Brian Cicali

Brian Cicali, Ph.D., M.S.

Research Assistant Professor

Department: Pharmaceutics
Business Phone: (407) 313-7087
Business Email:

About Brian Cicali

Brian Cicali received his B.S. in pharmacology and toxicology from the Philadelphia College of Pharmacy, his M.S. in computational science from Stockton University, and his Ph.D. in pharmaceutical sciences from the University of Florida College of Pharmacy. He has previously held positions at GlaxoSmithKline (2013-2015), Tabula Rasa HealthCare (2016-2018), and worked as an ORISE predoctoral fellow at the U.S. F.D.A. (2019, 2020). He has received numerous awards for his research and publications including a Distinguished Research Fellowship from Stockton University (2016), the Dr. Allen J. Speigel Endowed Graduate Fellowship (2019) from University of Florida’s Department of Pharmaceutics, the Robert and Stephany Ruffolo Graduate Education and Research Fellowship (2021) from the University of Florida College of Pharmacy, the CPT:PSP award for most outstanding paper of 2019, the 2020 Most Informative Scientific Report from Simcyp academic awards, highlighted as a young leader in pharmacy by the Canadian Health Network (2022), and multiple poster awards from various conferences. Brian also serves in multiple leadership roles within national and international organizations, including the International Federation of Pharmaceuticals (FIP), American College of Clinical Pharmacology (ACCP), the International Society of Pharmacometrics (ISoP), and the American Society of Clinical Pharmacology and Therapeutics (ASCPT). His research interests focus on the use of quantitative clinical pharmacology methods to optimize drug safety and efficacy, as well as the integration of real-world evidence into clinical pharmacology analyses.


Determining the Exposure Threshold for Levonorgestrel Efficacy Using an Integrated Model Based Meta-Analysis Approach.
Clinical pharmacology and therapeutics. 111(2):509-518 [DOI] 10.1002/cpt.2457. [PMID] 34674227.
Development of a Translational Exposure-Bracketing Approach to Streamline the Development of Hormonal Contraceptive Drug Products.
Clinical pharmacology and therapeutics. 112(4):909-916 [DOI] 10.1002/cpt.2690. [PMID] 35723889.
Macrolide Treatment Failure due to Drug-Drug Interactions: Real-World Evidence to Evaluate a Pharmacological Hypothesis.
Pharmaceutics. 14(4) [DOI] 10.3390/pharmaceutics14040704. [PMID] 35456537.
Physiologically Based Pharmacokinetic Modeling to Assess the Impact of CYP2D6-Mediated Drug-Drug Interactions on Tramadol and O-Desmethyltramadol Exposures via Allosteric and Competitive Inhibition.
Journal of clinical pharmacology. 62(1):76-86 [DOI] 10.1002/jcph.1951. [PMID] 34383318.
A Pharmacoepidemiologic Approach to Evaluate Real-world Effectiveness of Hormonal Contraceptives in the Presence of Drug-drug Interactions.
Epidemiology (Cambridge, Mass.). 32(2):268-276 [DOI] 10.1097/EDE.0000000000001302. [PMID] 33196560.
A Valid Warning or Clinical Lore: an Evaluation of Safety Outcomes of Remdesivir in Patients with Impaired Renal Function from a Multicenter Matched Cohort.
Antimicrobial agents and chemotherapy. 65(2) [DOI] 10.1128/AAC.02290-20. [PMID] 33229428.
Comparative pharmacovigilance assessment of mortality with pimavanserin in Parkinson disease-related psychosis.
Journal of managed care & specialty pharmacy. 27(6):785-790 [DOI] 10.18553/jmcp.2021.27.6.785. [PMID] 34057395.
Comparison of contraceptive failures associated with CYP3A4-inducing drug-drug interactions by route of hormonal contraceptive in an adverse event reporting system.
Contraception. 103(4):222-224 [DOI] 10.1016/j.contraception.2020.12.002. [PMID] 33345974.
Correction for Ackley et al., “A Valid Warning or Clinical Lore: an Evaluation of Safety Outcomes of Remdesivir in Patients with Impaired Renal Function from a Multicenter Matched Cohort”.
Antimicrobial agents and chemotherapy. 65(7) [DOI] 10.1128/AAC.00943-21. [PMID] 34137640.
Quantitative Assessment of Levonorgestrel Binding Partner Interplay and Drug-Drug Interactions Using Physiologically Based Pharmacokinetic Modeling.
CPT: pharmacometrics & systems pharmacology. 10(1):48-58 [DOI] 10.1002/psp4.12572. [PMID] 33217171.
Risk Assessment of Drug-Induced Long QT Syndrome for Some COVID-19 Repurposed Drugs.
Clinical and translational science. 14(1):20-28 [DOI] 10.1111/cts.12882. [PMID] 32888379.
Safety signals for QT prolongation or Torsades de Pointes associated with azithromycin with or without chloroquine or hydroxychloroquine.
Research in social & administrative pharmacy : RSAP. 17(2):483-486 [DOI] 10.1016/j.sapharm.2020.04.016. [PMID] 32327397.
Use of Drug Claims Data and a Medication Risk Score to Assess the Impact of CYP2D6 Drug Interactions among Opioid Users on Healthcare Costs.
Journal of personalized medicine. 11(11) [DOI] 10.3390/jpm11111174. [PMID] 34834526.
Assessing the impact of cystic fibrosis on the antipyretic response of ibuprofen in children: Physiologically-based modeling as a candle in the dark.
British journal of clinical pharmacology. 86(11):2247-2255 [DOI] 10.1111/bcp.14326. [PMID] 32335930.
Breaking the rules for studies using real-world observational data: the case of direct-acting anticoagulants and antiepileptic drugs.
European heart journal. Cardiovascular pharmacotherapy. 6(3):155-156 [DOI] 10.1093/ehjcvp/pvz053. [PMID] 31593242.
Reproducibility of Quantitative Systems Pharmacology Models: Current Challenges and Future Opportunities.
CPT: pharmacometrics & systems pharmacology. 8(4):205-210 [DOI] 10.1002/psp4.12390. [PMID] 30697975.
Syntheses and analytical characterizations of N-alkyl-arylcyclohexylamines.
Drug testing and analysis. 8(8):801-15 [DOI] 10.1002/dta.1861. [PMID] 26360516.
[Fetal urodynamics. Preliminary echographic study in drug-dependent patients].
Minerva ginecologica. 37(11):681-4 [PMID] 3908984.

Contact Details

(407) 313-7087
Business Mailing:
Business Street:
6550 SANGER RD OFC 420