Margaret O James

Margaret O James Ph.D.

Jack C. Massey Professor

Department: Medicinal Chemistry
Business Phone: (352) 273-7707
Business Email: mojames@ufl.edu

About Margaret O James

Margaret James, Ph.D., investigates factors affecting the metabolism and toxicity of drugs and other xenobiotics in humans and animal species, including aquatic species. She was chosen as the Jack C Massey Professor of Pharmacy in 2006, as a University of Florida Research Foundation Professor, 1997-2000, and as a UF Term professor 2018-2021. Her laboratory studies mechanisms of uptake, biotransformation, excretion and toxicity of xenobiotics, especially environmental chemicals. Dr. James also investigates the influence of xenobiotics on the metabolism of steroid hormones.

Honors & Awards

Fellow
2011 · American Association for the Advancement of Science

Research Profile

Drug Biotransformation and Toxicology: Role of glutathione transferase zeta in the metabolism of dichloroacetic acid.

Dichloroacetate is both an orphan drug, used to reverse the Warburg effect in cancer cells and to treat acquired and congenital lactic acidosis, and an environmental pollutant found in chlorinated drinking water. The first step in metabolism of dichloroacetate is glutathione-dependent dehalogenation to glyoxylate, catalyzed by GSTZ1, an enzyme whose physiological function is in isomerization of tyrosine catabolites. As well as the studying the biotransformation of dichloroacetate, we are interested in understanding the toxicological effects of exposure to this agent.

Publications

2018 Drug metabolism and disposition: the biological fate of chemicals
2015 Biochemical and Biophysical Research Communications
2014 Acta Crystallographica. Section F, Structural Biology and Crystallization Communications
2013 Journal of Biochemical and Molecular Toxicology
2008 Journal of Pharmacology and Experimental Therapeutics
1998 Environmental Health Perspectives

Grants

March 2019 – August 2019
Molecular and Genomic Approaches in Alleviating Environmental Pollution
EGYPTIAN CULTURAL AND EDU BUR · Principal Investigator
September 2016ACTIVE
Developmental Pharmacology of Mitochondrial and Cytosolic GSTZ1
NATL INST OF HLTH NIGMS · Principal Investigator
September 2012 – August 2016
Developmental Pharmacology of Cytosolic and
NATL INST OF HLTH NIGMS · Principal Investigator
June 2011 – April 2017
Health Impact of Deepwater Horizon Spill in Eastern Gulf
NATL INST OF HLTH NIEHS · Project Manager

Education

1993
D.Sc.
University of London
1972-1975
Post-doctoral Fellow
National Institute of Environmental Health Sciences
1972
Ph.D.
St. Mary’s Medical School
1969
B.Sc.
University College London