Hartmut Derendorf, Ph.D.

Distinguished Professor Emeritus

Department: Dean's Office

Business Phone: (352) 273-7856

Business Email: hartmut@cop.ufl.edu

CV: View Curriculum Vitae

About Hartmut Derendorf

Hartmut Derendorf is a distinguished professor emeritus of pharmaceutics at the University of Florida College of Pharmacy in Gainesville. He received his B.S. (1976) and Ph.D. (1979, summa cum laude) in Pharmacy from the University of Münster, Germany and then joined the University of Florida, first as a Postdoctoral Fellow (1981/82) and later (1983) as a faculty member. He has been teaching Biopharmaceutics, Pharmacokinetics and Clinical Pharmacokinetics. He was awarded numerous teaching awards such as the UF Teaching Improvement Award, HHMI Distinguished Mentorship Award, UF Research Foundation Professorship, CVS Pharmacy Endowed Professorship, International Educator of the Year Award and UF Doctoral Advisor/Mentoring Award. He has supervised over 50 Ph.D. students.

Prof. Derendorf has published over 500 scientific publications with an h-index (Scopus) of 60 and given over 900 presentations at national or international meetings. He has published ten textbooks in English and German. He is Editor or Associate Editor of the Journal of Clinical Pharmacology, International Journal of Clinical Pharmacology & Therapeutics, International Journal of Antimicrobial Agents and Die Pharmazie, and serves on the Editorial Board of several other Journals. His research interests include the pharmacokinetics and pharmacodynamics of corticosteroids, analgesics, antibiotics as well as drug interactions.

Prof. Derendorf has served as President of ACCP (American College of Clinical Pharmacology) in 2006/08 and President of ISAP (International Society of Antiinfective Pharmacology) in 2004/06. He won the McKeen-Cattell Award for the best publication in J. Clin. Pharmacology (1994) and the Faculty Award of the University of Utrecht (2005). In 2003, he was awarded the Nathaniel T. Kwit Distinguished Service Award of ACCP and the Research Achievement Award in Clinical Science of the American Association of Pharmaceutical Sciences (AAPS). He is a Fellow of AAPS and ACCP as well as a former review panel member of the NASA Human Research Program. In 2010, he was awarded the Volwiler Award of the American Association of Colleges of Pharmacy (AACP) as well as the ACCP Distinguished Investigator Award, the highest research awards of both organizations. In 2013, he was awarded the First Leadership Award of the International Society of Pharmacometrics (ISOP). In 2015 he received the Merit Medal of the Westphalian Chamber of Pharmacy as well as the ACCP Mentorship Award. In 2018, he was awarded the ASCPT Mentor Award and the UF Doctoral Advisor/Mentoring Award. Furthermore, he held the Gerhard Levy Distinguished Lectureship at the University of Buffalo (2019) and received the Barré Prize of the University of Montreal (2020). He also served as the 18th University of Florida Distinguished Alumni Professor.

Accomplishments

Barré Prize

2020 · University of Montreal

Gerhard Levy Distinguished Lectureship

2019 · University of Buffalo

Fellowship FISAC

2019 · International Society of Antimicrobial Chemotherapy (ISAC)

Mentor Award

2018 · American Society for Clinical Pharmacology and Therapeutics

Doctoral Advisor/Mentoring Award

2018 · University of Florida

Mentorship Award

2015 · American College of Clinical Pharmacy

Merit Medal

2015 · Westphalian Chamber of Pharmacy

Leadership Award

2013 · International Society of Pharmacometrics

Volwiler Award

2010 · American Association of Colleges of Pharmacy

Distinguished Investigator Award

2010 · American College of Clinical Pharmacy

Research Achievement Award in Clinical Science

2003 · American Association of Pharmaceutical Scientists

Nathaniel T. Kwit Distinguished Service Award

2003 · American College of Clinical Pharmacy

Fellowship FAAPS

1996 · American Association of Pharmaceutical Scientists (AAPS)

Fellowship FCP

1988 · American College of Clinical Pharmacology (ACCP)

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0003-4016-1370

Publications

2020

Calculated initial parenteral treatment of bacterial infections: Pharmacokinetics and pharmacodynamics.

GMS infectious diseases

2020

Roger W. Jelliffe, M.D. (1929-2020).

Clinical pharmacokinetics

2020

One Giant Leap for Pharmacology.

Pharmaceutical research

2020

Carvacrol loaded nanostructured lipid carriers as a promising parenteral formulation for leishmaniasis treatment.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2020

Evaluation of the Effects of Maytenus ilicifolia on the Activities of Cytochrome P450 3A and P-glycoprotein.

Current drug metabolism

2020

Excessive lysosomal ion-trapping of hydroxychloroquine and azithromycin.

International journal of antimicrobial agents

2019

Pharmacokinetics of Oxytetracycline in the Giant Danio (Devario Aequipinnatus) Following Bath Immersion

Aquaculture

2019

Pharmacokinetic and Pharmacodynamic Characterization of Tetrahydrocannabinol-Induced Cannabinoid Dependence After Chronic Passive Cannabis Smoke Exposure in Rats.

Cannabis and cannabinoid research

2019

Impact of Ethnicity-Specific Hepatic Microsomal Scaling Factor, Liver Weight, and Cytochrome P450 (CYP) 1A2 Content on Physiologically Based Prediction of CYP1A2-Mediated Pharmacokinetics in Young and Elderly Chinese Adults.

Clinical pharmacokinetics

2019

Gastric-acid-mediated drug-drug interactions with direct-acting antiviral medications for hepatitis C virus infection: clinical relevance and mitigation strategies.

Drug discovery today

2019

Drug-Drug Interactions: Progress Over the Past Decade and Looking Ahead to the Future.

Clinical pharmacology and therapeutics

2019

Medications in Space: In Search of a Pharmacologist’s Guide to the Galaxy.

Pharmaceutical research

2019

Development of apratoxin S10 (Apra S10) as an anti-pancreatic cancer agent and its preliminary evaluation in an orthotopic patient-derived xenograft (PDX) model.

Investigational new drugs

2019

Development and Validation of a Sensitive UFLC-MS/MS Method for Quantification of Quercitrin in Plasma: Application to a Tissue Distribution Study

ACS Omega

2019

Determination of Dermal Pharmacokinetics by Microdialysis Sampling in Rats.

Current protocols in pharmacology

2019

Clinical Pharmacokinetics and Pharmacodynamics of Ceftazidime-Avibactam Combination: A Model-Informed Strategy for its Clinical Development.

Clinical pharmacokinetics

2019

Bioanalytical method development and validation for determination of fibroblast growth factor peptide and its application to pharmacokinetic studies.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

2019

Dose optimization of moxifloxacin and linezolid against tuberculosis using mathematical modeling and simulation.

International journal of antimicrobial agents

2018

Nonlinear Protein Binding: Not What You Think.

Journal of pharmaceutical sciences

2018

Simultaneous Retrodialysis by Calibrator for Rapid In Vivo Recovery Determination in Target Site Microdialysis.

Journal of pharmaceutical sciences

2018

Simultaneous quantification of cannabinoids tetrahydrocannabinol, cannabidiol and CB1 receptor antagonist in rat plasma: An application to characterize pharmacokinetics after passive cannabis smoke inhalation and co-administration of rimonabant.

Journal of pharmaceutical and biomedical analysis

2018

Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice.

Diabetes

2018

Quantitative Estimation of Plasma Free Drug Fraction in Patients With Varying Degrees of Hepatic Impairment: A Methodological Evaluation.

Journal of pharmaceutical sciences

2018

Quantitative determination of armodafinil in human plasma by liquid chromatography-electrospray mass spectrometry: Application to a clinical study.

Biomedical chromatography : BMC

2018

Mycobacterium tuberculosis Strains H37ra and H37rv have equivalent minimum inhibitory concentrations to most antituberculosis drugs.

International journal of mycobacteriology

2018

Core Entrustable Professional Activities in Clinical Pharmacology: Pearls for Clinical Practice: Drug-Drug and Food-Drug Interactions.

Journal of clinical pharmacology

2018

Moxifloxacin target site concentrations in patients with pulmonary TB utilizing microdialysis: a clinical pharmacokinetic study.

The Journal of antimicrobial chemotherapy

2018

Enhanced in vitro activity of tigecycline in the presence of chelating agents.

International journal of antimicrobial agents

2018

Development of clinical pharmacy services in Australia, Austria, Belgium, Bosnia-Herzegovina, Canada, Germany, Japan, Kosovo, Switzerland, the Netherlands, Thailand, USA and correlation with educational standards, level of research, and implemen.

International journal of clinical pharmacology and therapeutics

2018

Dermal pharmacokinetics of pyrazinamide determined by microdialysis sampling in rats.

International journal of antimicrobial agents

2018

A mathematical model-based analysis of the time-kill kinetics of ceftazidime/avibactam against Pseudomonas aeruginosa.

The Journal of antimicrobial chemotherapy

2018

A comparison of linezolid lung tissue concentrations among patients with drug-resistant tuberculosis.

The European respiratory journal

2018

Mycobacterium Tuberculosis Strains H37Ra and H37Rv Have Equivalent Minimum Inhibitory Concentrations to Most Antituberculosis Drugs

International Journal of Mycobacteriology

2017

Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist.

Journal of pharmaceutical sciences

2017

Utility of Microdialysis in Infectious Disease Drug Development and Dose Optimization.

The AAPS journal

2017

Prediction of in Vivo and in Vitro Infection Model Results Using a Semimechanistic Model of Avibactam and Aztreonam Combination Against Multidrug Resistant Organisms

CPT: pharmacometrics & systems pharmacology

2017

Tissue Distribution of a Therapeutic Monoclonal Antibody Determined by Large Pore Microdialysis.

Journal of pharmaceutical sciences

2017

Lung Tissue Concentrations of Pyrazinamide among Patients with Drug-Resistant Pulmonary Tuberculosis.

Antimicrobial agents and chemotherapy

2017

A need to revisit clinical breakpoints of tigecycline: effect of atypical non-linear plasma protein binding.

International journal of antimicrobial agents

2017

Drugs in space: Pharmacokinetics and pharmacodynamics in astronauts.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2017

Potentiation of ceftazidime by avibactam against β-lactam-resistant Pseudomonas aeruginosa in an in vitro infection model.

The Journal of antimicrobial chemotherapy

2016

Role of Divalent Metal Ions in Atypical Nonlinear Plasma Protein Binding Behavior of Tigecycline.

Journal of pharmaceutical sciences

2016

Race-Specific Pharmacodynamic Model of Propofol-Induced Loss of Consciousness.

Journal of clinical pharmacology

2016

Microdialysis of Large Molecules.

Journal of pharmaceutical sciences

2016

In vitro pharmacokinetics/pharmacodynamics of the combination of avibactam and aztreonam against MDR organisms.

The Journal of antimicrobial chemotherapy

2016

Pharmacokinetics and pharmacodynamics in antibiotic dose optimization.

Expert opinion on drug metabolism & toxicology

2016

Ciclesonide: A Pro-Soft Drug Approach for Mitigation of Side Effects of Inhaled Corticosteroids.

Journal of pharmaceutical sciences

2016

Ceftobiprole medocaril (BAL-5788) for the treatment of complicated skin infections.

Expert review of anti-infective therapy

2016

A Tribute to Dr. Marcus E. Brewster: October 14, 1957-September 15, 2014.

Journal of pharmaceutical sciences

2016

Gentamicin dosing strategy in patients with end-stage renal disease receiving haemodialysis: evaluation using a semi-mechanistic pharmacokinetic/pharmacodynamic model.

The Journal of antimicrobial chemotherapy

2015

In memoriam: William A. Craig.

Antimicrobial agents and chemotherapy

2015

Theory and Application of Microdialysis in Pharmacokinetic Studies.

Current drug metabolism

2015

Simultaneous Characterization of Intravenous and Oral Pharmacokinetics of Lychnopholide in Rats by Transit Compartment Model.

Planta medica

2015

Quantitation of the impact of CYP3A5 A6986G polymorphism on quetiapine pharmacokinetics by simulation of target attainment.

Clinical pharmacology in drug development

2015

Pharmacokinetic evaluation of avicularin using a model-based development approach.

Planta medica

2015

Pharmacokinetic and pharmacodynamic implications in inhalable antimicrobial therapy.

Advanced drug delivery reviews

2015

Exploring in Vitro Antipseudomonal Activity of Synergistic Tigecycline-Tetracycline Combinations.

Clinical Pharmacology & Therapeutics

2015

Effect of reducing the paediatric stavudine dose by half: a physiologically-based pharmacokinetic model.

International journal of antimicrobial agents

2015

Enzyme- and transporter-mediated beverage-drug interactions: An update on fruit juices and green tea.

Journal of clinical pharmacology

2015

Does the Anesthetic Urethane Influence the Pharmacokinetics of Antifungal Drugs? A Population Pharmacokinetic Investigation in Rats.

Journal of pharmaceutical sciences

2015

Development and validation of a HPLC-MS/MS method for the determination of phytolaccagenin in rat plasma and application to a pharmacokinetic study.

Journal of pharmaceutical and biomedical analysis

2015

Concentration-response studies and modelling of the pharmacodynamics of linezolid: Staphylococcus aureus versus Enterococcus faecium.

International journal of antimicrobial agents

2015

Concentration-Response Studies and Modelling of the Pharmacodynamics of Linezolid: Staphylococcus Aureus Versus Enterococcus Faecium

International Journal of Antimicrobial Agents

2015

Cavitary penetration of levofloxacin among patients with multidrug-resistant tuberculosis.

Antimicrobial agents and chemotherapy

2015

Evaluation of in vitro synergy between vertilmicin and ceftazidime against Pseudomonas aeruginosa using a semi-mechanistic pharmacokinetic/pharmacodynamic model.

International journal of antimicrobial agents

2014

Role of microdialysis in pharmacokinetics and pharmacodynamics: current status and future directions.

Clinical pharmacokinetics

2014

Relevance of Liver Failure for Anti-Infective Agents: From Pharmacokinetic Alterations to Dosage Adjustments.

Therapeutic advances in infectious disease

2014

Protein binding of rifapentine and its 25-desacetyl metabolite in patients with pulmonary tuberculosis.

Antimicrobial agents and chemotherapy

2014

Predicting pediatric age-matched weight and body mass index.

The AAPS journal

2014

Pharmacokinetics of para-aminosalicylic acid in HIV-uninfected and HIV-coinfected tuberculosis patients receiving antiretroviral therapy, managed for multidrug-resistant and extensively drug-resistant tuberculosis.

Antimicrobial agents and chemotherapy

2014

Population pharmacokinetics of cilengitide in adult and pediatric cancer patients from a nonlinear mixed-effects analysis.

Journal of clinical pharmacology

2014

Population pharmacokinetic modeling of the unbound levofloxacin concentrations in rat plasma and prostate tissue measured by microdialysis.

Antimicrobial agents and chemotherapy

2014

Monte Carlo Simulation To Determine the Effect of Atypical Nonlinear Plasma Protein Binding On Clinical Breakpoint of Tigecycline

Clinical Pharmacology & Therapeutics

2014

Estimation of intracellular concentration of stavudine triphosphate in HIV-infected children given a reduced dose of 0.5 milligrams per kilogram twice daily.

Antimicrobial agents and chemotherapy

2014

Measuring drug distribution in the critically ill patient.

Advanced drug delivery reviews

2014

Metal Ion Chelation By Tigecycline Explains Atypical Nonlinear Plasma Protein Binding Behavior

Clinical Pharmacology & Therapeutics

2014

Application of pharmacokinetic/pharmacodynamic modelling and simulation for the prediction of target attainment of ceftobiprole against meticillin-resistant Staphylococcus aureus using minimum inhibitory concentration and time-kill curve based approaches.

International journal of antimicrobial agents

2014

Comparison of Skin Permeability for Three Diclofenac Topical Formulations: An in Vitro Study

Die Pharmazie

2014

Determination of atypical nonlinear plasma−protein-binding behavior of tigecycline using an in vitro microdialysis technique.

Journal of pharmaceutical sciences

2014

Enhanced penetration of moxifloxacin into rat prostate tissue evidenced by microdialysis.

International journal of antimicrobial agents

2014

Largazole pharmacokinetics in rats by LC-MS/MS.

Marine drugs

2013

When is protein binding important?

Journal of pharmaceutical sciences

2013

Vancomycin (Van) Administered By Continuous Infusion (Ci) Should Be Dosed According To Clearance (Cl) and Not Based On the Patient’s Body Weight

International Journal of Antimicrobial Agents

2013

The Report of the 2012-2013 Research and Graduate Affairs Committee

American Journal of Pharmaceutical Education

2013

Journal of pharmacokinetics and pharmacodynamics

2013

Pharmacokinetics and pharmacodynamics of ponesimod, a selective S1P1 receptor modulator, in the first-in-human study.

British journal of clinical pharmacology

2013

Pharmacokinetic properties of pure xanthones in comparison to a mangosteen fruit extract in rats.

Planta medica

2013

Oral adherence monitoring using a breath test to supplement highly active antiretroviral therapy.

AIDS and behavior

2013

Pharmacokinetics of modified-release prednisone tablets in healthy subjects and patients with rheumatoid arthritis.

Journal of clinical pharmacology

2013

Importance of relating efficacy measures to unbound drug concentrations for anti-infective agents.

Clinical microbiology reviews

2013

Grapefruit-medication interactions.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

2013

Feasibility of a breath test for monitoring adherence to vaginal administration of antiretroviral microbicide gels.

Journal of clinical pharmacology

2013

Electroencephalogram effects of armodafinil: comparison with behavioral alertness.

Journal of clinical pharmacology

2013

A novel breath test to directly measure use of vaginal gel and condoms.

AIDS and behavior

2013

A Markov chain model to evaluate the effect of CYP3A5 and ABCB1 polymorphisms on adverse events associated with tacrolimus in pediatric renal transplantation.

The AAPS journal

2013

Influence of CYP3A5 6986A > G and ABCB1 3435C > T Polymorphisms on Adverse Events Associated With Tacrolimus in Jordanian Pediatric Renal Transplant Patients.

Clinical pharmacology in drug development

2012

The Pharmacokinetic Properties of Pure Gamma-Mangostin in Rats in Comparison To Mangosteen Extract

Planta Medica

2012

The concentration-dependent binding of linagliptin (BI 1356) and its implication on efficacy and safety.

International journal of clinical pharmacology and therapeutics

2012

Skin and soft tissue concentrations of tedizolid (formerly torezolid), a novel oxazolidinone, following a single oral dose in healthy volunteers.

International journal of antimicrobial agents

2012

Population Pharmacokinetics of Steady-State Carbamazepine in Egyptian Epilepsy Patients

Journal of Clinical Pharmacy and Therapeutics

2012

Pharmacokinetics of valerenic acid in rats after intravenous and oral administrations.

Planta medica

2012

Pharmacokinetic-Pharmacodynamic Modeling of Armodafinil: Effects On Alertness and Electroen-Cephalogram of Sleep Deprived Adults

Clinical Pharmacology & Therapeutics

2012

Modeling of Investigative Static Global Assessment Score (Isga) in Acne Vulgaris.

Clinical Pharmacology & Therapeutics

2012

Pharmacokinetics of Natural Compounds

Planta Medica

2012

Herb-drug interactions.

Planta medica

2012

Model-based drug approval – the rubber hits the road.

International journal of clinical pharmacology and therapeutics

2012

Ascending Single-Dose Study With Ponesimod, a Selective Sip1 Receptor Agonist: Safety, Pharmacokinetics, Pharmacodynamics, and Modeling.

Clinical Pharmacology & Therapeutics

2012

Bioavailability and disposition of azelastine and fluticasone propionate when delivered by MP29-02, a novel aqueous nasal spray.

British journal of clinical pharmacology

2012

Dermal pharmacokinetics of Terpinen-4-ol following topical administration of Zingiber cassumunar (plai) oil.

Planta medica

2012

Pharmacokinetic Analysis of Two Flavorants Used in a Novel Breath-Based System (Smart (Tm)) Designed To Assess Use of Vaginally Applied Products.

Clinical Pharmacology & Therapeutics

2012

Electroencephalogram-based pharmacodynamic measures: a review.

International journal of clinical pharmacology and therapeutics

2012

Disease Progression Modeling of Inflammatory Lesion Counts (Les) in Acne Vulgaris.

Clinical Pharmacology & Therapeutics

2011

The effect of critical illness on drug distribution.

Current pharmaceutical biotechnology

2011

Suppression of ciprofloxacin-induced resistant Pseudomonas aeruginosa in a dynamic kill curve system.

International journal of antimicrobial agents

2011

Simulation-based sodium thiosulfate dosing strategies for the treatment of calciphylaxis.

Clinical journal of the American Society of Nephrology : CJASN

2011

Serum concentrations and clinical effects of atorvastatin in patients taking grapefruit juice daily.

British journal of clinical pharmacology

2011

Role of pharmacokinetics in establishing bioequivalence for orally inhaled drug products: workshop summary report.

Journal of aerosol medicine and pulmonary drug delivery

2011

Repeated pre-exposure to tobacco smoke potentiates subsequent locomotor responses to nicotine and tobacco smoke but not amphetamine in adult rats.

Pharmacology, biochemistry, and behavior

2011

Protein binding: do we ever learn?

Antimicrobial agents and chemotherapy

2011

Population Pharmacokinetics of Methotrexate in Egyptian Children With Lymphoblastic Leukemia

Therapeutic Drug Monitoring

2011

Population Pharmacokinetics for Individualization of Tacrolimus Dose in Jordanian Pediatric Renal Transplant Recipients

Therapeutic Drug Monitoring

2011

Population Pharmacokinetics and Pharmacodynamics of Armodafinil: Effects On Electroencephalogram and Alertness of Sleep Deprived Adults

2011

Pharmacometrics in dose finding or dose optimization of anti-retroviral and anti-tubercular drugs.

Infectious disorders drug targets

2011

Pharmacokinetics of Cefpodoxime in Plasma and Subcutaneous Fluid Following Oral Administration of Cefpodoxime Proxetil in Male Beagle Dogs

Journal of Veterinary Pharmacology and Therapeutics

2011

PA-824 exhibits time-dependent activity in a murine model of tuberculosis.

Antimicrobial agents and chemotherapy

2011

HPLC method validation for the quantification of lomustine to study pharmacokinetics of thermosensitive liposome-encapsulated lomustine containing iohexol for CT imaging in C6 glioma rats.

European journal of drug metabolism and pharmacokinetics

2011

Fixed Dosing Versus Body Size-Based Dosing of Anticancer Drugs in Adults: a Population Pharmacokinetic Approach

Clinical Pharmacology & Therapeutics

2011

Development and validation of a LC-MS/MS method based on a new 96-well Hybrid-SPE™-precipitation technique for quantification of CYP450 substrates/metabolites in rat plasma.

Analytical and bioanalytical chemistry

2011

Clinical pharmacokinetics of meropenem and biapenem in bile and dosing considerations for biliary tract infections based on site-specific pharmacodynamic target attainment.

Antimicrobial agents and chemotherapy

2011

Absolute/relative bioavailability and metabolism of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (tetraenes) after intravenous and oral single doses to rats.

Planta medica

2011

Population pharmacokinetic model of human insulin following different routes of administration.

Journal of clinical pharmacology

2011

Pharmacokinetics of Intranasal Scopolamine Gel Formulation During Antiorthostatic Bedrest – a Microgravity Analog

2010

Class-dependent relevance of tissue distribution in the interpretation of anti-infective pharmacokinetic/pharmacodynamic indices.

International journal of antimicrobial agents

2010

Comparison of the pharmacokinetic properties of vancomycin, linezolid, tigecyclin, and daptomycin.

European journal of medical research

2010

In vitro pharmacodynamic models to determine the effect of antibacterial drugs.

The Journal of antimicrobial chemotherapy

2010

Human serum binding and its effect on the pharmacodynamics of the lantibiotic MU1140.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2010

Underdosing of ertapenem in critically ill patients with pneumonia confirmed by Monte Carlo simulations.

International journal of antimicrobial agents

2010

Tobacco smoke exposure induces nicotine dependence in rats.

Psychopharmacology

2010

Thromboelastographic and pharmacokinetic profiles of micro- and macro-emulsions of propofol in swine.

Biopharmaceutics & drug disposition

2010

Simultaneous HPLC analysis of triamcinolone acetonide and budesonide in microdialysate and rat plasma: application to a pharmacokinetic study.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2010

Significance of protein binding in pharmacokinetics and pharmacodynamics.

Journal of pharmaceutical sciences

2010

Resistance and the management of complicated skin and skin structure infections: the role of ceftobiprole.

Therapeutics and clinical risk management

2010

Preadolescent tobacco smoke exposure leads to acute nicotine dependence but does not affect the rewarding effects of nicotine or nicotine withdrawal in adulthood in rats.

Pharmacology, biochemistry, and behavior

2010

Population Pharmacokinetics of Caspofungin in Patients With Acute Leukemia Or Allogenic Or Autologous Blood Stem Cell Transplantation

2010

Role of drug absorption in the pharmacokinetics of therapeutic interventions for stroke.

Annals of the New York Academy of Sciences

2010

Pharmacometrics as a discipline is entering the “industrialization” phase: standards, automation, knowledge sharing, and training are critical for future success.

Journal of clinical pharmacology

2010

Pharmacokinetic/pharmacodynamic profile of posaconazole.

Clinical pharmacokinetics

2010

Pharmacokinetic/Pharmacodynamic Model-Based Combination Therapy Approach To Target Antibiotic Resistant Populations Emerged From Ciprofloxacin Exposure

Die Pharmazie

2010

Pharmacokinetic and pharmacodynamic evaluation of the lantibiotic MU1140.

Journal of pharmaceutical sciences

2010

Pediatric Dosing and Body Size in Biotherapeutics.

Pharmaceutics

2010

Modeling of Target Lesion Scores Over Time in a Psoriasis Microplaque Assay.

Clinical Pharmacology & Therapeutics

2010

Modeling of Lesion Scores Over Time in a Psoriasis

2010

Population pharmacokinetics and pharmacodynamics of inhaled ciclesonide and fluticasone propionate in patients with persistent asthma.

Journal of clinical pharmacology

2009

Pharmacokinetic/pharmacodynamic modelling and in vitro simulation of dynamic voriconazole-Candida interactions.

International journal of antimicrobial agents

2009

Toxicological and Pharmacokinetic Evaluation of Concomitant Intake of Grapefruit Juice and Simvastatin in Rats after Repeated Treatment over 28 Days.

Planta medica

2009

Soft-tissue penetration of ceftobiprole in healthy volunteers determined by in vivo microdialysis.

Antimicrobial agents and chemotherapy

2009

Soft tissue penetration of cefuroxime determined by clinical microdialysis in morbidly obese patients undergoing abdominal surgery.

International journal of antimicrobial agents

2009

Pk/Pd Studies Focusing On Physical Dependence of Fentanyl in Rats

Clinical Pharmacology & Therapeutics

2009

Pharmacokinetics and tissue distribution of dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides after oral administration in rats.

Planta medica

2009

Pharmacokinetic-pharmacodynamic modeling of the in vitro activities of oxazolidinone antimicrobial agents against methicillin-resistant Staphylococcus aureus.

Antimicrobial agents and chemotherapy

2009

Preliminary Evaluation of Gc-Ms for the Determination of Terpinen-4-Ol in Cutaneous Microdialysis Samples

Drug Metabolism Reviews

2009

Influence of the Duffy Antigen On Pharmacokinetics and Pharmacodynamics of Recombinant Monocyte Chemoattractant Protein (Mcp-1, Ccl-2) in Vivo

International Journal of Immunopathology and Pharmacology

2009

Effects of Plasma Protein Binding On Half-Life of Elimination

2009

Development and validation of a LC-MS quantification method for the lantibiotic MU1140 in rat plasma.

Journal of pharmaceutical and biomedical analysis

2009

Bioavailability of Dodeca-2E,4E,8E,10E/Z-Tetraenoic Acid Isobutylamides After Oral Administration in Rats and Distribution in Various Tissues

Planta Medica

2009

Cortisol suppression as a surrogate marker for inhaled corticosteroid-induced growth retardation in children.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2009

Clinical pharmacokinetics and pharmacodynamics of tigecycline.

Clinical pharmacokinetics

2009

Ceftobiprole: a novel cephalosporin with activity against Gram-positive and Gram-negative pathogens, including methicillin-resistant Staphylococcus aureus (MRSA).

International journal of antimicrobial agents

2009

Pharmacodynamic activity of the lantibiotic MU1140.

International journal of antimicrobial agents

2008

Pharmacokinetics of anthocyanins and antioxidant effects after the consumption of anthocyanin-rich acai juice and pulp (Euterpe oleracea Mart.) in human healthy volunteers.

Journal of agricultural and food chemistry

2008

Pharmacokinetics of Luteolin and Metabolites in Rats

Natural Product Communications

2008

PK/PD: new insights for antibacterial and antiviral applications.

Current opinion in pharmacology

2008

Population pharmacodynamic model of bronchodilator response to inhaled albuterol in children and adults with asthma.

Chest

2008

The Candida albicans phosphatase Inp51p interacts with the EH domain protein Irs4p, regulates phosphatidylinositol-4,5-bisphosphate levels and influences hyphal formation, the cell integrity pathway and virulence.

Microbiology (Reading, England)

2008

Potential of pharmacokinetic profiling for detecting herbal interactions with drugs.

Clinical pharmacokinetics

2008

Proposal for a standardised identification of the mono-exponential terminal phase for orally administered drugs.

Biopharmaceutics & drug disposition

2008

Tissue concentrations: do we ever learn?

The Journal of antimicrobial chemotherapy

2008

Population Pharmacokinetics of the Bradykinin B2 Receptor Antagonist Icatibant in Phase I and Ii Clinical Trials

2008

Pharmacokinetic Profiling of Dodeca-2E,4E,8E,10E/Z-Tetraenoic Acid Isobutylamides in Rats Using Liquid Chromatography Tandem Mass Spectrometry

Planta Medica

2008

Estimation of Lithium Clearance From Routine Clinical Data in Egyptian Bipolar Patients. a Population Pharmacokinetic Approach

International Journal of Clinical Pharmacology and Therapeutics

2008

Effects of fentanyl dose and exposure duration on the affective and somatic signs of fentanyl withdrawal in rats.

Neuropharmacology

2008

Effect of protein binding on the pharmacological activity of highly bound antibiotics.

Antimicrobial agents and chemotherapy

2008

Effect of grapefruit juice, naringin, naringenin, and bergamottin on the intestinal carrier-mediated transport of talinolol in rats.

Journal of agricultural and food chemistry

2008

Duffy antigen modifies the chemokine response in human endotoxemia.

Critical care medicine

2008

Combination of Clinical Microdialysis and in Vitro Pharmacodynamics for Dose Optimization of Beta-Lactam Antibiotics

2008

Clinical microdialysis in skin and soft tissues: an update.

Journal of clinical pharmacology

2008

Assessment of the impact of dosing time on the pharmacokinetics/pharmacodynamics of prednisolone.

The AAPS journal

2008

Anesthesia in Space – Pk/Pd Modeling of Propofol in Simulated Microgravity

2008

A pharmacokinetic/pharmacodynamic mathematical model accurately describes the activity of voriconazole against Candida spp. in vitro.

International journal of antimicrobial agents

2008

Molecular and Clinical Pharmacology of Intranasal Corticosteroids: Clinical and Therapeutic Implications

Allergy

2007

Integration of pharmacokinetic/pharmacodynamic modeling and simulation in the development of new anti-infective agents – minimum inhibitory concentration versus time-kill curves.

Expert opinion on drug discovery

2007

Pharmacokinetic/pharmacodynamic modeling of in vitro activity of azithromycin against four different bacterial strains.

International journal of antimicrobial agents

2007

Pharmacokinetic and pharmacodynamic properties of inhaled ciclesonide.

Journal of clinical pharmacology

2007

Measurement of voriconazole activity against Candida albicans, C. glabrata, and C. parapsilosis isolates using time-kill methods validated by high-performance liquid chromatography.

Antimicrobial agents and chemotherapy

2007

Grapefruit juice-drug interactions: Grapefruit juice and its components inhibit P-glycoprotein (ABCB1) mediated transport of talinolol in Caco-2 cells.

Journal of pharmaceutical sciences

2007

Polymethoxylated flavones and other phenolic derivates from citrus in their inhibitory effects on P-glycoprotein-mediated transport of talinolol in Caco-2 cells.

Journal of agricultural and food chemistry

2007

Ertapenem in critically ill patients with early-onset ventilator-associated pneumonia: pharmacokinetics with special consideration of free-drug concentration.

The Journal of antimicrobial chemotherapy

2007

Clinical trials and dipyridamole formulation selection.

Cerebrovascular diseases (Basel, Switzerland)

2007

AAPS-FDA Workshop White Paper: microdialysis principles, application, and regulatory perspectives.

Journal of clinical pharmacology

2007

AAPS-FDA workshop white paper: microdialysis principles, application and regulatory perspectives.

Pharmaceutical research

2007

Ertapenem: the new carbapenem 5 years after first FDA licensing for clinical practice.

Expert opinion on pharmacotherapy

2006

Variation of flavonoids and furanocoumarins in grapefruit juices: a potential source of variability in grapefruit juice-drug interaction studies.

Journal of agricultural and food chemistry

2006

Variability in response to cardiovascular drugs.

Current clinical pharmacology

2006

The systemic safety of inhaled corticosteroid therapy: a focus on ciclesonide.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

2006

The influence of formulation on the dissolution profile of diclofenac sodium tablets.

Drug Development Communications

2006

Relevance of pharmacokinetics and pharmacodynamics of inhaled corticosteroids to asthma.

The European respiratory journal

2006

Pharmacokinetic/pharmacodynamic profile of voriconazole.

Clinical pharmacokinetics

2006

Penetration of ertapenem into skeletal muscle and subcutaneous adipose tissue in healthy volunteers measured by in vivo microdialysis.

The Journal of antimicrobial chemotherapy

2006

Once-daily tobramycin in cystic fibrosis: better for clinical outcome than thrice-daily tobramycin but more resistance development?

The Journal of antimicrobial chemotherapy

2006

Pharmacokinetic/pharmacodynamic modeling of total lymphocytes and selected subtypes after oral budesonide.

Journal of pharmacokinetics and pharmacodynamics

2006

Microdialysis as a tool in local pharmacodynamics.

The AAPS journal

2006

Isolation and HPLC quantitative analysis of antioxidant flavonoids from Alternanthera tenella Colla.

Zeitschrift fur Naturforschung. C, Journal of biosciences

2006

Hyperforin in St. John’s wort drug interactions.

European journal of clinical pharmacology

2006

Characterizing the effects of caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata isolates by simultaneous time-kill and postantifungal-effect experiments.

Antimicrobial agents and chemotherapy

2006

Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum l.) polyphenols after ingestion of a standardized extract in healthy human volunteers.

Journal of agricultural and food chemistry

2006

[New antibiotics for treatment of MRSA infections. Comparison of treatment with vancomycin].

Medizinische Monatsschrift fur Pharmazeuten

2006

[Achieving eradication of MRSA colonization in patients. Therapeutic options].

Medizinische Monatsschrift fur Pharmazeuten

2006

Moxifloxacin distribution in the interstitial space of infected decubitus ulcer tissue of patients with spinal cord injury measured by in vivo microdialysis.

Scandinavian journal of infectious diseases

2005

Pharmacokinetic/pharmacodynamic evaluation of anti-infective agents.

Expert review of anti-infective therapy

2005

What is the best marker for inhaled corticosteroid safety?

Allergy and asthma proceedings

2005

Tissue penetration of cefpodoxime and cefixime in healthy subjects.

Journal of clinical pharmacology

2005

Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update.

The Journal of antimicrobial chemotherapy

2005

Population pharmacokinetics of eniporide and its metabolite in healthy subjects and patients with acute myocardial infarction.

Journal of clinical pharmacology

2005

Pharmacokinetics of piperacillin-tazobactam: intermittent dosing versus continuous infusion.

International journal of antimicrobial agents

2005

Pharmacokinetic-pharmacodynamic modelling of antibacterial activity of cefpodoxime and cefixime in in vitro kinetic models.

International journal of antimicrobial agents

2005

Tissue penetration of cefpodoxime into the skeletal muscle and lung in rats.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2005

Microdialysis for in vivo pharmacokinetic/pharmacodynamic characterization of anti-infective drugs.

Current opinion in pharmacology

2005

Application of two-point assay of digoxin serum concentration in studying population pharmacokinetics in Egyptian pediatric patients with heart failure: does it make sense?

American journal of therapeutics

2005

Comparative pharmacology, bioavailability, pharmacokinetics, and pharmacodynamics of inhaled glucocorticosteroids.

Immunology and allergy clinics of North America

2005

Corticosteroid pharmacokinetic/pharmacodynamic parameters and their relationship to safety and efficacy.

Allergy and asthma proceedings

2005

Penetration of ertapenem into different pulmonary compartments of patients undergoing lung surgery.

Journal of clinical pharmacology

2005

Effect of simulated microgravity on the disposition and tissue penetration of ciprofloxacin in healthy volunteers.

Journal of clinical pharmacology

2005

Dipyridamole bioavailability in subjects with reduced gastric acidity.

Journal of clinical pharmacology

2004

Differences in drug pharmacokinetics between East Asians and Caucasians and the role of genetic polymorphisms.

Journal of clinical pharmacology

2004

How the lung handles drugs: pharmacokinetics and pharmacodynamics of inhaled corticosteroids.

Proceedings of the American Thoracic Society

2004

In vitro microdialysis sampling of docetaxel.

Journal of pharmaceutical and biomedical analysis

2004

Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: distribution in tissue.

Antimicrobial agents and chemotherapy

2004

Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: kill curves versus MIC.

Antimicrobial agents and chemotherapy

2004

Pharmacokinetic herb-drug interactions: are preventive screenings necessary and appropriate?

Planta medica

2004

Physiological, pharmacokinetic, and pharmacodynamic changes in space.

Journal of clinical pharmacology

2004

PK-PD modelling of the effect of cefaclor on four different bacterial strains.

International journal of antimicrobial agents

2004

Risk-benefit value of inhaled glucocorticoids: a pharmacokinetic/pharmacodynamic perspective.

Journal of clinical pharmacology

2004

Intranasal loteprednol etabonate in healthy male subjects: pharmacokinetics and effects on endogenous cortisol.

Journal of clinical pharmacology

2003

Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children.

Journal of clinical pharmacology

2003

Single- and multiple-dose pharmacokinetics of oral creatine.

Journal of clinical pharmacology

2003

Risk-benefit value of inhaled corticosteroids: a pharmacokinetic/pharmacodynamic perspective.

Chest

2003

Pharmacokinetic/pharmacodynamic modeling of luteinizing hormone (LH) suppression and LH surge delay by cetrorelix after single and multiple doses in healthy premenopausal women.

Journal of clinical pharmacology

2003

Inhaled corticosteroids: past lessons and future issues.

The Journal of allergy and clinical immunology

2003

Antimicrobial tissue concentrations.

Infectious disease clinics of North America

2003

Microdialysis of triamcinolone acetonide in rat muscle.

Journal of pharmaceutical sciences

2002

Systemic availability and pharmacokinetics of thymol in humans.

Journal of clinical pharmacology

2002

Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs.

International journal of antimicrobial agents

2002

Rational dosing of antibiotics: the use of plasma concentrations versus tissue concentrations.

International journal of antimicrobial agents

2002

Pharmacokinetics and bioavailability of herbal medicinal products.

Phytomedicine : international journal of phytotherapy and phytopharmacology

2002

Pharmacokinetic/pharmacodynamic studies in drug product development.

Journal of pharmaceutical sciences

2002

Population pharmacokinetics of digoxin in Egyptian pediatric patients: impact of one data point utilization.

American journal of therapeutics

2002

Interstitial tissue concentrations of cefpodoxime.

The Journal of antimicrobial chemotherapy

2002

How important are gender differences in pharmacokinetics?

Clinical pharmacokinetics

2002

Comparative target site pharmacokinetics of immediate- and modified-release formulations of cefaclor in humans.

Journal of clinical pharmacology

2002

Bioavailability and metabolism of mometasone furoate: pharmacology versus methodology.

Journal of clinical pharmacology

2002

Novel formulations of cetrorelix acetate in healthy men: pharmacodynamic effects and noncompartmental pharmacokinetics.

Journal of clinical pharmacology

2001

Evaluation of pulmonary absorption using pharmacokinetic methods.

Journal of Aerosol Medicine

2000

Optimized therapeutic ratio of inhaled corticosteroids using retrometabolism.

Die Pharmazie

1999

Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: concepts and perspectives.

Pharmaceutical Research

1998

Influence of plasma expansion on plasma protein binding of ketorolac.

Journal of clinical anesthesia

1990

Pharmacokinetics of amikacin in critically ill neonatal foals treated for presumed or confirmed sepsis.

Equine veterinary journal

Grants

Jul 2017 – Jun 2018

Clinical Pharmacokinetics/Dynamics Fellowship 2017-2018

GLAXO SMITHKLINE · Principal Investigator

Mar 2017 – Dec 2017

Organize 11th Symposium on New Development in Clinical Pharmacy and Clinical Pharmacology

BOEHRINGER INGELHEIM INTL GmbH · Principal Investigator

Feb 2017 ACTIVE

FGF-P: A Multipotential Mitigation Agent for Gastrointestinal Syndrome

NATL INST OF HLTH NIAID ·

Jan 2017 – Jun 2017

Food-Drug Interactions

FL DEPT OF CITRUS · Principal Investigator

Sep 2016 – Aug 2017

AFPE Fellowship: Investigating a Novel Anitmicrobial Combination: Tigecycline-Tetracycline again P. Aeruginosa

AMER FOU FOR PHARM EDU · Mentor

Jul 2016 ACTIVE

Tobacco: relationship between reduced nicotine content and reinforcement in rats

NATL INST OF HLTH NIDA ·

Jul 2016 – Dec 2018

Clinical Pharmacokinetic/Dynamics Fellowship

GLAXO SMITHKLINE · Project Manager

Jul 2016 – Dec 2016

Clinical Pharmacokinetic/Dynamics Fellowship

GLAXO SMITHKLINE · Principal Investigator

Mar 2016 – Sep 2017

Inflight Pharmacokinetic and Pharmacodynamic Responses to Medications Commonly used in Spaceflight

BAYLOR UNIV · Principal Investigator

Feb 2016 – Jan 2018

A Clinical Pharmacology Study of a Novel Drug Regimen for Pre XDR and XDR Tuberculosis

EMORY UNIV · Project Manager

Aug 2015 – Jun 2016

Grapefruit-Drug Interaction

GOLIN-HARRIS INTERNATIONAL INC · Principal Investigator

Aug 2015 ACTIVE

CTSI Institutional Support

UF DIV OF SPONSORED RES MATCHING FUNDS · Project Manager

Jul 2015 – Aug 2016

Clinical pharmacokinetics/dynamics fellowship

GLAXO SMITHKLINE · Principal Investigator

Mar 2015 – Dec 2018

Determination of Drug Levels in Interstitial Fluid for T

HOFFMANN LA ROCHE · Project Manager

Jul 2014 – Jun 2016

Master Fellowship Agreement – Clinical Pharmacokinetics/

GLAXO SMITHKLINE · Principal Investigator

Jul 2013 – Dec 2016

Center for Food-Drug Interaction

FL DEPT OF CITRUS · Principal Investigator

May 2013 – May 2016

A Study to Evaluate the Feasibility of Microdialysis to

GLAXO SMITHKLINE · Principal Investigator

Jul 2007 – Aug 2016

Clinical and Translational Science Institute

UF RESEARCH FOU · Project Manager

Dec 2004 ACTIVE

Pfizer Graduate Fellowship Award

PFIZER INC · Project Manager

Patents

Issued June 2005

Microdialysis Probes and Methods of Use

#6,904,309

Contact Details

Phones:

Business:: (352) 273-7856

Emails:

Business:: hartmut@cop.ufl.edu