Shainnel O Eans

Shainnel O Eans

Biological Scientist III

Department: Pharmacodynamics
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Kratom Alkaloids, Natural and Semi-Synthetic, Show Less Physical Dependence and Ameliorate Opioid Withdrawal.
Cellular and molecular neurobiology. [DOI] 10.1007/s10571-020-01034-7. [PMID] 33433723.
Lyophilized Kratom Tea as a Therapeutic Option for Opioid Dependence.
Drug and alcohol dependence. 216 [DOI] 10.1016/j.drugalcdep.2020.108310. [PMID] 33017752.
Multifunctional opioid receptor agonism and antagonism by a novel macrocyclic tetrapeptide prevents reinstatement of morphine-seeking behaviour.
British journal of pharmacology. 177(18):4209-4222 [DOI] 10.1111/bph.15165. [PMID] 32562259.
Phenylalanine Stereoisomers of CJ-15,208 and [d-Trp]CJ-15,208 Exhibit Distinctly Different Opioid Activity Profiles.
Molecules (Basel, Switzerland). 25(17) [DOI] 10.3390/molecules25173999. [PMID] 32887303.
Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine’s Biological Activity.
Journal of medicinal chemistry. 63(10):5119-5138 [DOI] 10.1021/acs.jmedchem.9b01924. [PMID] 31913038.
Design, Synthesis, and Characterization of the Macrocyclic Tetrapeptide cyclo[Pro-Sar-Phe-d-Phe]: A Mixed Opioid Receptor Agonist-Antagonist Following Oral Administration.
ACS chemical neuroscience. 11(9):1324-1336 [DOI] 10.1021/acschemneuro.0c00086. [PMID] 32251585.
Antinociceptive activity of thiazole-containing cyclized DAMGO and Leu-(Met) enkephalin analogs.
Organic & biomolecular chemistry. 17(21):5305-5315 [DOI] 10.1039/c9ob00882a. [PMID] 31094391.
Characterization of Sigma 1 Receptor Antagonist CM-304 and Its Analog, AZ-66: Novel Therapeutics Against Allodynia and Induced Pain.
Frontiers in pharmacology. 10 [DOI] 10.3389/fphar.2019.00678. [PMID] 31258480.
A stable isotope dilution tandem mass spectrometry method of major kavalactones and its applications.
PloS one. 13(5) [DOI] 10.1371/journal.pone.0197940. [PMID] 29795658.
A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation.
Organic & biomolecular chemistry. 15(37):7796-7801 [DOI] 10.1039/c7ob01924f. [PMID] 28875208.
Conditional Human Immunodeficiency Virus Transactivator of Transcription Protein Expression Induces Depression-like Effects and Oxidative Stress.
Biological psychiatry. Cognitive neuroscience and neuroimaging. 2(7):599-609 [DOI] 10.1016/j.bpsc.2017.04.002. [PMID] 29057370.
Selective κ receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice.
British journal of pharmacology. 174(15):2444-2456 [DOI] 10.1111/bph.13854. [PMID] 28494108.
Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine Bis-piperazines.
ACS combinatorial science. 18(1):51-64 [DOI] 10.1021/acscombsci.5b00126. [PMID] 26651386.
Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2.
Journal of medicinal chemistry. 59(18):8381-97 [DOI] 10.1021/acs.jmedchem.6b00748. [PMID] 27556704.
Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities.
European journal of medicinal chemistry. 92:270-81 [DOI] 10.1016/j.ejmech.2014.12.049. [PMID] 25559207.
Synthesis and characterization of a dual kappa-delta opioid receptor agonist analgesic blocking cocaine reward behavior.
ACS chemical neuroscience. 6(11):1813-24 [DOI] 10.1021/acschemneuro.5b00153. [PMID] 26325040.
Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at μ (MOR), δ (DOR), and κ (KOR) Opioid Receptors.
Journal of medicinal chemistry. 58(12):4905-17 [DOI] 10.1021/jm501637c. [PMID] 25996309.
HIV-1 Tat protein exposure potentiates ethanol reward and reinstates extinguished ethanol-conditioned place preference.
Current HIV research. 12(6):415-23 [PMID] 25760047.
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Nonpeptide small molecule agonist and antagonist original leads for neuropeptide FF1 and FF2 receptors.
Journal of medicinal chemistry. 57(21):8903-27 [DOI] 10.1021/jm500989n. [PMID] 25268943.
Stress-induced increases in depression-like and cocaine place-conditioned behaviors are reversed by disruption of memories during reconsolidation.
Behavioural pharmacology. 25(5-6):599-608 [DOI] 10.1097/FBP.0000000000000074. [PMID] 25083575.
Central administration of angiotensin IV rapidly enhances novel object recognition among mice.
Neuropharmacology. 70:247-53 [DOI] 10.1016/j.neuropharm.2013.01.025. [PMID] 23416700.
Discovery of novel antinociceptive α-conotoxin analogues from the direct in vivo screening of a synthetic mixture-based combinatorial library.
ACS combinatorial science. 15(3):153-61 [DOI] 10.1021/co300152x. [PMID] 23414173.
The macrocyclic peptide natural product CJ-15,208 is orally active and prevents reinstatement of extinguished cocaine-seeking behavior.
Journal of natural products. 76(3):433-8 [DOI] 10.1021/np300697k. [PMID] 23327691.
The macrocyclic tetrapeptide [D-Trp]CJ-15,208 produces short-acting κ opioid receptor antagonism in the CNS after oral administration.
British journal of pharmacology. 169(2):426-36 [DOI] 10.1111/bph.12132. [PMID] 23425081.
Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(2):947-54 [DOI] 10.1096/fj.11-192831. [PMID] 22038051.
Unexpected opioid activity profiles of analogues of the novel peptide kappa opioid receptor ligand CJ-15,208.
ChemMedChem. 6(9):1739-45 [DOI] 10.1002/cmdc.201100113. [PMID] 21761566.
Isolation and spatial expression analysis of a partial esterase gene of Culex nigripalpus (Diptera: Culicidae).
Journal of medical entomology. 46(6):1370-5 [PMID] 19960682.
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