Guillaume De Lartigue

Guillaume De Lartigue, Ph.D.

Assistant Professor

Department: Pharmacodynamics
Business Email: gdelartigue@cop.ufl.edu

About Guillaume De Lartigue

Dr. de Lartigue graduated with a BS (hons) in Medical Biochemistry from the University of London in 2002. He received a Wellcome Trust PhD studentship, and joined the lab Prof. Graham Dockray FRS at the University of Liverpool working on determining the mechanisms of vagal afferent gut-brain signaling in the regulation of food intake. He moved to the lab of Dr. Helen Raybould at UC Davis in 2009 where he demonstrated that gut-brain signaling is disrupted in response to chronic ingestion of calorie-rich diets, and that this disruption is sufficient for the development of obesity. In 2013, Dr. de Lartigue was awarded a NIH K99/R00 Pathways to Independence grant to develop novel techniques to better study gut-brain signaling and determine whether vagal afferent neurons could be targeted for the treatment of obesity. In 2015, Dr. de Lartigue was jointly appointed as an Assistant Fellow at the John B. Pierce Laboratory and Assistant Professor in Department of Cellular and Molecular Physiology at the Yale School of Medicine. Research in the de Lartigue lab focuses on defining the role of vagal afferent neurons in health and disease. He was recruited to the Department of Pharmacodynamics at the University of Florida in 2018.

Research Profile

The overarching focus of my lab revolves around the neurobiology of feeding. We are specifically interested in an understudied set of peripheral neurons that make up the sensory arm of the vagus nerve. These neurons form a direct anatomical link between the gut and the brain and provide a rapid neural mechanism for conveying information about the gastrointestinal environment to the brain. Although electrical stimulation of the vagus nerve is proving effective in treating a number of diseases, a lack of tools available to study the role of specific subsets of vagal neurons in physiological and disease states has led to an incomplete understanding of this pathway. We make use of molecular and genetic tools to target, image, and trace projections from subpopulations of sensory vagal neurons that innervate the gut to study the signals that active them and the circuits they recruit. In combination with behavioral, physiologic, and neurochemical techniques we study the role of vagal sensory neurons in the control feeding behaviors.

Ongoing projects in the lab include to 1) define the role of reversible, food‚Äźdependent, switching in the neurochemical phenotype of sensory vagal neurons, 2) identify mechanisms that cause disruption in gut-brain signaling during diet-induced obesity, and 3) uncover neural circuits that are recruited by vagal sensory neurons in response to metabolic signals from the gut.

Publications

2020
Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain.
Cell reports. 30(6):2028-2039.e4 [DOI] 10.1016/j.celrep.2020.01.045. [PMID] 32049029.
2020
tVNS Increases Liking of Orally Sampled Low-Fat Foods: A Pilot Study.
Frontiers in human neuroscience. 14 [DOI] 10.3389/fnhum.2020.600995. [PMID] 33328943.
2020
Non-canonical cholinergic anti-inflammatory pathway in IBD.
Nature reviews. Gastroenterology & hepatology. 17(11):651-652 [DOI] 10.1038/s41575-020-0356-y. [PMID] 32759984.
2020
Intact vagal gut-brain signalling prevents hyperphagia and excessive weight gain in response to high-fat high-sugar diet.
Acta physiologica (Oxford, England). [DOI] 10.1111/apha.13530. [PMID] 32603548.
2020
Dissecting the Role of Subtypes of Gastrointestinal Vagal Afferents.
Frontiers in physiology. 11 [DOI] 10.3389/fphys.2020.00643. [PMID] 32595525.
2020
Gut microbiota composition modulates inflammation and structure of the vagal afferent pathway.
Physiology & behavior. 225 [DOI] 10.1016/j.physbeh.2020.113082. [PMID] 32682966.
2020
Ghrelin Signaling Affects Feeding Behavior, Metabolism, and Memory through the Vagus Nerve.
Current biology : CB. 30(22):4510-4518.e6 [DOI] 10.1016/j.cub.2020.08.069. [PMID] 32946754.
2020
Gut microbiota sPARk vagus nerve excitation.
The Journal of physiology. 598(11):2043-2044 [DOI] 10.1113/JP279763. [PMID] 32187377.
2019
Deletion of leptin receptors in vagal afferent neurons disrupts estrogen signaling, body weight, food intake and hormonal controls of feeding in female mice.
American journal of physiology. Endocrinology and metabolism. 316(4):E568-E577 [DOI] 10.1152/ajpendo.00296.2018. [PMID] 30753113.
2019
Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver
Brain Behavior and Immunity.
2019
Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver.
Brain, behavior, and immunity. 81:444-454 [DOI] 10.1016/j.bbi.2019.06.041. [PMID] 31271871.
2019
Dorsal striatum dopamine oscillations: Setting the pace of food anticipatory activity.
Acta physiologica (Oxford, England). 225(1) [DOI] 10.1111/apha.13152. [PMID] 29920950.
2018
New horizons for future research – Critical issues to consider for maximizing research excellence and impact.
Molecular metabolism. 14:53-59 [DOI] 10.1016/j.molmet.2018.05.007. [PMID] 29886182.
2018
A Neural Circuit for Gut-Induced Reward.
Cell. 175(3):665-678.e23 [DOI] 10.1016/j.cell.2018.08.049. [PMID] 30245012.
2018
A Neural Circuit for Gut-Induced Reward.
Cell. 175(3):887-888 [DOI] 10.1016/j.cell.2018.10.018. [PMID] 30340046.
2018
Gut vagal sensory signaling regulates hippocampus function through multi-order pathways.
Nature communications. 9(1) [DOI] 10.1038/s41467-018-04639-1. [PMID] 29872139.
2018
Mechanisms of vagal plasticity influencing feeding behavior.
Brain research. 1693(Pt B):146-150 [DOI] 10.1016/j.brainres.2018.03.030. [PMID] 29903616.
2017
Validation and characterization of a novel method for selective vagal deafferentation of the gut.
American journal of physiology. Gastrointestinal and liver physiology. 313(4):G342-G352 [DOI] 10.1152/ajpgi.00095.2017. [PMID] 28705805.
2017
XIVth Little Brain Big Brain: next-generation enteric neuroscience.
Nature reviews. Gastroenterology & hepatology. 14(3):135-136 [DOI] 10.1038/nrgastro.2016.199. [PMID] 28053339.
2016
Novel developments in vagal afferent nutrient sensing and its role in energy homeostasis.
Current opinion in pharmacology. 31:38-43 [DOI] 10.1016/j.coph.2016.08.007. [PMID] 27591963.
2016
Role of the vagus nerve in the development and treatment of diet-induced obesity.
The Journal of physiology. 594(20):5791-5815 [DOI] 10.1113/JP271538. [PMID] 26959077.
2015
Chronic exposure to low dose bacterial lipopolysaccharide inhibits leptin signaling in vagal afferent neurons.
Physiology & behavior. 139:188-94 [DOI] 10.1016/j.physbeh.2014.10.032. [PMID] 25446227.
2014
Ability of GLP-1 to decrease food intake is dependent on nutritional status.
Physiology & behavior. 135:222-9 [DOI] 10.1016/j.physbeh.2014.06.015. [PMID] 24955496.
2014
Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity.
Molecular metabolism. 3(6):595-607 [DOI] 10.1016/j.molmet.2014.06.003. [PMID] 25161883.
2014
Putative roles of neuropeptides in vagal afferent signaling.
Physiology & behavior. 136:155-69 [DOI] 10.1016/j.physbeh.2014.03.011. [PMID] 24650553.
2014
Vagal plasticity the key to obesity.
Molecular metabolism. 3(9):855-6 [DOI] 10.1016/j.molmet.2014.09.009. [PMID] 25506551.
2012
Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats.
PloS one. 7(3) [DOI] 10.1371/journal.pone.0032967. [PMID] 22412960.
2012
Bifidobacteria isolated from infants and cultured on human milk oligosaccharides affect intestinal epithelial function.
Journal of pediatric gastroenterology and nutrition. 55(3):321-7 [DOI] 10.1097/MPG.0b013e31824fb899. [PMID] 22383026.
2011
Diet-induced obesity leads to the development of leptin resistance in vagal afferent neurons.
American journal of physiology. Endocrinology and metabolism. 301(1):E187-95 [DOI] 10.1152/ajpendo.00056.2011. [PMID] 21521717.
2011
Effect of ghrelin receptor antagonist on meal patterns in cholecystokinin type 1 receptor null mice.
Physiology & behavior. 103(2):181-7 [DOI] 10.1016/j.physbeh.2011.01.018. [PMID] 21277881.
2011
Vagal afferent neurons in high fat diet-induced obesity; intestinal microflora, gut inflammation and cholecystokinin.
Physiology & behavior. 105(1):100-5 [DOI] 10.1016/j.physbeh.2011.02.040. [PMID] 21376066.
2010
Cocaine- and amphetamine-regulated transcript mediates the actions of cholecystokinin on rat vagal afferent neurons.
Gastroenterology. 138(4):1479-90 [DOI] 10.1053/j.gastro.2009.10.034. [PMID] 19854189.
2010
EGR1 Is a target for cooperative interactions between cholecystokinin and leptin, and inhibition by ghrelin, in vagal afferent neurons.
Endocrinology. 151(8):3589-99 [DOI] 10.1210/en.2010-0106. [PMID] 20534729.
2008
Cholecystokinin regulates expression of Y2 receptors in vagal afferent neurons serving the stomach.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(45):11583-92 [DOI] 10.1523/JNEUROSCI.2493-08.2008. [PMID] 18987194.
2007
Cocaine- and amphetamine-regulated transcript: stimulation of expression in rat vagal afferent neurons by cholecystokinin and suppression by ghrelin.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(11):2876-82 [PMID] 17360909.
View on: PubMed

Grants

Jul 2020 ACTIVE
Consequence and mechanism of diet-driven vagal remodeling on gut-brain feeding behavior
Role: Principal Investigator
Funding: UNIV OF GEORGIA via NATL INST OF HLTH NIDDK
Feb 2020 ACTIVE
Interrogating stress-relieving neural circuits to alleviate cardiovascular disease
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Feb 2019 ACTIVE
Evaluating the therapeutic potential of vagal CART circuitry for treating metabolic disease
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Dec 2018 – Jan 2020
Microbiome-vagal-brain signaling: impact on the reward system and food intake
Role: Principal Investigator
Funding: UNIV OF GEORGIA via NATL INST OF HLTH NIDDK

Education

Ph.D.
2007 · University of Liverpool
B.Sc.
2002 · Royal Holloway, University of London

Teaching Profile

Courses Taught
2020
PHA6910 Supervised Research
2020
PHA7979 Advanced Research
2020
PHA6971 Research for Master’s Thesis
2020
PHA7980 Research for Doctoral Dissertation
2019
PHA7939 Journal Colloquy in Pharmacodynamics
2019
PHA6512L Experiential Research Training in Pharmacodynamics
2019
PHA5561 Pathphys-Pt Assess II
2019
PHA6935 Selected Topics in Pharmacy
2018
PHA5878C Pt Care 3: Cv and Pulm
2020-2021
PHA5930 Sem Pharm Research

Contact Details

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