Qi-Yin Chen

Qi-Yin Chen, Ph.D.

Research Assistant Professor

Department: Medicinal Chemistry
Business Phone: (352) 273-7739
Business Email: chenqyufl@ufl.edu

About Qi-Yin Chen

Qi-Yin Chen, Ph.D., serves as a research scientist in Dr. Hendrik Luesch’s group in the department of Medicinal Chemistry. During his postdocs, he worked on the synthesis of bioprobes (natural product based), total synthesis of natural products, methodology of organic synthesis and the synthesis of pharmaceutical molecules. In 2008, he joined Dr. Luesch’s group where his research includes total synthesis and modification of (marine) natural products and the synthesis of pharmaceutical molecules.

Research Profile

Total synthesis of natural products, synthesis of pharmaceutical compounds, synthesis of bioprobes, drug discovery and development.

Publications

2014
Evaluation of class I HDAC isoform selectivity of largazole analogues.
Bioorganic & medicinal chemistry letters. 24(16):3728-31 [DOI] 10.1016/j.bmcl.2014.07.006. [PMID] 25070421.
2014
Improved total synthesis and biological evaluation of potent apratoxin S4 based anticancer agents with differential stability and further enhanced activity.
Journal of medicinal chemistry. 57(7):3011-29 [DOI] 10.1021/jm4019965. [PMID] 24660812.
2014
Largazole pharmacokinetics in rats by LC-MS/MS.
Marine drugs. 12(3):1623-40 [DOI] 10.3390/md12031623. [PMID] 24658499.
2014
Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties.
ACS medicinal chemistry letters. 5(8):905-10 [DOI] 10.1021/ml500170r. [PMID] 25147612.
2011
Systematic Chemical Mutagenesis Identifies a Potent Novel Apratoxin A/E Hybrid with Improved in Vivo Antitumor Activity.
ACS medicinal chemistry letters. 2(11):861-865 [PMID] 22081789.
View on: PubMed
2009
Convenient and efficient preparations of azodye-labeled peptides.
Chemical biology & drug design. 73(6):611-7 [DOI] 10.1111/j.1747-0285.2009.00813.x. [PMID] 19635052.
2009
Design, synthesis, and structure-activity relationship of a novel series of 2-aryl 5-(4-oxo-3-phenethyl-2-thioxothiazolidinylidenemethyl)furans as HIV-1 entry inhibitors.
Journal of medicinal chemistry. 52(23):7631-9 [DOI] 10.1021/jm900450n. [PMID] 19746983.
2008
Convenient preparations of azo-dye labeled amino acids and amines.
Organic & biomolecular chemistry. 6(13):2400-4 [DOI] 10.1039/b802846j. [PMID] 18563275.

Grants

Dec 2015 – Mar 2017
Synthesis of Largazole
Role: Principal Investigator
Funding: OCEANYX PHARMACEUTICALS

Patents

Published August 2016
Macrocyclic Therapeutic Agents, Methods of Manufacture, and Methods of Treatment
#US-2017-0057996

Education

Ph.D.
2005 · Chinese Academy of Science Institute of Chemistry
M.S.
2000 · Central South University of Technology
B.S.
1997 · Henan Normal University

Contact Details

Phones:
Business:
(352) 273-7739
Emails:
Business:
chenqyufl@ufl.edu