Hartmut Derendorf

Hartmut Derendorf, Ph.D.

Distinguished Professor Emeritus (Deceased)

Department: Pharmaceutics
Business Phone: (352) 273-7856
Business Email: hartmut@cop.ufl.edu

About Hartmut Derendorf

Hartmut Derendorf is a distinguished professor emeritus of pharmaceutics at the University of Florida College of Pharmacy in Gainesville. He received his B.S. (1976) and Ph.D. (1979, summa cum laude) in Pharmacy from the University of Münster, Germany and then joined the University of Florida, first as a Postdoctoral Fellow (1981/82) and later (1983) as a faculty member. He has been teaching Biopharmaceutics, Pharmacokinetics and Clinical Pharmacokinetics. He was awarded numerous teaching awards such as the UF Teaching Improvement Award, HHMI Distinguished Mentorship Award, UF Research Foundation Professorship, CVS Pharmacy Endowed Professorship, International Educator of the Year Award and UF Doctoral Advisor/Mentoring Award. He has supervised over 50 Ph.D. students.

Prof. Derendorf has published over 500 scientific publications with an h-index (Scopus) of 60 and given over 900 presentations at national or international meetings. He has published ten textbooks in English and German. He is Editor or Associate Editor of the Journal of Clinical Pharmacology, International Journal of Clinical Pharmacology & Therapeutics, International Journal of Antimicrobial Agents and Die Pharmazie, and serves on the Editorial Board of several other Journals. His research interests include the pharmacokinetics and pharmacodynamics of corticosteroids, analgesics, antibiotics as well as drug interactions.

Prof. Derendorf has served as President of ACCP (American College of Clinical Pharmacology) in 2006/08 and President of ISAP (International Society of Antiinfective Pharmacology) in 2004/06. He won the McKeen-Cattell Award for the best publication in J. Clin. Pharmacology (1994) and the Faculty Award of the University of Utrecht (2005). In 2003, he was awarded the Nathaniel T. Kwit Distinguished Service Award of ACCP and the Research Achievement Award in Clinical Science of the American Association of Pharmaceutical Sciences (AAPS). He is a Fellow of AAPS and ACCP as well as a former review panel member of the NASA Human Research Program. In 2010, he was awarded the Volwiler Award of the American Association of Colleges of Pharmacy (AACP) as well as the ACCP Distinguished Investigator Award, the highest research awards of both organizations. In 2013, he was awarded the First Leadership Award of the International Society of Pharmacometrics (ISOP). In 2015 he received the Merit Medal of the Westphalian Chamber of Pharmacy as well as the ACCP Mentorship Award. In 2018, he was awarded the ASCPT Mentor Award and the UF Doctoral Advisor/Mentoring Award. Furthermore, he held the Gerhard Levy Distinguished Lectureship at the University of Buffalo (2019) and received the Barré Prize of the University of Montreal (2020). He also served as the 18th University of Florida Distinguished Alumni Professor.

Accomplishments

Barré Prize
2020 · University of Montreal
Gerhard Levy Distinguished Lectureship
2019 · University of Buffalo
Fellowship FISAC
2019 · International Society of Antimicrobial Chemotherapy (ISAC)
Mentor Award
2018 · American Society for Clinical Pharmacology and Therapeutics
Doctoral Advisor/Mentoring Award
2018 · University of Florida
Mentorship Award
2015 · American College of Clinical Pharmacy
Merit Medal
2015 · Westphalian Chamber of Pharmacy
Leadership Award
2013 · International Society of Pharmacometrics
Volwiler Award
2010 · American Association of Colleges of Pharmacy
Distinguished Investigator Award
2010 · American College of Clinical Pharmacy
Research Achievement Award in Clinical Science
2003 · American Association of Pharmaceutical Scientists
Nathaniel T. Kwit Distinguished Service Award
2003 · American College of Clinical Pharmacy
Fellowship FAAPS
1996 · American Association of Pharmaceutical Scientists (AAPS)
Fellowship FCP
1988 · American College of Clinical Pharmacology (ACCP)

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0003-4016-1370

Publications

2021
Model-Informed Drug Development for Anti-Infectives: State of the Art and Future.
Clinical pharmacology and therapeutics. [DOI] 10.1002/cpt.2198. [PMID] 33555032.
2021
Tobacco smoke exposure enhances reward sensitivity in male and female rats.
Psychopharmacology. [DOI] 10.1007/s00213-020-05736-0. [PMID] 33410984.
2021
Science and Evidence-Based Review and Approval of COVID-19 Vaccines: A Statement of Support for the US FDA.
Journal of clinical pharmacology. 61(3):277-279 [DOI] 10.1002/jcph.1794. [PMID] 33274473.
2020
Carvacrol loaded nanostructured lipid carriers as a promising parenteral formulation for leishmaniasis treatment.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 150 [DOI] 10.1016/j.ejps.2020.105335. [PMID] 32272211.
2020
Evaluation of the Effects of Maytenus ilicifolia on the Activities of Cytochrome P450 3A and P-glycoprotein.
Current drug metabolism. 21(4):281-290 [DOI] 10.2174/1389200221666200512112718. [PMID] 32394829.
2020
Excessive lysosomal ion-trapping of hydroxychloroquine and azithromycin.
International journal of antimicrobial agents. 55(6) [DOI] 10.1016/j.ijantimicag.2020.106007. [PMID] 32389720.
2020
One Giant Leap for Pharmacology.
Pharmaceutical research. 37(3) [DOI] 10.1007/s11095-020-02788-x. [PMID] 32124057.
2020
Roger W. Jelliffe, M.D. (1929-2020).
Clinical pharmacokinetics. 59(9) [DOI] 10.1007/s40262-020-00928-5. [PMID] 32789605.
2020
Calculated initial parenteral treatment of bacterial infections: Pharmacokinetics and pharmacodynamics.
GMS infectious diseases. 8 [DOI] 10.3205/id000061. [PMID] 32373442.
2019
Pharmacokinetics of Oxytetracycline in the Giant Danio (Devario Aequipinnatus) Following Bath Immersion
Aquaculture. 498:12-16 [DOI] 10.1016/j.aquaculture.2018.08.027.
2019
Pharmacokinetic and Pharmacodynamic Characterization of Tetrahydrocannabinol-Induced Cannabinoid Dependence After Chronic Passive Cannabis Smoke Exposure in Rats.
Cannabis and cannabinoid research. 4(4):240-254 [DOI] 10.1089/can.2019.0049. [PMID] 32042924.
2019
Medications in Space: In Search of a Pharmacologist’s Guide to the Galaxy.
Pharmaceutical research. 36(10) [DOI] 10.1007/s11095-019-2679-3. [PMID] 31414302.
2019
Impact of Ethnicity-Specific Hepatic Microsomal Scaling Factor, Liver Weight, and Cytochrome P450 (CYP) 1A2 Content on Physiologically Based Prediction of CYP1A2-Mediated Pharmacokinetics in Young and Elderly Chinese Adults.
Clinical pharmacokinetics. 58(7):927-941 [DOI] 10.1007/s40262-019-00737-5. [PMID] 30767128.
2019
Drug-Drug Interactions: Progress Over the Past Decade and Looking Ahead to the Future.
Clinical pharmacology and therapeutics. 105(6):1289-1291 [DOI] 10.1002/cpt.1410. [PMID] 30977519.
2019
Gastric-acid-mediated drug-drug interactions with direct-acting antiviral medications for hepatitis C virus infection: clinical relevance and mitigation strategies.
Drug discovery today. 24(3):845-857 [DOI] 10.1016/j.drudis.2019.01.003. [PMID] 30648608.
2019
Development of apratoxin S10 (Apra S10) as an anti-pancreatic cancer agent and its preliminary evaluation in an orthotopic patient-derived xenograft (PDX) model.
Investigational new drugs. 37(2):364-374 [DOI] 10.1007/s10637-018-0647-0. [PMID] 30073464.
2019
Development and Validation of a Sensitive UFLC-MS/MS Method for Quantification of Quercitrin in Plasma: Application to a Tissue Distribution Study
ACS Omega. 4(2):3527-3533 [DOI] 10.1021/acsomega.8b03154.
2019
Determination of Dermal Pharmacokinetics by Microdialysis Sampling in Rats.
Current protocols in pharmacology. 85(1) [DOI] 10.1002/cpph.58. [PMID] 31026128.
2019
Clinical Pharmacokinetics and Pharmacodynamics of Ceftazidime-Avibactam Combination: A Model-Informed Strategy for its Clinical Development.
Clinical pharmacokinetics. 58(5):545-564 [DOI] 10.1007/s40262-018-0705-y. [PMID] 30097887.
2019
Bioanalytical method development and validation for determination of fibroblast growth factor peptide and its application to pharmacokinetic studies.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 135:83-93 [DOI] 10.1016/j.ejpb.2018.12.011. [PMID] 30582960.
2019
Dose optimization of moxifloxacin and linezolid against tuberculosis using mathematical modeling and simulation.
International journal of antimicrobial agents. 53(3):275-283 [DOI] 10.1016/j.ijantimicag.2018.10.012. [PMID] 30385322.
2018
Mycobacterium tuberculosis Strains H37ra and H37rv have equivalent minimum inhibitory concentrations to most antituberculosis drugs.
International journal of mycobacteriology. 7(2):156-161 [DOI] 10.4103/ijmy.ijmy_33_18. [PMID] 29900893.
2018
Simultaneous Retrodialysis by Calibrator for Rapid In Vivo Recovery Determination in Target Site Microdialysis.
Journal of pharmaceutical sciences. 107(8):2259-2265 [DOI] 10.1016/j.xphs.2018.04.021. [PMID] 29715477.
2018
Simultaneous quantification of cannabinoids tetrahydrocannabinol, cannabidiol and CB1 receptor antagonist in rat plasma: An application to characterize pharmacokinetics after passive cannabis smoke inhalation and co-administration of rimonabant.
Journal of pharmaceutical and biomedical analysis. 160:119-125 [DOI] 10.1016/j.jpba.2018.07.004. [PMID] 30077950.
2018
Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice.
Diabetes. 67(9):1867-1879 [DOI] 10.2337/db18-0158. [PMID] 29712667.
2018
Quantitative determination of armodafinil in human plasma by liquid chromatography-electrospray mass spectrometry: Application to a clinical study.
Biomedical chromatography : BMC. 32(11) [DOI] 10.1002/bmc.4342. [PMID] 30003558.
2018
Nonlinear Protein Binding: Not What You Think.
Journal of pharmaceutical sciences. 107(7):1754-1760 [DOI] 10.1016/j.xphs.2018.03.023. [PMID] 29626534.
2018
Mycobacterium Tuberculosis Strains H37Ra and H37Rv Have Equivalent Minimum Inhibitory Concentrations to Most Antituberculosis Drugs
International Journal of Mycobacteriology. 7(2):156-161 [DOI] 10.4103/ijmy.ijmy\_33\_18.
2018
Quantitative Estimation of Plasma Free Drug Fraction in Patients With Varying Degrees of Hepatic Impairment: A Methodological Evaluation.
Journal of pharmaceutical sciences. 107(7):1948-1956 [DOI] 10.1016/j.xphs.2018.02.021. [PMID] 29518400.
2018
Enhanced in vitro activity of tigecycline in the presence of chelating agents.
International journal of antimicrobial agents. 51(5):799-802 [DOI] 10.1016/j.ijantimicag.2017.12.027. [PMID] 29305959.
2018
Development of clinical pharmacy services in Australia, Austria, Belgium, Bosnia-Herzegovina, Canada, Germany, Japan, Kosovo, Switzerland, the Netherlands, Thailand, USA and correlation with educational standards, level of research, and implemen.
International journal of clinical pharmacology and therapeutics. 56(11):518-530 [DOI] 10.5414/CP203264. [PMID] 30106363.
2018
A comparison of linezolid lung tissue concentrations among patients with drug-resistant tuberculosis.
The European respiratory journal. 51(2) [DOI] 10.1183/13993003.02166-2017. [PMID] 29437945.
2018
Dermal pharmacokinetics of pyrazinamide determined by microdialysis sampling in rats.
International journal of antimicrobial agents. 51(2):190-196 [DOI] 10.1016/j.ijantimicag.2017.10.001. [PMID] 29032112.
2018
Core Entrustable Professional Activities in Clinical Pharmacology: Pearls for Clinical Practice: Drug-Drug and Food-Drug Interactions.
Journal of clinical pharmacology. 58(6):704-716 [DOI] 10.1002/jcph.1088. [PMID] 29513896.
2018
A mathematical model-based analysis of the time-kill kinetics of ceftazidime/avibactam against Pseudomonas aeruginosa.
The Journal of antimicrobial chemotherapy. 73(5):1295-1304 [DOI] 10.1093/jac/dkx537. [PMID] 29415212.
2018
Moxifloxacin target site concentrations in patients with pulmonary TB utilizing microdialysis: a clinical pharmacokinetic study.
The Journal of antimicrobial chemotherapy. 73(2):477-483 [DOI] 10.1093/jac/dkx421. [PMID] 29186509.
2017
Utility of Microdialysis in Infectious Disease Drug Development and Dose Optimization.
The AAPS journal. 19(2):334-342 [DOI] 10.1208/s12248-016-0020-1. [PMID] 27943149.
2017
Tissue Distribution of a Therapeutic Monoclonal Antibody Determined by Large Pore Microdialysis.
Journal of pharmaceutical sciences. 106(9):2853-2859 [DOI] 10.1016/j.xphs.2017.03.033. [PMID] 28414146.
2017
Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist.
Journal of pharmaceutical sciences. 106(9):2188-2194 [DOI] 10.1016/j.xphs.2017.04.072. [PMID] 28479350.
2017
Prediction of in Vivo and in Vitro Infection Model Results Using a Semimechanistic Model of Avibactam and Aztreonam Combination Against Multidrug Resistant Organisms
CPT: pharmacometrics & systems pharmacology. 6(3):197-207 [DOI] 10.1002/psp4.12159. [PMID] 28145085.
2017
Potentiation of ceftazidime by avibactam against β-lactam-resistant Pseudomonas aeruginosa in an in vitro infection model.
The Journal of antimicrobial chemotherapy. 72(4):1109-1117 [DOI] 10.1093/jac/dkw535. [PMID] 28077672.
2017
Lung Tissue Concentrations of Pyrazinamide among Patients with Drug-Resistant Pulmonary Tuberculosis.
Antimicrobial agents and chemotherapy. 61(6) [DOI] 10.1128/AAC.00226-17. [PMID] 28373198.
2017
Drugs in space: Pharmacokinetics and pharmacodynamics in astronauts.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 109S:S2-S8 [DOI] 10.1016/j.ejps.2017.05.025. [PMID] 28533143.
2017
A need to revisit clinical breakpoints of tigecycline: effect of atypical non-linear plasma protein binding.
International journal of antimicrobial agents. 49(4):449-455 [DOI] 10.1016/j.ijantimicag.2016.12.008. [PMID] 28237830.
2016
Role of Divalent Metal Ions in Atypical Nonlinear Plasma Protein Binding Behavior of Tigecycline.
Journal of pharmaceutical sciences. 105(11):3409-3414 [DOI] 10.1016/j.xphs.2016.07.013. [PMID] 27616672.
2016
Race-Specific Pharmacodynamic Model of Propofol-Induced Loss of Consciousness.
Journal of clinical pharmacology. 56(9):1141-50 [DOI] 10.1002/jcph.716. [PMID] 26865382.
2016
Pharmacokinetics and pharmacodynamics in antibiotic dose optimization.
Expert opinion on drug metabolism & toxicology. 12(1):93-114 [DOI] 10.1517/17425255.2016.1123250. [PMID] 26652832.
2016
Microdialysis of Large Molecules.
Journal of pharmaceutical sciences. 105(11):3233-3242 [DOI] 10.1016/j.xphs.2016.08.016. [PMID] 27671236.
2016
Ceftobiprole medocaril (BAL-5788) for the treatment of complicated skin infections.
Expert review of anti-infective therapy. 14(11):997-1006 [PMID] 27690689.
View on: PubMed
2016
Gentamicin dosing strategy in patients with end-stage renal disease receiving haemodialysis: evaluation using a semi-mechanistic pharmacokinetic/pharmacodynamic model.
The Journal of antimicrobial chemotherapy. 71(4):1012-21 [DOI] 10.1093/jac/dkv428. [PMID] 26702923.
2016
Ciclesonide: A Pro-Soft Drug Approach for Mitigation of Side Effects of Inhaled Corticosteroids.
Journal of pharmaceutical sciences. 105(9):2509-2514 [DOI] 10.1016/j.xphs.2016.05.004. [PMID] 27339407.
2016
A Tribute to Dr. Marcus E. Brewster: October 14, 1957-September 15, 2014.
Journal of pharmaceutical sciences. 105(9):2466-2467 [DOI] 10.1016/j.xphs.2016.02.001. [PMID] 27012223.
2016
In vitro pharmacokinetics/pharmacodynamics of the combination of avibactam and aztreonam against MDR organisms.
The Journal of antimicrobial chemotherapy. 71(7):1866-80 [DOI] 10.1093/jac/dkw082. [PMID] 27107096.
2015
Exploring in Vitro Antipseudomonal Activity of Synergistic Tigecycline-Tetracycline Combinations.
Clinical Pharmacology & Therapeutics. 97(1)
2015
Simultaneous Characterization of Intravenous and Oral Pharmacokinetics of Lychnopholide in Rats by Transit Compartment Model.
Planta medica. 81(12-13):1121-7 [DOI] 10.1055/s-0035-1546214. [PMID] 26218336.
2015
Quantitation of the impact of CYP3A5 A6986G polymorphism on quetiapine pharmacokinetics by simulation of target attainment.
Clinical pharmacology in drug development. 4(5):387-94 [DOI] 10.1002/cpdd.172. [PMID] 27137148.
2015
Pharmacokinetic evaluation of avicularin using a model-based development approach.
Planta medica. 81(5):373-81 [DOI] 10.1055/s-0035-1545728. [PMID] 25782034.
2015
Pharmacokinetic and pharmacodynamic implications in inhalable antimicrobial therapy.
Advanced drug delivery reviews. 85:57-64 [DOI] 10.1016/j.addr.2015.03.002. [PMID] 25770775.
2015
In memoriam: William A. Craig.
Antimicrobial agents and chemotherapy. 59(6) [DOI] 10.1128/AAC.00849-15. [PMID] 25896702.
2015
Evaluation of in vitro synergy between vertilmicin and ceftazidime against Pseudomonas aeruginosa using a semi-mechanistic pharmacokinetic/pharmacodynamic model.
International journal of antimicrobial agents. 45(2):151-60 [DOI] 10.1016/j.ijantimicag.2014.09.017. [PMID] 25465523.
2015
Theory and Application of Microdialysis in Pharmacokinetic Studies.
Current drug metabolism. 16(10):919-31 [PMID] 26264199.
View on: PubMed
2015
Effect of reducing the paediatric stavudine dose by half: a physiologically-based pharmacokinetic model.
International journal of antimicrobial agents. 45(4):413-9 [DOI] 10.1016/j.ijantimicag.2014.12.016. [PMID] 25697412.
2015
Does the Anesthetic Urethane Influence the Pharmacokinetics of Antifungal Drugs? A Population Pharmacokinetic Investigation in Rats.
Journal of pharmaceutical sciences. 104(10):3314-8 [DOI] 10.1002/jps.24552. [PMID] 26087701.
2015
Development and validation of a HPLC-MS/MS method for the determination of phytolaccagenin in rat plasma and application to a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis. 107:82-8 [DOI] 10.1016/j.jpba.2014.12.025. [PMID] 25575173.
2015
Concentration-response studies and modelling of the pharmacodynamics of linezolid: Staphylococcus aureus versus Enterococcus faecium.
International journal of antimicrobial agents. 45(1):54-60 [DOI] 10.1016/j.ijantimicag.2014.07.028. [PMID] 25455852.
2015
Concentration-Response Studies and Modelling of the Pharmacodynamics of Linezolid: Staphylococcus Aureus Versus Enterococcus Faecium
International Journal of Antimicrobial Agents. 45(1):54-60 [DOI] 10.1016/j.ijantimicag.2014.10.07.028.
2015
Enzyme- and transporter-mediated beverage-drug interactions: An update on fruit juices and green tea.
Journal of clinical pharmacology. 55(12):1313-31 [DOI] 10.1002/jcph.563. [PMID] 26095990.
2015
Cavitary penetration of levofloxacin among patients with multidrug-resistant tuberculosis.
Antimicrobial agents and chemotherapy. 59(6):3149-55 [DOI] 10.1128/AAC.00379-15. [PMID] 25779583.
2014
Role of microdialysis in pharmacokinetics and pharmacodynamics: current status and future directions.
Clinical pharmacokinetics. 53(3):205-212 [DOI] 10.1007/s40262-014-0131-8. [PMID] 24452811.
2014
Relevance of Liver Failure for Anti-Infective Agents: From Pharmacokinetic Alterations to Dosage Adjustments.
Therapeutic advances in infectious disease. 2(1):17-42 [PMID] 24949199.
View on: PubMed
2014
Protein binding of rifapentine and its 25-desacetyl metabolite in patients with pulmonary tuberculosis.
Antimicrobial agents and chemotherapy. 58(8):4904-10 [DOI] 10.1128/AAC.01730-13. [PMID] 24841270.
2014
Predicting pediatric age-matched weight and body mass index.
The AAPS journal. 16(6):1372-9 [DOI] 10.1208/s12248-014-9657-9. [PMID] 25155824.
2014
Population pharmacokinetics of cilengitide in adult and pediatric cancer patients from a nonlinear mixed-effects analysis.
Journal of clinical pharmacology. 54(12):1391-9 [DOI] 10.1002/jcph.343. [PMID] 24911832.
2014
Population pharmacokinetic modeling of the unbound levofloxacin concentrations in rat plasma and prostate tissue measured by microdialysis.
Antimicrobial agents and chemotherapy. 58(2):678-86 [DOI] 10.1128/AAC.01884-13. [PMID] 24217697.
2014
Pharmacokinetics of para-aminosalicylic acid in HIV-uninfected and HIV-coinfected tuberculosis patients receiving antiretroviral therapy, managed for multidrug-resistant and extensively drug-resistant tuberculosis.
Antimicrobial agents and chemotherapy. 58(10):6242-50 [DOI] 10.1128/AAC.03073-14. [PMID] 25114132.
2014
Monte Carlo Simulation To Determine the Effect of Atypical Nonlinear Plasma Protein Binding On Clinical Breakpoint of Tigecycline
Clinical Pharmacology & Therapeutics. 95(1)
2014
Comparison of skin permeability for three diclofenac topical formulations: an in vitro study.
Die Pharmazie. 69(1):27-31 [PMID] 24601219.
View on: PubMed
2014
Measuring drug distribution in the critically ill patient.
Advanced drug delivery reviews. 77:22-6 [DOI] 10.1016/j.addr.2014.08.014. [PMID] 25194997.
2014
Largazole pharmacokinetics in rats by LC-MS/MS.
Marine drugs. 12(3):1623-40 [DOI] 10.3390/md12031623. [PMID] 24658499.
2014
Estimation of intracellular concentration of stavudine triphosphate in HIV-infected children given a reduced dose of 0.5 milligrams per kilogram twice daily.
Antimicrobial agents and chemotherapy. 58(2):1084-91 [DOI] 10.1128/AAC.01717-13. [PMID] 24295968.
2014
Enhanced penetration of moxifloxacin into rat prostate tissue evidenced by microdialysis.
International journal of antimicrobial agents. 44(4):327-33 [DOI] 10.1016/j.ijantimicag.2014.06.011. [PMID] 25218157.
2014
Determination of atypical nonlinear plasma−protein-binding behavior of tigecycline using an in vitro microdialysis technique.
Journal of pharmaceutical sciences. 103(3):1013-9 [DOI] 10.1002/jps.23872. [PMID] 24549736.
2014
Application of pharmacokinetic/pharmacodynamic modelling and simulation for the prediction of target attainment of ceftobiprole against meticillin-resistant Staphylococcus aureus using minimum inhibitory concentration and time-kill curve based approaches.
International journal of antimicrobial agents. 43(1):60-7 [DOI] 10.1016/j.ijantimicag.2013.08.016. [PMID] 24183800.
2014
Metal Ion Chelation By Tigecycline Explains Atypical Nonlinear Plasma Protein Binding Behavior
Clinical Pharmacology & Therapeutics. 95(1)
2013
Vancomycin (Van) Administered By Continuous Infusion (Ci) Should Be Dosed According To Clearance (Cl) and Not Based On the Patient’s Body Weight
International Journal of Antimicrobial Agents. 42
2013
The Report of the 2012-2013 Research and Graduate Affairs Committee
American Journal of Pharmaceutical Education. 77
2013
Sex related differences on valproic acid pharmacokinetics after oral single dose.
Journal of pharmacokinetics and pharmacodynamics. 40(4):479-86 [DOI] 10.1007/s10928-013-9323-3. [PMID] 23784346.
2013
Pharmacokinetics of modified-release prednisone tablets in healthy subjects and patients with rheumatoid arthritis.
Journal of clinical pharmacology. 53(3):326-33 [DOI] 10.1177/0091270012444315. [PMID] 23444285.
2013
Pharmacokinetics and pharmacodynamics of ponesimod, a selective S1P1 receptor modulator, in the first-in-human study.
British journal of clinical pharmacology. 76(6):888-96 [DOI] 10.1111/bcp.12129. [PMID] 23594176.
2013
Pharmacokinetic properties of pure xanthones in comparison to a mangosteen fruit extract in rats.
Planta medica. 79(8):646-53 [DOI] 10.1055/s-0032-1328543. [PMID] 23673465.
2013
Oral adherence monitoring using a breath test to supplement highly active antiretroviral therapy.
AIDS and behavior. 17(1):298-306 [DOI] 10.1007/s10461-012-0318-7. [PMID] 23001413.
2013
When is protein binding important?
Journal of pharmaceutical sciences. 102(9):3458-67 [DOI] 10.1002/jps.23559. [PMID] 23650013.
2013
Importance of relating efficacy measures to unbound drug concentrations for anti-infective agents.
Clinical microbiology reviews. 26(2):274-88 [DOI] 10.1128/CMR.00092-12. [PMID] 23554417.
2013
Grapefruit-medication interactions.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 185(6) [DOI] 10.1503/cmaj.113-2109. [PMID] 23550054.
2013
Feasibility of a breath test for monitoring adherence to vaginal administration of antiretroviral microbicide gels.
Journal of clinical pharmacology. 53(1):103-11 [DOI] 10.1177/0091270011434157. [PMID] 23400750.
2013
Electroencephalogram effects of armodafinil: comparison with behavioral alertness.
Journal of clinical pharmacology. 53(10):1058-71 [DOI] 10.1002/jcph.143. [PMID] 23913585.
2013
A novel breath test to directly measure use of vaginal gel and condoms.
AIDS and behavior. 17(6):2211-21 [DOI] 10.1007/s10461-012-0390-z. [PMID] 23321948.
2013
Influence of CYP3A5 6986A > G and ABCB1 3435C > T Polymorphisms on Adverse Events Associated With Tacrolimus in Jordanian Pediatric Renal Transplant Patients.
Clinical pharmacology in drug development. 2(1):67-78 [DOI] 10.1002/cpdd.22. [PMID] 27121561.
2013
A Markov chain model to evaluate the effect of CYP3A5 and ABCB1 polymorphisms on adverse events associated with tacrolimus in pediatric renal transplantation.
The AAPS journal. 15(4):1189-99 [DOI] 10.1208/s12248-013-9528-9. [PMID] 23990505.
2012
The Pharmacokinetic Properties of Pure Gamma-Mangostin in Rats in Comparison To Mangosteen Extract
Planta Medica. 78
2012
Skin and soft tissue concentrations of tedizolid (formerly torezolid), a novel oxazolidinone, following a single oral dose in healthy volunteers.
International journal of antimicrobial agents. 40(1):51-4 [DOI] 10.1016/j.ijantimicag.2012.03.006. [PMID] 22584101.
2012
Population Pharmacokinetics of Steady-State Carbamazepine in Egyptian Epilepsy Patients
Journal of Clinical Pharmacy and Therapeutics. 37(3):352-355 [DOI] 10.1111/j.1365-2710.2011.01296.x. [PMID] 21883329.
2012
Pharmacokinetics of valerenic acid in rats after intravenous and oral administrations.
Planta medica. 78(6):575-81 [DOI] 10.1055/s-0031-1298301. [PMID] 22411722.
2012
Pharmacokinetics of Natural Compounds
Planta Medica. 78
2012
Pharmacokinetic-Pharmacodynamic Modeling of Armodafinil: Effects On Alertness and Electroen-Cephalogram of Sleep Deprived Adults
Clinical Pharmacology & Therapeutics. 91:S7-S8
2012
Pharmacokinetic Analysis of Two Flavorants Used in a Novel Breath-Based System (Smart (Tm)) Designed To Assess Use of Vaginally Applied Products.
Clinical Pharmacology & Therapeutics. 91:S67-S68
2012
The concentration-dependent binding of linagliptin (BI 1356) and its implication on efficacy and safety.
International journal of clinical pharmacology and therapeutics. 50(5):323-30 [PMID] 22541836.
View on: PubMed
2012
Herb-drug interactions.
Planta medica. 78(13) [DOI] 10.1055/s-0032-1315285. [PMID] 22951920.
2012
Model-based drug approval – the rubber hits the road.
International journal of clinical pharmacology and therapeutics. 50(9) [PMID] 22981143.
View on: PubMed
2012
Ascending Single-Dose Study With Ponesimod, a Selective Sip1 Receptor Agonist: Safety, Pharmacokinetics, Pharmacodynamics, and Modeling.
Clinical Pharmacology & Therapeutics. 91
2012
Bioavailability and disposition of azelastine and fluticasone propionate when delivered by MP29-02, a novel aqueous nasal spray.
British journal of clinical pharmacology. 74(1):125-33 [DOI] 10.1111/j.1365-2125.2012.04222.x. [PMID] 22356350.
2012
Modeling of Investigative Static Global Assessment Score (Isga) in Acne Vulgaris.
Clinical Pharmacology & Therapeutics. 91
2012
Disease Progression Modeling of Inflammatory Lesion Counts (Les) in Acne Vulgaris.
Clinical Pharmacology & Therapeutics. 91
2012
Electroencephalogram-based pharmacodynamic measures: a review.
International journal of clinical pharmacology and therapeutics. 50(3):162-84 [PMID] 22373830.
View on: PubMed
2012
Dermal pharmacokinetics of Terpinen-4-ol following topical administration of Zingiber cassumunar (plai) oil.
Planta medica. 78(16):1761-6 [DOI] 10.1055/s-0032-1315262. [PMID] 23027380.
2011
Simulation-based sodium thiosulfate dosing strategies for the treatment of calciphylaxis.
Clinical journal of the American Society of Nephrology : CJASN. 6(5):1155-9 [DOI] 10.2215/CJN.09671010. [PMID] 21441129.
2011
Serum concentrations and clinical effects of atorvastatin in patients taking grapefruit juice daily.
British journal of clinical pharmacology. 72(3):434-41 [DOI] 10.1111/j.1365-2125.2011.03996.x. [PMID] 21501216.
2011
Role of pharmacokinetics in establishing bioequivalence for orally inhaled drug products: workshop summary report.
Journal of aerosol medicine and pulmonary drug delivery. 24(3):119-35 [DOI] 10.1089/jamp.2011.0878. [PMID] 21453049.
2011
Repeated pre-exposure to tobacco smoke potentiates subsequent locomotor responses to nicotine and tobacco smoke but not amphetamine in adult rats.
Pharmacology, biochemistry, and behavior. 100(1):109-18 [DOI] 10.1016/j.pbb.2011.08.005. [PMID] 21871478.
2011
Protein binding: do we ever learn?
Antimicrobial agents and chemotherapy. 55(7):3067-74 [DOI] 10.1128/AAC.01433-10. [PMID] 21537013.
2011
Population Pharmacokinetics of Methotrexate in Egyptian Children With Lymphoblastic Leukemia
Therapeutic Drug Monitoring. 33
2011
Population Pharmacokinetics for Individualization of Tacrolimus Dose in Jordanian Pediatric Renal Transplant Recipients
Therapeutic Drug Monitoring. 33:545-546
2011
Population Pharmacokinetics and Pharmacodynamics of Armodafinil: Effects On Electroencephalogram and Alertness of Sleep Deprived Adults
. 51
2011
Population pharmacokinetic model of human insulin following different routes of administration.
Journal of clinical pharmacology. 51(7):1015-24 [DOI] 10.1177/0091270010378520. [PMID] 20940337.
2011
Pharmacometrics in dose finding or dose optimization of anti-retroviral and anti-tubercular drugs.
Infectious disorders drug targets. 11(2):157-66 [PMID] 21406049.
View on: PubMed
2011
PA-824 exhibits time-dependent activity in a murine model of tuberculosis.
Antimicrobial agents and chemotherapy. 55(1):239-45 [DOI] 10.1128/AAC.00849-10. [PMID] 20937781.
2011
HPLC method validation for the quantification of lomustine to study pharmacokinetics of thermosensitive liposome-encapsulated lomustine containing iohexol for CT imaging in C6 glioma rats.
European journal of drug metabolism and pharmacokinetics. 36(2):61-9 [DOI] 10.1007/s13318-011-0030-4. [PMID] 21380568.
2011
Fixed Dosing Versus Body Size-Based Dosing of Anticancer Drugs in Adults: a Population Pharmacokinetic Approach
Clinical Pharmacology & Therapeutics. 89
2011
Development and validation of a LC-MS/MS method based on a new 96-well Hybrid-SPE™-precipitation technique for quantification of CYP450 substrates/metabolites in rat plasma.
Analytical and bioanalytical chemistry. 400(8):2371-81 [DOI] 10.1007/s00216-010-4618-3. [PMID] 21225250.
2011
Clinical pharmacokinetics of meropenem and biapenem in bile and dosing considerations for biliary tract infections based on site-specific pharmacodynamic target attainment.
Antimicrobial agents and chemotherapy. 55(12):5609-15 [DOI] 10.1128/AAC.00497-11. [PMID] 21947393.
2011
Absolute/relative bioavailability and metabolism of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (tetraenes) after intravenous and oral single doses to rats.
Planta medica. 77(16):1794-9 [DOI] 10.1055/s-0030-1271120. [PMID] 21604240.
2011
Suppression of ciprofloxacin-induced resistant Pseudomonas aeruginosa in a dynamic kill curve system.
International journal of antimicrobial agents. 37(6):519-24 [DOI] 10.1016/j.ijantimicag.2011.01.021. [PMID] 21497064.
2011
Pharmacokinetics of Intranasal Scopolamine Gel Formulation During Antiorthostatic Bedrest – a Microgravity Analog
. 51:1337-1338
2011
Pharmacokinetics of Cefpodoxime in Plasma and Subcutaneous Fluid Following Oral Administration of Cefpodoxime Proxetil in Male Beagle Dogs
Journal of Veterinary Pharmacology and Therapeutics. 34(2):130-135 [DOI] 10.1111/j.1365-2885.2010.01198.x. [PMID] 21395603.
2011
The effect of critical illness on drug distribution.
Current pharmaceutical biotechnology. 12(12):2030-6 [PMID] 21554214.
View on: PubMed
2010
Comparison of the pharmacokinetic properties of vancomycin, linezolid, tigecyclin, and daptomycin.
European journal of medical research. 15(12):533-43 [PMID] 21163728.
View on: PubMed
2010
Class-dependent relevance of tissue distribution in the interpretation of anti-infective pharmacokinetic/pharmacodynamic indices.
International journal of antimicrobial agents. 35(5):431-8 [DOI] 10.1016/j.ijantimicag.2010.01.023. [PMID] 20219329.
2010
Underdosing of ertapenem in critically ill patients with pneumonia confirmed by Monte Carlo simulations.
International journal of antimicrobial agents. 35(1):96-7 [DOI] 10.1016/j.ijantimicag.2009.09.007. [PMID] 19896806.
2010
Tobacco smoke exposure induces nicotine dependence in rats.
Psychopharmacology. 208(1):143-58 [DOI] 10.1007/s00213-009-1716-z. [PMID] 19936715.
2010
Thromboelastographic and pharmacokinetic profiles of micro- and macro-emulsions of propofol in swine.
Biopharmaceutics & drug disposition. 31(5-6):269-77 [DOI] 10.1002/bdd.709. [PMID] 20578214.
2010
Simultaneous HPLC analysis of triamcinolone acetonide and budesonide in microdialysate and rat plasma: application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 878(29):2967-73 [DOI] 10.1016/j.jchromb.2010.08.048. [PMID] 20884303.
2010
Significance of protein binding in pharmacokinetics and pharmacodynamics.
Journal of pharmaceutical sciences. 99(3):1107-22 [DOI] 10.1002/jps.21916. [PMID] 19852037.
2010
Role of drug absorption in the pharmacokinetics of therapeutic interventions for stroke.
Annals of the New York Academy of Sciences. 1207:134-42 [DOI] 10.1111/j.1749-6632.2010.05729.x. [PMID] 20955436.
2010
Preadolescent tobacco smoke exposure leads to acute nicotine dependence but does not affect the rewarding effects of nicotine or nicotine withdrawal in adulthood in rats.
Pharmacology, biochemistry, and behavior. 95(4):401-9 [DOI] 10.1016/j.pbb.2010.02.018. [PMID] 20211642.
2010
Population Pharmacokinetics of Caspofungin in Patients With Acute Leukemia Or Allogenic Or Autologous Blood Stem Cell Transplantation
. 50
2010
Population pharmacokinetics and pharmacodynamics of inhaled ciclesonide and fluticasone propionate in patients with persistent asthma.
Journal of clinical pharmacology. 50(10):1118-27 [DOI] 10.1177/0091270009354994. [PMID] 20150524.
2010
Resistance and the management of complicated skin and skin structure infections: the role of ceftobiprole.
Therapeutics and clinical risk management. 6:485-95 [DOI] 10.2147/TCRM.S5823. [PMID] 20957140.
2010
Pharmacokinetic/pharmacodynamic profile of posaconazole.
Clinical pharmacokinetics. 49(6):379-96 [DOI] 10.2165/11319340-000000000-00000. [PMID] 20481649.
2010
Pharmacokinetic/Pharmacodynamic Model-Based Combination Therapy Approach To Target Antibiotic Resistant Populations Emerged From Ciprofloxacin Exposure
Die Pharmazie. 65(6):417-420 [DOI] 10.1691/ph.2010.0032R. [PMID] 20614689.
2010
Pharmacokinetic and pharmacodynamic evaluation of the lantibiotic MU1140.
Journal of pharmaceutical sciences. 99(5):2521-8 [DOI] 10.1002/jps.22015. [PMID] 20039385.
2010
Pediatric Dosing and Body Size in Biotherapeutics.
Pharmaceutics. 2(4):389-418 [PMID] 27721364.
View on: PubMed
2010
Modeling of Target Lesion Scores Over Time in a Psoriasis Microplaque Assay.
Clinical Pharmacology & Therapeutics. 87:S56-S57
2010
Modeling of Lesion Scores Over Time in a Psoriasis
. 50
2010
In vitro pharmacodynamic models to determine the effect of antibacterial drugs.
The Journal of antimicrobial chemotherapy. 65(2):186-201 [DOI] 10.1093/jac/dkp434. [PMID] 20026612.
2010
Human serum binding and its effect on the pharmacodynamics of the lantibiotic MU1140.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 41(5):658-64 [DOI] 10.1016/j.ejps.2010.09.005. [PMID] 20869439.
2010
Pharmacometrics as a discipline is entering the “industrialization” phase: standards, automation, knowledge sharing, and training are critical for future success.
Journal of clinical pharmacology. 50(9 Suppl):9S-19S [DOI] 10.1177/0091270010377788. [PMID] 20881213.
2009
Pharmacokinetic/pharmacodynamic modelling and in vitro simulation of dynamic voriconazole-Candida interactions.
International journal of antimicrobial agents. 34(3):240-5 [DOI] 10.1016/j.ijantimicag.2009.02.006. [PMID] 19339162.
2009
Toxicological and Pharmacokinetic Evaluation of Concomitant Intake of Grapefruit Juice and Simvastatin in Rats after Repeated Treatment over 28 Days.
Planta medica. 75(11):1196-202 [DOI] 10.1055/s-0029-1185534. [PMID] 19350484.
2009
Soft-tissue penetration of ceftobiprole in healthy volunteers determined by in vivo microdialysis.
Antimicrobial agents and chemotherapy. 53(7):2773-6 [DOI] 10.1128/AAC.01409-08. [PMID] 19364847.
2009
Soft tissue penetration of cefuroxime determined by clinical microdialysis in morbidly obese patients undergoing abdominal surgery.
International journal of antimicrobial agents. 34(3):231-5 [DOI] 10.1016/j.ijantimicag.2009.03.019. [PMID] 19411164.
2009
Preliminary Evaluation of Gc-Ms for the Determination of Terpinen-4-Ol in Cutaneous Microdialysis Samples
Drug Metabolism Reviews. 41
2009
Pharmacokinetics and tissue distribution of dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides after oral administration in rats.
Planta medica. 75(12):1306-13 [DOI] 10.1055/s-0029-1185631. [PMID] 19399718.
2009
Pharmacokinetic-pharmacodynamic modeling of the in vitro activities of oxazolidinone antimicrobial agents against methicillin-resistant Staphylococcus aureus.
Antimicrobial agents and chemotherapy. 53(12):5039-45 [DOI] 10.1128/AAC.00633-09. [PMID] 19786607.
2009
Pk/Pd Studies Focusing On Physical Dependence of Fentanyl in Rats
Clinical Pharmacology & Therapeutics. 85
2009
Influence of the Duffy Antigen On Pharmacokinetics and Pharmacodynamics of Recombinant Monocyte Chemoattractant Protein (Mcp-1, Ccl-2) in Vivo
International Journal of Immunopathology and Pharmacology. 22:615-625
2009
Effects of Plasma Protein Binding On Half-Life of Elimination
. 49
2009
Bioavailability of Dodeca-2E,4E,8E,10E/Z-Tetraenoic Acid Isobutylamides After Oral Administration in Rats and Distribution in Various Tissues
Planta Medica. 75
2009
Development and validation of a LC-MS quantification method for the lantibiotic MU1140 in rat plasma.
Journal of pharmaceutical and biomedical analysis. 49(4):970-5 [DOI] 10.1016/j.jpba.2008.12.022. [PMID] 19269770.
2009
Cortisol suppression as a surrogate marker for inhaled corticosteroid-induced growth retardation in children.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 36(1):110-21 [DOI] 10.1016/j.ejps.2008.10.016. [PMID] 19028577.
2009
Clinical pharmacokinetics and pharmacodynamics of tigecycline.
Clinical pharmacokinetics. 48(9):575-84 [DOI] 10.2165/11317100-000000000-00000. [PMID] 19725592.
2009
Ceftobiprole: a novel cephalosporin with activity against Gram-positive and Gram-negative pathogens, including methicillin-resistant Staphylococcus aureus (MRSA).
International journal of antimicrobial agents. 34(1):1-7 [DOI] 10.1016/j.ijantimicag.2008.12.012. [PMID] 19261449.
2009
Pharmacodynamic activity of the lantibiotic MU1140.
International journal of antimicrobial agents. 33(1):70-4 [DOI] 10.1016/j.ijantimicag.2008.07.028. [PMID] 18835136.
2008
Pharmacokinetics of anthocyanins and antioxidant effects after the consumption of anthocyanin-rich acai juice and pulp (Euterpe oleracea Mart.) in human healthy volunteers.
Journal of agricultural and food chemistry. 56(17):7796-802 [DOI] 10.1021/jf8007037. [PMID] 18693743.
2008
Pharmacokinetics of Luteolin and Metabolites in Rats
Natural Product Communications. 3:2029-2036
2008
PK/PD: new insights for antibacterial and antiviral applications.
Current opinion in pharmacology. 8(5):549-56 [DOI] 10.1016/j.coph.2008.06.010. [PMID] 18625339.
2008
Population pharmacodynamic model of bronchodilator response to inhaled albuterol in children and adults with asthma.
Chest. 134(5):981-989 [DOI] 10.1378/chest.07-2991. [PMID] 18583517.
2008
The Candida albicans phosphatase Inp51p interacts with the EH domain protein Irs4p, regulates phosphatidylinositol-4,5-bisphosphate levels and influences hyphal formation, the cell integrity pathway and virulence.
Microbiology (Reading, England). 154(Pt 11):3296-3308 [DOI] 10.1099/mic.0.2008/018002-0. [PMID] 18957583.
2008
Potential of pharmacokinetic profiling for detecting herbal interactions with drugs.
Clinical pharmacokinetics. 47(6):383-97 [PMID] 18479173.
View on: PubMed
2008
Proposal for a standardised identification of the mono-exponential terminal phase for orally administered drugs.
Biopharmaceutics & drug disposition. 29(3):145-57 [PMID] 18098336.
View on: PubMed
2008
Tissue concentrations: do we ever learn?
The Journal of antimicrobial chemotherapy. 61(2):235-7 [PMID] 18065413.
View on: PubMed
2008
Population Pharmacokinetics of the Bradykinin B2 Receptor Antagonist Icatibant in Phase I and Ii Clinical Trials
. 48
2008
Pharmacokinetic Profiling of Dodeca-2E,4E,8E,10E/Z-Tetraenoic Acid Isobutylamides in Rats Using Liquid Chromatography Tandem Mass Spectrometry
Planta Medica. 74
2008
Estimation of Lithium Clearance From Routine Clinical Data in Egyptian Bipolar Patients. a Population Pharmacokinetic Approach
International Journal of Clinical Pharmacology and Therapeutics. 46:617-626
2008
Effects of fentanyl dose and exposure duration on the affective and somatic signs of fentanyl withdrawal in rats.
Neuropharmacology. 55(5):812-8 [DOI] 10.1016/j.neuropharm.2008.06.034. [PMID] 18634811.
2008
Effect of protein binding on the pharmacological activity of highly bound antibiotics.
Antimicrobial agents and chemotherapy. 52(11):3994-4000 [DOI] 10.1128/AAC.00427-08. [PMID] 18779351.
2008
Effect of grapefruit juice, naringin, naringenin, and bergamottin on the intestinal carrier-mediated transport of talinolol in rats.
Journal of agricultural and food chemistry. 56(12):4840-5 [DOI] 10.1021/jf0728451. [PMID] 18494494.
2008
Duffy antigen modifies the chemokine response in human endotoxemia.
Critical care medicine. 36(1):159-65 [PMID] 18007272.
View on: PubMed
2008
Combination of Clinical Microdialysis and in Vitro Pharmacodynamics for Dose Optimization of Beta-Lactam Antibiotics
. 48
2008
Clinical microdialysis in skin and soft tissues: an update.
Journal of clinical pharmacology. 48(3):351-64 [DOI] 10.1177/0091270007312152. [PMID] 18285620.
2008
Assessment of the impact of dosing time on the pharmacokinetics/pharmacodynamics of prednisolone.
The AAPS journal. 10(2):331-41 [DOI] 10.1208/s12248-008-9038-3. [PMID] 18581240.
2008
Anesthesia in Space – Pk/Pd Modeling of Propofol in Simulated Microgravity
. 48
2008
A pharmacokinetic/pharmacodynamic mathematical model accurately describes the activity of voriconazole against Candida spp. in vitro.
International journal of antimicrobial agents. 31(4):369-74 [DOI] 10.1016/j.ijantimicag.2007.11.015. [PMID] 18215509.
2008
Molecular and clinical pharmacology of intranasal corticosteroids: clinical and therapeutic implications.
Allergy. 63(10):1292-300 [DOI] 10.1111/j.1398-9995.2008.01750.x. [PMID] 18782107.
2007
Polymethoxylated flavones and other phenolic derivates from citrus in their inhibitory effects on P-glycoprotein-mediated transport of talinolol in Caco-2 cells.
Journal of agricultural and food chemistry. 55(7):2563-8 [PMID] 17348674.
View on: PubMed
2007
Integration of pharmacokinetic/pharmacodynamic modeling and simulation in the development of new anti-infective agents – minimum inhibitory concentration versus time-kill curves.
Expert opinion on drug discovery. 2(6):849-60 [DOI] 10.1517/17460441.2.6.849. [PMID] 23489002.
2007
Pharmacokinetic and pharmacodynamic properties of inhaled ciclesonide.
Journal of clinical pharmacology. 47(6):782-9 [PMID] 17412829.
View on: PubMed
2007
Measurement of voriconazole activity against Candida albicans, C. glabrata, and C. parapsilosis isolates using time-kill methods validated by high-performance liquid chromatography.
Antimicrobial agents and chemotherapy. 51(8):2985-7 [PMID] 17517840.
View on: PubMed
2007
Grapefruit juice-drug interactions: Grapefruit juice and its components inhibit P-glycoprotein (ABCB1) mediated transport of talinolol in Caco-2 cells.
Journal of pharmaceutical sciences. 96(10):2808-17 [PMID] 17542018.
View on: PubMed
2007
Pharmacokinetic/pharmacodynamic modeling of in vitro activity of azithromycin against four different bacterial strains.
International journal of antimicrobial agents. 29(3):263-70 [PMID] 17194570.
View on: PubMed
2007
Ertapenem in critically ill patients with early-onset ventilator-associated pneumonia: pharmacokinetics with special consideration of free-drug concentration.
The Journal of antimicrobial chemotherapy. 59(2):277-84 [PMID] 17185298.
View on: PubMed
2007
Clinical trials and dipyridamole formulation selection.
Cerebrovascular diseases (Basel, Switzerland). 23(1):72-3; author reply 73 [PMID] 17108677.
View on: PubMed
2007
AAPS-FDA Workshop White Paper: microdialysis principles, application, and regulatory perspectives.
Journal of clinical pharmacology. 47(5):589-603 [PMID] 17442685.
View on: PubMed
2007
AAPS-FDA workshop white paper: microdialysis principles, application and regulatory perspectives.
Pharmaceutical research. 24(5):1014-25 [PMID] 17458685.
View on: PubMed
2007
Ertapenem: the new carbapenem 5 years after first FDA licensing for clinical practice.
Expert opinion on pharmacotherapy. 8(2):237-56 [PMID] 17257093.
View on: PubMed
2006
Variation of flavonoids and furanocoumarins in grapefruit juices: a potential source of variability in grapefruit juice-drug interaction studies.
Journal of agricultural and food chemistry. 54(1):249-55 [PMID] 16390207.
View on: PubMed
2006
Variability in response to cardiovascular drugs.
Current clinical pharmacology. 1(1):35-46 [PMID] 18666376.
View on: PubMed
2006
The systemic safety of inhaled corticosteroid therapy: a focus on ciclesonide.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 97(2):149-57 [PMID] 16937743.
View on: PubMed
2006
The influence of formulation on the dissolution profile of diclofenac sodium tablets.
Drug Development Communications. 32(9):1103-9 [DOI] 10.1080/03639040600815152 . [PMID] 17012123.
2006
Relevance of pharmacokinetics and pharmacodynamics of inhaled corticosteroids to asthma.
The European respiratory journal. 28(5):1042-50 [DOI] 10.1183/09031936.00074905. [PMID] 17074919.
2006
Pharmacokinetic/pharmacodynamic profile of voriconazole.
Clinical pharmacokinetics. 45(7):649-63 [PMID] 16802848.
View on: PubMed
2006
Penetration of ertapenem into skeletal muscle and subcutaneous adipose tissue in healthy volunteers measured by in vivo microdialysis.
The Journal of antimicrobial chemotherapy. 58(3):632-6 [PMID] 16840426.
View on: PubMed
2006
Once-daily tobramycin in cystic fibrosis: better for clinical outcome than thrice-daily tobramycin but more resistance development?
The Journal of antimicrobial chemotherapy. 58(4):822-9 [PMID] 16885180.
View on: PubMed
2006
Pharmacokinetic/pharmacodynamic modeling of total lymphocytes and selected subtypes after oral budesonide.
Journal of pharmacokinetics and pharmacodynamics. 33(4):441-59 [PMID] 16633890.
View on: PubMed
2006
Microdialysis as a tool in local pharmacodynamics.
The AAPS journal. 8(2):E222-35 [PMID] 16796373.
View on: PubMed
2006
Isolation and HPLC quantitative analysis of antioxidant flavonoids from Alternanthera tenella Colla.
Zeitschrift fur Naturforschung. C, Journal of biosciences. 61(1-2):19-25 [PMID] 16610211.
View on: PubMed
2006
Hyperforin in St. John’s wort drug interactions.
European journal of clinical pharmacology. 62(3):225-33 [PMID] 16477470.
View on: PubMed
2006
Characterizing the effects of caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata isolates by simultaneous time-kill and postantifungal-effect experiments.
Antimicrobial agents and chemotherapy. 50(7):2569-72 [PMID] 16801448.
View on: PubMed
2006
Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum l.) polyphenols after ingestion of a standardized extract in healthy human volunteers.
Journal of agricultural and food chemistry. 54(23):8956-61 [PMID] 17090147.
View on: PubMed
2006
[New antibiotics for treatment of MRSA infections. Comparison of treatment with vancomycin].
Medizinische Monatsschrift fur Pharmazeuten. 29(2):56-62; quiz 63 [PMID] 16506589.
View on: PubMed
2006
[Achieving eradication of MRSA colonization in patients. Therapeutic options].
Medizinische Monatsschrift fur Pharmazeuten. 29(1):17-21 [PMID] 16463549.
View on: PubMed
2006
Moxifloxacin distribution in the interstitial space of infected decubitus ulcer tissue of patients with spinal cord injury measured by in vivo microdialysis.
Scandinavian journal of infectious diseases. 38(10):904-8 [PMID] 17008236.
View on: PubMed
2005
Pharmacokinetic/pharmacodynamic evaluation of anti-infective agents.
Expert review of anti-infective therapy. 3(3):361-73 [PMID] 15954853.
View on: PubMed
2005
What is the best marker for inhaled corticosteroid safety?
Allergy and asthma proceedings. 26(2):89-93 [PMID] 15971465.
View on: PubMed
2005
Tissue penetration of cefpodoxime and cefixime in healthy subjects.
Journal of clinical pharmacology. 45(5):564-9 [PMID] 15831780.
View on: PubMed
2005
Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update.
The Journal of antimicrobial chemotherapy. 55(5):601-7 [PMID] 15772142.
View on: PubMed
2005
Population pharmacokinetics of eniporide and its metabolite in healthy subjects and patients with acute myocardial infarction.
Journal of clinical pharmacology. 45(6):631-9 [PMID] 15901744.
View on: PubMed
2005
Pharmacokinetics of piperacillin-tazobactam: intermittent dosing versus continuous infusion.
International journal of antimicrobial agents. 25(1):62-7 [PMID] 15620828.
View on: PubMed
2005
Pharmacokinetic-pharmacodynamic modelling of antibacterial activity of cefpodoxime and cefixime in in vitro kinetic models.
International journal of antimicrobial agents. 25(2):120-9 [PMID] 15664481.
View on: PubMed
2005
Tissue penetration of cefpodoxime into the skeletal muscle and lung in rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 25(4-5):439-44 [PMID] 15905079.
View on: PubMed
2005
Microdialysis for in vivo pharmacokinetic/pharmacodynamic characterization of anti-infective drugs.
Current opinion in pharmacology. 5(5):495-9 [PMID] 16084767.
View on: PubMed
2005
Application of two-point assay of digoxin serum concentration in studying population pharmacokinetics in Egyptian pediatric patients with heart failure: does it make sense?
American journal of therapeutics. 12(4):320-7 [PMID] 16041195.
View on: PubMed
2005
Comparative pharmacology, bioavailability, pharmacokinetics, and pharmacodynamics of inhaled glucocorticosteroids.
Immunology and allergy clinics of North America. 25(3):469-88 [PMID] 16054538.
View on: PubMed
2005
Corticosteroid pharmacokinetic/pharmacodynamic parameters and their relationship to safety and efficacy.
Allergy and asthma proceedings. 26(5):327-35 [PMID] 16450564.
View on: PubMed
2005
Penetration of ertapenem into different pulmonary compartments of patients undergoing lung surgery.
Journal of clinical pharmacology. 45(6):659-65 [PMID] 15901747.
View on: PubMed
2005
Effect of simulated microgravity on the disposition and tissue penetration of ciprofloxacin in healthy volunteers.
Journal of clinical pharmacology. 45(7):822-31 [PMID] 15951472.
View on: PubMed
2005
Dipyridamole bioavailability in subjects with reduced gastric acidity.
Journal of clinical pharmacology. 45(7):845-50 [PMID] 15951475.
View on: PubMed
2004
Differences in drug pharmacokinetics between East Asians and Caucasians and the role of genetic polymorphisms.
Journal of clinical pharmacology. 44(10):1083-105 [PMID] 15342610.
View on: PubMed
2004
How the lung handles drugs: pharmacokinetics and pharmacodynamics of inhaled corticosteroids.
Proceedings of the American Thoracic Society. 1(4):356-63 [PMID] 16113458.
View on: PubMed
2004
In vitro microdialysis sampling of docetaxel.
Journal of pharmaceutical and biomedical analysis. 36(4):807-13 [PMID] 15533674.
View on: PubMed
2004
Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: distribution in tissue.
Antimicrobial agents and chemotherapy. 48(5):1441-53 [PMID] 15105091.
View on: PubMed
2004
Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: kill curves versus MIC.
Antimicrobial agents and chemotherapy. 48(2):369-77 [PMID] 14742182.
View on: PubMed
2004
Pharmacokinetic herb-drug interactions: are preventive screenings necessary and appropriate?
Planta medica. 70(9):784-91 [PMID] 15386186.
View on: PubMed
2004
Physiological, pharmacokinetic, and pharmacodynamic changes in space.
Journal of clinical pharmacology. 44(8):837-53 [PMID] 15286087.
View on: PubMed
2004
PK-PD modelling of the effect of cefaclor on four different bacterial strains.
International journal of antimicrobial agents. 23(3):218-25 [PMID] 15164961.
View on: PubMed
2004
Risk-benefit value of inhaled glucocorticoids: a pharmacokinetic/pharmacodynamic perspective.
Journal of clinical pharmacology. 44(1):37-47 [PMID] 14681340.
View on: PubMed
2004
Intranasal loteprednol etabonate in healthy male subjects: pharmacokinetics and effects on endogenous cortisol.
Journal of clinical pharmacology. 44(5):510-9 [PMID] 15102872.
View on: PubMed
2003
Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children.
Journal of clinical pharmacology. 43(4):386-96 [PMID] 12723459.
View on: PubMed
2003
Single- and multiple-dose pharmacokinetics of oral creatine.
Journal of clinical pharmacology. 43(1):29-37 [PMID] 12520625.
View on: PubMed
2003
Risk-benefit value of inhaled corticosteroids: a pharmacokinetic/pharmacodynamic perspective.
Chest. 123(3 Suppl):430S-1S [PMID] 12629020.
View on: PubMed
2003
Pharmacokinetic/pharmacodynamic modeling of luteinizing hormone (LH) suppression and LH surge delay by cetrorelix after single and multiple doses in healthy premenopausal women.
Journal of clinical pharmacology. 43(3):243-51 [PMID] 12638392.
View on: PubMed
2003
Inhaled corticosteroids: past lessons and future issues.
The Journal of allergy and clinical immunology. 112(3 Suppl):S1-40 [PMID] 14515117.
View on: PubMed
2003
Antimicrobial tissue concentrations.
Infectious disease clinics of North America. 17(3):599-613 [PMID] 14711079.
View on: PubMed
2003
Microdialysis of triamcinolone acetonide in rat muscle.
Journal of pharmaceutical sciences. 92(2):394-7 [PMID] 12532388.
View on: PubMed
2002
Systemic availability and pharmacokinetics of thymol in humans.
Journal of clinical pharmacology. 42(7):731-7 [PMID] 12092740.
View on: PubMed
2002
Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs.
International journal of antimicrobial agents. 19(4):355-8 [PMID] 11978507.
View on: PubMed
2002
Rational dosing of antibiotics: the use of plasma concentrations versus tissue concentrations.
International journal of antimicrobial agents. 19(4):285-90 [PMID] 11978499.
View on: PubMed
2002
Pharmacokinetics and bioavailability of herbal medicinal products.
Phytomedicine : international journal of phytotherapy and phytopharmacology. 9 Suppl 3:1-33 [PMID] 12222652.
View on: PubMed
2002
Pharmacokinetic/pharmacodynamic studies in drug product development.
Journal of pharmaceutical sciences. 91(1):18-31 [PMID] 11782894.
View on: PubMed
2002
Population pharmacokinetics of digoxin in Egyptian pediatric patients: impact of one data point utilization.
American journal of therapeutics. 9(6):492-8 [PMID] 12424506.
View on: PubMed
2002
Interstitial tissue concentrations of cefpodoxime.
The Journal of antimicrobial chemotherapy. 50 Suppl:19-22 [PMID] 12077156.
View on: PubMed
2002
How important are gender differences in pharmacokinetics?
Clinical pharmacokinetics. 41(5):329-42 [PMID] 12036391.
View on: PubMed
2002
Comparative target site pharmacokinetics of immediate- and modified-release formulations of cefaclor in humans.
Journal of clinical pharmacology. 42(4):403-11 [PMID] 11936565.
View on: PubMed
2002
Bioavailability and metabolism of mometasone furoate: pharmacology versus methodology.
Journal of clinical pharmacology. 42(4):383-7 [PMID] 11936562.
View on: PubMed
2002
Novel formulations of cetrorelix acetate in healthy men: pharmacodynamic effects and noncompartmental pharmacokinetics.
Journal of clinical pharmacology. 42(9):995-1001 [PMID] 12211225.
View on: PubMed
2001
Evaluation of pulmonary absorption using pharmacokinetic methods.
Journal of Aerosol Medicine. 14 Suppl 1:S9-17 [DOI] 10.1089/08942680150506295. [PMID] 11424896.
2000
Optimized therapeutic ratio of inhaled corticosteroids using retrometabolism.
Die Pharmazie. 55(3):223-7 [PMID] 10756545.
View on: PubMed
1999
Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: concepts and perspectives.
Pharmaceutical research. 16(2):176-85 [PMID] 10100300.
View on: PubMed
1998
Influence of plasma expansion on plasma protein binding of ketorolac.
Journal of clinical anesthesia. 10(6):464-8 [PMID] 9793809.
View on: PubMed
1990
Pharmacokinetics of amikacin in critically ill neonatal foals treated for presumed or confirmed sepsis.
Equine veterinary journal. 22(1):18-22 [PMID] 2298186.
View on: PubMed

Grants

Jul 2017 – Jun 2018
Clinical Pharmacokinetics/Dynamics Fellowship 2017-2018
Role: Principal Investigator
Funding: GLAXO SMITHKLINE
Mar 2017 – Dec 2017
Organize 11th Symposium on New Development in Clinical Pharmacy and Clinical Pharmacology
Role: Principal Investigator
Funding: BOEHRINGER INGELHEIM INTL GmbH
Feb 2017 – Feb 2021
FGF-P: A Multipotential Mitigation Agent for Gastrointestinal Syndrome
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jan 2017 – Jun 2017
Food-Drug Interactions
Role: Principal Investigator
Funding: FL DEPT OF CITRUS
Sep 2016 – Aug 2017
AFPE Fellowship: Investigating a Novel Anitmicrobial Combination: Tigecycline-Tetracycline again P. Aeruginosa
Role: Other
Funding: AMER FOU FOR PHARM EDU
Jul 2016 – Jan 2021
Tobacco: relationship between reduced nicotine content and reinforcement in rats
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDA
Jul 2016 – Dec 2016
Clinical Pharmacokinetic/Dynamics Fellowship
Role: Principal Investigator
Funding: GLAXO SMITHKLINE
Mar 2016 – Sep 2017
Inflight Pharmacokinetic and Pharmacodynamic Responses to Medications Commonly used in Spaceflight
Role: Principal Investigator
Funding: BAYLOR UNIV via NASA
Feb 2016 – Jan 2018
A Clinical Pharmacology Study of a Novel Drug Regimen for Pre XDR and XDR Tuberculosis
Role: Project Manager
Funding: EMORY UNIV via NATL INST OF HLTH NIAID
Aug 2015 – Jun 2016
Grapefruit-Drug Interaction
Role: Principal Investigator
Funding: GOLIN-HARRIS INTERNATIONAL INC
Aug 2015 – Dec 2020
CTSI Institutional Support
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Jul 2015 – Aug 2016
Clinical pharmacokinetics/dynamics fellowship
Role: Principal Investigator
Funding: GLAXO SMITHKLINE
Jul 2014 – Jun 2016
Master Fellowship Agreement – Clinical Pharmacokinetics/dynamics Fellowship
Role: Principal Investigator
Funding: GLAXO SMITHKLINE
Jul 2013 – Dec 2016
Center for Food-Drug Interaction
Role: Principal Investigator
Funding: FL DEPT OF CITRUS
May 2013 – May 2016
A Study to Evaluate the Feasibility of Microdialysis to Determine Skin Concentrations of Retapamulin in Healthy Volunteers
Role: Principal Investigator
Funding: GLAXO SMITHKLINE
Jul 2007 – Aug 2016
Clinical and Translational Science Institute
Role: Project Manager
Funding: UF RESEARCH FOU

Patents

Issued June 2005
Microdialysis Probes and Methods of Use
#6,904,309

Teaching Profile

Courses Taught
2020-2021
PHA6418 Model-Informed Drug Development
2008-2018
PHA7980 Research for Doctoral Dissertation
2007-2018
PHA7979 Advanced Research
2006,2008-2010,2010-2014,2012-2017,2014-2018,2016-2018
PHA6125 Pharmacokinetics and Biopharmaceutics
2006-2016
PHA5128 Dose Optimization 2
2016
PHA4912 Undergraduate Research in Pharmaceutics
2014-2015
PHA6938 Research Seminar
2010-2014
PHA6971 Research for Master’s Thesis
2009-2010,2012-2013
PHA5905 Clin Pharm Research
2011
PHA6935 Sel Topics Pharmacy
2009-2010
PHA4905 Prob in Pharmaceutics
2010
IDH4917 Undergrad Research
2006-2007
PHA5121 Adv Clin Pharmacokin

Contact Details

Phones:
Business:
(352) 273-7856
Emails: