0.
[PMID] 31160810.
2019
Qualitative study of system-level factors related to genomic implementation.
Genetics in medicine : official journal of the American College of Medical Genetics.
21(7):1534-1540
[DOI] 10.1038/s41436-018-0378-9.
[PMID] 30467402.
2019
Subsequent Event Risk in Individuals With Established Coronary Heart Disease.
Circulation. Genomic and precision medicine.
12(4)
[DOI] 10.1161/CIRCGEN.119.002470.
[PMID] 30896328.
2019
β2 -Adrenergic Receptor Gene Affects the Heart Rate Response of β-Blockers: Evidence From 3 Clinical Studies.
Journal of clinical pharmacology.
59(11):1462-1470
[DOI] 10.1002/jcph.1443.
[PMID] 31090079.
2018
Blood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies.
BMC medical genomics.
11(1)
[DOI] 10.1186/s12920-018-0370-x.
[PMID] 29925376.
2018
Clinical implementation of rapid CYP2C19 genotyping to guide antiplatelet therapy after percutaneous coronary intervention.
Journal of translational medicine.
16(1)
[DOI] 10.1186/s12967-018-1469-8.
[PMID] 29642909.
2018
Generic Cost-Effectiveness Models: A Proof of Concept of a Tool for Informed Decision-Making for Public Health Precision Medicine.
Public health genomics.
21(5-6):217-227
[DOI] 10.1159/000500725.
[PMID] 31189173.
2018
Genetic Variants Influencing Plasma Renin Activity in Hypertensive Patients From the PEAR Study (Pharmacogenomic Evaluation of Antihypertensive Responses).
Circulation. Genomic and precision medicine.
11(4)
[DOI] 10.1161/CIRCGEN.117.001854.
[PMID] 29650764.
2018
Genome Wide Association Study Identifies the HMGCS2 Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients.
Journal of the American Heart Association.
7(6)
[DOI] 10.1161/JAHA.117.007339.
[PMID] 29523524.
2018
Genome-Wide Association Approach Identified Novel Genetic Predictors of Heart Rate Response to β-Blockers.
Journal of the American Heart Association.
7(5)
[DOI] 10.1161/JAHA.117.006463.
[PMID] 29478026.
2018
Implementation of Standardized Clinical Processes for TPMT Testing in a Diverse Multidisciplinary Population: Challenges and Lessons Learned.
Clinical and translational science.
11(2):175-181
[DOI] 10.1111/cts.12533.
[PMID] 29351371.
2018
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Nature genetics.
50(4):524-537
[DOI] 10.1038/s41588-018-0058-3.
[PMID] 29531354.
2018
Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.
JACC. Cardiovascular interventions.
11(2):181-191
[DOI] 10.1016/j.jcin.2017.07.022.
[PMID] 29102571.
2018
Multisite Investigation of Strategies for the Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy.
Clinical pharmacology and therapeutics.
104(4):664-674
[DOI] 10.1002/cpt.1006.
[PMID] 29280137.
2018
Proton pump inhibitors: from CYP2C19 pharmacogenetics to precision medicine.
Expert opinion on drug metabolism & toxicology.
14(4):447-460
[DOI] 10.1080/17425255.2018.1461835.
[PMID] 29620484.
2018
Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects.
Clinical pharmacology and therapeutics.
103(5):778-786
[DOI] 10.1002/cpt.1048.
[PMID] 29460415.
2018
Targeted sequencing identifies a missense variant in the BEST3 gene associated with antihypertensive response to hydrochlorothiazide.
Pharmacogenetics and genomics.
28(11):251-255
[DOI] 10.1097/FPC.0000000000000353.
[PMID] 30289819.
2018
Whole Transcriptome Profiling: An RNA-Seq Primer and Implications for Pharmacogenomics Research.
Clinical and translational science.
11(2):153-161
[DOI] 10.1111/cts.12511.
[PMID] 28945944.
2017
Blood pressure response to metoprolol and chlorthalidone in European and African Americans with hypertension.
Journal of clinical hypertension (Greenwich, Conn.).
19(12):1301-1308
[DOI] 10.1111/jch.13094.
[PMID] 28940643.
2017
Comparison of Whole-Genome Sequencing Methods for Analysis of Three Methicillin-Resistant Staphylococcus aureus Outbreaks.
Journal of clinical microbiology.
55(6):1946-1953
[DOI] 10.1128/JCM.00029-17.
[PMID] 28404677.
2017
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms.
Nature genetics.
49(7):1113-1119
[DOI] 10.1038/ng.3874.
[PMID] 28530674.
2017
Genetic Variants Associated With Uncontrolled Blood Pressure on Thiazide Diuretic/β-Blocker Combination Therapy in the PEAR (Pharmacogenomic Evaluation of Antihypertensive Responses) and INVEST (International Verapamil-SR Trandolapril Study) Trials.
Journal of the American Heart Association.
6(11)
[DOI] 10.1161/JAHA.117.006522.
[PMID] 29097388.
2017
Genetic variation at 16q24.2 is associated with small vessel stroke.
Annals of neurology.
81(3):383-394
[DOI] 10.1002/ana.24840.
[PMID] 27997041.
2017
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The American journal of cardiology.
94(4):535-8
[PMID] 15325950.
2004
Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension.
Clinical pharmacology and therapeutics.
76(6):536-44
[PMID] 15592325.
2004
Sequencing complex diseases With HapMap.
Genetics.
168(1):503-11
[PMID] 15454560.
2003
A haplotype-based algorithm for multilocus linkage disequilibrium mapping of quantitative trait loci with epistasis.
Genetics.
163(4):1533-48
[PMID] 12702696.
2003
Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol.
Clinical pharmacology and therapeutics.
74(1):44-52
[PMID] 12844134.
2003
Drug receptor/effector polymorphisms and pharmacogenetics: current status and challenges.
Pharmacogenetics.
13(9):525-34
[PMID] 12972951.
2003
Pharmacogenetics: potential for individualized drug therapy through genetics.
Trends in genetics : TIG.
19(11):660-6
[PMID] 14585618.
2003
The evolving role of nesiritide in advanced or decompensated heart failure.
Pharmacotherapy.
23(10):1266-80
[PMID] 14594345.
2002
Beta-adrenergic receptor polymorphisms: cardiovascular disease associations and pharmacogenetics.
Pharmaceutical research.
19(12):1779-87
[PMID] 12523655.
2002
Collection of genomic DNA by the noninvasive mouthwash method for use in pharmacogenetic studies.
Pharmacotherapy.
22(8):954-60
[PMID] 12173798.
2002
Dobutamine pharmacodynamics during dobutamine stress echocardiography and the impact of beta-blocker withdrawal: a report from the Women’s Ischemic Syndrome Evaluation Study.
Pharmacotherapy.
22(8):939-46
[PMID] 12173796.
2002
Molecular diagnostics as a predictive tool: genetics of drug efficacy and toxicity.
Trends in molecular medicine.
8(6):300-5
[PMID] 12067617.
2002
Pharmacogenetics of cardiovascular drugs.
Briefings in functional genomics & proteomics.
1(1):66-79
[PMID] 15251067.
2002
Pharmacogenetics, pharmacogenomics, and cardiovascular therapeutics: the way forward.
American journal of cardiovascular drugs : drugs, devices, and other interventions.
2(5):287-96
[PMID] 14727958.
2002
Pharmacogenomics: A Scientific Revolution in Pharmaceutical Sciences and Pharmacy Practice. Report of the 2001/02 Academic Affairs Committee
American Journal of Pharmaceutical Education.
66:12S-15S
2001
Determination of Human Beta2-Adrenoceptor Haplotypes by Denaturation Selective Amplification and Subtractive Genotyping
.
1(4):315-322
2001
Drug target pharmacogenomics: an overview.
American journal of pharmacogenomics : genomics-related research in drug development and clinical practice.
1(4):271-81
[PMID] 12083959.
2001
Effects of beta1-adrenoceptor genetic polymorphisms on resting hemodynamics in patients undergoing diagnostic testing for ischemia
American Journal of Cardiology.
88(9):1034-1037
[DOI] 10.1016/S0002-9149(01)01986-5.
[PMID] 11704005.
2001
INVEST Substudies: Design and Patient Characteristics
Clinical Cardiology.
24(11):9-11
2001
Pharmacogenomics: The Inherited Basis for Inter-Individual Differences in Drug Response
.
2:9-39
2001
The Effect of Gut Metabolism on Tacrolimus Bioavailability in Renal Transplant Recipients
.
71(9):1303-1307
2000
CYP1A2 and CYP2D6 4-hydroxylate propranolol and both reactions exhibit racial differences.
Journal of Pharmacology and Experimental Therapeutics.
294(3):1099-105
[PMID] 10945865.
2000
Effects of COER-Verapamil on Circadian Pattern of Forearm Vascular Resistance and Blood Pressure
.
40(12):1480-1487
2000
Gender Differences in Labetalol Kinetics: Importance of Determining Stereoisomer Kinetics for Racemic Drugs
Pharmacotherapy.
20(6):622-628
2000
Importance of Beta2 Adrenergic Receptor Genotype, Gender and Race on Albuterol-Evoked Bronchodilation in Asthmatics
Pulmonary Pharmacology & Therapeutics.
13(3):127-134
2000
Predictability of the Effects of Race or Ethnicity on Pharmacokinetics of Drugs (Invited Review)
.
38(2):53-60
2000
Sequencing of Beta2-Adrenoceptor Gene PCR Products Using Taq BigDye Terminator Chemistry Results in Inaccurate Base-Calling
Biotechniques.
29(5):962-964
2000
Simple Method for Determination of Terbutaline Plasma Concentration by High Performance Liquid Chromatography
.
741(2):307-312
1999
Effects of Gender and Race on Albuterol Pharmacokinetics
Pharmacotherapy.
19(2):157-161
1999
Impact of Genetic Polymorphisms of the Beta2-Adrenergic Receptor on Albuterol Bronchodilator Pharmacodynamics
Clinical Pharmacology & Therapeutics.
65(5):519-525
1999
Intranasal DDAVP-Induced Increases in Plasma Von Willebrand Factor Alter the Pharmacokinetics of High-Purity Factor VIII Concentrates in Severe Hemophilia A Patients
.
5(2):88-95
1998
The Role of Endothelin-1 in Heart Failure and Hypertension
Pharmacotherapy.
18:706-719
1997
Differences Between Blacks and Whites in Plasma Protein Binding of Drugs
.
51:485-488
1997
Influence of Race or Ethnicity on Pharmacokinetics of Drugs
Journal of Pharmaceutical Sciences.
86(12):1328-1333
1996
Metoprolol Metabolism Via Cytochrome P450 2D6 in Ethnic Populations
.
24(3):350-355
1996
Racial Differences in Propranolol Enantiomer Kinetics Following Simultaneous IV and Oral Administration
British Journal of Clinical Pharmacology.
42(3):339-346
1995
Influence of Metabolites on Protein Binding of Verapamil Enantiomers
British Journal of Clinical Pharmacology.
39(5):536-538
1995
Lymphocyte Beta2-Receptor Activity, Metoprolol Kinetics and Response to Metoprolol in Hypertensive Black Men
Pharmacotherapy.
15(2):150-157
1995
Metoprolol Minimizes Nighttime Blood Pressure Dip in Hypertensive Black Males
American Journal of Hypertension.
8(3):254-259
1995
Racial Differences in Beta-Adrenoceptor-Mediated Responsiveness
Journal of Cardiovascular Pharmacology.
25(1):90-96
1995
Racial Differences in Sensitivity to the Negative Chronotropic Effects of Propranolol in Healthy Males
Clinical Pharmacology & Therapeutics.
57(6):678-683
1993
Differences in Apparent Sensitivities of Chronotropy and Inotropy to Propranolol
.
34:256-262
1993
Direct High Performance Liquid Chromatographic Determination in Urine of the Enantiomers of Propranolol and its Major Basic Metabolite 4-Hydroxypropranolol
Journal of Chromatography a.
612(2):215-221
1993
Racial Differences in Lymphocyte Beta-Receptor Sensitivity to Propranolol
Life Sciences.
53(4):297-304
1992
Racial Differences in Propranolol Pharmacokinetics
Clinical Pharmacology & Therapeutics.
51(5):495-500
1991
Diastolic Dysfunction in Congestive Heart Failure
.
10(11):850-861
1990
Comparison of Hypersensitivity to Adrenergic Stimulation After Abrupt Withdrawal of Propranolol and Nadolol: Influence of Half-Life Differences
.
120(3):572-579
1990
Comparison of Single Dose and Steady State Nadolol Plasma Concentrations
Pharmaceutical Research.
7(9):953-956
1990
Use of Beta-Adrenergic Blocking Agents in Congestive Heart Failure
.
9(11):853-863
1989
Biphasic Pattern of Hypersensitivity Following Acute Propranolol Withdrawal in Normal Subjects
Life Sciences.
45(17):1547-1551
1989
Drug- or Hormone-Induced Adaptation: Model of Adrenergic Hypersensitivity
Journal of Pharmacokinetics and Pharmacodynamics.
17(3):347-364
1987
Lovastatin: A New Cholesterol Lowering Agent
Pharmacotherapy.
7(6):198-210
1986
Dose- and Time-Dependent Binding and Kinetics of Pindolol in Patients with Congestive Heart Failure
.
26(4):253-257
1986
Management of Pediatric Patients with Bronchiolitis in the Emergency Department
.
8:18-21
1985
Management of Bronchiolitis
.
4(3):299-303
1985
Prophylactic Antibiotics in Plastic Surgery
.
7:29-30
Grants
May 2023
ACTIVE
Training Program for Applied Research and Development in Genomic Medicine
Role: Principal Investigator
Funding: NATL INST OF HLTH NHGRI
Jul 2022
ACTIVE
Integrated, Individualized, and Intelligent Prescribing (I3P) Clinical Trial Network
Role: Principal Investigator
Funding: VANDERBILT UNIVERSITY MEDICAL CENTER
via NATL INST OF HLTH NHGRI
Dec 2021
– Nov 2022
Impact of CYP2D6 genotypes and inhibitors on opioid therapy in patients with pain
Role: Other
Funding: AMER COL OF CLINICAL PHAR
Sep 2021
– Aug 2023
Warfarin Pharmacogenetics at UF Health
Role: Co-Investigator
Funding: UF HEALTH SHANDS HOSPITAL
Jan 2020
– Dec 2021
Personalizing thiazide therapy through clinical and microRNA biomarkers of response to thiazides
Role: Other
Funding: AMER HEART ASSOCIATION
Sep 2018
ACTIVE
Sparking Advancements in Genomic Medicine?
Role: Principal Investigator
Funding: NATL INST OF HLTH NHGRI
Jan 2018
ACTIVE
Training Program for Applied Research and Development in Genomic Medicine
Role: Principal Investigator
Funding: NATL INST OF HLTH NHGRI
Jul 2016
– Sep 2020
A stem cell tactic to promote personalized medicine
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
Jul 2016
– Jun 2018
A Stem Cell Tactic to Promote Personalized Medicine in Hypertension
Role: Faculty
Funding: AMER HEART ASSOCIATION
Oct 2015
– Mar 2019
OneFlorida Clinical Research Consortium Phase II
Role: Project Manager
Funding: PATIENT-CENTERED OUTCOMES RES INST
Jul 2014
– Dec 2015
Using Different OMICS for the Identification of Novel Biomarkers of Blood Pressure Response to Antihypertensive Drugs
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION
Jun 2013
– Sep 2018
Genomic Medicine Implementation: The Personalized Medicine Program
Role: Principal Investigator
Funding: NATL INST OF HLTH NHGRI
Mar 2011
– Feb 2016
Secondary Prevention of Subcortical Stroke Prevention Genetics Substudy Timing
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Aug 2010
– Jul 2017
Pharmacogenomic Evaluation of Antihypertensive Responses.
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Jul 2007
– Aug 2016
Clinical and Translational Science Institute
Role: Project Manager
Funding: UF RESEARCH FOU
Education
Postdoctoral Fellowship in Pharmacokinetics/Clinical Pharmacology
1987-1989
·
The Ohio State University
Pharm.D.
1987
·
The University of Texas at Austin and The University of Texas Health Science Center at San Antonio
B.S.
1985
·
The Ohio State University
Contact Details
Phones:
- Business:
- (352) 273-6309
Emails:
- Business:
- julie.johnson@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100484
GAINESVILLE FL 32610 - Business Street:
-
1225 CENTER DR
HPNP 4332
GAINESVILLE FL 326103007