Hartmut Derendorf, Ph.D.
Distinguished Professor Emeritus (Deceased)
About Hartmut Derendorf
Hartmut Derendorf is a distinguished professor emeritus of pharmaceutics at the University of Florida College of Pharmacy in Gainesville. He received his B.S. (1976) and Ph.D. (1979, summa cum laude) in Pharmacy from the University of Münster, Germany and then joined the University of Florida, first as a Postdoctoral Fellow (1981/82) and later (1983) as a faculty member. He has been teaching Biopharmaceutics, Pharmacokinetics and Clinical Pharmacokinetics. He was awarded numerous teaching awards such as the UF Teaching Improvement Award, HHMI Distinguished Mentorship Award, UF Research Foundation Professorship, CVS Pharmacy Endowed Professorship, International Educator of the Year Award and UF Doctoral Advisor/Mentoring Award. He has supervised over 50 Ph.D. students.
Prof. Derendorf has published over 500 scientific publications with an h-index (Scopus) of 60 and given over 900 presentations at national or international meetings. He has published ten textbooks in English and German. He is Editor or Associate Editor of the Journal of Clinical Pharmacology, International Journal of Clinical Pharmacology & Therapeutics, International Journal of Antimicrobial Agents and Die Pharmazie, and serves on the Editorial Board of several other Journals. His research interests include the pharmacokinetics and pharmacodynamics of corticosteroids, analgesics, antibiotics as well as drug interactions.
Prof. Derendorf has served as President of ACCP (American College of Clinical Pharmacology) in 2006/08 and President of ISAP (International Society of Antiinfective Pharmacology) in 2004/06. He won the McKeen-Cattell Award for the best publication in J. Clin. Pharmacology (1994) and the Faculty Award of the University of Utrecht (2005). In 2003, he was awarded the Nathaniel T. Kwit Distinguished Service Award of ACCP and the Research Achievement Award in Clinical Science of the American Association of Pharmaceutical Sciences (AAPS). He is a Fellow of AAPS and ACCP as well as a former review panel member of the NASA Human Research Program. In 2010, he was awarded the Volwiler Award of the American Association of Colleges of Pharmacy (AACP) as well as the ACCP Distinguished Investigator Award, the highest research awards of both organizations. In 2013, he was awarded the First Leadership Award of the International Society of Pharmacometrics (ISOP). In 2015 he received the Merit Medal of the Westphalian Chamber of Pharmacy as well as the ACCP Mentorship Award. In 2018, he was awarded the ASCPT Mentor Award and the UF Doctoral Advisor/Mentoring Award. Furthermore, he held the Gerhard Levy Distinguished Lectureship at the University of Buffalo (2019) and received the Barré Prize of the University of Montreal (2020). He also served as the 18th University of Florida Distinguished Alumni Professor.
Accomplishments
Barré Prize
2020
·
University of Montreal
Gerhard Levy Distinguished Lectureship
2019
·
University of Buffalo
Fellowship FISAC
2019
·
International Society of Antimicrobial Chemotherapy (ISAC)
Mentor Award
2018
·
American Society for Clinical Pharmacology and Therapeutics
Doctoral Advisor/Mentoring Award
2018
·
University of Florida
Mentorship Award
2015
·
American College of Clinical Pharmacy
Merit Medal
2015
·
Westphalian Chamber of Pharmacy
Leadership Award
2013
·
International Society of Pharmacometrics
Volwiler Award
2010
·
American Association of Colleges of Pharmacy
Distinguished Investigator Award
2010
·
American College of Clinical Pharmacy
Research Achievement Award in Clinical Science
2003
·
American Association of Pharmaceutical Scientists
Nathaniel T. Kwit Distinguished Service Award
2003
·
American College of Clinical Pharmacy
Fellowship FAAPS
1996
·
American Association of Pharmaceutical Scientists (AAPS)
Fellowship FCP
1988
·
American College of Clinical Pharmacology (ACCP)
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0003-4016-1370
Publications
2021
Model-Informed Drug Development for Anti-Infectives: State of the Art and Future.
Clinical pharmacology and therapeutics.
[DOI] 10.1002/cpt.2198.
[PMID] 33555032.
2021
Tobacco smoke exposure enhances reward sensitivity in male and female rats.
Psychopharmacology.
[DOI] 10.1007/s00213-020-05736-0.
[PMID] 33410984.
2021
Science and Evidence-Based Review and Approval of COVID-19 Vaccines: A Statement of Support for the US FDA.
Journal of clinical pharmacology.
61(3):277-279
[DOI] 10.1002/jcph.1794.
[PMID] 33274473.
2020
Carvacrol loaded nanostructured lipid carriers as a promising parenteral formulation for leishmaniasis treatment.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
150
[DOI] 10.1016/j.ejps.2020.105335.
[PMID] 32272211.
2020
Evaluation of the Effects of Maytenus ilicifolia on the Activities of Cytochrome P450 3A and P-glycoprotein.
Current drug metabolism.
21(4):281-290
[DOI] 10.2174/1389200221666200512112718.
[PMID] 32394829.
2020
Excessive lysosomal ion-trapping of hydroxychloroquine and azithromycin.
International journal of antimicrobial agents.
55(6)
[DOI] 10.1016/j.ijantimicag.2020.106007.
[PMID] 32389720.
2020
One Giant Leap for Pharmacology.
Pharmaceutical research.
37(3)
[DOI] 10.1007/s11095-020-02788-x.
[PMID] 32124057.
2020
Roger W. Jelliffe, M.D. (1929-2020).
Clinical pharmacokinetics.
59(9)
[DOI] 10.1007/s40262-020-00928-5.
[PMID] 32789605.
2020
Calculated initial parenteral treatment of bacterial infections: Pharmacokinetics and pharmacodynamics.
GMS infectious diseases.
8
[DOI] 10.3205/id000061.
[PMID] 32373442.
2019
Pharmacokinetics of Oxytetracycline in the Giant Danio (Devario Aequipinnatus) Following Bath Immersion
Aquaculture.
498:12-16
[DOI] 10.1016/j.aquaculture.2018.08.027.
View on:
Publisher’s Site
2019
Pharmacokinetic and Pharmacodynamic Characterization of Tetrahydrocannabinol-Induced Cannabinoid Dependence After Chronic Passive Cannabis Smoke Exposure in Rats.
Cannabis and cannabinoid research.
4(4):240-254
[DOI] 10.1089/can.2019.0049.
[PMID] 32042924.
2019
Medications in Space: In Search of a Pharmacologist’s Guide to the Galaxy.
Pharmaceutical research.
36(10)
[DOI] 10.1007/s11095-019-2679-3.
[PMID] 31414302.
2019
Impact of Ethnicity-Specific Hepatic Microsomal Scaling Factor, Liver Weight, and Cytochrome P450 (CYP) 1A2 Content on Physiologically Based Prediction of CYP1A2-Mediated Pharmacokinetics in Young and Elderly Chinese Adults.
Clinical pharmacokinetics.
58(7):927-941
[DOI] 10.1007/s40262-019-00737-5.
[PMID] 30767128.
2019
Drug-Drug Interactions: Progress Over the Past Decade and Looking Ahead to the Future.
Clinical pharmacology and therapeutics.
105(6):1289-1291
[DOI] 10.1002/cpt.1410.
[PMID] 30977519.
2019
Gastric-acid-mediated drug-drug interactions with direct-acting antiviral medications for hepatitis C virus infection: clinical relevance and mitigation strategies.
Drug discovery today.
24(3):845-857
[DOI] 10.1016/j.drudis.2019.01.003.
[PMID] 30648608.
2019
Development of apratoxin S10 (Apra S10) as an anti-pancreatic cancer agent and its preliminary evaluation in an orthotopic patient-derived xenograft (PDX) model.
Investigational new drugs.
37(2):364-374
[DOI] 10.1007/s10637-018-0647-0.
[PMID] 30073464.
2019
Development and Validation of a Sensitive UFLC-MS/MS Method for Quantification of Quercitrin in Plasma: Application to a Tissue Distribution Study
ACS Omega.
4(2):3527-3533
[DOI] 10.1021/acsomega.8b03154.
View on:
Publisher’s Site
2019
Determination of Dermal Pharmacokinetics by Microdialysis Sampling in Rats.
Current protocols in pharmacology.
85(1)
[DOI] 10.1002/cpph.58.
[PMID] 31026128.
2019
Clinical Pharmacokinetics and Pharmacodynamics of Ceftazidime-Avibactam Combination: A Model-Informed Strategy for its Clinical Development.
Clinical pharmacokinetics.
58(5):545-564
[DOI] 10.1007/s40262-018-0705-y.
[PMID] 30097887.
2019
Bioanalytical method development and validation for determination of fibroblast growth factor peptide and its application to pharmacokinetic studies.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
135:83-93
[DOI] 10.1016/j.ejpb.2018.12.011.
[PMID] 30582960.
2019
Dose optimization of moxifloxacin and linezolid against tuberculosis using mathematical modeling and simulation.
International journal of antimicrobial agents.
53(3):275-283
[DOI] 10.1016/j.ijantimicag.2018.10.012.
[PMID] 30385322.
2018
Mycobacterium tuberculosis Strains H37ra and H37rv have equivalent minimum inhibitory concentrations to most antituberculosis drugs.
International journal of mycobacteriology.
7(2):156-161
[DOI] 10.4103/ijmy.ijmy_33_18.
[PMID] 29900893.
2018
Simultaneous Retrodialysis by Calibrator for Rapid In Vivo Recovery Determination in Target Site Microdialysis.
Journal of pharmaceutical sciences.
107(8):2259-2265
[DOI] 10.1016/j.xphs.2018.04.021.
[PMID] 29715477.
2018
Simultaneous quantification of cannabinoids tetrahydrocannabinol, cannabidiol and CB1 receptor antagonist in rat plasma: An application to characterize pharmacokinetics after passive cannabis smoke inhalation and co-administration of rimonabant.
Journal of pharmaceutical and biomedical analysis.
160:119-125
[DOI] 10.1016/j.jpba.2018.07.004.
[PMID] 30077950.
2018
Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice.
Diabetes.
67(9):1867-1879
[DOI] 10.2337/db18-0158.
[PMID] 29712667.
2018
Quantitative determination of armodafinil in human plasma by liquid chromatography-electrospray mass spectrometry: Application to a clinical study.
Biomedical chromatography : BMC.
32(11)
[DOI] 10.1002/bmc.4342.
[PMID] 30003558.
2018
Nonlinear Protein Binding: Not What You Think.
Journal of pharmaceutical sciences.
107(7):1754-1760
[DOI] 10.1016/j.xphs.2018.03.023.
[PMID] 29626534.
2018
Mycobacterium Tuberculosis Strains H37Ra and H37Rv Have Equivalent Minimum Inhibitory Concentrations to Most Antituberculosis Drugs
International Journal of Mycobacteriology.
7(2):156-161
[DOI] 10.4103/ijmy.ijmy\_33\_18.
View on:
Publisher’s Site
2018
Quantitative Estimation of Plasma Free Drug Fraction in Patients With Varying Degrees of Hepatic Impairment: A Methodological Evaluation.
Journal of pharmaceutical sciences.
107(7):1948-1956
[DOI] 10.1016/j.xphs.2018.02.021.
[PMID] 29518400.
2018
Enhanced in vitro activity of tigecycline in the presence of chelating agents.
International journal of antimicrobial agents.
51(5):799-802
[DOI] 10.1016/j.ijantimicag.2017.12.027.
[PMID] 29305959.
2018
Development of clinical pharmacy services in Australia, Austria, Belgium, Bosnia-Herzegovina, Canada, Germany, Japan, Kosovo, Switzerland, the Netherlands, Thailand, USA and correlation with educational standards, level of research, and implemen.
International journal of clinical pharmacology and therapeutics.
56(11):518-530
[DOI] 10.5414/CP203264.
[PMID] 30106363.
2018
A comparison of linezolid lung tissue concentrations among patients with drug-resistant tuberculosis.
The European respiratory journal.
51(2)
[DOI] 10.1183/13993003.02166-2017.
[PMID] 29437945.
2018
Dermal pharmacokinetics of pyrazinamide determined by microdialysis sampling in rats.
International journal of antimicrobial agents.
51(2):190-196
[DOI] 10.1016/j.ijantimicag.2017.10.001.
[PMID] 29032112.
2018
Core Entrustable Professional Activities in Clinical Pharmacology: Pearls for Clinical Practice: Drug-Drug and Food-Drug Interactions.
Journal of clinical pharmacology.
58(6):704-716
[DOI] 10.1002/jcph.1088.
[PMID] 29513896.
2018
A mathematical model-based analysis of the time-kill kinetics of ceftazidime/avibactam against Pseudomonas aeruginosa.
The Journal of antimicrobial chemotherapy.
73(5):1295-1304
[DOI] 10.1093/jac/dkx537.
[PMID] 29415212.
2018
Moxifloxacin target site concentrations in patients with pulmonary TB utilizing microdialysis: a clinical pharmacokinetic study.
The Journal of antimicrobial chemotherapy.
73(2):477-483
[DOI] 10.1093/jac/dkx421.
[PMID] 29186509.
2017
Utility of Microdialysis in Infectious Disease Drug Development and Dose Optimization.
The AAPS journal.
19(2):334-342
[DOI] 10.1208/s12248-016-0020-1.
[PMID] 27943149.
2017
Tissue Distribution of a Therapeutic Monoclonal Antibody Determined by Large Pore Microdialysis.
Journal of pharmaceutical sciences.
106(9):2853-2859
[DOI] 10.1016/j.xphs.2017.03.033.
[PMID] 28414146.
2017
Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist.
Journal of pharmaceutical sciences.
106(9):2188-2194
[DOI] 10.1016/j.xphs.2017.04.072.
[PMID] 28479350.
2017
Prediction of in Vivo and in Vitro Infection Model Results Using a Semimechanistic Model of Avibactam and Aztreonam Combination Against Multidrug Resistant Organisms
CPT: pharmacometrics & systems pharmacology.
6(3):197-207
[DOI] 10.1002/psp4.12159.
[PMID] 28145085.
2017
Potentiation of ceftazidime by avibactam against β-lactam-resistant Pseudomonas aeruginosa in an in vitro infection model.
The Journal of antimicrobial chemotherapy.
72(4):1109-1117
[DOI] 10.1093/jac/dkw535.
[PMID] 28077672.
2017
Lung Tissue Concentrations of Pyrazinamide among Patients with Drug-Resistant Pulmonary Tuberculosis.
Antimicrobial agents and chemotherapy.
61(6)
[DOI] 10.1128/AAC.00226-17.
[PMID] 28373198.
2017
Drugs in space: Pharmacokinetics and pharmacodynamics in astronauts.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
109S:S2-S8
[DOI] 10.1016/j.ejps.2017.05.025.
[PMID] 28533143.
2017
A need to revisit clinical breakpoints of tigecycline: effect of atypical non-linear plasma protein binding.
International journal of antimicrobial agents.
49(4):449-455
[DOI] 10.1016/j.ijantimicag.2016.12.008.
[PMID] 28237830.
2016
Role of Divalent Metal Ions in Atypical Nonlinear Plasma Protein Binding Behavior of Tigecycline.
Journal of pharmaceutical sciences.
105(11):3409-3414
[DOI] 10.1016/j.xphs.2016.07.013.
[PMID] 27616672.
2016
Race-Specific Pharmacodynamic Model of Propofol-Induced Loss of Consciousness.
Journal of clinical pharmacology.
56(9):1141-50
[DOI] 10.1002/jcph.716.
[PMID] 26865382.
2016
Pharmacokinetics and pharmacodynamics in antibiotic dose optimization.
Expert opinion on drug metabolism & toxicology.
12(1):93-114
[DOI] 10.1517/17425255.2016.1123250.
[PMID] 26652832.
2016
Microdialysis of Large Molecules.
Journal of pharmaceutical sciences.
105(11):3233-3242
[DOI] 10.1016/j.xphs.2016.08.016.
[PMID] 27671236.
2016
Ceftobiprole medocaril (BAL-5788) for the treatment of complicated skin infections.
Expert review of anti-infective therapy.
14(11):997-1006
[PMID] 27690689.
View on:
PubMed
2016
Gentamicin dosing strategy in patients with end-stage renal disease receiving haemodialysis: evaluation using a semi-mechanistic pharmacokinetic/pharmacodynamic model.
The Journal of antimicrobial chemotherapy.
71(4):1012-21
[DOI] 10.1093/jac/dkv428.
[PMID] 26702923.
2016
Ciclesonide: A Pro-Soft Drug Approach for Mitigation of Side Effects of Inhaled Corticosteroids.
Journal of pharmaceutical sciences.
105(9):2509-2514
[DOI] 10.1016/j.xphs.2016.05.004.
[PMID] 27339407.
2016
A Tribute to Dr. Marcus E. Brewster: October 14, 1957-September 15, 2014.
Journal of pharmaceutical sciences.
105(9):2466-2467
[DOI] 10.1016/j.xphs.2016.02.001.
[PMID] 27012223.
2016
In vitro pharmacokinetics/pharmacodynamics of the combination of avibactam and aztreonam against MDR organisms.
The Journal of antimicrobial chemotherapy.
71(7):1866-80
[DOI] 10.1093/jac/dkw082.
[PMID] 27107096.
2015
Exploring in Vitro Antipseudomonal Activity of Synergistic Tigecycline-Tetracycline Combinations.
Clinical Pharmacology & Therapeutics.
97(1)
2015
Simultaneous Characterization of Intravenous and Oral Pharmacokinetics of Lychnopholide in Rats by Transit Compartment Model.
Planta medica.
81(12-13):1121-7
[DOI] 10.1055/s-0035-1546214.
[PMID] 26218336.
2015
Quantitation of the impact of CYP3A5 A6986G polymorphism on quetiapine pharmacokinetics by simulation of target attainment.
Clinical pharmacology in drug development.
4(5):387-94
[DOI] 10.1002/cpdd.172.
[PMID] 27137148.
2015
Pharmacokinetic evaluation of avicularin using a model-based development approach.
Planta medica.
81(5):373-81
[DOI] 10.1055/s-0035-1545728.
[PMID] 25782034.
2015
Pharmacokinetic and pharmacodynamic implications in inhalable antimicrobial therapy.
Advanced drug delivery reviews.
85:57-64
[DOI] 10.1016/j.addr.2015.03.002.
[PMID] 25770775.
2015
In memoriam: William A. Craig.
Antimicrobial agents and chemotherapy.
59(6)
[DOI] 10.1128/AAC.00849-15.
[PMID] 25896702.
2015
Evaluation of in vitro synergy between vertilmicin and ceftazidime against Pseudomonas aeruginosa using a semi-mechanistic pharmacokinetic/pharmacodynamic model.
International journal of antimicrobial agents.
45(2):151-60
[DOI] 10.1016/j.ijantimicag.2014.09.017.
[PMID] 25465523.
2015
Theory and Application of Microdialysis in Pharmacokinetic Studies.
Current drug metabolism.
16(10):919-31
[PMID] 26264199.
View on:
PubMed
2015
Effect of reducing the paediatric stavudine dose by half: a physiologically-based pharmacokinetic model.
International journal of antimicrobial agents.
45(4):413-9
[DOI] 10.1016/j.ijantimicag.2014.12.016.
[PMID] 25697412.
2015
Does the Anesthetic Urethane Influence the Pharmacokinetics of Antifungal Drugs? A Population Pharmacokinetic Investigation in Rats.
Journal of pharmaceutical sciences.
104(10):3314-8
[DOI] 10.1002/jps.24552.
[PMID] 26087701.
2015
Development and validation of a HPLC-MS/MS method for the determination of phytolaccagenin in rat plasma and application to a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
107:82-8
[DOI] 10.1016/j.jpba.2014.12.025.
[PMID] 25575173.
2015
Concentration-response studies and modelling of the pharmacodynamics of linezolid: Staphylococcus aureus versus Enterococcus faecium.
International journal of antimicrobial agents.
45(1):54-60
[DOI] 10.1016/j.ijantimicag.2014.07.028.
[PMID] 25455852.
2015
Concentration-Response Studies and Modelling of the Pharmacodynamics of Linezolid: Staphylococcus Aureus Versus Enterococcus Faecium
International Journal of Antimicrobial Agents.
45(1):54-60
[DOI] 10.1016/j.ijantimicag.2014.10.07.028.
View on:
Publisher’s Site
2015
Enzyme- and transporter-mediated beverage-drug interactions: An update on fruit juices and green tea.
Journal of clinical pharmacology.
55(12):1313-31
[DOI] 10.1002/jcph.563.
[PMID] 26095990.
2015
Cavitary penetration of levofloxacin among patients with multidrug-resistant tuberculosis.
Antimicrobial agents and chemotherapy.
59(6):3149-55
[DOI] 10.1128/AAC.00379-15.
[PMID] 25779583.
2014
Role of microdialysis in pharmacokinetics and pharmacodynamics: current status and future directions.
Clinical pharmacokinetics.
53(3):205-212
[DOI] 10.1007/s40262-014-0131-8.
[PMID] 24452811.
2014
Relevance of Liver Failure for Anti-Infective Agents: From Pharmacokinetic Alterations to Dosage Adjustments.
Therapeutic advances in infectious disease.
2(1):17-42
[PMID] 24949199.
View on:
PubMed
2014
Protein binding of rifapentine and its 25-desacetyl metabolite in patients with pulmonary tuberculosis.
Antimicrobial agents and chemotherapy.
58(8):4904-10
[DOI] 10.1128/AAC.01730-13.
[PMID] 24841270.
2014
Predicting pediatric age-matched weight and body mass index.
The AAPS journal.
16(6):1372-9
[DOI] 10.1208/s12248-014-9657-9.
[PMID] 25155824.
2014
Population pharmacokinetics of cilengitide in adult and pediatric cancer patients from a nonlinear mixed-effects analysis.
Journal of clinical pharmacology.
54(12):1391-9
[DOI] 10.1002/jcph.343.
[PMID] 24911832.
2014
Population pharmacokinetic modeling of the unbound levofloxacin concentrations in rat plasma and prostate tissue measured by microdialysis.
Antimicrobial agents and chemotherapy.
58(2):678-86
[DOI] 10.1128/AAC.01884-13.
[PMID] 24217697.
2014
Pharmacokinetics of para-aminosalicylic acid in HIV-uninfected and HIV-coinfected tuberculosis patients receiving antiretroviral therapy, managed for multidrug-resistant and extensively drug-resistant tuberculosis.
Antimicrobial agents and chemotherapy.
58(10):6242-50
[DOI] 10.1128/AAC.03073-14.
[PMID] 25114132.
2014
Monte Carlo Simulation To Determine the Effect of Atypical Nonlinear Plasma Protein Binding On Clinical Breakpoint of Tigecycline
Clinical Pharmacology & Therapeutics.
95(1)
2014
Comparison of skin permeability for three diclofenac topical formulations: an in vitro study.
Die Pharmazie.
69(1):27-31
[PMID] 24601219.
View on:
PubMed
2014
Measuring drug distribution in the critically ill patient.
Advanced drug delivery reviews.
77:22-6
[DOI] 10.1016/j.addr.2014.08.014.
[PMID] 25194997.
2014
Largazole pharmacokinetics in rats by LC-MS/MS.
Marine drugs.
12(3):1623-40
[DOI] 10.3390/md12031623.
[PMID] 24658499.
2014
Estimation of intracellular concentration of stavudine triphosphate in HIV-infected children given a reduced dose of 0.5 milligrams per kilogram twice daily.
Antimicrobial agents and chemotherapy.
58(2):1084-91
[DOI] 10.1128/AAC.01717-13.
[PMID] 24295968.
2014
Enhanced penetration of moxifloxacin into rat prostate tissue evidenced by microdialysis.
International journal of antimicrobial agents.
44(4):327-33
[DOI] 10.1016/j.ijantimicag.2014.06.011.
[PMID] 25218157.
2014
Determination of atypical nonlinear plasma−protein-binding behavior of tigecycline using an in vitro microdialysis technique.
Journal of pharmaceutical sciences.
103(3):1013-9
[DOI] 10.1002/jps.23872.
[PMID] 24549736.
2014
Application of pharmacokinetic/pharmacodynamic modelling and simulation for the prediction of target attainment of ceftobiprole against meticillin-resistant Staphylococcus aureus using minimum inhibitory concentration and time-kill curve based approaches.
International journal of antimicrobial agents.
43(1):60-7
[DOI] 10.1016/j.ijantimicag.2013.08.016.
[PMID] 24183800.
2014
Metal Ion Chelation By Tigecycline Explains Atypical Nonlinear Plasma Protein Binding Behavior
Clinical Pharmacology & Therapeutics.
95(1)
2013
Vancomycin (Van) Administered By Continuous Infusion (Ci) Should Be Dosed According To Clearance (Cl) and Not Based On the Patient’s Body Weight
International Journal of Antimicrobial Agents.
42
2013
The Report of the 2012-2013 Research and Graduate Affairs Committee
American Journal of Pharmaceutical Education.
77
2013
Sex related differences on valproic acid pharmacokinetics after oral single dose.
Journal of pharmacokinetics and pharmacodynamics.
40(4):479-86
[DOI] 10.1007/s10928-013-9323-3.
[PMID] 23784346.
2013
Pharmacokinetics of modified-release prednisone tablets in healthy subjects and patients with rheumatoid arthritis.
Journal of clinical pharmacology.
53(3):326-33
[DOI] 10.1177/0091270012444315.
[PMID] 23444285.
2013
Pharmacokinetics and pharmacodynamics of ponesimod, a selective S1P1 receptor modulator, in the first-in-human study.
British journal of clinical pharmacology.
76(6):888-96
[DOI] 10.1111/bcp.12129.
[PMID] 23594176.
2013
Pharmacokinetic properties of pure xanthones in comparison to a mangosteen fruit extract in rats.
Planta medica.
79(8):646-53
[DOI] 10.1055/s-0032-1328543.
[PMID] 23673465.
2013
Oral adherence monitoring using a breath test to supplement highly active antiretroviral therapy.
AIDS and behavior.
17(1):298-306
[DOI] 10.1007/s10461-012-0318-7.
[PMID] 23001413.
2013
When is protein binding important?
Journal of pharmaceutical sciences.
102(9):3458-67
[DOI] 10.1002/jps.23559.
[PMID] 23650013.
2013
Importance of relating efficacy measures to unbound drug concentrations for anti-infective agents.
Clinical microbiology reviews.
26(2):274-88
[DOI] 10.1128/CMR.00092-12.
[PMID] 23554417.
2013
Grapefruit-medication interactions.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.
185(6)
[DOI] 10.1503/cmaj.113-2109.
[PMID] 23550054.
2013
Feasibility of a breath test for monitoring adherence to vaginal administration of antiretroviral microbicide gels.
Journal of clinical pharmacology.
53(1):103-11
[DOI] 10.1177/0091270011434157.
[PMID] 23400750.
2013
Electroencephalogram effects of armodafinil: comparison with behavioral alertness.
Journal of clinical pharmacology.
53(10):1058-71
[DOI] 10.1002/jcph.143.
[PMID] 23913585.
2013
A novel breath test to directly measure use of vaginal gel and condoms.
AIDS and behavior.
17(6):2211-21
[DOI] 10.1007/s10461-012-0390-z.
[PMID] 23321948.
2013
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The Pharmacokinetic Properties of Pure Gamma-Mangostin in Rats in Comparison To Mangosteen Extract
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Skin and soft tissue concentrations of tedizolid (formerly torezolid), a novel oxazolidinone, following a single oral dose in healthy volunteers.
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Population Pharmacokinetics of Steady-State Carbamazepine in Egyptian Epilepsy Patients
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Pharmacokinetic-Pharmacodynamic Modeling of Armodafinil: Effects On Alertness and Electroen-Cephalogram of Sleep Deprived Adults
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Pharmacokinetic Analysis of Two Flavorants Used in a Novel Breath-Based System (Smart (Tm)) Designed To Assess Use of Vaginally Applied Products.
Clinical Pharmacology & Therapeutics.
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Ascending Single-Dose Study With Ponesimod, a Selective Sip1 Receptor Agonist: Safety, Pharmacokinetics, Pharmacodynamics, and Modeling.
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Bioavailability and disposition of azelastine and fluticasone propionate when delivered by MP29-02, a novel aqueous nasal spray.
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Modeling of Investigative Static Global Assessment Score (Isga) in Acne Vulgaris.
Clinical Pharmacology & Therapeutics.
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Disease Progression Modeling of Inflammatory Lesion Counts (Les) in Acne Vulgaris.
Clinical Pharmacology & Therapeutics.
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2011
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2011
Repeated pre-exposure to tobacco smoke potentiates subsequent locomotor responses to nicotine and tobacco smoke but not amphetamine in adult rats.
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Population Pharmacokinetics of Methotrexate in Egyptian Children With Lymphoblastic Leukemia
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HPLC method validation for the quantification of lomustine to study pharmacokinetics of thermosensitive liposome-encapsulated lomustine containing iohexol for CT imaging in C6 glioma rats.
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Fixed Dosing Versus Body Size-Based Dosing of Anticancer Drugs in Adults: a Population Pharmacokinetic Approach
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Development and validation of a LC-MS/MS method based on a new 96-well Hybrid-SPE™-precipitation technique for quantification of CYP450 substrates/metabolites in rat plasma.
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Clinical pharmacokinetics of meropenem and biapenem in bile and dosing considerations for biliary tract infections based on site-specific pharmacodynamic target attainment.
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Pharmacokinetics of Intranasal Scopolamine Gel Formulation During Antiorthostatic Bedrest – a Microgravity Analog
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Pharmacokinetics of Cefpodoxime in Plasma and Subcutaneous Fluid Following Oral Administration of Cefpodoxime Proxetil in Male Beagle Dogs
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Pharmacokinetic/Pharmacodynamic Model-Based Combination Therapy Approach To Target Antibiotic Resistant Populations Emerged From Ciprofloxacin Exposure
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Modeling of Target Lesion Scores Over Time in a Psoriasis Microplaque Assay.
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Pharmacometrics as a discipline is entering the “industrialization” phase: standards, automation, knowledge sharing, and training are critical for future success.
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Toxicological and Pharmacokinetic Evaluation of Concomitant Intake of Grapefruit Juice and Simvastatin in Rats after Repeated Treatment over 28 Days.
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Preliminary Evaluation of Gc-Ms for the Determination of Terpinen-4-Ol in Cutaneous Microdialysis Samples
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Pharmacokinetics and tissue distribution of dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides after oral administration in rats.
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Pharmacokinetic-pharmacodynamic modeling of the in vitro activities of oxazolidinone antimicrobial agents against methicillin-resistant Staphylococcus aureus.
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Pk/Pd Studies Focusing On Physical Dependence of Fentanyl in Rats
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Influence of the Duffy Antigen On Pharmacokinetics and Pharmacodynamics of Recombinant Monocyte Chemoattractant Protein (Mcp-1, Ccl-2) in Vivo
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Effects of Plasma Protein Binding On Half-Life of Elimination
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Cortisol suppression as a surrogate marker for inhaled corticosteroid-induced growth retardation in children.
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Estimation of Lithium Clearance From Routine Clinical Data in Egyptian Bipolar Patients. a Population Pharmacokinetic Approach
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Anesthesia in Space – Pk/Pd Modeling of Propofol in Simulated Microgravity
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Measurement of voriconazole activity against Candida albicans, C. glabrata, and C. parapsilosis isolates using time-kill methods validated by high-performance liquid chromatography.
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Characterizing the effects of caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata isolates by simultaneous time-kill and postantifungal-effect experiments.
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PubMed
2006
Moxifloxacin distribution in the interstitial space of infected decubitus ulcer tissue of patients with spinal cord injury measured by in vivo microdialysis.
Scandinavian journal of infectious diseases.
38(10):904-8
[PMID] 17008236.
View on:
PubMed
2005
Pharmacokinetic/pharmacodynamic evaluation of anti-infective agents.
Expert review of anti-infective therapy.
3(3):361-73
[PMID] 15954853.
View on:
PubMed
2005
What is the best marker for inhaled corticosteroid safety?
Allergy and asthma proceedings.
26(2):89-93
[PMID] 15971465.
View on:
PubMed
2005
Tissue penetration of cefpodoxime and cefixime in healthy subjects.
Journal of clinical pharmacology.
45(5):564-9
[PMID] 15831780.
View on:
PubMed
2005
Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update.
The Journal of antimicrobial chemotherapy.
55(5):601-7
[PMID] 15772142.
View on:
PubMed
2005
Population pharmacokinetics of eniporide and its metabolite in healthy subjects and patients with acute myocardial infarction.
Journal of clinical pharmacology.
45(6):631-9
[PMID] 15901744.
View on:
PubMed
2005
Pharmacokinetics of piperacillin-tazobactam: intermittent dosing versus continuous infusion.
International journal of antimicrobial agents.
25(1):62-7
[PMID] 15620828.
View on:
PubMed
2005
Pharmacokinetic-pharmacodynamic modelling of antibacterial activity of cefpodoxime and cefixime in in vitro kinetic models.
International journal of antimicrobial agents.
25(2):120-9
[PMID] 15664481.
View on:
PubMed
2005
Tissue penetration of cefpodoxime into the skeletal muscle and lung in rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
25(4-5):439-44
[PMID] 15905079.
View on:
PubMed
2005
Microdialysis for in vivo pharmacokinetic/pharmacodynamic characterization of anti-infective drugs.
Current opinion in pharmacology.
5(5):495-9
[PMID] 16084767.
View on:
PubMed
2005
Application of two-point assay of digoxin serum concentration in studying population pharmacokinetics in Egyptian pediatric patients with heart failure: does it make sense?
American journal of therapeutics.
12(4):320-7
[PMID] 16041195.
View on:
PubMed
2005
Comparative pharmacology, bioavailability, pharmacokinetics, and pharmacodynamics of inhaled glucocorticosteroids.
Immunology and allergy clinics of North America.
25(3):469-88
[PMID] 16054538.
View on:
PubMed
2005
Corticosteroid pharmacokinetic/pharmacodynamic parameters and their relationship to safety and efficacy.
Allergy and asthma proceedings.
26(5):327-35
[PMID] 16450564.
View on:
PubMed
2005
Penetration of ertapenem into different pulmonary compartments of patients undergoing lung surgery.
Journal of clinical pharmacology.
45(6):659-65
[PMID] 15901747.
View on:
PubMed
2005
Effect of simulated microgravity on the disposition and tissue penetration of ciprofloxacin in healthy volunteers.
Journal of clinical pharmacology.
45(7):822-31
[PMID] 15951472.
View on:
PubMed
2005
Dipyridamole bioavailability in subjects with reduced gastric acidity.
Journal of clinical pharmacology.
45(7):845-50
[PMID] 15951475.
View on:
PubMed
2004
Differences in drug pharmacokinetics between East Asians and Caucasians and the role of genetic polymorphisms.
Journal of clinical pharmacology.
44(10):1083-105
[PMID] 15342610.
View on:
PubMed
2004
How the lung handles drugs: pharmacokinetics and pharmacodynamics of inhaled corticosteroids.
Proceedings of the American Thoracic Society.
1(4):356-63
[PMID] 16113458.
View on:
PubMed
2004
In vitro microdialysis sampling of docetaxel.
Journal of pharmaceutical and biomedical analysis.
36(4):807-13
[PMID] 15533674.
View on:
PubMed
2004
Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: distribution in tissue.
Antimicrobial agents and chemotherapy.
48(5):1441-53
[PMID] 15105091.
View on:
PubMed
2004
Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: kill curves versus MIC.
Antimicrobial agents and chemotherapy.
48(2):369-77
[PMID] 14742182.
View on:
PubMed
2004
Pharmacokinetic herb-drug interactions: are preventive screenings necessary and appropriate?
Planta medica.
70(9):784-91
[PMID] 15386186.
View on:
PubMed
2004
Physiological, pharmacokinetic, and pharmacodynamic changes in space.
Journal of clinical pharmacology.
44(8):837-53
[PMID] 15286087.
View on:
PubMed
2004
PK-PD modelling of the effect of cefaclor on four different bacterial strains.
International journal of antimicrobial agents.
23(3):218-25
[PMID] 15164961.
View on:
PubMed
2004
Risk-benefit value of inhaled glucocorticoids: a pharmacokinetic/pharmacodynamic perspective.
Journal of clinical pharmacology.
44(1):37-47
[PMID] 14681340.
View on:
PubMed
2004
Intranasal loteprednol etabonate in healthy male subjects: pharmacokinetics and effects on endogenous cortisol.
Journal of clinical pharmacology.
44(5):510-9
[PMID] 15102872.
View on:
PubMed
2003
Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children.
Journal of clinical pharmacology.
43(4):386-96
[PMID] 12723459.
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PubMed
2003
Single- and multiple-dose pharmacokinetics of oral creatine.
Journal of clinical pharmacology.
43(1):29-37
[PMID] 12520625.
View on:
PubMed
2003
Risk-benefit value of inhaled corticosteroids: a pharmacokinetic/pharmacodynamic perspective.
Chest.
123(3 Suppl):430S-1S
[PMID] 12629020.
View on:
PubMed
2003
Pharmacokinetic/pharmacodynamic modeling of luteinizing hormone (LH) suppression and LH surge delay by cetrorelix after single and multiple doses in healthy premenopausal women.
Journal of clinical pharmacology.
43(3):243-51
[PMID] 12638392.
View on:
PubMed
2003
Inhaled corticosteroids: past lessons and future issues.
The Journal of allergy and clinical immunology.
112(3 Suppl):S1-40
[PMID] 14515117.
View on:
PubMed
2003
Antimicrobial tissue concentrations.
Infectious disease clinics of North America.
17(3):599-613
[PMID] 14711079.
View on:
PubMed
2003
Microdialysis of triamcinolone acetonide in rat muscle.
Journal of pharmaceutical sciences.
92(2):394-7
[PMID] 12532388.
View on:
PubMed
2002
Systemic availability and pharmacokinetics of thymol in humans.
Journal of clinical pharmacology.
42(7):731-7
[PMID] 12092740.
View on:
PubMed
2002
Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs.
International journal of antimicrobial agents.
19(4):355-8
[PMID] 11978507.
View on:
PubMed
2002
Rational dosing of antibiotics: the use of plasma concentrations versus tissue concentrations.
International journal of antimicrobial agents.
19(4):285-90
[PMID] 11978499.
View on:
PubMed
2002
Pharmacokinetics and bioavailability of herbal medicinal products.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
9 Suppl 3:1-33
[PMID] 12222652.
View on:
PubMed
2002
Pharmacokinetic/pharmacodynamic studies in drug product development.
Journal of pharmaceutical sciences.
91(1):18-31
[PMID] 11782894.
View on:
PubMed
2002
Population pharmacokinetics of digoxin in Egyptian pediatric patients: impact of one data point utilization.
American journal of therapeutics.
9(6):492-8
[PMID] 12424506.
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PubMed
2002
Interstitial tissue concentrations of cefpodoxime.
The Journal of antimicrobial chemotherapy.
50 Suppl:19-22
[PMID] 12077156.
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PubMed
2002
How important are gender differences in pharmacokinetics?
Clinical pharmacokinetics.
41(5):329-42
[PMID] 12036391.
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PubMed
2002
Comparative target site pharmacokinetics of immediate- and modified-release formulations of cefaclor in humans.
Journal of clinical pharmacology.
42(4):403-11
[PMID] 11936565.
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PubMed
2002
Bioavailability and metabolism of mometasone furoate: pharmacology versus methodology.
Journal of clinical pharmacology.
42(4):383-7
[PMID] 11936562.
View on:
PubMed
2002
Novel formulations of cetrorelix acetate in healthy men: pharmacodynamic effects and noncompartmental pharmacokinetics.
Journal of clinical pharmacology.
42(9):995-1001
[PMID] 12211225.
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PubMed
2001
Evaluation of pulmonary absorption using pharmacokinetic methods.
Journal of Aerosol Medicine.
14 Suppl 1:S9-17
[DOI] 10.1089/08942680150506295.
[PMID] 11424896.
2000
Optimized therapeutic ratio of inhaled corticosteroids using retrometabolism.
Die Pharmazie.
55(3):223-7
[PMID] 10756545.
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PubMed
1999
Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: concepts and perspectives.
Pharmaceutical research.
16(2):176-85
[PMID] 10100300.
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PubMed
1998
Influence of plasma expansion on plasma protein binding of ketorolac.
Journal of clinical anesthesia.
10(6):464-8
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PubMed
1990
Pharmacokinetics of amikacin in critically ill neonatal foals treated for presumed or confirmed sepsis.
Equine veterinary journal.
22(1):18-22
[PMID] 2298186.
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PubMed
Grants
Jul 2017
– Jun 2018
Clinical Pharmacokinetics/Dynamics Fellowship 2017-2018
Role: Principal Investigator
Funding: GLAXO SMITHKLINE
Mar 2017
– Dec 2017
Organize 11th Symposium on New Development in Clinical Pharmacy and Clinical Pharmacology
Role: Principal Investigator
Funding: BOEHRINGER INGELHEIM INTL GmbH
Feb 2017
– Feb 2021
FGF-P: A Multipotential Mitigation Agent for Gastrointestinal Syndrome
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jan 2017
– Jun 2017
Food-Drug Interactions
Role: Principal Investigator
Funding: FL DEPT OF CITRUS
Sep 2016
– Aug 2017
AFPE Fellowship: Investigating a Novel Anitmicrobial Combination: Tigecycline-Tetracycline again P. Aeruginosa
Role: Other
Funding: AMER FOU FOR PHARM EDU
Jul 2016
– Jan 2021
Tobacco: relationship between reduced nicotine content and reinforcement in rats
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDA
Jul 2016
– Dec 2016
Clinical Pharmacokinetic/Dynamics Fellowship
Role: Principal Investigator
Funding: GLAXO SMITHKLINE
Mar 2016
– Sep 2017
Inflight Pharmacokinetic and Pharmacodynamic Responses to Medications Commonly used in Spaceflight
Role: Principal Investigator
Funding: BAYLOR UNIV
via NASA
Feb 2016
– Jan 2018
A Clinical Pharmacology Study of a Novel Drug Regimen for Pre XDR and XDR Tuberculosis
Role: Project Manager
Funding: EMORY UNIV
via NATL INST OF HLTH NIAID
Aug 2015
– Jun 2016
Grapefruit-Drug Interaction
Role: Principal Investigator
Funding: GOLIN-HARRIS INTERNATIONAL INC
Aug 2015
– Dec 2020
CTSI Institutional Support
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Jul 2015
– Aug 2016
Clinical pharmacokinetics/dynamics fellowship
Role: Principal Investigator
Funding: GLAXO SMITHKLINE
Jul 2014
– Jun 2016
Master Fellowship Agreement – Clinical Pharmacokinetics/dynamics Fellowship
Role: Principal Investigator
Funding: GLAXO SMITHKLINE
Jul 2013
– Dec 2016
Center for Food-Drug Interaction
Role: Principal Investigator
Funding: FL DEPT OF CITRUS
May 2013
– May 2016
A Study to Evaluate the Feasibility of Microdialysis to Determine Skin Concentrations of Retapamulin in Healthy Volunteers
Role: Principal Investigator
Funding: GLAXO SMITHKLINE
Jul 2007
– Aug 2016
Clinical and Translational Science Institute
Role: Project Manager
Funding: UF RESEARCH FOU
Patents
Issued
June 2005
Microdialysis Probes and Methods of Use
#6,904,309
Teaching Profile
Courses Taught
2020-2021
PHA6418 Model-Informed Drug Development
2008-2018
PHA7980 Research for Doctoral Dissertation
2007-2018
PHA7979 Advanced Research
2006,2008-2010,2010-2014,2012-2017,2014-2018,2016-2018
PHA6125 Pharmacokinetics and Biopharmaceutics
2006-2016
PHA5128 Dose Optimization 2
2016
PHA4912 Undergraduate Research in Pharmaceutics
2014-2015
PHA6938 Research Seminar
2010-2014
PHA6971 Research for Master’s Thesis
2009-2010,2012-2013
PHA5905 Clin Pharm Research
2011
PHA6935 Sel Topics Pharmacy
2009-2010
PHA4905 Prob in Pharmaceutics
2010
IDH4917 Undergrad Research
2006-2007
PHA5121 Adv Clin Pharmacokin
Contact Details
Phones:
- Business:
- (352) 273-7856
Emails:
- Business:
- hartmut@cop.ufl.edu