Guenther Hochhaus

Guenther Hochhaus, Ph.D.

Professor

Department: Pharmaceutics
Business Phone: (352) 273-7861
Business Email: hochhaus@cop.ufl.edu

About Guenther Hochhaus

Hochhaus evaluates anti-asthma drugs in the body (pharmacokinetics) to understand the relationship between the drug properties and the pharmacodynamic effects. His work linking pharmacokinetic-pharmacodynamic approaches with a rational drug delivery design has proven to be a powerful tool in streamlining drug development for inhalation drugs. To provide a strong research program in pharmaceutics and actively seek outside support; to participate in teaching and education of undergraduate, graduate students and postdoctoral associates. The courses include undergraduate class “Principles of Dose Optimization I (PHA 5127)”, and graduate class “Pharmaceutical Analysis I (PHA 6416)”.

Publications

2021
Semi-mechanistic PK/PD model to assess pulmonary targeting of beclomethasone dipropionate and its active metabolite.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. [DOI] 10.1016/j.ejps.2021.105699. [PMID] 33444744.
2020
Urgent Appeal from International Society for Aerosols in Medicine (ISAM) During COVID-19: Clinical Decision Makers and Governmental Agencies Should Consider the Inhaled Route of Administration: A Statement from the ISAM Regulatory and Standardization Issues Networking Group.
Journal of aerosol medicine and pulmonary drug delivery. 33(4):235-238 [DOI] 10.1089/jamp.2020.1622. [PMID] 32589076.
2020
Huntington’s Disease Progression: A Population Modeling Approach to Characterization Using Clinical Rating Scales.
Journal of clinical pharmacology. 60(8):1051-1060 [DOI] 10.1002/jcph.1598. [PMID] 32416008.
2020
Quantitative Assessment of Pulmonary Targeting of Inhaled Corticosteroids Using Ex Vivo Receptor Binding Studies.
The AAPS journal. 22(2) [DOI] 10.1208/s12248-019-0404-0. [PMID] 32002694.
2019
Pharmacokinetic and pharmacodynamic modeling of gut hormone peptide YY(3-36) after pulmonary delivery.
Drug development and industrial pharmacy. 45(7):1101-1110 [DOI] 10.1080/03639045.2019.1593443. [PMID] 31039626.
2019
Characterization of a dextran-budesonide prodrug for inhalation therapy
European Journal of Pharmaceutical Sciences. 129:58-67 [DOI] 10.1016/j.ejps.2018.11.038. [PMID] 30521945.
2018
Effects of lipid formulations on clove extract spray dried powders: comparison of physicochemical properties, storage stability and in vitro intestinal permeation.
Pharmaceutical development and technology. 23(10):1047-1056 [DOI] 10.1080/10837450.2017.1314491. [PMID] 28368215.
2015
A Systematic Analysis of the Sensitivity of Plasma Pharmacokinetics to Detect Differences in the Pulmonary Performance of Inhaled Fluticasone Propionate Products Using a Model-Based Simulation Approach
Aaps Journal. 17(4):999-1010 [DOI] 10.1208/s12248-015-9768-y. [PMID] 25933600.
2015
A Systematic Analysis of the Sensitivity of Plasma Pharmacokinetics to Detect Differences in the Pulmonary Performance of Inhaled Fluticasone Propionate Products Using a Model-Based Simulation Approach.
The AAPS journal. 17(4):999-1010 [DOI] 10.1208/s12248-015-9768-y. [PMID] 25933600.
2015
Application of the modified chi-square ratio statistic in a stepwise procedure for cascade impactor equivalence testing.
The AAPS journal. 17(2):370-9 [DOI] 10.1208/s12248-014-9698-0. [PMID] 25515206.
2015
Cholestenoic Acid, An Endogenous Cholesterol Metabolite, Is a Potent Gamma-Secretase Modulator
Molecular neurodegeneration. 10 [DOI] 10.1186/s13024-015-0021-z. [PMID] 26169917.
2015
Current Scientific and Regulatory Approaches for Development of Orally Inhaled and Nasal Drug Products: Overview of the IPAC-RS/University of Florida Orlando Inhalation Conference.
The AAPS journal. 17(5):1305-11 [DOI] 10.1208/s12248-015-9791-z. [PMID] 26033698.
2015
Pharmacokinetics of Orally Inhaled Drug Products
Aaps Journal. 17(3):769-775 [DOI] 10.1208/s12248-015-9736-6. [PMID] 25762449.
2015
Quantitative characterization of circadian rhythm of pulmonary function in asthmatic patients treated with inhaled corticosteroids.
Journal of pharmacokinetics and pharmacodynamics. 42(4):391-9 [DOI] 10.1007/s10928-015-9420-6. [PMID] 26099861.
2014
Pharmacokinetics and pharmacodynamics of glycopyrrolate following a continuous-rate infusion in the horse.
Journal of veterinary pharmacology and therapeutics. 37(2):133-44 [DOI] 10.1111/jvp.12074. [PMID] 23902283.
2014
Population pharmacokinetic modeling of the unbound levofloxacin concentrations in rat plasma and prostate tissue measured by microdialysis.
Antimicrobial agents and chemotherapy. 58(2):678-86 [DOI] 10.1128/AAC.01884-13. [PMID] 24217697.
2013
Preliminary Development of Disease Progression Model for Huntington’s Disease
Clinical Pharmacology & Therapeutics. 93
2013
Evaluation of the Feasibility of Pharmacodynamic Bioequivalence Studies of Inhaled Corticosteroids Through Monte Carlo Simulations
Journal of Aerosol Medicine and Pulmonary Drug Delivery. 26
2013
Development of An in Vitro Test Method for Dissolution of Inhaled Corticosteroids
Journal of Aerosol Medicine and Pulmonary Drug Delivery. 26:A58-A59
2013
Development of a placebo effect model combined with a dropout model for bipolar disorder.
Journal of pharmacokinetics and pharmacodynamics. 40(3):359-68 [DOI] 10.1007/s10928-013-9305-5. [PMID] 23456101.
2013
Bioequivalence of inhaled drugs: fundamentals, challenges and perspectives.
Therapeutic delivery. 4(3):343-67 [DOI] 10.4155/tde.12.161. [PMID] 23442081.
2013
A sensitivity analysis of the modified chi-square ratio statistic for equivalence testing of aerodynamic particle size distribution.
The AAPS journal. 15(2):465-76 [DOI] 10.1208/s12248-013-9453-y. [PMID] 23344791.
2013
A pharmacokinetic simulation tool for inhaled corticosteroids.
The AAPS journal. 15(1):159-71 [DOI] 10.1208/s12248-012-9420-z. [PMID] 23139018.
2013
Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Detection and Quantification of Flunisolide in Tissue Culture Medium
Analytical Letters. 46(9):1355-1363 [DOI] 10.1080/00032719.2013.766797.
2013
A stability analysis of a modified version of the chi-square ratio statistic: implications for equivalence testing of aerodynamic particle size distribution.
The AAPS journal. 15(1):1-9 [DOI] 10.1208/s12248-012-9410-1. [PMID] 23008161.
2012
Nonlinear pharmacokinetics of visnagin in rats after intravenous bolus administration.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 45(1-2):79-89 [DOI] 10.1016/j.ejps.2011.10.023. [PMID] 22085634.
2012
Pharmacokinetic evaluation of visnagin and Ammi visnaga aqueous extract after oral administration in rats.
Planta medica. 78(17):1831-6 [DOI] 10.1055/s-0032-1315393. [PMID] 23096256.
2011
Systemic exposure to fluticasone MDI delivered through antistatic chambers.
The Journal of allergy and clinical immunology. 128(5):1113-5.e1 [DOI] 10.1016/j.jaci.2011.06.014. [PMID] 21783234.
2010
Targeting retinal and choroid neovascularization using the small molecule inhibitor carboxyamidotriazole.
Brain research bulletin. 81(2-3):320-6 [DOI] 10.1016/j.brainresbull.2009.08.001. [PMID] 19679174.
2010
Feasibility of localized immunosuppression: 1. Exploratory studies with glucocorticoids in a biohybrid device designed for cell transplantation.
Die Pharmazie. 65(6):421-8 [PMID] 20614690.
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2010
Feasibility of localized immunosuppression: 2. PLA microspheres for the sustained local delivery of a soft immunosuppressant.
Die Pharmazie. 65(6):429-35 [PMID] 20614691.
View on: PubMed
2010
Simulation-Based Evaluation of T(Max) as a Pharmacokinteic Parameter To Assess Bioequivalence of Inhaled Corticosteroids
. 50
2009
Chronic blockade of hindbrain glucocorticoid receptors reduces blood pressure responses to novel stress and attenuates adaptation to repeated stress.
American journal of physiology. Regulatory, integrative and comparative physiology. 296(5):R1445-54 [DOI] 10.1152/ajpregu.00095.2008. [PMID] 19279295.
2009
Budesonide and ciclesonide: effect of tissue binding on pulmonary receptor binding.
Drug metabolism and disposition: the biological fate of chemicals. 37(7):1421-6 [DOI] 10.1124/dmd.108.026039. [PMID] 19364829.
2008
Evaluation of the Administration Time Effect On the Cumulative Cortisol Suppression and Cumulative Lymphocytes Suppression for Once-Daily Inhaled Corticosteroids: a Population Modeling/Simulation Approach
Journal of clinical pharmacology. 48(9):1069-1080 [DOI] 10.1177/0091270008320607. [PMID] 18728243.
2008
Transrepression and Transactivation Potencies of Inhaled Glucocorticoids
Die Pharmazie. 63(12):893-898 [DOI] 10.1691/ph.2008.8638. [PMID] 19177906.
2008
Slow Release Formulations of Inhaled Rifampin
Aaps Journal. 10(2):342-348 [DOI] 10.1208/s12248-008-9044-5. [PMID] 18584334.
2008
Simultaneous Determination of Dexamethasone, Dexamethasone 21-Acetate, and Paclitaxel in a Simulated Biological Matrix By Rp-Hplc: Assay Development and Validation
Journal of Liquid Chromatography and Related Technologies. 31(10):1478-1491 [DOI] 10.1080/10826070802039515.
2008
Fluticasone furoate nasal spray in allergic rhinitis.
Drugs of today (Barcelona, Spain : 1998). 44(4):251-60 [PMID] 18536783.
View on: PubMed
2008
Pharmacokinetic/pharmacodynamic profile of mometasone furoate nasal spray: potential effects on clinical safety and efficacy.
Clinical therapeutics. 30(1):1-13 [DOI] 10.1016/j.clinthera.2008.01.005. [PMID] 18343239.
2008
Nonpeptide somatostatin receptor agonists specifically target ocular neovascularization via the somatostatin type 2 receptor.
Investigative ophthalmology & visual science. 49(11):5094-102 [DOI] 10.1167/iovs.08-2289. [PMID] 18599562.
2008
Relative Receptor Affinity Comparisons Among Inhaled/Intranasal Corticosteroids: Perspectives On Clinical Relevance
Respiratory Research. 9 [DOI] 10.1186/1465-9921-9-75. [PMID] 19025651.
2006
Differences in the glucocorticoid to progesterone receptor selectivity of inhaled glucocorticoids.
The European respiratory journal. 27(3):511-6 [PMID] 16507850.
View on: PubMed
2006
Do intensive care patients need an individualized dosing regimen for levofloxacin?
International journal of clinical pharmacology and therapeutics. 44(6):262-9 [PMID] 16800098.
View on: PubMed
2006
Influence of the N-acetylation polymorphism on the metabolism of talampanel: an investigation in fasted and fed subjects genotyped for NAT2 variants.
Die Pharmazie. 61(2):125-34 [PMID] 16526560.
View on: PubMed
2006
Lung bioavailability of hydrofluoroalkane fluticasone in young children when delivered by an antistatic chamber/mask.
The Journal of pediatrics. 149(6):793-7 [PMID] 17137894.
View on: PubMed
2006
Metabolism of mometasone furoate and biological activity of the metabolites.
Drug metabolism and disposition: the biological fate of chemicals. 34(2):225-33 [PMID] 16251254.
View on: PubMed
2006
Pharmacokinetic/pharmacodynamic modeling of total lymphocytes and selected subtypes after oral budesonide.
Journal of pharmacokinetics and pharmacodynamics. 33(4):441-59 [PMID] 16633890.
View on: PubMed
2006
Pharmacological effects of some newly developed soft anticholinergics and a receptor-binding QSAR study.
Die Pharmazie. 61(2):148-53 [PMID] 16526564.
View on: PubMed
2006
Pulmonary targeting of sustained release formulation of budesonide in neonatal rats.
Journal of drug targeting. 14(10):680-6 [PMID] 17162737.
View on: PubMed
2005
Interpretation of absorption rate data for inhaled fluticasone propionate obtained in compartmental pharmacokinetic modeling.
International journal of clinical pharmacology and therapeutics. 43(3):117-22 [PMID] 15792395.
View on: PubMed
2005
What is the best marker for inhaled corticosteroid safety?
Allergy and asthma proceedings. 26(2):89-93 [PMID] 15971465.
View on: PubMed
2005
Brain permeability of inhaled corticosteroids.
The Journal of pharmacy and pharmacology. 57(9):1159-67 [PMID] 16105236.
View on: PubMed
2005
A sensitive liquid chromatography-tandem mass spectrometry method for the quantification of mometasone furoate in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 819(1):175-9 [PMID] 15797536.
View on: PubMed
2004
A novel method for polymer coating of plasmid DNA: initial investigations into the use of pulse laser deposition and gene delivery.
Journal of drug targeting. 12(4):237-41 [PMID] 15506172.
View on: PubMed
2004
Age effects on the pharmacokinetics of tityustoxin from Tityus serrulatus scorpion venom in rats.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 37(3):385-90 [PMID] 15060708.
View on: PubMed
2004
Characterization of degradation products of mometasone furoate.
Die Pharmazie. 59(5):367-73 [PMID] 15212303.
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2004
Drugs used in the treatment of opioid tolerance and physical dependence: a review.
International journal of clinical pharmacology and therapeutics. 42(4):191-203 [PMID] 15124977.
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2004
Evaluation of oral budesonide in the treatment of active distal ulcerative colitis.
Drugs of today (Barcelona, Spain : 1998). 40(7):589-601 [PMID] 15510233.
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2004
How the lung handles drugs: pharmacokinetics and pharmacodynamics of inhaled corticosteroids.
Proceedings of the American Thoracic Society. 1(4):356-63 [PMID] 16113458.
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2004
In vitro performance characteristics of valved holding chamber and spacer devices with a fluticasone metered-dose inhaler.
Pharmacotherapy. 24(2):159-66 [PMID] 14998215.
View on: PubMed
2004
Metabolism of dynorphin A(1-13).
Die Pharmazie. 59(5):339-43 [PMID] 15212298.
View on: PubMed
2004
New developments in corticosteroids.
Proceedings of the American Thoracic Society. 1(3):269-74 [DOI] 10.1513/pats.200402-007MS. [PMID] 16113445.
2004
Possibilities in improvement of glucocorticoid treatments in asthma with special reference to loteprednol etabonate.
Die Pharmazie. 59(5):409-11 [PMID] 15212311.
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2004
Stabilized dynorphin derivatives for modulating antinociceptive activity in morphine tolerant rats: effect of different routes of administration.
The AAPS journal. 6(4) [PMID] 15760101.
View on: PubMed
2003
In vitro performance of two common valved holding chambers with a chlorofluorocarbon-free beclomethasone metered-dose inhaler.
Pharmacotherapy. 23(12):1538-44 [DOI] 10.1592/phco.23.15.1538.31960. [PMID] 14695033.
2003
Pharmacodynamics of omalizumab: implications for optimised dosing strategies and clinical efficacy in the treatment of allergic asthma.
Current medical research and opinion. 19(6):491-8 [PMID] 14594521.
View on: PubMed
2003
SPE/RIA vs LC/MS for measurement of low levels of budesonide in plasma.
Biomedical chromatography : BMC. 17(1):14-20 [PMID] 12583000.
View on: PubMed
2003
Population pharmacokinetics and pharmacodynamics of ciclesonide.
Journal of clinical pharmacology. 43(4):365-78 [PMID] 12723457.
View on: PubMed
2002
In vitro deposition of fluticasone aerosol from a metered-dose inhaler with and without two common valved holding chambers.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 88(2):204-8 [PMID] 11868926.
View on: PubMed
2001
Receptor binding studies of soft anticholinergic agents.
AAPS pharmSci. 3(4) [PMID] 12049493.
View on: PubMed
2001
Pharmacokinetics of plasmid DNA in the rat.
Pharmaceutical research. 18(1):67-74 [PMID] 11336355.
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2001
Pharmacokinetics and rectal bioavailability of hydrocortisone acetate after single and multiple administration in healthy subjects and patients.
Journal of clinical pharmacology. 41(5):536-41 [PMID] 11361050.
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2001
Single-dose and steady-state pharmacokinetic and pharmacodynamic evaluation of therapeutically clinically equivalent doses of inhaled fluticasone propionate and budesonide, given as Diskus or Turbohaler dry-powder inhalers to healthy subjects.
Journal of clinical pharmacology. 41(12):1329-38 [PMID] 11762560.
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2001
Evaluation of pulmonary absorption using pharmacokinetic methods.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine. 14 Suppl 1:S9-17 [PMID] 11424896.
View on: PubMed
2001
Current concepts in pharmacokinetics and their implications for clinical medicine.
Wiener klinische Wochenschrift. 113(15-16):566-72 [PMID] 11571833.
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2001
Pharmacokinetics and pharmacodynamics of dexamethasone sodium-m-sulfobenzoate (DS) after intravenous and intramuscular administration: a comparison with dexamethasone phosphate (DP).
Journal of clinical pharmacology. 41(4):425-34 [PMID] 11304899.
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2000
A sensitive LC-MS/MS method for the quantification of fluticasone propionate in human plasma.
Journal of pharmaceutical and biomedical analysis. 22(1):123-9 [PMID] 10727131.
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2000
An interactive algorithm for the assessment of cumulative cortisol suppression during inhaled corticosteroid therapy.
AAPS pharmSci. 2(3) [PMID] 11741238.
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2000
Evolution of pharmacokinetics and pharmacokinetic/dynamic correlations during the 20th century.
Journal of clinical pharmacology. 40(9):908-17 [PMID] 10975063.
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2000
Loteprednol etabonate: a soft steroid for the treatment of allergic diseases of the airways.
Drugs of today (Barcelona, Spain : 1998). 36(5):313-20 [PMID] 12861354.
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2000
Optimized therapeutic ratio of inhaled corticosteroids using retrometabolism.
Die Pharmazie. 55(3):223-7 [PMID] 10756545.
View on: PubMed
1999
Assessment of complex peptide degradation pathways via structured multicompartmental modeling approaches: the metabolism of dynorphin A1-13 and related fragments in human plasma.
Journal of pharmaceutical sciences. 88(9):938-44 [PMID] 10479358.
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1999
Mechanism-based PK/PD model for the lymphocytopenia induced by endogenous and exogenous corticosteroids.
International journal of clinical pharmacology and therapeutics. 37(8):367-76 [PMID] 10475139.
View on: PubMed
1999
Kinetic modeling of plasmid DNA degradation in rat plasma.
AAPS pharmSci. 1(3) [PMID] 11741205.
View on: PubMed
1999
Analysis of leucine enkephalin by high-performance liquid chromatography using enzymatic derivatization by tyrosinase and electrochemical or fluorescence detection.
Journal of pharmaceutical and biomedical analysis. 19(6):855-64 [PMID] 10698551.
View on: PubMed
1999
A pharmacokinetic/pharmacodynamic approach to predict the cumulative cortisol suppression of inhaled corticosteroids.
Journal of pharmacokinetics and biopharmaceutics. 27(2):127-47 [PMID] 10567952.
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1998
A selective HPLC/RIA for the determination of budesonide.
Journal of pharmaceutical and biomedical analysis. 17(8):1235-42 [PMID] 9800642.
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1998
Displacement of [3H]-L-glutamate in rat brain membranes by metabolic dynorphin fragments.
Die Pharmazie. 53(2):142-3 [PMID] 9540113.
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1998
Effect of dose and release rate on pulmonary targeting of liposomal triamcinolone acetonide phosphate.
Pharmaceutical research. 15(3):461-5 [PMID] 9563078.
View on: PubMed
1998
Pharmacokinetic and pharmacodynamic aspects of salmeterol therapy.
International journal of clinical pharmacology and therapeutics. 36(12):652-60 [PMID] 9877002.
View on: PubMed
1998
Pharmacokinetic and pharmacodynamic evaluation of fluticasone propionate after inhaled administration.
European journal of clinical pharmacology. 53(6):459-67 [PMID] 9551705.
View on: PubMed
1998
Pharmacokinetics and pharmacodynamics of inhaled corticosteroids.
The Journal of allergy and clinical immunology. 101(4 Pt 2):S440-6 [PMID] 9563369.
View on: PubMed
1998
Pharmacokinetics of intravenous dynorphin A(1-13) in opioid-naive and opioid-treated human volunteers.
Clinical pharmacology and therapeutics. 64(1):27-38 [PMID] 9695716.
View on: PubMed
1997
Pharmacokinetics of methylprednisolone and prednisolone after single and multiple oral administration.
Journal of clinical pharmacology. 37(10):916-25 [PMID] 9505983.
View on: PubMed
1997
Pharmacokinetic/pharmacodynamic evaluation of systemic effects of flunisolide after inhalation.
Journal of clinical pharmacology. 37(10):893-903 [PMID] 9505980.
View on: PubMed
1997
Pharmacokinetic/pharmacodynamic aspects of aerosol therapy using glucocorticoids as a model.
Journal of clinical pharmacology. 37(10):881-92 [PMID] 9505979.
View on: PubMed
1997
An HPLC/RIA method for dynorphin A1-13 and its main metabolites in human blood.
Journal of pharmaceutical and biomedical analysis. 16(1):101-9 [PMID] 9447557.
View on: PubMed
1997
Clinical PK/PD modelling as a tool in drug development of corticosteroids.
International journal of clinical pharmacology and therapeutics. 35(10):481-8 [PMID] 9352400.
View on: PubMed
1997
Dependency of cortisol suppression on the administration time of inhaled corticosteroids.
Journal of clinical pharmacology. 37(8):704-10 [PMID] 9378842.
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1996
Pulmonary targeting of liposomal triamcinolone acetonide phosphate.
Pharmaceutical research. 13(11):1699-703 [PMID] 8956337.
View on: PubMed
1996
Pharmacokinetics and pharmacodynamics of cloprednol.
International journal of clinical pharmacology and therapeutics. 34(1):1-5 [PMID] 8688990.
View on: PubMed
1996
Interspecies comparison of in vitro plasma degradation of dynorphin A 1-13.
Die Pharmazie. 51(8):581-5 [PMID] 8794468.
View on: PubMed
1996
Metabolism of dynorphin A1-13 in human CSF.
Neurochemical research. 21(10):1213-9 [PMID] 8923483.
View on: PubMed
1995
Assessment of glucocorticoid lung targeting by ex-vivo receptor binding studies in rats.
Pharmaceutical research. 12(1):134-7 [PMID] 7724475.
View on: PubMed
1995
Metabolism of dynorphin A 1-13 in human blood and plasma.
Pharmaceutical research. 12(8):1165-70 [PMID] 7494829.
View on: PubMed
1995
Pharmacokinetic and pharmacodynamic evaluation of triamcinolone acetonide after intravenous, oral, and inhaled administration.
Journal of clinical pharmacology. 35(12):1187-93 [PMID] 8750370.
View on: PubMed
1995
Pharmacokinetic interaction between endogenous cortisol and exogenous corticosteroids.
Die Pharmazie. 50(9):610-3 [PMID] 7480097.
View on: PubMed
1995
Pharmacokinetic/pharmacodynamic evaluation of deflazacort in comparison to methylprednisolone and prednisolone.
Pharmaceutical research. 12(7):1096-100 [PMID] 7494809.
View on: PubMed
1995
Pharmacokinetics of triamcinolone acetonide after intravenous, oral, and inhaled administration.
Journal of clinical pharmacology. 35(3):302-5 [PMID] 7608322.
View on: PubMed
1994
[Problems of equivalency points during therapy with glucocorticoids. A comparison of the clinical pharmacokinetics and pharmacodynamics of prednisolone and methylprednisolone].
Deutsche medizinische Wochenschrift (1946). 119(48):1671-6 [PMID] 7988369.
View on: PubMed
1994
Clinical pharmacology of pancreatic enzymes in patients with cystic fibrosis and in vitro performance of microencapsulated formulations.
Journal of clinical pharmacology. 34(2):158-66 [PMID] 8163716.
View on: PubMed
1994
Leucine enkephalin-tyrosinase reaction products–identification and biological activity.
Biochimica et biophysica acta. 1222(1):95-100 [PMID] 8186271.
View on: PubMed
1993
Generic and alternative brand-name pharmaceutical equivalents: select with caution.
American journal of hospital pharmacy. 50(2):323-9 [PMID] 8480793.
View on: PubMed
1993
Prednicarbate after different forms of administration. Plasma levels of drug and metabolites and effects on endogenous cortisol levels in humans.
Current problems in dermatology. 21:147-56 [PMID] 8299368.
View on: PubMed
1993
Receptor-based pharmacokinetic-pharmacodynamic analysis of corticosteroids.
Journal of clinical pharmacology. 33(2):115-23 [PMID] 8440759.
View on: PubMed
1993
Studies on the pharmacokinetics and metabolism of prednicarbate after cutaneous and oral administration.
Skin pharmacology : the official journal of the Skin Pharmacology Society. 6(3):179-86 [PMID] 8274287.
View on: PubMed
1992
Pharmacokinetics and pharmacodynamics of prednisolone after intravenous and oral administration.
International journal of clinical pharmacology, therapy, and toxicology. 30(9):317-24 [PMID] 1428295.
View on: PubMed
1992
Pharmacokinetic/pharmacodynamic characteristics of the beta-2-agonists terbutaline, salbutamol and fenoterol.
International journal of clinical pharmacology, therapy, and toxicology. 30(9):342-62 [PMID] 1358833.
View on: PubMed
1992
Pharmacokinetic characterization and tissue distribution of the new glucocorticoid soft drug loteprednol etabonate in rats and dogs.
Journal of pharmaceutical sciences. 81(12):1210-5 [PMID] 1491342.
View on: PubMed
1992
A selective HPLC/RIA for dexamethasone and its prodrug dexamethasone-21-sulphobenzoate sodium in biological fluids.
Biomedical chromatography : BMC. 6(6):283-6 [PMID] 1286285.
View on: PubMed
1992
Pharmacokinetic/dynamic correlation of pulmonary and cardiac effects of fenoterol in asthmatic patients after different routes of administration.
Pharmaceutical research. 9(3):291-7 [PMID] 1614958.
View on: PubMed
1991
A new fluorogenic assay for tyrosine-containing peptides.
Journal of pharmaceutical and biomedical analysis. 9(7):557-63 [PMID] 1817676.
View on: PubMed
1991
A selective LC/RIA for dexamethasone and its prodrug dexamethasone-21-isonicotinate in biological fluids.
Journal of pharmaceutical and biomedical analysis. 9(9):761-7 [PMID] 1821154.
View on: PubMed
1991
cAMP accumulation in opioid-sensitive SH-SY5Y neuroblastoma cells is modified by estradiol and progesterone.
Molecular and cellular endocrinology. 78(3):155-62 [PMID] 1663875.
View on: PubMed
1991
Glucocorticoid activity and structure activity relationships in a series of some novel 17 alpha-ether-substituted steroids: influence of 17 alpha-substituents.
Drug design and discovery. 8(2):117-25 [PMID] 1793774.
View on: PubMed
1991
Soft drugs–10. Blanching activity and receptor binding affinity of a new type of glucocorticoid: loteprednol etabonate.
The Journal of steroid biochemistry and molecular biology. 38(2):149-54 [PMID] 2004037.
View on: PubMed
1990
An avidin-biotin based enzyme-linked immunosorbent assay for dynorphin A 1-13.
Journal of pharmaceutical and biomedical analysis. 8(6):541-5 [PMID] 1982703.
View on: PubMed
1990
Binding affinities of rimexolone (ORG 6216), flunisolide and their putative metabolites for the glucocorticoid receptor of human synovial tissue.
Agents and actions. 30(3-4):377-80 [PMID] 2386110.
View on: PubMed
1990
Oral bioavailability of triamcinolone tablets and a triamcinolone diacetate suspension.
Pharmaceutical research. 7(5):558-60 [PMID] 1973290.
View on: PubMed
1986
HPLC determination of glucocorticoid alcohols, their phosphates and hydrocortisone in aqueous solutions and biological fluids.
Journal of pharmaceutical and biomedical analysis. 4(2):197-206 [PMID] 16867616.
View on: PubMed
1985
Simultaneous determination of glucocorticoid alcohols, their succinates and hydrocortisone in plasma.
Journal of pharmaceutical and biomedical analysis. 3(6):566-73 [PMID] 16867648.
View on: PubMed
1983
Identification of glucocorticoid receptors in normal and neoplastic adult human lung.
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. 182(1):71-8 [PMID] 6856988.
View on: PubMed

Grants

Oct 2020 – Oct 2020
GSK Fellowship – Jose Francis Year 2
Role: Other
Funding: GLAXO SMITHKLINE
Oct 2019 – Jul 2020
GSK Fellowship – Jose Francis Year 1
Role: Principal Investigator
Funding: GLAXO SMITHKLINE
Sep 2019 ACTIVE
Systematic evaluation of the ex-throat plume properties of MDI formulations
Role: Principal Investigator
Funding: US FOOD AND DRUG ADMN
Sep 2019 ACTIVE
A Multiscale Computational Framework for Bioequivalence of Orally Inhaled Drugs
Role: Principal Investigator
Funding: CFD RESEARCH CORP via US FOOD AND DRUG ADMN
Jul 2019 – Jul 2020
Clinical Pharmacokinetics/Dynamics Fellowship 2018-2019 – Sagar Bachav
Role: Principal Investigator
Funding: GLAXO SMITHKLINE
Jul 2018 – Jul 2019
Clinical Pharmacokinetics/Dynamics Fellowship 2017-2018 – Sagar Bachav
Role: Principal Investigator
Funding: GLAXO SMITHKLINE
Sep 2016 – Mar 2018
Pharmacokinetic Comparison of Locally Acting Orally Inhaled Drug Products
Role: Co-Investigator
Funding: US FOOD AND DRUG ADMN
Feb 2016 – Dec 2016
Methacholine stability test over 8 months (months 0-8)-batch 2
Role: Principal Investigator
Funding: COMPLEWARE CORPORATION
Aug 2015 – Nov 2016
Methacholine Stability Testing with Ion Exchange Method
Role: Principal Investigator
Funding: COMPLEWARE CORPORATION
Jul 2015 – Jan 2017
Further Characterization of the Modified Chi-square Ratio Test for the Comparison of Cascade Impactor Profiles
Role: Principal Investigator
Funding: INTL PHARM AEROSOL CONSRT REG AND SCIENC
Apr 2015 ACTIVE
Peptidic Kappa Opioid Receptor Ligands as Potential Treatments for Drug Addiction
Role: Project Manager
Funding: NATL INST OF HLTH NIDA
Mar 2015 – Dec 2018
Determination of Drug Levels in Interstitial Fluid for Therapeutic IgG by Microdialysis and its Relevance for Pharmacokinetic and Pharmacodynamic
Role: Principal Investigator
Funding: HOFFMANN LA ROCHE
Dec 2014 – Feb 2020
Comprehensive Evaluation of Formulation Effects on Metered Dose Inhaler Performance
Role: Principal Investigator
Funding: US FOOD AND DRUG ADMN
Sep 2013 – Apr 2020
Study to Investigate the Sensitivity of Pharmacokinetics in Detecting Differences in Physicochemical Properties of the Active in Suspension Nasal Products for Local Action
Role: Co-Investigator
Funding: US FOOD AND DRUG ADMN
Sep 2013 – Dec 2016
Stability of Fluticasone Proprionate Capsules for Inhalation
Role: Principal Investigator
Funding: FEFA via US DEPT OF HLTH AND HUMAN SER
Sep 2013 – Feb 2017
An Optimized Dissolution Test System for Orally Inhaled Drugs: Development and Va
Role: Principal Investigator
Funding: US FOOD AND DRUG ADMN
Aug 2012 – Jul 2017
Does P-glycoprotein Restrict Access of Budesonide but not Fluticasone Propionate to the Placenta and Fetus?
Role: Principal Investigator
Funding: ASTRAZENECA
Sep 2011 – Sep 2016
Pharmacokinetic Comparison of Locally Acting Inhaled Drug Products pt II
Role: Principal Investigator
Funding: FEFA via US DEPT OF HLTH AND HUMAN SER

Patents

Issued November 2001
Development of a Bootstrap Application for Resampling Pharmacokinetic and Toxicokinetic Data.
#Tu1021748
Issued January 2006
Methods for Preparing Coated Drug Particles and Pharmaceutical Formulations Thereof
#6,984,404

Education

Ph.D.
1984 · University of Munster
B.Sc.
1980 · Elisabeth Apotheke

Teaching Profile

Courses Taught
2016,2018-2020,2020-2021
PHA5878C Pt Care 3: Cv and Pulm
2008-2021
PHA7980 Research for Doctoral Dissertation
2008-2021
PHA7979 Advanced Research
2007,2009-2011,2011-2015,2013-2019,2015-2020,2017-2020,2019-2020
PHA6416 Pharmaceutical Analysis I
2010-2014,2020-2021
PHA6971 Research for Master’s Thesis
2017-2018,2020
PHA6910 Supervised Research
2016-2019
PHA5132 Prin Drug Ther Indiv
2006,2014-2017,2017
PHA6938 Research Seminar
2006-2015
PHA5127 Dose Optimization 1
2015
PHA4912 Undergraduate Research in Pharmaceutics
2013-2014
PHA5905 Clin Pharm Research
2010-2011
PHA6936 Adv Topics Pharm Sci
2011
PHA6935 Sel Topics Pharmacy

Contact Details

Phones:
Business:
(352) 273-7861
Emails: