Reginald Frye, Pharm.D., Ph.D., FCCP

Professor And Chair

Department: Pharmacotherapy & Translational Research

Business Phone: (352) 273-5453

Business Email: frye@cop.ufl.edu

CV: View Curriculum Vitae

About Reginald Frye

Dr. Frye is a Professor and Chair for the Department of Pharmacotherapy and Translational Research College of Pharmacy. He received a B.S. in Biology from Oglethorpe University, a Pharm.D. from Mercer University School of Pharmacy, and a Ph.D. in Clinical Pharmaceutical Sciences from the University of Pittsburgh School of Pharmacy. After completing graduate work, Dr. Frye remained on faculty at the University of Pittsburgh from 1995 until 2003, being promoted to Associate Professor with tenure in 2002. He joined the faculty at the University of Florida in July 2003 and in July 2012, he was promoted to Professor.

Publications

2019

Effect of pterostilbene on <i>in vitro</i> drug metabolizing enzyme activity

Saudi Pharmaceutical Journal

2018

Pioglitazone Improves Hepatic Mitochondrial Function in a Mouse Model of Nonalcoholic Steatohepatitis

American Journal of Physiology-Endocrinology and Metabolism

2018

Relative Bioavailability of Silybin a and Silybin B From 2 Multiconstituent Dietary Supplement Formulations Containing Milk Thistle Extract: a Single-Dose Study

Clinical Therapeutics

2018

Metabolomic Association Between Venous Thromboembolism in Critically Ill Trauma Patients and Kynurenine Pathway of Tryptophan Metabolism

2018

A Genetic Score Associates With Pioglitazone Response in Patients With Non-Alcoholic Steatohepatitis

Frontiers in Pharmacology

2017

Effect of Low-Furanocoumarin Hybrid Grapefruit Juice Consumption on Midazolam Pharmacokinetics

The Journal of Clinical Pharmacology

2017

The Effect of Milk Thistle (Silybum Marianum) and Its Main Flavonolignans on Cyp2C8 Enzyme Activity in Human Liver Microsomes

Chemico-Biological Interactions

2017

Concentration-Dependent Response to Pioglitazone in Nonalcoholic Steatohepatitis

Alimentary Pharmacology & Therapeutics

2016

Novel Plasma Biomarker of Atenolol-Induced Hyperglycemia Identified Through a Metabolomics-Genomics Integrative Approach

2016

A Genetic Response Score for Hydrochlorothiazide Use Insights From Genomics and Metabolomics Integration

Hypertension

2016

Presence of Arachidonoyl-Carnitine Is Associated With Adverse Cardiometabolic Responses in Hypertensive Patients Treated With Atenolol

2015

Integrating Metabolomics and Genomics Reveals Novel Biomarkers of Hydrochlorothiazide Response in Pharmacogenomic Evaluation of Antihypertensive Responses (Pear) Study.

Clinical Pharmacology & Therapeutics

2015

Association of Branched and Aromatic Amino Acids Levels With Metabolic Syndrome and Impaired Fasting Glucose in Hypertensive Patients

Metabolic Syndrome and Related Disorders

2015

Metabolomics, Genomics and Lipidomics Reveal Novel Signatures of Hydrochlorothiazide Response in Pharmacogenomic Evaluation of Antihypertensive Responses (Pear) Study.

Clinical Pharmacology & Therapeutics

2014

Multivariate Analysis of Factors That Influence Improvement in Nonalcoholic Fatty Liver Disease (Nafld) After Pioglitazone Treatment.

Pharmacotherapy

2014

Pharmacodynamic Association of Pioglitazone and Its Active Metabolites With Liver Outcomes Among Patients Diagnosed With Nonalcoholic Steatohepatitis.

Clinical Pharmacology & Therapeutics

2014

Is Diabetes Mellitus-Linked Amino Acid Signature Associated With Beta-Blocker-Induced Impaired Fasting Glucose?

Circulation-Cardiovascular Genetics

2014

A Validated Liquid Chromatography Tandem Mass Spectrometry Method for Simultaneous Determination of Pioglitazone, Hydroxypioglitazone, and Ketopioglitazone in Human Plasma and Its Application To a Clinical Study

Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences

2014

Effect of Pterostilbene On in Vitro Drug-Metabolizing Enzyme Activity.

Clinical Pharmacology & Therapeutics

2014

The Effects of Milk Thistle (Silybum Marianum) On Human Cytochrome P450 Activity

2013

Inhibitory Effect of Six Commonly Used Herbal Extracts On Cyp2C8 Enzyme Activity

Clinical Pharmacology & Therapeutics

2013

Tick-Tock … Genes Working Round the Clock: Associations With Sleep and Acute and Chronic Post-Thoracotomy Pain

Journal of pain (Online)

2013

Pharmacometabolomics Reveals Racial Differences in Response To Atenolol Treatment

PLOS One

2013

Milk Thistle Herb-Drug Interaction Study: No Effect On Cyp3A, Cyp2C9, and Cyp2D6 Activities in Healthy Participants

Clinical Pharmacology & Therapeutics

2013

Pharmacokinetic Properties of Pure Xanthones in Comparison To a Mangosteen Fruit Extract in Rats

Planta Medica

2012

The Pharmacokinetic Properties of Pure Gamma-Mangostin in Rats in Comparison To Mangosteen Extract

Planta Medica

2012

Pharmacokinetics of Valerenic Acid in Rats After Intravenous and Oral Administrations

Planta Medica

2012

Effects of High-Fructose Corn Syrup and Sucrose On the Pharmacokinetics of Fructose and Acute Metabolic and Hemodynamic Responses in Healthy Subjects

Metabolism-Clinical and Experimental

2012

A Preliminary Study on the Effects of Self-Reported Dietary Caffeine on Pain Experience and Postoperative Analgesia

Journal of Caffeine Research

2012

Cyclophosphamide and 4-Hydroxycyclophosphamide Pharmacokinetics in Patients With Glomerulonephritis Secondary To Lupus and Small Vessel Vasculitis

British Journal of Clinical Pharmacology

2011

Pharmacokinetics of Alpha-Mangostin in Rats After Intravenous and Oral Application

Molecular Nutrition & Food Research

2011

Nicotine as a Factor in Stress Responsiveness Among Detoxified Alcoholics

Alcohol and Alcoholism

2011

Interaction of Sorafenib and Cytochrome P450 Isoenzymes in Patients With Advanced Melanoma: a Phase I/Ii Pharmacokinetic Interaction Study

Cancer Chemotherapy and Pharmacology

2011

Absolute/Relative Bioavailability and Metabolism of Dodeca-2E,4E,8Z,10E/Z-Tetraenoic Acid Isobutylamides (Tetraenes) After Intravenous and Oral Single Doses To Rats

Planta Medica

2011

Inhibitory Effects of Commonly Used Herbal Extracts On Ugt1A4. 1A6, and 1A9 Enzyme Activities

Clinical Pharmacology & Therapeutics

2011

Effects of Herbal Supplements On Drug Glucuronidation. Review of Clinical, Animal, and in Vitro Studies

Planta Medica

2011

Effect of Cytochrome P450 3A5 Genotype On Atorvastatin Pharmacokinetics and Its Interaction With Clarithromycin

Pharmacotherapy

2011

Nicotine and Salivary Cortisol Effects On Attentional Efficiency in Detoxified Alcohol Dependent Individuals

Alcoholism-Clinical and Experimental Research

2011

Inhibitory Effects of Commonly Used Herbal Extracts On Udp-Glucuronosyltransferase 1A4, 1A6, and 1A9 Enzyme Activities

2010

Inhibition of Intestinal and Hepatic Glucuronidation of Mycophenolic Acid By Ginkgo Biloba Extract and Flavonoids

2010

Atenolol Exposure and Risk for Development of Adverse Metabolic Effects: a Pilot Study

Pharmacotherapy

2010

Validation and Application of a Liquid Chromatography-Tandem Mass Spectrometric Method for Quantification of the Drug Transport Probe Fexofenadine in Human Plasma Using 96-Well Filter Plates

Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences

2010

Use of Enantiomeric Bupropion and Hydroxybupropion To Assess Cyp2B6 Activity in Glomerular Kidney Diseases

The Journal of Clinical Pharmacology

2010

Effect of Abcg2 Genotypes On the Pharmacokinetics of A771726, An Active Metabolite of Leflunomide and Relationship With Serum Uric Acid Levels.

Clinical Pharmacology & Therapeutics

2010

Inhibitory Effects of Commonly Used Herbal Extracts On Ugt1A1 Enzyme Activity

Xenobiotica

2010

Evaluation of Inhibitory Potential of Herbal Extracts On Ugt1A1 Activity in Vitro.

Clinical Pharmacology & Therapeutics

2009

Determination of Visnagin in Rat Plasma By Liquid Chromatography With Tandem Mass Spectrometry and Its Application To in Vivo Pharmacokinetic Studies

Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences

2009

Pharmacokinetics and Tissue Distribution of Dodeca-2E,4E,8E,10E/Z-Tetraenoic Acid Isobutylamides After Oral Administration in Rats

Planta Medica

2009

A Sensitive and Specific Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Intracellular and Extracellular Uric Acid

Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences

2009

Early Atorvastatin Reduces Hemorrhage After Acute Cerebral Ischemia in Diabetic Rats

Journal of Pharmacology and Experimental Therapeutics

2009

Toxicological and Pharmacokinetic Evaluation of Concomitant Intake of Grapefruit Juice and Simvastatin in Rats after Repeated Treatment over 28 Days.

Planta Medica

2009

Simultaneous Determination of Uric Acid Metabolites Allantoin, 6-Aminouracil, and Triuret in Human Urine Using Liquid Chromatography-Mass Spectrometry

Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences

2009

Bioavailability of Dodeca-2E,4E,8E,10E/Z-Tetraenoic Acid Isobutylamides After Oral Administration in Rats and Distribution in Various Tissues

Planta Medica

2009

Esrd Impairs Nonrenal Clearance of Fexofenadine But Not Midazolam

Journal of the American Society of Nephrology

2008

The Pharmacokinetics of Fexofenadine But Not Midazolam Are Altered in End-Stage Renal Disease.

Clinical Pharmacology & Therapeutics

2008

Changes in Coenzyme Q10 (Coq10) Following High-Dose Atorvastatin Therapy.

Clinical Pharmacology & Therapeutics

2008

Determination of Mycophenolic Acid Glucuronide in Microsomal Incubations Using High Performance Liquid Chromatography-Tandem Mass Spectrometry

Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences

2008

Pharmacokinetic Profiling of Dodeca-2E,4E,8E,10E/Z-Tetraenoic Acid Isobutylamides in Rats Using Liquid Chromatography Tandem Mass Spectrometry

Planta Medica

2008

A summer research training program to foster PharmD students' interest in research.

American Journal of Pharmaceutical Education

2008

Effect of Therapeutic Hypothermia On the Phamacokinetics of Fexofenadine in Cardiac Arrest Survivors

Critical Care Medicine

2008

Simplified Method for Determination of Clarithromycin in Human Plasma Using Protein Precipitation in a 96-Well Format and Liquid Chromatography-Tandem Mass Spectrometry

Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences

2008

Interpopulation Variation Frequency of Human Inosine 5 `-Monophosphate Dehydrogenase Type Ii (Impdh2) Genetic Polymorphisms

Genetic Testing

2008

Plasma Coenzyme Q10 Predicts Lipid-Towering Response To High-Dose Atorvastatin

Journal of Clinical Lipidology

2008

Determination of N-Desethylamodiaquine By Hydrophilic Interaction Liquid Chromatography With Tandem Mass Spectrometry: Application To in Vitro Drug Metabolism Studies

Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences

2008

Effect of Ginkgo Biloba and Valerian Root Extracts On Mycophenolic Acid Glucuronide Formation in Human Liver Microsomes.

Clinical Pharmacology & Therapeutics

2006

Liver disease selectively modulates cytochrome P450–mediated metabolism

Clinical Pharmacology & Therapeutics

2004

Effect of St John's wort on imatinib mesylate pharmacokinetics.

Clinical Pharmacology & Therapeutics

Grants

Jul 2015 – Jun 2016

AHEC Tobacco Training and Cessation

FL DEPT OF HLTH · Project Manager

Sep 2008 ACTIVE

Multiple Sponsors Project

MULTIPLE SPONSORS · Principal Investigator

Education

Ph.D.

1995 · University of Pittsburgh

Pharm.D.

1990 · Mercer University

B.S.

1986 · Oglethorpe University

Contact Details

Phones:

Business:: (352) 273-5453

Emails:

Business:: frye@cop.ufl.edu