Shainnel O Eans,
Biological Scientist III
Department:
Pharmacodynamics
Business Email:
shaieans@ufl.edu
Publications
2023
Identification and Pharmacological Characterization of a Low-Liability Antinociceptive Bifunctional MOR/DOR Cyclic Peptide.
Molecules (Basel, Switzerland).
28(22)
[DOI] 10.3390/molecules28227548.
[PMID] 38005269.
2023
Solid-Phase Synthesis of the Bicyclic Peptide OL-CTOP Containing Two Disulfide Bridges, and an Assessment of Its In Vivo μ-Opioid Receptor Antagonism after Nasal Administration.
Molecules (Basel, Switzerland).
28(4)
[DOI] 10.3390/molecules28041822.
[PMID] 36838810.
2023
Structure-based design of bitopic ligands for the µ-opioid receptor.
Nature.
613(7945):767-774
[DOI] 10.1038/s41586-022-05588-y.
[PMID] 36450356.
2023
Tryptophan Substitution in CJ-15,208 (cyclo[Phe-D-Pro-Phe-Trp]) Introduces δ-Opioid Receptor Antagonism, Preventing Antinociceptive Tolerance and Stress-Induced Reinstatement of Extinguished Cocaine-Conditioned Place Preference.
Pharmaceuticals (Basel, Switzerland).
16(9)
[DOI] 10.3390/ph16091218.
[PMID] 37765026.
2022
An analog of [d-Trp]CJ-15,208 exhibits kappa opioid receptor antagonism following oral administration and prevents stress-induced reinstatement of extinguished morphine conditioned place preference.
Pharmacology, biochemistry, and behavior.
217
[DOI] 10.1016/j.pbb.2022.173405.
[PMID] 35584724.
2022
Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics.
International journal of molecular sciences.
23(17)
[DOI] 10.3390/ijms23179623.
[PMID] 36077029.
2022
Characterization of CM-398, a Novel Selective Sigma-2 Receptor Ligand, as a Potential Therapeutic for Neuropathic Pain.
Molecules (Basel, Switzerland).
27(11)
[DOI] 10.3390/molecules27113617.
[PMID] 35684553.
2022
Examination of the Novel Sigma-1 Receptor Antagonist, SI 1/28, for Antinociceptive and Anti-allodynic Efficacy against Multiple Types of Nociception with Fewer Liabilities of Use.
International journal of molecular sciences.
23(2)
[DOI] 10.3390/ijms23020615.
[PMID] 35054797.
2022
Expression of Human Immunodeficiency Virus Transactivator of Transcription (HIV-Tat1-86) Protein Alters Nociceptive Processing that is Sensitive to Anti-Oxidant and Anti-Inflammatory Interventions.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.
17(1-2):152-164
[DOI] 10.1007/s11481-021-09985-4.
[PMID] 33619645.
2022
SRI-32743, a novel allosteric modulator, attenuates HIV-1 Tat protein-induced inhibition of the dopamine transporter and alleviates the potentiation of cocaine reward in HIV-1 Tat transgenic mice.
Neuropharmacology.
220
[DOI] 10.1016/j.neuropharm.2022.109239.
[PMID] 36126727.
2021
A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects.
Journal of medicinal chemistry.
64(18):13873-13892
[DOI] 10.1021/acs.jmedchem.1c01273.
[PMID] 34505767.
2021
Binge ethanol consumption-associated behavioral impairments in male mice using a gelatin-based drinking-in-the dark model.
Alcohol (Fayetteville, N.Y.).
95:25-36
[DOI] 10.1016/j.alcohol.2021.05.001.
[PMID] 34029701.
2021
Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site.
eLife.
10
[DOI] 10.7554/eLife.56519.
[PMID] 33555255.
2021
Kratom Alkaloids as Probes for Opioid Receptor Function: Pharmacological Characterization of Minor Indole and Oxindole Alkaloids from Kratom.
ACS chemical neuroscience.
12(14):2661-2678
[DOI] 10.1021/acschemneuro.1c00149.
[PMID] 34213886.
2021
Kratom Alkaloids, Natural and Semi-Synthetic, Show Less Physical Dependence and Ameliorate Opioid Withdrawal.
Cellular and molecular neurobiology.
41(5):1131-1143
[DOI] 10.1007/s10571-020-01034-7.
[PMID] 33433723.
2021
Oxidative Metabolism as a Modulator of Kratom’s Biological Actions.
Journal of medicinal chemistry.
64(22):16553-16572
[DOI] 10.1021/acs.jmedchem.1c01111.
[PMID] 34783240.
2021
Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects.
Proceedings of the National Academy of Sciences of the United States of America.
118(16)
[DOI] 10.1073/pnas.2000017118.
[PMID] 33846240.
2020
Design, Synthesis, and Characterization of the Macrocyclic Tetrapeptide cyclo[Pro-Sar-Phe-d-Phe]: A Mixed Opioid Receptor Agonist-Antagonist Following Oral Administration.
ACS chemical neuroscience.
11(9):1324-1336
[DOI] 10.1021/acschemneuro.0c00086.
[PMID] 32251585.
2020
Lyophilized Kratom Tea as a Therapeutic Option for Opioid Dependence.
Drug and alcohol dependence.
216
[DOI] 10.1016/j.drugalcdep.2020.108310.
[PMID] 33017752.
2020
Multifunctional opioid receptor agonism and antagonism by a novel macrocyclic tetrapeptide prevents reinstatement of morphine-seeking behaviour.
British journal of pharmacology.
177(18):4209-4222
[DOI] 10.1111/bph.15165.
[PMID] 32562259.
2020
Phenylalanine Stereoisomers of CJ-15,208 and [d-Trp]CJ-15,208 Exhibit Distinctly Different Opioid Activity Profiles.
Molecules (Basel, Switzerland).
25(17)
[DOI] 10.3390/molecules25173999.
[PMID] 32887303.
2020
Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine’s Biological Activity.
Journal of medicinal chemistry.
63(10):5119-5138
[DOI] 10.1021/acs.jmedchem.9b01924.
[PMID] 31913038.
2019
Antinociceptive activity of thiazole-containing cyclized DAMGO and Leu-(Met) enkephalin analogs.
Organic & biomolecular chemistry.
17(21):5305-5315
[DOI] 10.1039/c9ob00882a.
[PMID] 31094391.
2019
Characterization of Sigma 1 Receptor Antagonist CM-304 and Its Analog, AZ-66: Novel Therapeutics Against Allodynia and Induced Pain.
Frontiers in pharmacology.
10
[DOI] 10.3389/fphar.2019.00678.
[PMID] 31258480.
2018
A stable isotope dilution tandem mass spectrometry method of major kavalactones and its applications.
PloS one.
13(5)
[DOI] 10.1371/journal.pone.0197940.
[PMID] 29795658.
2017
A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation.
Organic & biomolecular chemistry.
15(37):7796-7801
[DOI] 10.1039/c7ob01924f.
[PMID] 28875208.
2017
Conditional Human Immunodeficiency Virus Transactivator of Transcription Protein Expression Induces Depression-like Effects and Oxidative Stress.
Biological psychiatry. Cognitive neuroscience and neuroimaging.
2(7):599-609
[DOI] 10.1016/j.bpsc.2017.04.002.
[PMID] 29057370.
2017
Selective κ receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice.
British journal of pharmacology.
174(15):2444-2456
[DOI] 10.1111/bph.13854.
[PMID] 28494108.
2016
Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine Bis-piperazines.
ACS combinatorial science.
18(1):51-64
[DOI] 10.1021/acscombsci.5b00126.
[PMID] 26651386.
2016
Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2.
Journal of medicinal chemistry.
59(18):8381-97
[DOI] 10.1021/acs.jmedchem.6b00748.
[PMID] 27556704.
2015
Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at μ (MOR), δ (DOR), and κ (KOR) Opioid Receptors.
Journal of medicinal chemistry.
58(12):4905-17
[DOI] 10.1021/jm501637c.
[PMID] 25996309.
2015
Synthesis and characterization of a dual kappa-delta opioid receptor agonist analgesic blocking cocaine reward behavior.
ACS chemical neuroscience.
6(11):1813-24
[DOI] 10.1021/acschemneuro.5b00153.
[PMID] 26325040.
2014
HIV-1 Tat protein exposure potentiates ethanol reward and reinstates extinguished ethanol-conditioned place preference.
Current HIV research.
12(6):415-23
[PMID] 25760047.
2014
Nonpeptide small molecule agonist and antagonist original leads for neuropeptide FF1 and FF2 receptors.
Journal of medicinal chemistry.
57(21):8903-27
[DOI] 10.1021/jm500989n.
[PMID] 25268943.
2014
Stress-induced increases in depression-like and cocaine place-conditioned behaviors are reversed by disruption of memories during reconsolidation.
Behavioural pharmacology.
25(5-6):599-608
[DOI] 10.1097/FBP.0000000000000074.
[PMID] 25083575.
2013
Central administration of angiotensin IV rapidly enhances novel object recognition among mice.
Neuropharmacology.
70:247-53
[DOI] 10.1016/j.neuropharm.2013.01.025.
[PMID] 23416700.
2013
Discovery of novel antinociceptive α-conotoxin analogues from the direct in vivo screening of a synthetic mixture-based combinatorial library.
ACS combinatorial science.
15(3):153-61
[DOI] 10.1021/co300152x.
[PMID] 23414173.
2013
The macrocyclic peptide natural product CJ-15,208 is orally active and prevents reinstatement of extinguished cocaine-seeking behavior.
Journal of natural products.
76(3):433-8
[DOI] 10.1021/np300697k.
[PMID] 23327691.
2012
Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
26(2):947-54
[DOI] 10.1096/fj.11-192831.
[PMID] 22038051.
2011
Unexpected opioid activity profiles of analogues of the novel peptide kappa opioid receptor ligand CJ-15,208.
ChemMedChem.
6(9):1739-45
[DOI] 10.1002/cmdc.201100113.
[PMID] 21761566.
2009
Isolation and spatial expression analysis of a partial esterase gene of Culex nigripalpus (Diptera: Culicidae).
Journal of medical entomology.
46(6):1370-5
[PMID] 19960682.
Contact Details
Emails:
- Business:
- shaieans@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100487
GAINESVILLE FL 32610 - Business Street:
-
1345 CENTER DR RM P2 08
GAINESVILLE FL 32610