Scott W Harden

Scott W Harden, D.M.D., Ph.D.

Research Scientist

Department: Pharmacodynamics
Business Phone: (352) 273-7704
Business Email: swharden@ufl.edu

About Scott W Harden

Scott W Harden studied molecular biology and microbiology at the University of Central Florida in 2007, then moved to Gainesville for dental school in 2009. Scott entered the DMD/PhD program and completed dental school while earning a PhD in the field of Neuroscience. As a scientist with academic and clinical training, Scott now uses advanced electrophysiological and optical techniques to characterize novel signaling pathways in the brain. Scott’s interest in cellular physiology and affinity for technology lead him to pursue answers for biological questions which lie at the intersection of science, medicine, and technology.

Teaching Profile

Courses Taught
2023
PHA5878C Pt Care 3: Cv and Pulm

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-0757-1979

Publications

2024
Alleviating Hypertension by Selectively Targeting Angiotensin Receptor-Expressing Vagal Sensory Neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(9) [DOI] 10.1523/JNEUROSCI.1154-23.2023. [PMID] 38242697.
2024
Chronic intermittent hypoxia remodels catecholaminergic nerve innervation in mouse atria
The Journal of Physiology. 602(1):49-71 [DOI] 10.1113/jp284961.
2023
Catecholaminergic axon innervation and morphology in flat‐mounts of atria and ventricles of mice
Journal of Comparative Neurology. 531(5):596-617 [DOI] 10.1002/cne.25444. [PMID] 36591925.
2023
Circuit and cell-specific contributions to decision making involving risk of explicit punishment in male and female rats.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2023.01.15.524142. [PMID] 36711946.
2023
Topographical mapping of catecholaminergic axon innervation in the flat-mounts of the mouse atria: a quantitative analysis.
Scientific reports. 13(1) [DOI] 10.1038/s41598-023-27727-9. [PMID] 37029119.
2022
A Novel Organ-Specific Approach to Selectively Target Sensory Afferents Innervating the Aortic Arch.
Frontiers in physiology. 13 [DOI] 10.3389/fphys.2022.841078. [PMID] 35399269.
2022
A rapid in vitro assay for evaluating the effects of acetylcholinesterase inhibitors and reactivators in the rat basolateral amygdala.
Frontiers in cellular neuroscience. 16 [DOI] 10.3389/fncel.2022.1066312. [PMID] 36479275.
2022
Targeting angiotensin type-2 receptors located on pressor neurons in the nucleus of the solitary tract to relieve hypertension in mice
Cardiovascular Research. 118(3):883-896 [DOI] 10.1093/cvr/cvab085. [PMID] 33723600.
2021
An Angiotensin-Responsive Connection from the Lamina Terminalis to the Paraventricular Nucleus of the Hypothalamus Evokes Vasopressin Secretion to Increase Blood Pressure in Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 41(7):1429-1442 [DOI] 10.1523/JNEUROSCI.1600-20.2020. [PMID] 33328294.
2021
Dendritic osmosensors modulate activity-induced calcium influx in oxytocinergic magnocellular neurons of the mouse PVN
eLife. 10 [DOI] 10.7554/elife.63486.
2020
Endogenous oxytocin inhibits hypothalamic corticotrophin‐releasing hormone neurones following acute hypernatraemia
Journal of Neuroendocrinology. 32(3) [DOI] 10.1111/jne.12839. [PMID] 32133707.
2020
Region-specific effects of HIV-1 Tat on intrinsic electrophysiological properties of pyramidal neurons in mouse prefrontal cortex and hippocampus
Journal of Neurophysiology. 123(4):1332-1341 [DOI] 10.1152/jn.00029.2020. [PMID] 32101482.
2019
Optogenetic dissection of basolateral amygdala contributions to intertemporal choice in young and aged rats
eLife. 8 [DOI] 10.7554/elife.46174.
2019
Optogenetic dissection of basolateral amygdala contributions to intertemporal choice in young and aged rats
eLife. 8 [DOI] 10.7554/elife.46174.
2019
Oxytocin Receptors Are Expressed by Glutamatergic Prefrontal Cortical Neurons That Selectively Modulate Social Recognition
The Journal of Neuroscience. 39(17):3249-3263 [DOI] 10.1523/jneurosci.2944-18.2019.
2016
Oxytocin depolarizes fast-spiking hilar interneurons and induces GABA release onto mossy cells of the rat dentate gyrus.
Hippocampus. 26(9):1124-39 [DOI] 10.1002/hipo.22595. [PMID] 27068005.
2014
A method for high purity intestinal epithelial cell culture from adult human and murine tissues for the investigation of innate immune function.
Journal of immunological methods. 414:20-31 [DOI] 10.1016/j.jim.2014.08.002. [PMID] 25193428.
2013
Augmented LPS responsiveness in type 1 diabetes-derived osteoclasts.
Journal of cellular physiology. 228(2):349-61 [DOI] 10.1002/jcp.24138. [PMID] 22718269.
2010
Impairment of baroreflex control of heart rate and structural changes of cardiac ganglia in conscious streptozotocin (STZ)-induced diabetic mice.
Autonomic neuroscience : basic & clinical. 155(1-2):39-48 [DOI] 10.1016/j.autneu.2010.01.004. [PMID] 20171940.
2010
Impairment of baroreflex control of heart rate in conscious transgenic mice of type 1 diabetes (OVE26).
Autonomic neuroscience : basic & clinical. 152(1-2):67-74 [DOI] 10.1016/j.autneu.2009.09.020. [PMID] 19910264.
2010
Maternal diabetes increases small conductance Ca2+-activated K+ (SK) currents that alter action potential properties and excitability of cardiac motoneurons in the nucleus ambiguus.
Journal of neurophysiology. 104(4):2125-38 [DOI] 10.1152/jn.00671.2009. [PMID] 20668269.
2010
Structural remodeling of vagal afferent innervation of aortic arch and nucleus ambiguus (NA) projections to cardiac ganglia in a transgenic mouse model of type 1 diabetes (OVE26).
The Journal of comparative neurology. 518(14):2771-93 [DOI] 10.1002/cne.22363. [PMID] 20506475.
2009
Chronic intermittent hypoxia impairs heart rate responses to AMPA and NMDA and induces loss of glutamate receptor neurons in nucleus ambiguous of F344 rats.
American journal of physiology. Regulatory, integrative and comparative physiology. 296(2):R299-308 [DOI] 10.1152/ajpregu.90412.2008. [PMID] 19020286.
2009
Diabetes induces neural degeneration in nucleus ambiguus (NA) and attenuates heart rate control in OVE26 mice.
Experimental neurology. 220(1):34-43 [DOI] 10.1016/j.expneurol.2009.07.006. [PMID] 19615367.
2009
Impaired baroreflex control of renal sympathetic nerve activity in type 1 diabetic mice (OVE26).
Neuroscience. 161(1):78-85 [DOI] 10.1016/j.neuroscience.2009.02.083. [PMID] 19303918.
2009
Vagal afferent innervation and remodeling in the aortic arch of young-adult fischer 344 rats following chronic intermittent hypoxia.
Neuroscience. 164(2):658-66 [DOI] 10.1016/j.neuroscience.2009.06.066. [PMID] 19580847.

Education

D.M.D.
2016 · University of Florida College of Dentistry
Ph.D.
2016 · University of Florida College of Medicine
M.S.
2009 · University of Central Florida College of Medicine

Contact Details

Phones:
Business:
(352) 273-7704
Emails:
Business:
swharden@ufl.edu
Addresses:
Business Mailing:
PO Box 100487
GAINESVILLE FL 32610
Business Street:
MSB P2-09
MSB P2-09
GAINESVILLE FL 326110001