Takato Hiranita

Takato Hiranita, Ph.D.

Research Assistant Professor

Department: Pharmacodynamics
Business Phone: (352) 294-5411
Business Email: takatohiranita@cop.ufl.edu

About Takato Hiranita

Takato Hiranita, Ph.D., joined the University of Florida College of Pharmacy in May 2018 as a research assistant professor in the Department of Pharmacodynamics. Dr. Hiranita received his B.S. degree in the Department of Pharmaceutical Sciences (Molecular Bioformatics) from Kyushu University, and his Ph.D. in the Department of Pharmacology (Pharmaceutical Sciences) from the Graduate School of Pharmaceutical Sciences, Kyushu University. Upon completion of his doctoral studies under the supervision of Drs. Tsuneyuki Yamamoto and Kazuhide Inoue, Dr. Hiranita has joined the laboratory of Dr. Jonathan L. Katz at the National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), as a postdoctoral research fellow. Dr. Hiranita was a Staff Fellow in the Division of Neurotoxicology, National Center for Toxicological Research (NCTR), Food and Drug Administration (FDA), where he was the head of a rodent behavioral and neurochemical pharmacology lab. Dr. Hiranita is an Adjunct Basic Science Associate Professor at the Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences College of Medicine (UAMS). Dr. Hiranita was the principal investigator for studies from the Center for Tobacco Products ($5.1M) and Drug Enforcement Administration ($2.4M).

Research Profile

Dr. Hiranita’s research interests are preclinical abuse potential and efficacy assessments of novel compounds as medications for drug abuse using intravenous drug self-administration procedures. Drugs of interest include atypical dopamine uptake inhibitors and sigma receptor ligands.

Publications

2020
Effects of benztropine analogs on delay discounting in rats.
Psychopharmacology. 237(12):3783-3794 [DOI] 10.1007/s00213-020-05655-0. [PMID] 32964243.
2020
The discriminative stimulus effects of epibatidine in C57BL/6J mice.
Behavioural pharmacology. 31(6):565-573 [DOI] 10.1097/FBP.0000000000000555. [PMID] 32209809.
2020
Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for Mu-Opioid Receptor and Opioid-Like Behavioral Effects in Rats.
The Journal of pharmacology and experimental therapeutics. [DOI] 10.1124/jpet.120.000189. [PMID] 33384303.
2020
Evaluation of the rewarding effects of mitragynine and 7-hydroxymitragynine in an intracranial self-stimulation procedure in male and female rats.
Drug and alcohol dependence. 215 [DOI] 10.1016/j.drugalcdep.2020.108235. [PMID] 32889450.
2020
Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids.
Journal of medicinal chemistry. 63(1):433-439 [DOI] 10.1021/acs.jmedchem.9b01465. [PMID] 31834797.
2020
Modafinil potentiates cocaine self-administration by a dopamine-independent mechanism: possible involvement of gap junctions.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 45(9):1518-1526 [DOI] 10.1038/s41386-020-0680-5. [PMID] 32340023.
2019
Pharmacological characterization of mitragynine, the primary constituent in Kratom, as a potential medication for opioid use disorder.
Journal of pharmacological and toxicological methods. 99 [DOI] 10.1016/j.vascn.2019.05.012. [PMID] 31963089.
2019
The effects of mitragynine and morphine on schedule-controlled responding and antinociception in rats.
Psychopharmacology. 236(9):2725-2734 [DOI] 10.1007/s00213-019-05247-7. [PMID] 31098655.
2018
Dopamine Transporter Dynamics of N-Substituted Benztropine Analogs with Atypical Behavioral Effects.
The Journal of pharmacology and experimental therapeutics. 366(3):527-540 [DOI] 10.1124/jpet.118.250498. [PMID] 29945932.
2017
A Role for Sigma Receptors in Stimulant Self-Administration and Addiction.
Handbook of experimental pharmacology. 244:177-218 [DOI] 10.1007/164_2016_94. [PMID] 28110353.
2017
Positron emission tomography (PET) imaging of nicotine-induced dopamine release in squirrel monkeys using [18F]Fallypride.
Drug and alcohol dependence. 179:254-259 [DOI] 10.1016/j.drugalcdep.2017.07.013. [PMID] 28818716.
2017
The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats.
The Journal of biological chemistry. 292(27):11250-11261 [DOI] 10.1074/jbc.M116.774075. [PMID] 28495886.
2017
σ Receptor Effects of N-Substituted Benztropine Analogs: Implications for Antagonism of Cocaine Self-Administration.
The Journal of pharmacology and experimental therapeutics. 362(1):2-13 [DOI] 10.1124/jpet.117.241109. [PMID] 28442581.
2016
Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain.
Nature communications. 7 [DOI] 10.1038/ncomms10652. [PMID] 26879809.
2016
Lack of Specific Involvement of (+)-Naloxone and (+)-Naltrexone on the Reinforcing and Neurochemical Effects of Cocaine and Opioids.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 41(11):2772-81 [DOI] 10.1038/npp.2016.91. [PMID] 27296151.
2016
Lack of Effects of Toll-Like Receptor 4 Antagonists on the Reinforcing Effects of Cocaine and Remifentanil.
Journal of alcoholism and drug dependence. 4(6) [DOI] 10.4172/2329-6488. [PMID] 28070538.
2016
Importance of Substrate-Coupled Proton Antiport by the Vesicular Monoamine Transporter in the Actions of Amphetamines in Drosophila Brain.
Journal of alcoholism and drug dependence. 4(6) [DOI] 10.4172/2329-6488.1000e136. [PMID] 28164142.
2016
Identification of the Sigma-2 Receptor: Distinct from the Progesterone Receptor Membrane Component 1 (PGRMC1).
Journal of alcoholism and drug dependence. 4 [PMID] 27376101.
View on: PubMed
2016
Identification of Antagonists Selective for Sigma Receptor Subtypes that are Active In vivo.
Journal of alcoholism and drug dependence. 4(4) [PMID] 27588298.
View on: PubMed
2016
Blockade of Cocaine or σ Receptor Agonist Self Administration by Subtype-Selective σ Receptor Antagonists.
The Journal of pharmacology and experimental therapeutics. 358(1):109-24 [DOI] 10.1124/jpet.116.232728. [PMID] 27189970.
2016
A role for sigma receptors in stimulant self-administration and addiction.
Behavioural pharmacology. 27(2-3 Spec Issue):100-15 [DOI] 10.1097/FBP.0000000000000209. [PMID] 26650253.
2016
(-)-Trans-Δ9-Tetrahydrocannabinol-Like Discriminative-Stimulus Effects of Gabapentin in Cannabis Users.
Journal of alcoholism and drug dependence. 4(1) [PMID] 27376100.
View on: PubMed
2016
Dopamine D₂-Like Receptors and Behavioral Economics of Food Reinforcement.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 41(4):971-8 [DOI] 10.1038/npp.2015.223. [PMID] 26205210.
2016
DAT Conformation Does Not Predict the Ability of Atypical Dopamine Uptake Inhibitors to Substitute for Cocaine.
Journal of alcoholism and drug dependence. 4(4) [PMID] 27588299.
View on: PubMed
2015
Self-Administration of JWH-018 A Synthetic Cannabinoid in Experimentally Naïve Rats.
Journal of alcoholism and drug dependence. 3(6) [PMID] 27398395.
View on: PubMed
2015
Cocaine Antagonists; Studies on Cocaine Self-Administration.
Journal of alcoholism and drug dependence. 3(5) [PMID] 27398394.
View on: PubMed
2015
DAT isn’t all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling.
Molecular psychiatry. 20(12):1525-37 [DOI] 10.1038/mp.2014.177. [PMID] 25644383.
2015
Differential Roles for Dopamine D1-Like and D2-Like Receptors in Mediating the Reinforcing Effects of Cocaine: Convergent Evidence from Pharmacological and Genetic Studies.
Journal of alcoholism and drug dependence. 3(4) [PMID] 27390753.
View on: PubMed
2015
In Vivo Significance of In Vitro Studies on G-Protein-Coupled Receptor Heteromers.
Journal of alcoholism and drug dependence. 3(2) [PMID] 27377120.
View on: PubMed
2015
Medications Discovery: Importance of Assessment of Drug Self Administration Dose-Effect Curves.
Journal of alcoholism and drug dependence. 3(3) [PMID] 27413771.
View on: PubMed
2015
Preclinical Efficacy of Novel Vesicular Monoamine Transporter 2 Inhibitors as Antagonists of d-Methamphetamine Self-Administration in Rats.
Journal of alcoholism and drug dependence. 3(5) [PMID] 27398393.
View on: PubMed
2015
Self-Administration of an Endogenous Cannabinoid 2-Arachidonoylglycerol in Experimentally Naïve Rats.
Journal of alcoholism and drug dependence. 3(5) [PMID] 27376099.
View on: PubMed
2015
The Reinforcing Effects of Nicotine in Humans and Nonhuman Primates: A Review of Intravenous Self-Administration Evidence and Future Directions for Research.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 17(11):1297-310 [DOI] 10.1093/ntr/ntv002. [PMID] 25673111.
2015
Trace Amine-Associated Receptor Type 1 as A Target for The Development of Treatments for Stimulant Abuse.
Journal of alcoholism and drug dependence. 3(3) [PMID] 27390752.
View on: PubMed
2014
2-isoxazol-3-phenyltropane derivatives of cocaine: molecular and atypical system effects at the dopamine transporter.
The Journal of pharmacology and experimental therapeutics. 349(2):297-309 [DOI] 10.1124/jpet.113.212738. [PMID] 24518035.
2014
Choice for response alternatives differing in reinforcement frequency in dopamine D2 receptor mutant and Swiss-Webster mice.
Psychopharmacology. 231(16):3169-77 [DOI] 10.1007/s00213-014-3495-4. [PMID] 24682471.
2014
Preclinical efficacy of N-substituted benztropine analogs as antagonists of methamphetamine self-administration in rats.
The Journal of pharmacology and experimental therapeutics. 348(1):174-91 [DOI] 10.1124/jpet.113.208264. [PMID] 24194527.
2014
Preference for distinct functional conformations of the dopamine transporter alters the relationship between subjective effects of cocaine and stimulation of mesolimbic dopamine.
Biological psychiatry. 76(10):802-9 [DOI] 10.1016/j.biopsych.2014.03.031. [PMID] 24853388.
2014
Role of the σRs for Development of Medications.
Journal of alcoholism and drug dependence. 2(2) [PMID] 27398392.
View on: PubMed
2013
Self-administration of cocaine induces dopamine-independent self-administration of sigma agonists.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 38(4):605-15 [DOI] 10.1038/npp.2012.224. [PMID] 23187725.
2013
Stimulants as specific inducers of dopamine-independent σ agonist self-administration in rats.
The Journal of pharmacology and experimental therapeutics. 347(1):20-9 [DOI] 10.1124/jpet.113.207522. [PMID] 23908387.
2013
The stereotypy-inducing effects of N-substituted benztropine analogs alone and in combination with cocaine do not account for their blockade of cocaine self-administration.
Psychopharmacology. 225(3):733-42 [DOI] 10.1007/s00213-012-2862-2. [PMID] 22975727.
2012
Opioid activation of toll-like receptor 4 contributes to drug reinforcement.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(33):11187-200 [PMID] 22895704.
View on: PubMed
2011
A Role for Sigma Receptors in Stimulant Self Administration and Addiction.
Pharmaceuticals (Basel, Switzerland). 4(6):880-914 [PMID] 21904468.
View on: PubMed
2011
Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors.
The Journal of pharmacology and experimental therapeutics. 339(2):662-77 [DOI] 10.1124/jpet.111.185025. [PMID] 21859929.
2011
Lack of cocaine-like discriminative-stimulus effects of σ-receptor agonists in rats.
Behavioural pharmacology. 22(5-6):525-30 [DOI] 10.1097/FBP.0b013e328349ab22. [PMID] 21808192.
2011
Sigma receptor agonists: receptor binding and effects on mesolimbic dopamine neurotransmission assessed by microdialysis.
Biological psychiatry. 69(3):208-17 [DOI] 10.1016/j.biopsych.2010.07.026. [PMID] 20950794.
2010
A tryptamine-derived catecholaminergic enhancer, (-)-1-(benzofuran-2-yl)-2-propylaminopentane [(-)-BPAP], attenuates reinstatement of methamphetamine-seeking behavior in rats.
Neuroscience. 165(2):300-12 [DOI] 10.1016/j.neuroscience.2009.10.055. [PMID] 19883738.
2010
Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine.
The Journal of pharmacology and experimental therapeutics. 332(2):515-24 [DOI] 10.1124/jpet.109.159236. [PMID] 19892920.
2010
A cannabinoid CB(1) receptor antagonist ameliorates impairment of recognition memory on withdrawal from MDMA (Ecstasy).
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 35(2):515-20 [DOI] 10.1038/npp.2009.158. [PMID] 19829291.
2009
Assessment of reinforcing effects of benztropine analogs and their effects on cocaine self-administration in rats: comparisons with monoamine uptake inhibitors.
The Journal of pharmacology and experimental therapeutics. 329(2):677-86 [DOI] 10.1124/jpet.108.145813. [PMID] 19228996.
2009
Citalopram enhances cocaine’s subjective effects in rats.
Behavioural pharmacology. 20(8):759-62 [DOI] 10.1097/FBP.0b013e328333a267. [PMID] 20195220.
2008
Involvement of the GABA/benzodiazepine receptor in the axiolytic-like effect of nociceptin/orphanin FQ.
European journal of pharmacology. 590(1-3):185-9 [DOI] 10.1016/j.ejphar.2008.05.031. [PMID] 18586237.
2008
Methamphetamine-seeking behavior is due to inhibition of nicotinic cholinergic transmission by activation of cannabinoid CB1 receptors.
Neuropharmacology. 55(8):1300-6 [DOI] 10.1016/j.neuropharm.2008.08.012. [PMID] 18782581.
2008
Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants.
Human molecular genetics. 17(20):3191-203 [DOI] 10.1093/hmg/ddn215. [PMID] 18647754.
2008
Role of amygdaloid nuclei in the anxiolytic-like effect of nociceptin/orphanin FQ in rats.
Neuroscience letters. 431(1):66-70 [DOI] 10.1016/j.neulet.2007.11.023. [PMID] 18166271.
2006
Mode of interaction of amphiphilic alpha-helical peptide with phosphatidylcholines at the air-water interface.
Langmuir : the ACS journal of surfaces and colloids. 22(3):1182-92 [PMID] 16430282.
View on: PubMed
2006
Suppression of methamphetamine-seeking behavior by nicotinic agonists.
Proceedings of the National Academy of Sciences of the United States of America. 103(22):8523-7 [PMID] 16717181.
View on: PubMed
2005
[Drug-craving animal models and mechanisms].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 126(1):24-9, 23 [PMID] 16141614.
View on: PubMed
2004
Endocannabinoid system modulates relapse to methamphetamine seeking: possible mediation by the arachidonic acid cascade.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 29(8):1470-8 [PMID] 15085091.
View on: PubMed
2004
Naltrexone attenuates cue- but not drug-induced methamphetamine seeking: a possible mechanism for the dissociation of primary and secondary reward.
Brain research. 1021(2):272-6 [PMID] 15342276.
View on: PubMed
2004
New perspectives in the studies on endocannabinoid and cannabis: a role for the endocannabinoid-arachidonic acid pathway in drug reward and long-lasting relapse to drug taking.
Journal of pharmacological sciences. 96(4):382-8 [PMID] 15599102.
View on: PubMed
2004
Nicotine attenuates relapse to methamphetamine-seeking behavior (craving) in rats.
Annals of the New York Academy of Sciences. 1025:504-7 [PMID] 15542755.
View on: PubMed
2003
Miscibility behavior of dipalmitoylphosphatidylcholine with a single-chain partially fluorinated amphiphile in Langmuir monolayers.
Journal of colloid and interface science. 265(1):83-92 [PMID] 12927168.
View on: PubMed

Grants

Dec 2020 ACTIVE
Opioid use disorders: UF Pharmacy medications discovery and development
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDA
Apr 2019 ACTIVE
Kratom alkaloids: in vitro and in vivo pharmacological mechanisms
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDA
Dec 2018 – Nov 2020
Opioid use disorders: UF Pharmacy medications discovery and development
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDA

Education

Ph.D.
2007 · Kyushu University
M.S.
2004 · Kyushu University
B.S.
2002 · Kyushu University

Teaching Profile

Courses Taught
2020-2021
PHA4911 Undergraduate Research in Pharmacodynamics

Contact Details

Phones:
Business:
(352) 294-5411
Emails: