Julie A Johnson, Pharm.D.
Dean & Distinguished Professor
About Julie A Johnson
Julie A. Johnson, Pharm.D., is dean of the University of Florida College of Pharmacy and distinguished professor of Pharmacy and Medicine. She received her B.S. in Pharmacy from the Ohio State University and her Pharm.D. from the University of Texas at Austin and the UT Health Science Center at San Antonio. She completed a post-doctoral fellowship in cardiovascular pharmacology/pharmacokinetics at Ohio State.
Johnson’s research focuses on cardiovascular pharmacogenomics and genomic medicine implementation. She is an internationally-recognized leader in pharmacogenomics and genomic medicine, with over 300 peer reviewed publications and nearly $50 million in research funding as principal investigator. In 2015, 2016, 2017 she was named a Thomson Reuters (now Clarivate Analytics) Highly Cited Scientist in Pharmacology and Toxicology, and in 2018 in the Cross Discipline category, indicating she is in the top 1% of the most highly cited scientists in the field globally.
Johnson has served on the Nonprescription Drugs Advisory Committee of the FDA, the XNDA Study Section at NIH, and in numerous scientific capacities with NIH’s NHLBI. She has had leadership roles in the American College of Clinical Pharmacy (ACCP), the American Heart Association (AHA), and the American Society of Clinical Pharmacology and Therapeutics (ASCPT), for which she completed her term as President in 2017. She is an elected fellow of the ACCP, the AHA and the American College of Clinical Pharmacology (ACCP-Pharmacology). Johnson was elected to the National Academy of Medicine (formerly Institute of Medicine) in 2014 and has received numerous other awards including teaching awards from both the University of Tennessee (1996) and the University of Florida (2001); the Ohio State University Alumni Association William Oxley Thompson Award for early career achievement (1997), Leon I Goldberg Young Investigator Award from the ASCPT (2004), Paul Dawson Biotechnology Research Award, American Association of Colleges of Pharmacy (AACP) (2007), Therapeutic Frontiers Award (2009) and Russell R Miller Award for Contributions to the Literature (2010), both from ACCP, the Southeastern Universities Research Association Distinguished Scientist Award (2015); AACP Volwiler Research Achievement Award (2016), the ACCP-Pharmacology Distinguished Scientist Award (2019), and ACCP Paul Parker Medal (2019), among others.
Accomplishments
Distinguished Investigator Award
2019
·
American College of Clinical Pharmacology
Paul Parker Medal
2019
·
American College of Clinical Pharmacy
Volwiler Research Achievement Award
2016
·
American Association of Colleges of Pharmacy
Highly Cited Scientist
2015-2018
·
Clarivate Analytics
Distinguished Scientist Award
2015
·
Southeastern Universities Research Associate
Elected Member
2014
·
National Academy of Medicine
Honorary Fellow Award
2014
·
American College of Clinical Pharmacology
Russell Miller Award for Contribution to the Literature
2010
·
American College of Clinical Pharmacy
Fellow
2009
·
American Heart Association; Functional Genomics and Translational Biology Council
Therapeutic Frontiers Award
2009
·
American College of Clinical Pharmacy
Paul Dawson Biotechnology Research Award
2007
·
American Association of Colleges of Pharmacy
Leon I. Goldberg Young Investigator Award
2004
·
American Society for Clinical Pharmacology and Therapeutics
William Oxley Thompson Alumni Award
1997
·
The Ohio State University
Fellow
1996
·
American College of Clinical Pharmacy
Publications
2021
A hybrid implementation-effectiveness randomized trial of CYP2D6-guided postoperative pain management.
Genetics in medicine : official journal of the American College of Medical Genetics.
23(4):621-628
[DOI] 10.1038/s41436-020-01050-4.
[PMID] 33420349.
2021
Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality.
European heart journal.
[DOI] 10.1093/eurheartj/ehab107.
[PMID] 33748830.
2021
Impact of the CYP2C19*17 Allele on Outcomes in Patients Receiving Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.
Clinical pharmacology and therapeutics.
109(3):705-715
[DOI] 10.1002/cpt.2039.
[PMID] 32897581.
2021
Race-Specific Comparisons of Antihypertensive and Metabolic Effects of Hydrochlorothiazide and Chlorthalidone.
The American journal of medicine.
[DOI] 10.1016/j.amjmed.2020.12.015.
[PMID] 33434556.
2021
Tribute to Professor Hartmut Derendorf – 1953 to 2020: Driving force in Clinical Pharmacology and Mentor Extraordinaire.
Clinical pharmacology and therapeutics.
109(4):805-809
[DOI] 10.1002/cpt.2193.
[PMID] 33667324.
2020
A Scoping Review of the Evidence Behind Cytochrome P450 2D6 Isoenzyme Inhibitor Classifications.
Clinical pharmacology and therapeutics.
108(1):116-125
[DOI] 10.1002/cpt.1768.
[PMID] 31910286.
2020
Association of Factor V Leiden With Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data.
Circulation.
142(6):546-555
[DOI] 10.1161/CIRCULATIONAHA.119.045526.
[PMID] 32654539.
2020
Blending Traditional Vocational Services and Individualized Placement and Support for Formerly Incarcerated Veterans.
Psychiatric services (Washington, D.C.).
71(8):816-823
[DOI] 10.1176/appi.ps.201900421.
[PMID] 32393158.
2020
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing.
Clinical pharmacology and therapeutics.
[DOI] 10.1002/cpt.2015.
[PMID] 32770672.
2020
Clinical Pharmacology Education – The Decade Ahead.
Clinical pharmacology and therapeutics.
107(1):37-39
[DOI] 10.1002/cpt.1652.
[PMID] 31709518.
2020
Clinical Utility of Pharmacogene Panel-Based Testing in Patients Undergoing Percutaneous Coronary Intervention.
Clinical and translational science.
13(3):473-481
[DOI] 10.1111/cts.12729.
[PMID] 31758664.
2020
Combination Antihypertensive Therapy Prescribing and Blood Pressure Control in a Real-World Setting.
American journal of hypertension.
33(4):316-324
[DOI] 10.1093/ajh/hpz196.
[PMID] 31853537.
2020
Cost-effectiveness of CYP2C19-guided antiplatelet therapy in patients with acute coronary syndrome and percutaneous coronary intervention informed by real-world data.
The pharmacogenomics journal.
20(5):724-735
[DOI] 10.1038/s41397-020-0162-5.
[PMID] 32042096.
2020
Design and Early Implementation Successes and Challenges of a Pharmacogenetics Consult Clinic.
Journal of clinical medicine.
9(7)
[DOI] 10.3390/jcm9072274.
[PMID] 32708920.
2020
Evaluating the extent of reusability of CYP2C19 genotype data among patients genotyped for antiplatelet therapy selection.
Genetics in medicine : official journal of the American College of Medical Genetics.
22(11):1898-1902
[DOI] 10.1038/s41436-020-0894-2.
[PMID] 32678355.
2020
Examination of Metoprolol Pharmacokinetics and Pharmacodynamics Across CYP2D6 Genotype-Derived Activity Scores.
CPT: pharmacometrics & systems pharmacology.
9(12):678-685
[DOI] 10.1002/psp4.12563.
[PMID] 33067866.
2020
How to Transition from Single-Gene Pharmacogenetic Testing to Preemptive Panel-Based Testing: A Tutorial.
Clinical pharmacology and therapeutics.
108(3):557-565
[DOI] 10.1002/cpt.1912.
[PMID] 32460360.
2020
Pharmacogenetic factors affecting β-blocker metabolism and response.
Expert opinion on drug metabolism & toxicology.
16(10):953-964
[DOI] 10.1080/17425255.2020.1803279.
[PMID] 32726152.
2020
Response to: Heterogeneous Treatment Response by Race Cannot Be Claimed in the Absence of Evidence.
American journal of hypertension.
33(2)
[DOI] 10.1093/ajh/hpz168.
[PMID] 31891170.
2020
Sorting nexin 1 loss results in increased oxidative stress and hypertension.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
34(6):7941-7957
[DOI] 10.1096/fj.201902448R.
[PMID] 32293069.
2020
The Patient-Centered Future of Clinical Pharmacology.
Clinical pharmacology and therapeutics.
107(1):72-75
[DOI] 10.1002/cpt.1681.
[PMID] 31751490.
2019
A case for genotype-guided pain management.
Pharmacogenomics.
20(10):705-708
[DOI] 10.2217/pgs-2019-0068.
[PMID] 31368851.
2019
Antihypertensive therapy prescribing patterns and correlates of blood pressure control among hypertensive patients with chronic kidney disease.
Journal of clinical hypertension (Greenwich, Conn.).
21(1):91-101
[DOI] 10.1111/jch.13429.
[PMID] 30427124.
2019
Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events.
Circulation. Genomic and precision medicine.
12(4)
[DOI] 10.1161/CIRCGEN.119.002471.
[PMID] 30897348.
2019
Challenges and lessons learned from clinical pharmacogenetic implementation of multiple gene-drug pairs across ambulatory care settings.
Genetics in medicine : official journal of the American College of Medical Genetics.
21(10):2264-2274
[DOI] 10.1038/s41436-019-0500-7.
[PMID] 30926959.
2019
CYP2D6-guided opioid therapy improves pain control in CYP2D6 intermediate and poor metabolizers: a pragmatic clinical trial.
Genetics in medicine : official journal of the American College of Medical Genetics.
21(8):1842-1850
[DOI] 10.1038/s41436-018-0431-8.
[PMID] 30670877.
2019
Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals.
Clinical pharmacology and therapeutics.
105(6):1477-1491
[DOI] 10.1002/cpt.1323.
[PMID] 30506689.
2019
Effect of plasma MicroRNA on antihypertensive response to beta blockers in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) studies.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
131:93-98
[DOI] 10.1016/j.ejps.2019.02.013.
[PMID] 30753892.
2019
Essential Characteristics of Pharmacogenomics Study Publications.
Clinical pharmacology and therapeutics.
105(1):86-91
[DOI] 10.1002/cpt.1279.
[PMID] 30406943.
2019
Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals.
Hypertension (Dallas, Tex. : 1979).
74(3):614-622
[DOI] 10.1161/HYPERTENSIONAHA.118.12177.
[PMID] 31327267.
2019
Genome Wide Analysis Approach Suggests Chromosome 2 Locus to be Associated with Thiazide and Thiazide Like-Diuretics Blood Pressure Response.
Scientific reports.
9(1)
[DOI] 10.1038/s41598-019-53345-5.
[PMID] 31754133.
2019
Genome-wide association analysis of common genetic variants of resistant hypertension.
The pharmacogenomics journal.
19(3):295-304
[DOI] 10.1038/s41397-018-0049-x.
[PMID] 30237584.
2019
Genome-Wide Meta-Analysis of Blood Pressure Response to β1-Blockers: Results From ICAPS (International Consortium of Antihypertensive Pharmacogenomics Studies).
Journal of the American Heart Association.
8(16)
[DOI] 10.1161/JAHA.119.013115.
[PMID] 31423876.
2019
Genomic Association Analysis Reveals Variants Associated With Blood Pressure Response to Beta-Blockers in European Americans.
Clinical and translational science.
12(5):497-504
[DOI] 10.1111/cts.12643.
[PMID] 31033190.
2019
Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers.
PloS one.
14(9)
[DOI] 10.1371/journal.pone.0221957.
[PMID] 31532792.
2019
Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing.
Genetics in medicine : official journal of the American College of Medical Genetics.
21(10):2255-2263
[DOI] 10.1038/s41436-019-0484-3.
[PMID] 30894703.
2019
Novel Implementation of Genotype-Guided Proton Pump Inhibitor Medication Therapy in Children: A Pilot, Randomized, Multisite Pragmatic Trial.
Clinical and translational science.
12(2):172-179
[DOI] 10.1111/cts.12589.
[PMID] 30341969.
2019
Plasma Renin Activity Is a Predictive Biomarker of Blood Pressure Response in European but not in African Americans With Uncomplicated Hypertension.
American journal of hypertension.
32(7):668-675
[DOI] 10.1093/ajh/hpz022.
[PMID] 30753254.
2019
Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Nature genetics.
51(7):1192-1193
[DOI] 10.1038/s41588-019-0449-0.
[PMID] 31160810.
2019
Qualitative study of system-level factors related to genomic implementation.
Genetics in medicine : official journal of the American College of Medical Genetics.
21(7):1534-1540
[DOI] 10.1038/s41436-018-0378-9.
[PMID] 30467402.
2019
Subsequent Event Risk in Individuals With Established Coronary Heart Disease.
Circulation. Genomic and precision medicine.
12(4)
[DOI] 10.1161/CIRCGEN.119.002470.
[PMID] 30896328.
2019
β2 -Adrenergic Receptor Gene Affects the Heart Rate Response of β-Blockers: Evidence From 3 Clinical Studies.
Journal of clinical pharmacology.
59(11):1462-1470
[DOI] 10.1002/jcph.1443.
[PMID] 31090079.
2018
Blood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies.
BMC medical genomics.
11(1)
[DOI] 10.1186/s12920-018-0370-x.
[PMID] 29925376.
2018
Clinical implementation of rapid CYP2C19 genotyping to guide antiplatelet therapy after percutaneous coronary intervention.
Journal of translational medicine.
16(1)
[DOI] 10.1186/s12967-018-1469-8.
[PMID] 29642909.
2018
Generic Cost-Effectiveness Models: A Proof of Concept of a Tool for Informed Decision-Making for Public Health Precision Medicine.
Public health genomics.
21(5-6):217-227
[DOI] 10.1159/000500725.
[PMID] 31189173.
2018
Genetic Variants Influencing Plasma Renin Activity in Hypertensive Patients From the PEAR Study (Pharmacogenomic Evaluation of Antihypertensive Responses).
Circulation. Genomic and precision medicine.
11(4)
[DOI] 10.1161/CIRCGEN.117.001854.
[PMID] 29650764.
2018
Genome Wide Association Study Identifies the HMGCS2 Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients.
Journal of the American Heart Association.
7(6)
[DOI] 10.1161/JAHA.117.007339.
[PMID] 29523524.
2018
Genome-Wide Association Approach Identified Novel Genetic Predictors of Heart Rate Response to β-Blockers.
Journal of the American Heart Association.
7(5)
[DOI] 10.1161/JAHA.117.006463.
[PMID] 29478026.
2018
Implementation of Standardized Clinical Processes for TPMT Testing in a Diverse Multidisciplinary Population: Challenges and Lessons Learned.
Clinical and translational science.
11(2):175-181
[DOI] 10.1111/cts.12533.
[PMID] 29351371.
2018
Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.
JACC. Cardiovascular interventions.
11(2):181-191
[DOI] 10.1016/j.jcin.2017.07.022.
[PMID] 29102571.
2018
Multisite Investigation of Strategies for the Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy.
Clinical pharmacology and therapeutics.
104(4):664-674
[DOI] 10.1002/cpt.1006.
[PMID] 29280137.
2018
Proton pump inhibitors: from CYP2C19 pharmacogenetics to precision medicine.
Expert opinion on drug metabolism & toxicology.
14(4):447-460
[DOI] 10.1080/17425255.2018.1461835.
[PMID] 29620484.
2018
Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects.
Clinical pharmacology and therapeutics.
103(5):778-786
[DOI] 10.1002/cpt.1048.
[PMID] 29460415.
2018
Targeted sequencing identifies a missense variant in the BEST3 gene associated with antihypertensive response to hydrochlorothiazide.
Pharmacogenetics and genomics.
28(11):251-255
[DOI] 10.1097/FPC.0000000000000353.
[PMID] 30289819.
2018
Whole Transcriptome Profiling: An RNA-Seq Primer and Implications for Pharmacogenomics Research.
Clinical and translational science.
11(2):153-161
[DOI] 10.1111/cts.12511.
[PMID] 28945944.
2017
Blood pressure response to metoprolol and chlorthalidone in European and African Americans with hypertension.
Journal of clinical hypertension (Greenwich, Conn.).
19(12):1301-1308
[DOI] 10.1111/jch.13094.
[PMID] 28940643.
2017
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms.
Nature genetics.
49(7):1113-1119
[DOI] 10.1038/ng.3874.
[PMID] 28530674.
2017
Genetic Variants Associated With Uncontrolled Blood Pressure on Thiazide Diuretic/β-Blocker Combination Therapy in the PEAR (Pharmacogenomic Evaluation of Antihypertensive Responses) and INVEST (International Verapamil-SR Trandolapril Study) Trials.
Journal of the American Heart Association.
6(11)
[DOI] 10.1161/JAHA.117.006522.
[PMID] 29097388.
2017
Genetic variation at 16q24.2 is associated with small vessel stroke.
Annals of neurology.
81(3):383-394
[DOI] 10.1002/ana.24840.
[PMID] 27997041.
2017
Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide.
Hypertension (Dallas, Tex. : 1979).
69(1):51-59
[PMID] 27802415.
View on:
PubMed
2017
Genome-Wide Prioritization and Transcriptomics Reveal Novel Signatures Associated With Thiazide Diuretics Blood Pressure Response.
Circulation. Cardiovascular genetics.
10(1)
[DOI] 10.1161/CIRCGENETICS.116.001404.
[PMID] 28115488.
2017
Genome-wide study of resistant hypertension identified from electronic health records.
PloS one.
12(2)
[DOI] 10.1371/journal.pone.0171745.
[PMID] 28222112.
2017
Impact of the CYP2C19 genotype on voriconazole exposure in adults with invasive fungal infections.
Pharmacogenetics and genomics.
27(5):190-196
[DOI] 10.1097/FPC.0000000000000277.
[PMID] 28306618.
2017
Institutional profile: University of Florida Health Personalized Medicine Program.
Pharmacogenomics.
18(5):421-426
[DOI] 10.2217/pgs-2017-0028.
[PMID] 28346068.
2017
Pharmacogenetic Associations of β1-Adrenergic Receptor Polymorphisms With Cardiovascular Outcomes in the SPS3 Trial (Secondary Prevention of Small Subcortical Strokes).
Stroke.
48(5):1337-1343
[DOI] 10.1161/STROKEAHA.116.015936.
[PMID] 28351962.
2017
Relations Between Lipoprotein(A) Concentrations, Lpa Genetic Variants, and the Risk of Mortality in Patients With Established Coronary Heart Disease: a Molecular and Genetic Association Study
Lancet Diabetes and Endocrinology.
5(7):534-543
[DOI] 10.1016/S2213-8587(17)30096-7.
[PMID] 28566218.
2017
Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics.
Journal of the American Heart Association.
7(1)
[DOI] 10.1161/JAHA.117.006656.
[PMID] 29288159.
2017
Whole Transcriptome Sequencing Analyses Reveal Molecular Markers of Blood Pressure Response to Thiazide Diuretics.
Scientific reports.
7(1)
[DOI] 10.1038/s41598-017-16343-z.
[PMID] 29167564.
2016
A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration.
Hypertension (Dallas, Tex. : 1979).
68(3):621-9
[DOI] 10.1161/HYPERTENSIONAHA.116.07328.
[PMID] 27381900.
2016
CES1P1 variant -816A>C is not associated with hepatic carboxylesterase 1 expression and activity or antihypertensive effect of trandolapril.
European journal of clinical pharmacology.
72(6):681-7
[DOI] 10.1007/s00228-016-2029-x.
[PMID] 26915813.
2016
Comparison of Blood Pressure Control Rates Among Recommended Drug Selection Strategies for Initial Therapy of Hypertension.
American journal of hypertension.
29(10):1186-94
[DOI] 10.1093/ajh/hpw067.
[PMID] 27365079.
2016
CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease.
Journal of neurosurgery.
124(6):1746-51
[DOI] 10.3171/2015.6.JNS15795.
[PMID] 26587656.
2016
Effects of Using Personal Genotype Data on Student Learning and Attitudes in a Pharmacogenomics Course.
American journal of pharmaceutical education.
80(7)
[PMID] 27756930.
View on:
PubMed
2016
Genetic and Non-Genetic Factors Affecting Clopidogrel Efficacy in Egyptian Population
.
9(1):23-28
2016
Hypertension pharmacogenomics: in search of personalized treatment approaches.
Nature reviews. Nephrology.
12(2):110-22
[DOI] 10.1038/nrneph.2015.176.
[PMID] 26592190.
2016
Identification of Additional Risk Loci for Stroke and Small Vessel Disease: A Meta-Analysis of Genome Wide Association Studies
Lancet Neurology.
2016
Identification of Suitable Endogenous Normalizers for qRT-PCR Analysis of Plasma microRNA Expression in Essential Hypertension.
Molecular biotechnology.
58(3):179-87
[DOI] 10.1007/s12033-015-9912-z.
[PMID] 26798072.
2016
Impact of GGCX, STX1B, and FPGS Polymorphisms on Warfarin Dose Requirements in European Americans and Egyptians
.
9(1):36-42
2016
Implementation of inpatient models of pharmacogenetics programs.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
73(23):1944-1954
[PMID] 27864202.
View on:
PubMed
2016
Mechanisms and pharmacogenetic signals underlying thiazide diuretics blood pressure response.
Current opinion in pharmacology.
27:31-7
[DOI] 10.1016/j.coph.2016.01.005.
[PMID] 26874237.
2016
Melatonin Pathway and Atenolol-Related Glucose Dysregulation- Is There a Correlation?
.
9(2):114-122
2016
Novel plasma biomarker of atenolol-induced hyperglycemia identified through a metabolomics-genomics integrative approach.
Metabolomics : Official journal of the Metabolomic Society.
12(8)
[DOI] 10.1007/s11306-016-1076-8.
[PMID] 28217400.
2016
Pharmacists should jump onto the clinical pharmacogenetics train.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
73(23):2013-2016
[PMID] 27864209.
View on:
PubMed
2016
Pharmacogenomic Genome-Wide Meta-Analysis of Blood Pressure Response to β-Blockers in Hypertensive African Americans.
Hypertension (Dallas, Tex. : 1979).
67(3):556-63
[DOI] 10.1161/HYPERTENSIONAHA.115.06345.
[PMID] 26729753.
2016
Population-Specific Single Nucleotide Polymorphism Confers Increased Risk of Venous Thromboembolism in African Americans
.
2016
Population-specific single-nucleotide polymorphism confers increased risk of venous thromboembolism in African Americans.
Molecular genetics & genomic medicine.
4(5):513-20
[DOI] 10.1002/mgg3.226.
[PMID] 27652279.
2016
Presence of arachidonoyl-carnitine is associated with adverse cardiometabolic responses in hypertensive patients treated with atenolol.
Metabolomics : Official journal of the Metabolomic Society.
12(10)
[DOI] 10.1007/s11306-016-1098-2.
[PMID] 28217401.
2016
The IGNITE network: a model for genomic medicine implementation and research.
BMC medical genomics.
9
[DOI] 10.1186/s12920-015-0162-5.
[PMID] 26729011.
2015
A Genome-Wide Association Study of Ischemic Stroke and its Subtypes Identifies a Novel Locus Near TSPAN2 for Stroke Related to Atherosclerosis
Lancet Neurology.
2015
A novel simple method for determining CYP2D6 gene copy number and identifying allele(s) with duplication/multiplication.
PloS one.
10(1)
[DOI] 10.1371/journal.pone.0113808.
[PMID] 25625348.
2015
Assessments of Atenolol and Hydrochlorothiazide Treatment Reveal Novel Drug Response Phenotypes
.
4(11):669-679
2015
Association of branched and aromatic amino acids levels with metabolic syndrome and impaired fasting glucose in hypertensive patients.
Metabolic syndrome and related disorders.
13(5):195-202
[DOI] 10.1089/met.2014.0132.
[PMID] 25664967.
2015
CYP2C19 metabolizer status and clopidogrel efficacy in the Secondary Prevention of Small Subcortical Strokes (SPS3) study
Journal of the American Heart Association.
[DOI] 10.1161/JAHA.114.001652.
[PMID] 26019129.
2015
CYP2C19 metabolizer status and clopidogrel efficacy in the Secondary Prevention of Small Subcortical Strokes (SPS3) study.
Journal of the American Heart Association.
4(6)
[DOI] 10.1161/JAHA.114.001652.
[PMID] 26019129.
2015
Floppy mitral valve/mitral valve prolapse syndrome: Beta-adrenergic receptor polymorphism may contribute to the pathogenesis of symptoms
Journal of Cardiology.
[DOI] 10.1016/j.jjcc.2014.07.020.
[PMID] 25172623.
2015
Floppy mitral valve/mitral valve prolapse syndrome: Beta-adrenergic receptor polymorphism may contribute to the pathogenesis of symptoms.
Journal of cardiology.
65(5):434-8
[DOI] 10.1016/j.jjcc.2014.07.020.
[PMID] 25172623.
2015
Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association.
Circulation.
131(19):1715-36
[DOI] 10.1161/CIR.0000000000000211.
[PMID] 25882488.
2015
Genome-wide association study of warfarin maintenance dose in a Brazilian sample.
Pharmacogenomics.
16(11):1253-63
[DOI] 10.2217/PGS.15.73.
[PMID] 26265036.
2015
Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for tamoxifen pharmacogenetic studies.
Journal of the National Cancer Institute.
107(2)
[DOI] 10.1093/jnci/dju437.
[PMID] 25638249.
2015
Pharmacogenomics of hypertension: a genome‐wide, placebo‐controlled cross‐over study, using four classes of antihypertensive drugs.
Journal of the American Heart Association.
4(1)
[DOI] 10.1161/JAHA.115.001778.
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Plasma renin activity predicts blood pressure responses to beta-blocker and thiazide diuretic as monotherapy and add-on therapy for hypertension.
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Study of Vkorc1, Cyp2C9, and Cyp4F2 Polymorphisms and Their Association With Warfarin Dose Requirements in Egyptian Patients.
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Cxcl5/Ena-78 Genotype and Progression To Death Or Transplantation in Heart Failure Patients.
Clinical Pharmacology & Therapeutics.
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Data Trends and Results From An Hlb Testing Laboratory That Has Processed Over 64,000 Commercial and Research Samples Over a Two Year Period in Florida
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New England Journal of Medicine.
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Genotyping the GGGCGG tandem repeat promoter polymorphism in the 5-lipoxygenase enzyme gene (ALOX5) by pyrosequencing assay.
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Clinical cardiology.
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Very important pharmacogene summary: sulfotransferase 1A1.
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New England Journal of Medicine.
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A Polymorphism in the Nppa Gene Associates With Asthma
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Alpha-adducin polymorphism associated with increased risk of adverse cardiovascular outcomes: results from GENEtic Substudy of the INternational VErapamil SR-trandolapril STudy (INVEST-GENES).
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B1-Adrenergic Receptor Polymorphism Predicts Mental Stress-Induced Myocardial Ischemia in Patients With Coronary Artery Disease
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Beta-adrenergic receptor gene polymorphisms and hemodynamic response to dobutamine during dobutamine stress echocardiography.
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Simplified method for determination of clarithromycin in human plasma using protein precipitation in a 96-well format and liquid chromatography-tandem mass spectrometry.
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Epistatic Control of Human Obesity as Revealed by Linkage Disequilibrium Mapping: a Report from the NHLBI-Sponsored WISE Study
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The Pharmacogenetics Research Network: From SNP Discovery to Clinical Drug Response
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A Bivariate Functional Mapping Model for Identifying Haplotypes that Control Drug Response for Systolic and Diastolic Blood Pressures
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Genetic Determinants of -Blocker Response: Influence of Phenotype and Pharmacokinetics on Drug Target Pharmacogenetics
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A Pharmacodynamic Model of the Effects of Controlled-Onset Extended-Release Verapamil on 24 Hour Ambulatory Blood Pressure
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Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study
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Sequencing Drug Response with HapMap
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A Statistical Model for Functional Mapping of Quantitative Trait Loci Regulating Drug Response
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The Effect of Gut Metabolism on Tacrolimus Bioavailability in Renal Transplant Recipients
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Intranasal DDAVP-Induced Increases in Plasma Von Willebrand Factor Alter the Pharmacokinetics of High-Purity Factor VIII Concentrates in Severe Hemophilia A Patients
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Grants
Jan 2020
ACTIVE
Personalizing thiazide therapy through clinical and microRNA biomarkers of response to thiazides
Role: Other
Funding: AMER HEART ASSOCIATION
Sep 2018
ACTIVE
Sparking Advancements in Genomic Medicine?
Role: Principal Investigator
Funding: NATL INST OF HLTH NHGRI
Jan 2018
ACTIVE
Training Program for Applied Research and Development in Genomic Medicine
Role: Principal Investigator
Funding: NATL INST OF HLTH NHGRI
Jul 2016
– Sep 2020
A stem cell tactic to promote personalized medicine
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
Jul 2016
– Jun 2018
A Stem Cell Tactic to Promote Personalized Medicine in Hypertension
Role: Faculty
Funding: AMER HEART ASSOCIATION
Oct 2015
– Mar 2019
OneFlorida Clinical Research Consortium Phase II
Role: Project Manager
Funding: PATIENT-CENTERED OUTCOMES RES INST
Jul 2014
– Dec 2015
Using Different OMICS for the Identification of Novel Biomarkers of Blood Pressure Response to Antihypertensive Drugs
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION
Jun 2013
– Sep 2018
Genomic Medicine Implementation: The Personalized Medicine Program
Role: Principal Investigator
Funding: NATL INST OF HLTH NHGRI
Mar 2011
– Feb 2016
Secondary Prevention of Subcortical Stroke Prevention Genetics Substudy Timing
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Aug 2010
– Jul 2017
Pharmacogenomic Evaluation of Antihypertensive Responses.
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Jul 2007
– Aug 2016
Clinical and Translational Science Institute
Role: Project Manager
Funding: UF RESEARCH FOU
Patents
Published
May 2009
Use of Genetic Determinants in Cardiovascular Risk Assessment
#US 2010-0021903-A1
Published
August 2007
B-Blocker Pharmacogenetics in Heart Failure
#US-2008-0269346-A1
Published
July 2003
Beta-Adrenoceptor Genetic Polymorphisms and Obesity
#US-2004-0033524
Published
February 2002
Methods of Diagnosing Obesity and Products Related Thereto
#US-2002-0187491
Education
Postdoctoral Fellowship in Pharmacokinetics/Clinical Pharmacology
1987-1989
·
The Ohio State University
Pharm.D.
1987
·
The University of Texas at Austin and The University of Texas Health Science Center at San Antonio
B.S.
1985
·
The Ohio State University
Teaching Profile
Courses Taught
2013-2021
PHA7979 Advanced Research
2020
PHA6910 Supervised Research
2013-2021
PHA7980 Research for Doctoral Dissertation
2014-2018,2021
PHA6938 Research Seminar
2016
PHA6971 Research for Master’s Thesis
2015
GMS7794 Neuroscience Seminar
2009-2011,2013
PHA5907 Research in Phar Prac
2013
PHA5933 Select Top Pharmacy
2012-2013
PHA5787 Pharmacotherapy 5
2011-2012
PHA5782 Pharmacotherapy 2
2012
PHA5113 Personalized Medicine
2011-2012
PHA5784 Pharmacotherapy 4
2008,2010-2012,2012
PHA6449 Pharmacogenomics
2011
PHA5113C Thera Mon/Pharmacogen
2009-2010
PHA4907 Probs in Pharm Prac
2010
IDH4917 Undergrad Research
Contact Details
Phones:
- Business:
- (352) 273-6309
Emails:
- Business:
- julie.johnson@ufl.edu