Jinmai Jiang

Jinmai Jiang, Ph.D.

Research Assistant Professor

Department: Pharmaceutics
Business Phone: (352) 273-9119
Business Email: jjiang@ufl.edu

About Jinmai Jiang

Dr. Jiang joined the Department of Pharmaceutics at the University of Florida College of Pharmacy as a Research Assistant Professor in July 2015. His current research focuses on (1) Study of miRNA as extracellular biomarkers for human disease diagnosis and prognosis, (2) Study of therapeutic extracellular vesicles and cancer heterogeneity, (3) Study of inhibition and revere of Acinar-to-Ductal Metaplasia in 3D cell cultures. He has published 40 peer-reviewed papers and 3 book chapters.

Related Links:

Research Profile

RESEARCH INTEREST

• Inhibition and revere of Acinar-to-Ductal Metaplasia in 3D cell cultures. • Therapeutic extracellular vesicles and cancer heterogeneity. • miRNA as extracellular biomarkers for human disease diagnosis and prognosis.

Areas of Interest
  • Extracellular vesicles
  • Inhibition and reversion of the earliest events involved in pancreatic cancer development
  • Singe cell Multiomics
  • microRNA
Open Researcher and Contributor ID (ORCID)

0000-0002-2418-6781

Publications

2024
Epigenetic small-molecule screen for inhibition and reversal of acinar ductal metaplasia in mouse pancreatic organoids.
Frontiers in pharmacology. 15 [DOI] 10.3389/fphar.2024.1335246. [PMID] 38510657.
2023
Transcriptional Profile of Human Pancreatic Acinar Ductal Metaplasia.
Gastro hep advances. 2(4):532-543 [DOI] 10.1016/j.gastha.2023.02.003. [PMID] 37425649.
2022
Pharmacological inhibition and reversal of pancreatic acinar ductal metaplasia.
Cell death discovery. 8(1) [DOI] 10.1038/s41420-022-01165-4. [PMID] 36055991.
2021
Enrichment of the erythrocyte miR-451a in brain extracellular vesicles following impairment of the blood-brain barrier.
Neuroscience letters. 751 [DOI] 10.1016/j.neulet.2021.135829. [PMID] 33727125.
2020
Alterations in mouse spinal cord and sciatic nerve microRNAs after the chronic constriction injury (CCI) model of neuropathic pain.
Neuroscience letters. 731 [DOI] 10.1016/j.neulet.2020.135029. [PMID] 32380144.
2020
Human Colon Mucosal Biofilms and Murine Host Communicate via Altered mRNA and microRNA Expression during Cancer.
mSystems. 5(1) [DOI] 10.1128/mSystems.00451-19. [PMID] 31937674.
2020
Loss of RE-1 silencing transcription factor accelerates exocrine damage from pancreatic injury.
Cell death & disease. 11(2) [DOI] 10.1038/s41419-020-2269-7. [PMID] 32080178.
2020
Method for improved integrity of RNA isolated from Matrigel cultures.
MethodsX. 7 [DOI] 10.1016/j.mex.2020.100966. [PMID] 32637337.
2019
Knockout of Acinar Enriched microRNAs in Mice Promote Duct Formation But Not Pancreatic Cancer.
Scientific reports. 9(1) [DOI] 10.1038/s41598-019-47566-x. [PMID] 31367007.
2018
CD44 positive and sorafenib insensitive hepatocellular carcinomas respond to the ATP-competitive mTOR inhibitor INK128.
Oncotarget. 9(40):26032-26045 [DOI] 10.18632/oncotarget.25430. [PMID] 29899840.
2018
Correction for Pandharkar et al., “Studies on the Antileishmanial Mechanism of Action of the Arylimidamide DB766: Azole Interactions and Role of CYP5122A1”.
Antimicrobial agents and chemotherapy. 62(1) [DOI] 10.1128/AAC.01124-17. [PMID] 29269427.
2017
Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells.
Journal of extracellular vesicles. 6(1) [DOI] 10.1080/20013078.2017.1324730. [PMID] 28717420.
2017
Expression Profiling Identifies the Noncoding Processed Transcript of HNRNPU with Proliferative Properties in Pancreatic Ductal Adenocarcinoma.
Non-coding RNA. 3(3) [DOI] 10.3390/ncrna3030024. [PMID] 29657295.
2017
Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery.
Journal of extracellular vesicles. 6(1) [DOI] 10.1080/20013078.2017.1333882. [PMID] 28717424.
2017
miR-216 and miR-217 expression is reduced in transgenic mouse models of pancreatic adenocarcinoma, knockout of miR-216/miR-217 host gene is embryonic lethal.
Functional & integrative genomics. 17(2-3):203-212 [DOI] 10.1007/s10142-016-0512-1. [PMID] 27541609.
2017
miR-221 regulates CD44 in hepatocellular carcinoma through the PI3K-AKT-mTOR pathway.
Biochemical and biophysical research communications. 487(3):709-715 [DOI] 10.1016/j.bbrc.2017.04.121. [PMID] 28442344.
2016
Anti-invasion and anti-migration effects of miR-199a-3p in hepatocellular carcinoma are due in part to targeting CD151.
International journal of oncology. 49(5):2037-2045 [DOI] 10.3892/ijo.2016.3677. [PMID] 27599545.
2016
Globally increased ultraconserved noncoding RNA expression in pancreatic adenocarcinoma.
Oncotarget. 7(33):53165-53177 [DOI] 10.18632/oncotarget.10242. [PMID] 27363020.
2015
Dietary apigenin reduces LPS-induced expression of miR-155 restoring immune balance during inflammation.
Molecular nutrition & food research. 59(4):763-72 [DOI] 10.1002/mnfr.201400705. [PMID] 25641956.
2014
Studies on the antileishmanial mechanism of action of the arylimidamide DB766: azole interactions and role of CYP5122A1.
Antimicrobial agents and chemotherapy. 58(8):4682-9 [DOI] 10.1128/AAC.02405-14. [PMID] 24890590.
2013
Concomitant dysregulation of microRNAs miR-151-3p and miR-126 correlates with improved survival in resected cholangiocarcinoma.
HPB : the official journal of the International Hepato Pancreato Biliary Association. 15(4):260-4 [DOI] 10.1111/j.1477-2574.2012.00523.x. [PMID] 23458262.
2013
Tumor suppressive function of mir-205 in breast cancer is linked to HMGB3 regulation.
PloS one. 8(10) [DOI] 10.1371/journal.pone.0076402. [PMID] 24098490.
2011
miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor.
Biochemical and biophysical research communications. 406(4):518-23 [DOI] 10.1016/j.bbrc.2011.02.065. [PMID] 21329664.
2011
miR-221 silencing blocks hepatocellular carcinoma and promotes survival.
Cancer research. 71(24):7608-16 [DOI] 10.1158/0008-5472.CAN-11-1144. [PMID] 22009537.
2010
MicroRNAs are mediators of androgen action in prostate and muscle.
PloS one. 5(10) [DOI] 10.1371/journal.pone.0013637. [PMID] 21048966.
2010
miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines.
Biochemical and biophysical research communications. 403(1):120-5 [DOI] 10.1016/j.bbrc.2010.10.130. [PMID] 21055388.
2010
Strong inverse correlation between microRNA-125b and human papillomavirus DNA in productive infection.
Diagnostic molecular pathology : the American journal of surgical pathology, part B. 19(3):135-43 [DOI] 10.1097/PDM.0b013e3181c4daaa. [PMID] 20736742.
2009
MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes.
Cancer research. 69(19):7569-76 [DOI] 10.1158/0008-5472.CAN-09-0529. [PMID] 19773441.
2009
The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(48):15161-8 [DOI] 10.1523/JNEUROSCI.4966-09.2009. [PMID] 19955368.
2008
Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival.
Clinical cancer research : an official journal of the American Association for Cancer Research. 14(2):419-27 [DOI] 10.1158/1078-0432.CCR-07-0523. [PMID] 18223217.
2008
Epigenetic modification of CCAAT/enhancer binding protein alpha expression in acute myeloid leukemia.
Cancer research. 68(9):3142-51 [DOI] 10.1158/0008-5472.CAN-08-0483. [PMID] 18451139.
2008
High-throughput real-time PCR.
Methods in molecular biology (Clifton, N.J.). 429:89-98 [DOI] 10.1007/978-1-60327-040-3_7. [PMID] 18695961.
2008
Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts.
Biochemical and biophysical research communications. 370(3):473-7 [DOI] 10.1016/j.bbrc.2008.03.120. [PMID] 18387358.
2008
Real-time PCR quantification of precursor and mature microRNA.
Methods (San Diego, Calif.). 44(1):31-8 [PMID] 18158130.
2007
Expression profiling identifies microRNA signature in pancreatic cancer.
International journal of cancer. 120(5):1046-54 [PMID] 17149698.
2007
TGF-beta1 stimulates human AT1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathways.
American journal of physiology. Lung cellular and molecular physiology. 293(3):L790-9 [PMID] 17601799.
2007
The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microRNA-155 binding.
The Journal of biological chemistry. 282(33):24262-9 [PMID] 17588946.
2006
Increased expression of microRNA-155 in Epstein-Barr virus transformed lymphoblastoid cell lines.
Genes, chromosomes & cancer. 45(1):103-6 [PMID] 16175574.
2006
Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines.
Gastroenterology. 130(7):2113-29 [PMID] 16762633.
2005
Real-time expression profiling of microRNA precursors in human cancer cell lines.
Nucleic acids research. 33(17):5394-403 [PMID] 16192569.
2004
A high-throughput method to monitor the expression of microRNA precursors.
Nucleic acids research. 32(4) [PMID] 14985473.

Grants

Sep 2023 ACTIVE
2/3 Florida-California Cancer Research, Education & Engagement (CaRE2) Health Equity Center
Role: Other
Funding: NATL INST OF HLTH NCI
Apr 2022 – Sep 2023
Gene expression in bone marrow exosomes during differentiation, phase II
Role: Co-Investigator
Funding: ERIVAN BIO
Jun 2021 – Nov 2023
Modulation of microbiome function by host-derived noncoding small RNA
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID

Contact Details

Phones:
Business:
(352) 273-9119
Emails:
Business:
jjiang@ufl.edu
Addresses:
Business Mailing:
PO Box 100494
GAINESVILLE FL 32610
Business Street:
2033 MOWRY RD
CGRC 470
GAINESVILLE FL 326103010