Reginald Frye, Pharm.D., Ph.D., FCCP
Associate Dean For Faculty Development; Professor And Chair
Department:
Pharmacotherapy & Translational Research
Business Phone:
(352) 273-5453
Business Email:
fryerf@ufl.edu
About Reginald Frye
Reginald Frye, Pharm.D., Ph.D., is the UF College of Pharmacy’s associate dean for faculty development and a professor and chair for the department of pharmacotherapy and translational research. He received a B.S. in Biology from Oglethorpe University, a Pharm.D. from Mercer University School of Pharmacy, and a Ph.D. in Clinical Pharmaceutical Sciences from the University of Pittsburgh School of Pharmacy. After completing graduate work, Dr. Frye remained on faculty at the University of Pittsburgh from 1995 until 2003, being promoted to Associate Professor with tenure in 2002. He joined the faculty at the University of Florida in July 2003 and in July 2012, he was promoted to Professor.
Teaching Profile
Courses Taught
2016,2020-2021
PHA6971 Research for Master’s Thesis
2016,2020
PHA6910 Supervised Research
2006,2020-2022
PHA6935 Selected Topics in Pharmacy
2012-2021
PHA7980 Research for Doctoral Dissertation
2011-2022
PHA7979 Advanced Research
2018-2019
PHA5132 Prin Drug Ther Indiv
2008,2010-2012,2012-2018,2016-2018,2018
PHA6427 Pharmacogenetics of Drug Metabolism
2010-2011,2014-2018,2018
PHA5907 Research in Phar Prac
2014-2018,2021-2022
PHA6938 Research Seminar
2012-2016
PHA5113 Personalized Medicine
2016
PHA5933 Select Top Pharmacy
2014-2015
PHA4914 Undergraduate Research in Pharmacotherapy and Translational Research
2015
PHA5561C Physiol Bas Disease 2
2011,2013
PHA6633 Mtm: Cardiovascular
2011-2012
PHA5782 Pharmacotherapy 2
2012
PHA6635 Mtm: a Renal Focus
2006-2011
PHA5113C Thera Mon/Pharmacogen
2011
PHA5108L Pharmaceu Skls Lab 1
2021
PHA5930 Sem Pharm Research
Research Profile
Dr. Frye is a clinical pharmacologist by training and a licensed pharmacist. His search focuses on identifying factors that contribute to variability in drug response. In particular, he has focused on drug-metabolizing enzymes that contribute to pharmacokinetic variability observed with many drugs and natural products. Dr. Frye’s work in this area has been supported by NCCAM, NIDCR and NIGMS. He serves on the editorial boards of Annals of Pharmacotherapy and Frontiers in Pharmacogenetics and Pharmacogenomics; he served on the editorial boards of Pharmacotherapy and The Open Drug Metabolism Journal. He serves as an ad-hoc reviewer for many journals, including Drug Metabolism and Disposition and Clinical Pharmacology and Therapeutics.
Open Researcher and Contributor ID (ORCID)
0000-0002-1841-1401
Publications
2022
A randomized, cross‐over trial of metoprolol succinate formulations to evaluate
PK
and
PD
end points for therapeutic equivalence
Clinical and Translational Science.
15(7):1764-1775
[DOI] 10.1111/cts.13294.
[PMID] 35488487.
2022
The Influence of Cannabidiol on the Pharmacokinetics of Methylphenidate in Healthy Subjects
Medical Cannabis and Cannabinoids.
199-206
[DOI] 10.1159/000527189.
2021
Evaluating an interactive teaching approach with personal genotyping to provide pharmacy students with a knowledge base for clinical pharmacogenetics
JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY.
4(3):343-351
[DOI] 10.1002/jac5.1335.
2020
Examination of Metoprolol Pharmacokinetics and Pharmacodynamics Across CYP2D6 Genotype-Derived Activity Scores.
CPT: pharmacometrics & systems pharmacology.
9(12):678-685
[DOI] 10.1002/psp4.12563.
[PMID] 33067866.
2020
Intensive Care Unit Delirium in Surgical Patients Is Associated with Upregulation in Tryptophan Metabolism
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy.
40(6):500-506
[DOI] 10.1002/phar.2392.
2019
Effect of pterostilbene on in vitro drug metabolizing enzyme activity.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society.
27(3):406-412
[DOI] 10.1016/j.jsps.2019.01.001.
[PMID] 30976185.
2018
A Genetic Score Associates With Pioglitazone Response in Patients With Non-alcoholic Steatohepatitis.
Frontiers in pharmacology.
9
[DOI] 10.3389/fphar.2018.00752.
[PMID] 30065651.
2018
Metabolomic association between venous thromboembolism in critically ill trauma patients and kynurenine pathway of tryptophan metabolism.
Thrombosis research.
165:6-13
[DOI] 10.1016/j.thromres.2018.03.003.
[PMID] 29544199.
2018
Pioglitazone improves hepatic mitochondrial function in a mouse model of nonalcoholic steatohepatitis.
American journal of physiology. Endocrinology and metabolism.
315(2):E163-E173
[DOI] 10.1152/ajpendo.00023.2018.
[PMID] 29634314.
2018
Relative Bioavailability of Silybin A and Silybin B From 2 Multiconstituent Dietary Supplement Formulations Containing Milk Thistle Extract: A Single-dose Study.
Clinical therapeutics.
40(1):103-113.e1
[DOI] 10.1016/j.clinthera.2017.11.013.
[PMID] 29273470.
2017
Concentration-dependent response to pioglitazone in nonalcoholic steatohepatitis
Alimentary Pharmacology & Therapeutics.
46(1):56-61
[DOI] 10.1111/apt.14111.
[PMID] 28470881.
2017
Effect of Low-Furanocoumarin Hybrid Grapefruit Juice Consumption on Midazolam Pharmacokinetics.
Journal of clinical pharmacology.
57(3):305-311
[DOI] 10.1002/jcph.807.
[PMID] 27503364.
2017
Pharmacogenomics competencies in pharmacy practice: A blueprint for change.
Journal of the American Pharmacists Association : JAPhA.
57(1):120-125
[DOI] 10.1016/j.japh.2016.08.014.
[PMID] 27816542.
2017
Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics.
Journal of the American Heart Association.
7(1)
[DOI] 10.1161/JAHA.117.006656.
[PMID] 29288159.
2017
The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes
Chemico-Biological Interactions.
271:24-29
[DOI] 10.1016/j.cbi.2017.04.025.
2016
A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration.
Hypertension (Dallas, Tex. : 1979).
68(3):621-9
[DOI] 10.1161/HYPERTENSIONAHA.116.07328.
[PMID] 27381900.
2016
Early thrombin formation capacity in trauma patients and association with venous thromboembolism.
Thrombosis research.
147:13-15
[DOI] 10.1016/j.thromres.2016.09.024.
[PMID] 27664391.
2016
Novel plasma biomarker of atenolol-induced hyperglycemia identified through a metabolomics-genomics integrative approach.
Metabolomics : Official journal of the Metabolomic Society.
12(8)
[DOI] 10.1007/s11306-016-1076-8.
[PMID] 28217400.
2016
Presence of arachidonoyl-carnitine is associated with adverse cardiometabolic responses in hypertensive patients treated with atenolol.
Metabolomics : Official journal of the Metabolomic Society.
12(10)
[DOI] 10.1007/s11306-016-1098-2.
[PMID] 28217401.
2015
Association of branched and aromatic amino acids levels with metabolic syndrome and impaired fasting glucose in hypertensive patients.
Metabolic syndrome and related disorders.
13(5):195-202
[DOI] 10.1089/met.2014.0132.
[PMID] 25664967.
2015
Chapter 39. Pharmacogenetics and Pharmacogenomics
Handbook of Basic Pharmacokinetics … Including Clinical Applications, Seventh Edition.
216-232
2015
Enzyme- and transporter-mediated beverage-drug interactions: An update on fruit juices and green tea.
Journal of clinical pharmacology.
55(12):1313-31
[DOI] 10.1002/jcph.563.
[PMID] 26095990.
2015
Inhibitory effect of six herbal extracts on CYP2C8 enzyme activity in human liver microsomes.
Xenobiotica; the fate of foreign compounds in biological systems.
45(5):406-12
[DOI] 10.3109/00498254.2014.989935.
[PMID] 25430798.
2015
Integrating Metabolomics and Genomics Reveals Novel Biomarkers of Hydrochlorothiazide Response in Pharmacogenomic Evaluation of Antihypertensive Responses (Pear) Study.
Clinical Pharmacology & Therapeutics.
97(1)
2015
Integrating Metabolomics and Genomics Reveals Novel Biomarkers of Hydrochlorothiazide Response in Pharmacogenomic Evaluation of Antihypertensive Responses (Pear) Study.
Clinical Pharmacology & Therapeutics.
97(1)
2015
Metabolomics, Genomics and Lipidomics Reveal Novel Signatures of Hydrochlorothiazide Response in Pharmacogenomic Evaluation of Antihypertensive Responses (Pear) Study.
Clinical Pharmacology & Therapeutics.
97(1):S4-S5
[DOI] 10.1002/cpt.58.
2014
A validated liquid chromatography tandem mass spectrometry method for simultaneous determination of pioglitazone, hydroxypioglitazone, and ketopioglitazone in human plasma and its application to a clinical study
Journal of Chromatography B.
969:219-223
[DOI] 10.1016/j.jchromb.2014.08.019.
2014
Effect of Pterostilbene On in Vitro Drug-Metabolizing Enzyme Activity.
Clinical Pharmacology & Therapeutics.
95(1)
2014
In vivo alterations in drug metabolism and transport pathways in patients with chronic kidney diseases.
Pharmacotherapy.
34(2):114-22
[DOI] 10.1002/phar.1347.
[PMID] 24038489.
2014
Is diabetes mellitus-linked amino acid signature associated with β-blocker-induced impaired fasting glucose?
Circulation. Cardiovascular genetics.
7(2):199-205
[DOI] 10.1161/CIRCGENETICS.113.000421.
[PMID] 24627569.
2014
Multivariate Analysis of Factors That Influence Improvement in Nonalcoholic Fatty Liver Disease (Nafld) After Pioglitazone Treatment.
Pharmacotherapy.
34(10)
2014
Pharmacodynamic Association of Pioglitazone and Its Active Metabolites With Liver Outcomes Among Patients Diagnosed With Nonalcoholic Steatohepatitis.
Clinical Pharmacology & Therapeutics.
95(1)
2014
The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity.
Drug metabolism and disposition: the biological fate of chemicals.
42(10):1611-6
[DOI] 10.1124/dmd.114.057232.
[PMID] 25028567.
2014
The role of pharmacogenetics in the treatment of chronic hepatitis C infection.
Pharmacotherapy.
34(2):185-201
[DOI] 10.1002/phar.1349.
[PMID] 24114761.
2013
Current clinical evidence on pioglitazone pharmacogenomics.
Frontiers in pharmacology.
4
[DOI] 10.3389/fphar.2013.00147.
[PMID] 24324437.
2013
Inhibitory Effect of Six Commonly Used Herbal Extracts On Cyp2C8 Enzyme Activity
Clinical Pharmacology & Therapeutics.
93
2013
Milk Thistle Herb-Drug Interaction Study: No Effect On Cyp3A, Cyp2C9, and Cyp2D6 Activities in Healthy Participants
Clinical Pharmacology & Therapeutics.
93
2013
Pharmacokinetic properties of pure xanthones in comparison to a mangosteen fruit extract in rats.
Planta medica.
79(8):646-53
[DOI] 10.1055/s-0032-1328543.
[PMID] 23673465.
2013
Pharmacometabolomics reveals racial differences in response to atenolol treatment.
PloS one.
8(3)
[DOI] 10.1371/journal.pone.0057639.
[PMID] 23536766.
2013
Tick-Tock … Genes Working Round the Clock: Associations With Sleep and Acute and Chronic Post-Thoracotomy Pain
Journal of Pain.
14
2012
A Preliminary Study on the Effects of Self-Reported Dietary Caffeine on Pain Experience and Postoperative Analgesia.
Journal of caffeine research.
2(4):159-166
[PMID] 24761271.
2012
Cyclophosphamide and 4-hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis.
British journal of clinical pharmacology.
74(3):445-55
[DOI] 10.1111/j.1365-2125.2012.04223.x.
[PMID] 22380717.
2012
Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects.
Metabolism: clinical and experimental.
61(5):641-51
[DOI] 10.1016/j.metabol.2011.09.013.
[PMID] 22152650.
2012
Pharmacokinetics of valerenic acid in rats after intravenous and oral administrations.
Planta medica.
78(6):575-81
[DOI] 10.1055/s-0031-1298301.
[PMID] 22411722.
2011
Absolute/relative bioavailability and metabolism of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (tetraenes) after intravenous and oral single doses to rats.
Planta medica.
77(16):1794-9
[DOI] 10.1055/s-0030-1271120.
[PMID] 21604240.
2011
Effect of cytochrome P450 3A5 genotype on atorvastatin pharmacokinetics and its interaction with clarithromycin.
Pharmacotherapy.
31(10):942-50
[DOI] 10.1592/phco.31.10.942.
[PMID] 21950641.
2011
Effects of herbal supplements on drug glucuronidation. Review of clinical, animal, and in vitro studies.
Planta medica.
77(4):311-21
[DOI] 10.1055/s-0030-1250457.
[PMID] 21049395.
2011
Inhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activities.
Drug metabolism and disposition: the biological fate of chemicals.
39(9):1522-8
[DOI] 10.1124/dmd.111.039602.
[PMID] 21632963.
2011
Inhibitory Effects of Commonly Used Herbal Extracts On Ugt1A4. 1A6, and 1A9 Enzyme Activities
Clinical Pharmacology & Therapeutics.
89
2011
Interaction of Sorafenib and Cytochrome P450 Isoenzymes in Patients With Advanced Melanoma: a Phase I/Ii Pharmacokinetic Interaction Study
Cancer Chemotherapy and Pharmacology.
68(5):1111-1118
[DOI] 10.1007/s00280-011-1585-0.
[PMID] 21350850.
2011
Nicotine and Salivary Cortisol Effects On Attentional Efficiency in Detoxified Alcohol Dependent Individuals
Alcoholism-Clinical and Experimental Research.
35
2011
Nicotine as a factor in stress responsiveness among detoxified alcoholics.
Alcohol and alcoholism (Oxford, Oxfordshire).
46(1):39-51
[DOI] 10.1093/alcalc/agq070.
[PMID] 21045074.
2011
Pharmacokinetics of α-mangostin in rats after intravenous and oral application.
Molecular nutrition & food research.
55 Suppl 1:S67-74
[DOI] 10.1002/mnfr.201000511.
[PMID] 21254395.
2010
Atenolol exposure and risk for development of adverse metabolic effects: a pilot study.
Pharmacotherapy.
30(9):872-8
[DOI] 10.1592/phco.30.9.872.
[PMID] 20795842.
2010
Effect of Abcg2 Genotypes On the Pharmacokinetics of A771726, An Active Metabolite of Leflunomide and Relationship With Serum Uric Acid Levels.
Clinical Pharmacology & Therapeutics.
87
2010
Evaluation of Inhibitory Potential of Herbal Extracts On Ugt1A1 Activity in Vitro.
Clinical Pharmacology & Therapeutics.
87
2010
Inhibition of intestinal and hepatic glucuronidation of mycophenolic acid by Ginkgo biloba extract and flavonoids.
Drug metabolism and disposition: the biological fate of chemicals.
38(2):270-5
[DOI] 10.1124/dmd.109.030080.
[PMID] 19889883.
2010
Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity.
Xenobiotica; the fate of foreign compounds in biological systems.
40(10):663-9
[DOI] 10.3109/00498254.2010.505669.
[PMID] 20666626.
2010
Use of enantiomeric bupropion and hydroxybupropion to assess CYP2B6 activity in glomerular kidney diseases.
Journal of clinical pharmacology.
50(6):714-20
[DOI] 10.1177/0091270009353031.
[PMID] 20103693.
2010
Validation and application of a liquid chromatography-tandem mass spectrometric method for quantification of the drug transport probe fexofenadine in human plasma using 96-well filter plates.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
878(3-4):497-501
[DOI] 10.1016/j.jchromb.2009.12.022.
[PMID] 20045385.
2009
A sensitive and specific liquid chromatography-tandem mass spectrometry method for the determination of intracellular and extracellular uric acid.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
877(22):2032-8
[DOI] 10.1016/j.jchromb.2009.05.037.
[PMID] 19520625.
2009
Determination of visnagin in rat plasma by liquid chromatography with tandem mass spectrometry and its application to in vivo pharmacokinetic studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
877(7):653-6
[DOI] 10.1016/j.jchromb.2009.01.014.
[PMID] 19188097.
2009
Early atorvastatin reduces hemorrhage after acute cerebral ischemia in diabetic rats.
The Journal of pharmacology and experimental therapeutics.
330(2):532-40
[DOI] 10.1124/jpet.108.146951.
[PMID] 19478137.
2009
ESRD impairs nonrenal clearance of fexofenadine but not midazolam.
Journal of the American Society of Nephrology : JASN.
20(10):2269-76
[DOI] 10.1681/ASN.2009010082.
[PMID] 19696225.
2009
Pharmacokinetics and tissue distribution of dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides after oral administration in rats.
Planta medica.
75(12):1306-13
[DOI] 10.1055/s-0029-1185631.
[PMID] 19399718.
2009
Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
877(1-2):65-70
[DOI] 10.1016/j.jchromb.2008.11.029.
[PMID] 19081307.
2009
Toxicological and Pharmacokinetic Evaluation of Concomitant Intake of Grapefruit Juice and Simvastatin in Rats after Repeated Treatment over 28 Days.
Planta medica.
75(11):1196-202
[DOI] 10.1055/s-0029-1185534.
[PMID] 19350484.
2008
A summer research training program to foster PharmD students’ interest in research.
American journal of pharmaceutical education.
72(2)
[PMID] 18483591.
2008
Changes in Coenzyme Q10 (Coq10) Following High-Dose Atorvastatin Therapy.
Clinical Pharmacology & Therapeutics.
83
2008
Determination of mycophenolic acid glucuronide in microsomal incubations using high performance liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
870(2):251-4
[DOI] 10.1016/j.jchromb.2008.06.020.
[PMID] 18602350.
2008
Determination of N-desethylamodiaquine by hydrophilic interaction liquid chromatography with tandem mass spectrometry: application to in vitro drug metabolism studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
863(1):129-34
[DOI] 10.1016/j.jchromb.2008.01.017.
[PMID] 18255358.
2008
Effect of Ginkgo Biloba and Valerian Root Extracts On Mycophenolic Acid Glucuronide Formation in Human Liver Microsomes.
Clinical Pharmacology & Therapeutics.
83
2008
Effect of the acute phase response induced by endotoxin administration on the expression and activity of UGT isoforms in rats.
Drug metabolism letters.
2(4):248-55
[PMID] 19356101.
2008
Effect of Therapeutic Hypothermia On the Phamacokinetics of Fexofenadine in Cardiac Arrest Survivors
Critical Care Medicine.
36
2008
Interpopulation variation frequency of human inosine 5′-monophosphate dehydrogenase type II (IMPDH2) genetic polymorphisms.
Genetic testing.
12(4):513-6
[DOI] 10.1089/gte.2008.0049.
[PMID] 18976158.
2008
Pharmacokinetic Profiling of Dodeca-2E,4E,8E,10E/Z-Tetraenoic Acid Isobutylamides in Rats Using Liquid Chromatography Tandem Mass Spectrometry
Planta Medica.
74
2008
Plasma Coenzyme Q10 Predicts Lipid-lowering Response to High-Dose Atorvastatin.
Journal of clinical lipidology.
2(4):289-97
[DOI] 10.1016/j.jacl.2008.05.001.
[PMID] 19649137.
2008
Simplified method for determination of clarithromycin in human plasma using protein precipitation in a 96-well format and liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
871(1):130-4
[DOI] 10.1016/j.jchromb.2008.06.050.
[PMID] 18639501.
2008
The Pharmacokinetics of Fexofenadine But Not Midazolam Are Altered in End-Stage Renal Disease.
Clinical Pharmacology & Therapeutics.
83
2006
Effect of conjugated equine estrogens on oxidative metabolism in middle-aged and elderly postmenopausal women.
Journal of clinical pharmacology.
46(11):1299-307
[PMID] 17050794.
2006
Liver disease selectively modulates cytochrome P450–mediated metabolism.
Clinical pharmacology and therapeutics.
80(3):235-45
[PMID] 16952490.
2006
Validation of incorporating flurbiprofen into the Pittsburgh cocktail.
Clinical pharmacology and therapeutics.
80(3):257-63
[PMID] 16952492.
2005
Cytochrome P-450 activity is differentially altered in severely injured patients.
Critical care medicine.
33(3):541-6
[PMID] 15753745.
2005
Cytochrome P450 mRNA expression in peripheral blood lymphocytes as a predictor of enzyme induction.
European journal of clinical pharmacology.
61(8):583-93
[PMID] 16041547.
2005
Effect of age and postoperative time on cytochrome p450 enzyme activity following liver transplantation.
Journal of clinical pharmacology.
45(6):666-73
[PMID] 15901748.
2005
Pharmacokinetics of intraperitoneal cefepime in automated peritoneal dialysis.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.
25(4):380-6
[PMID] 16022096.
2004
Bioequivalence revisited: influence of age and sex on CYP enzymes.
Clinical pharmacology and therapeutics.
76(6):618-27
[PMID] 15592333.
2004
Determination of trimethoprim in low-volume human plasma by liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
807(2):301-5
[PMID] 15203044.
2004
Effect of St John’s wort on imatinib mesylate pharmacokinetics.
Clinical pharmacology and therapeutics.
76(4):323-9
[PMID] 15470331.
2004
Induction and inhibition of cytochromes P450 by the St. John’s wort constituent hyperforin in human hepatocyte cultures.
Drug metabolism and disposition: the biological fate of chemicals.
32(5):512-8
[PMID] 15100173.
2004
Probing the world of cytochrome P450 enzymes.
Molecular interventions.
4(3):157-62
[PMID] 15210869.
2004
Pyrosequencing method for genotyping cytochrome P450 CYP2C8 and CYP2C9 enzymes.
Clinical chemistry.
50(12):2392-5
[PMID] 15563491.
2004
Simplified method for determination of rosiglitazone in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
803(2):317-20
[PMID] 15063342.
2004
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
Drug metabolism and disposition: the biological fate of chemicals.
32(7):727-33
[PMID] 15205388.
2003
Coordinated intrahepatic and extrahepatic regulation of cytochrome p4502D6 in healthy subjects and in patients after liver transplantation.
Clinical pharmacology and therapeutics.
73(5):456-67
[PMID] 12732845.
2003
Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure.
Intensive care medicine.
29(6):980-984
[DOI] 10.1007/s00134-003-1758-3.
[PMID] 12698250.
2003
Determination of 20-hydroxyeicosatetraenoic acid in microsomal incubates using high-performance liquid chromatography-mass spectrometry (HPLC-MS).
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
794(2):363-72
[PMID] 12954388.
2003
Differences in flurbiprofen pharmacokinetics between CYP2C9*1/*1, *1/*2, and *1/*3 genotypes.
European journal of clinical pharmacology.
58(12):791-4
[PMID] 12698304.
2003
Effect of hepatic impairment on the pharmacokinetics of atomoxetine and its metabolites.
Clinical pharmacology and therapeutics.
73(3):178-91
[PMID] 12621383.
2003
Hepatic drug metabolism and transport in patients with kidney disease.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
42(5):906-25
[PMID] 14582035.
2003
Impaired 6-hydroxychlorzoxazone elimination in patients with kidney disease: Implication for cytochrome P450 2E1 pharmacogenetic studies.
Clinical pharmacology and therapeutics.
74(6):555-68
[PMID] 14663458.
2003
Influence of DHEA administration on 24-hour cortisol concentrations.
Journal of clinical psychopharmacology.
23(1):96-9
[PMID] 12544381.
2003
Stereoselective determination of the CYP2C19 probe drug mephenytoin in human urine by gas chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
783(1):265-71
[PMID] 12450547.
2003
Tolbutamide, flurbiprofen, and losartan as probes of CYP2C9 activity in humans.
Journal of clinical pharmacology.
43(1):84-91
[PMID] 12520632.
2002
Application of semisimultaneous midazolam administration for hepatic and intestinal cytochrome P450 3A phenotyping.
Clinical pharmacology and therapeutics.
72(6):718-28
[PMID] 12496753.
2002
Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects.
British journal of clinical pharmacology.
53(2):155-62
[PMID] 11851639.
2002
Effect of nortriptyline and paroxetine on CYP2D6 activity in depressed elderly patients.
Journal of clinical psychopharmacology.
22(5):481-6
[PMID] 12352271.
2002
Identification of omega hydroxy fatty acids in biological samples as their pentafluoropropyl derivatives by gas chromatography/mass spectrometry with positive and negative ion detection.
Rapid communications in mass spectrometry : RCM.
16(15):1411-5
[PMID] 12125016.
2002
Plasma levels of TNF-alpha and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure.
Journal of cardiac failure.
8(5):315-9
[PMID] 12411982.
2002
Rapid microtiter plate assay for determination of inulin in human plasma and dialysate.
Journal of pharmaceutical and biomedical analysis.
28(2):209-15
[PMID] 11929663.
2002
Sensitive liquid chromatographic method using fluorescence detection for the determination of estradiol 3- and 17-glucuronides in rat and human liver microsomal incubations: formation kinetics.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
774(1):33-8
[PMID] 12052720.
2000
Pharmacokinetics of intermittent intravenous cefazolin and tobramycin in patients treated with automated peritoneal dialysis.
Journal of the American Society of Nephrology : JASN.
11(7):1310-1316
[DOI] 10.1681/ASN.V1171310.
[PMID] 10864588.
1999
Effect of disulfiram-mediated CYP2E1 inhibition on the disposition of vesnarinone.
Journal of clinical pharmacology.
39(11):1177-83
[PMID] 10579149.
1997
Validation of the five-drug “Pittsburgh cocktail” approach for assessment of selective regulation of drug-metabolizing enzymes.
Clinical pharmacology and therapeutics.
62(4):365-76
[PMID] 9357387.
1990
Students’ experience in a phase III clinical trial.
American journal of hospital pharmacy.
47(5)
[PMID] 2337091.
Grants
Jul 2015
– Jun 2016
AHEC Tobacco Training and Cessation Program
Role: Project Manager
Funding: FL DEPT OF HLTH
Sep 2008
– May 2021
Multiple Sponsors Project
Role: Principal Investigator
Funding: MULTIPLE SPONSORS
Education
Ph.D.
1995
·
University of Pittsburgh
Pharm.D.
1990
·
Mercer University
B.S.
1986
·
Oglethorpe University
Contact Details
Phones:
- Business:
- (352) 273-5453
Emails:
- Business:
- fryerf@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100486
GAINESVILLE FL 32610 - Business Street:
-
1225 CENTER DR
HPNP 3333
GAINESVILLE FL 326103007