Larisa H Cavallari

Larisa H Cavallari, Pharm.D., BCPS, FCCP

Professor

Department: Pharmacotherapy & Translational Research
Business Phone: (352) 273-8245
Business Email: lcavallari@cop.ufl.edu

About Larisa H Cavallari

Dr. Cavallari received her B.S. Pharmacy and Pharm.D. degrees from the University of Georgia. She then completed a Pharmacy Practice Residency at the Veterans Affairs Medical Center in Memphis, Tennessee and a fellowship in Cardiovascular Pharmacogenomics at the University of Florida. Dr. Cavallari accepted a position as an Assistant Professor of Pharmacy Practice at the University of Illinois at Chicago after completing her training and was promoted to Associate Professor in 2009. While at UIC, she directed efforts to implement genotype-guided warfarin dosing for all patients newly starting warfarin during hospitalization. Dr. Cavallari joined the University of Florida Department of Pharmacotherapy and Translational Research as an Associate Professor in April, 2014, where she serves as director of the Center for Pharmacogenomics and Precision Medicine. She also serves as Director of the UF Health Precision Medicine Program. In 2021, she was promoted to professor. Her research involves discovery and clinical translation of genetic variants related to drug response and has been funded by the NIH, FDA, American Heart Association, and other awards.

Dr. Cavallari has served on both NIH and American Heart Association grant review committees and is a Board Certified Pharmacotherapy Specialist, Fellow of the American College of Clinical Pharmacy, former Chair of the American College of Clinical Pharmacy Research Institute, and Editorial Board Member for the Lexi-Comp pharmacogenetics series.

Accomplishments

Elected Regent
2019 · American College of Clinical Pharmacy
Elected Trustee
2013-2016 · Research Institute, American College of Clinical Pharmacy
Best Paper
2009 · International Congress on Clinical Pharmacy
Kenneth F. Finger Fellow Alumni Lecturer Award
2009 · University of Florida
Fellow
2008 · American College of Clinical Pharmacy
Hans Vahlteich Research Award
2007 · University of Illinois at Chicago
Faculty New Investigator
2004 · American Association of Colleges of Pharmacy-American Foundation for Pharmaceutical Education Pharmacy
Annual Meeting Best Student, Resident, Fellow Paper Award
2000 · American College of Clinical Pharmacy
Kenneth F. Finger Memorial Award for Excellence in Clinical Pharmacy Research
2000 · University of Florida
American Foundation for Pharmaceutical Education for the Biomedical Research Sciences Fellow
1999-2000 · University of Florida

Publications

2021
A hybrid implementation-effectiveness randomized trial of CYP2D6-guided postoperative pain management.
Genetics in medicine : official journal of the American College of Medical Genetics. 23(4):621-628 [DOI] 10.1038/s41436-020-01050-4. [PMID] 33420349.
2021
Acceptability, Feasibility, and Utility of Integrating Pharmacogenetic Testing into a Child Psychiatry Clinic.
Clinical and translational science. 14(2):589-598 [DOI] 10.1111/cts.12914. [PMID] 33166056.
2021
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing.
Clinical pharmacology and therapeutics. 109(6):1417-1423 [DOI] 10.1002/cpt.2015. [PMID] 32770672.
2021
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy.
Clinical pharmacology and therapeutics. [DOI] 10.1002/cpt.2149. [PMID] 33387367.
2021
Corrigendum to “Periprocedural Anticoagulation Management of Patients receiving Warfarin in Qatar: A Prospective Cohort Study”. [Current Problems in Cardiology Volume 46, Issue 6, June 2021, 100816].
Current problems in cardiology. [DOI] 10.1016/j.cpcardiol.2021.100899. [PMID] 34154818.
2021
Cost-effectiveness analysis of genotyping for HLA-B*15:02 in Indonesian patients with epilepsy using a generic model.
The pharmacogenomics journal. [DOI] 10.1038/s41397-021-00225-9. [PMID] 33824430.
2021
Determining the potential clinical value of panel-based pharmacogenetic testing in patients with chronic pain or gastroesophageal reflux disease.
The pharmacogenomics journal. [DOI] 10.1038/s41397-021-00244-6. [PMID] 34075203.
2021
Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network.
Genetics in medicine : official journal of the American College of Medical Genetics. 23(7):1185-1191 [DOI] 10.1038/s41436-021-01118-9. [PMID] 33782552.
2021
Evaluating an interactive teaching approach with personal genotyping to provide pharmacy students with a knowledge base for clinical pharmacogenetics
Journal of the American College of Clinical Pharmacy. 4:343-351 [DOI] 10.1002/jac5.1335.
2021
Genetic testing in patients undergoing percutaneous coronary intervention: rationale, evidence and practical recommendations.
Expert review of clinical pharmacology. 1-16 [DOI] 10.1080/17512433.2021.1927709. [PMID] 33993817.
2021
How to Integrate CYP2D6 Phenoconversion into Clinical Pharmacogenetics: A Tutorial.
Clinical pharmacology and therapeutics. [DOI] 10.1002/cpt.2354. [PMID] 34231197.
2021
Impact of the CYP2C19*17 Allele on Outcomes in Patients Receiving Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.
Clinical pharmacology and therapeutics. 109(3):705-715 [DOI] 10.1002/cpt.2039. [PMID] 32897581.
2021
Implications of Polymorphisms in the BCKDK and GATA-4 Gene Regions on Stable Warfarin Dose in African Americans.
Clinical and translational science. 14(2):492-496 [DOI] 10.1111/cts.12939. [PMID] 33278335.
2021
Moving Pharmacogenetics Into Practice: It’s All About the Evidence!
Clinical pharmacology and therapeutics. [DOI] 10.1002/cpt.2327. [PMID] 34101169.
2021
Multi-site Investigation of Genetic Determinants of Warfarin Dose Variability in Latinos.
Clinical and translational science. 14(1):268-276 [DOI] 10.1111/cts.12854. [PMID] 32860733.
2021
Opportunity for Genotype-Guided Prescribing Among Adult Patients in 11 US Health Systems.
Clinical pharmacology and therapeutics. 110(1):179-188 [DOI] 10.1002/cpt.2161. [PMID] 33428770.
2021
Periprocedural Anticoagulation Management of Patients receiving Warfarin in Qatar: A Prospective Cohort Study.
Current problems in cardiology. 46(6) [DOI] 10.1016/j.cpcardiol.2021.100816. [PMID] 33721568.
2021
Pharmacogenetics to guide cardiovascular drug therapy.
Nature reviews. Cardiology. [DOI] 10.1038/s41569-021-00549-w. [PMID] 33953382.
2021
PharmVar GeneFocus: CYP2C19.
Clinical pharmacology and therapeutics. 109(2):352-366 [DOI] 10.1002/cpt.1973. [PMID] 32602114.
2021
PharmVar GeneFocus: CYP2C9.
Clinical pharmacology and therapeutics. [DOI] 10.1002/cpt.2333. [PMID] 34109627.
2021
Recommendations for Clinical CYP2D6 Genotyping Allele Selection: A Joint Consensus Recommendation of the Association for Molecular Pathology, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, and European Society for Pharmacogenomics and Personalized Therapy.
The Journal of molecular diagnostics : JMD. [DOI] 10.1016/j.jmoldx.2021.05.013. [PMID] 34118403.
2020
A Scoping Review of the Evidence Behind Cytochrome P450 2D6 Isoenzyme Inhibitor Classifications.
Clinical pharmacology and therapeutics. 108(1):116-125 [DOI] 10.1002/cpt.1768. [PMID] 31910286.
2020
Beta-Blocker Dose Stratifies Mortality Risk in a Racially Diverse Heart Failure Population.
Journal of cardiovascular pharmacology. 75(3):250-258 [DOI] 10.1097/FJC.0000000000000779. [PMID] 31895871.
2020
Clinical Utility of Pharmacogene Panel-Based Testing in Patients Undergoing Percutaneous Coronary Intervention.
Clinical and translational science. 13(3):473-481 [DOI] 10.1111/cts.12729. [PMID] 31758664.
2020
Correction: Evaluating the extent of reusability of CYP2C19 genotype data among patients genotyped for antiplatelet therapy selection.
Genetics in medicine : official journal of the American College of Medical Genetics. 22(11) [DOI] 10.1038/s41436-020-0931-1. [PMID] 32747766.
2020
Cost-effectiveness of CYP2C19-guided antiplatelet therapy in patients with acute coronary syndrome and percutaneous coronary intervention informed by real-world data.
The pharmacogenomics journal. 20(5):724-735 [DOI] 10.1038/s41397-020-0162-5. [PMID] 32042096.
2020
Design and Early Implementation Successes and Challenges of a Pharmacogenetics Consult Clinic.
Journal of clinical medicine. 9(7) [DOI] 10.3390/jcm9072274. [PMID] 32708920.
2020
Development of Customizable Implementation Guides to Support Clinical Adoption of Pharmacogenomics: Experiences of the Implementing GeNomics In pracTicE (IGNITE) Network.
Pharmacogenomics and personalized medicine. 13:217-226 [DOI] 10.2147/PGPM.S241599. [PMID] 32765043.
2020
Effect of Genetic and Nongenetic Factors on the Clinical Response to Mineralocorticoid Receptor Antagonist Therapy in Egyptians with Heart Failure.
Clinical and translational science. 13(1):195-203 [DOI] 10.1111/cts.12702. [PMID] 31560448.
2020
Evaluating the extent of reusability of CYP2C19 genotype data among patients genotyped for antiplatelet therapy selection.
Genetics in medicine : official journal of the American College of Medical Genetics. 22(11):1898-1902 [DOI] 10.1038/s41436-020-0894-2. [PMID] 32678355.
2020
Examination of Metoprolol Pharmacokinetics and Pharmacodynamics Across CYP2D6 Genotype-Derived Activity Scores.
CPT: pharmacometrics & systems pharmacology. 9(12):678-685 [DOI] 10.1002/psp4.12563. [PMID] 33067866.
2020
Frequency and clinical outcomes of CYP2C19 genotype-guided escalation and de-escalation of antiplatelet therapy in a real-world clinical setting.
Genetics in medicine : official journal of the American College of Medical Genetics. 22(1):160-169 [DOI] 10.1038/s41436-019-0611-1. [PMID] 31316169.
2020
Genetic Factors Influencing Warfarin Dose in Black-African Patients: A Systematic Review and Meta-Analysis.
Clinical pharmacology and therapeutics. 107(6):1420-1433 [DOI] 10.1002/cpt.1755. [PMID] 31869433.
2020
How to Transition from Single-Gene Pharmacogenetic Testing to Preemptive Panel-Based Testing: A Tutorial.
Clinical pharmacology and therapeutics. 108(3):557-565 [DOI] 10.1002/cpt.1912. [PMID] 32460360.
2020
Prescribing Prevalence of Medications With Potential Genotype-Guided Dosing in Pediatric Patients.
JAMA network open. 3(12) [DOI] 10.1001/jamanetworkopen.2020.29411. [PMID] 33315113.
2020
Recommendations for Clinical Warfarin Genotyping Allele Selection: A Report of the Association for Molecular Pathology and the College of American Pathologists.
The Journal of molecular diagnostics : JMD. 22(7):847-859 [DOI] 10.1016/j.jmoldx.2020.04.204. [PMID] 32380173.
2020
The effect of genetic and nongenetic factors on warfarin dose variability in Qatari population.
The pharmacogenomics journal. 20(2):277-284 [DOI] 10.1038/s41397-019-0116-y. [PMID] 31653973.
2019
A case for genotype-guided de-escalation of antiplatelet therapy after percutaneous coronary angioplasty.
Future cardiology. 15(4):251-254 [DOI] 10.2217/fca-2019-0017. [PMID] 31385522.
2019
A case for genotype-guided pain management.
Pharmacogenomics. 20(10):705-708 [DOI] 10.2217/pgs-2019-0068. [PMID] 31368851.
2019
Challenges and lessons learned from clinical pharmacogenetic implementation of multiple gene-drug pairs across ambulatory care settings.
Genetics in medicine : official journal of the American College of Medical Genetics. 21(10):2264-2274 [DOI] 10.1038/s41436-019-0500-7. [PMID] 30926959.
2019
Cost-Effectiveness of Strategies to Personalize the Selection of P2Y12 Inhibitors in Patients with Acute Coronary Syndrome.
Cardiovascular drugs and therapy. 33(5):533-546 [DOI] 10.1007/s10557-019-06896-8. [PMID] 31367811.
2019
CYP2D6-guided opioid therapy improves pain control in CYP2D6 intermediate and poor metabolizers: a pragmatic clinical trial.
Genetics in medicine : official journal of the American College of Medical Genetics. 21(8):1842-1850 [DOI] 10.1038/s41436-018-0431-8. [PMID] 30670877.
2019
Development and Cross-Validation of High-Resolution Melting Analysis-Based Cardiovascular Pharmacogenetics Genotyping Panel.
Genetic testing and molecular biomarkers. 23(3):209-214 [DOI] 10.1089/gtmb.2018.0298. [PMID] 30758238.
2019
Differences in Warfarin Pharmacodynamics and Predictors of Response Among Three Racial Populations.
Clinical pharmacokinetics. 58(8):1077-1089 [DOI] 10.1007/s40262-019-00745-5. [PMID] 30815847.
2019
Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals.
Clinical pharmacology and therapeutics. 105(6):1477-1491 [DOI] 10.1002/cpt.1323. [PMID] 30506689.
2019
Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing.
Genetics in medicine : official journal of the American College of Medical Genetics. 21(10):2255-2263 [DOI] 10.1038/s41436-019-0484-3. [PMID] 30894703.
2019
Recommendations for Clinical CYP2C9 Genotyping Allele Selection: A Joint Recommendation of the Association for Molecular Pathology and College of American Pathologists.
The Journal of molecular diagnostics : JMD. 21(5):746-755 [DOI] 10.1016/j.jmoldx.2019.04.003. [PMID] 31075510.
2018
Association of Genetic Variants With Warfarin-Associated Bleeding Among Patients of African Descent.
JAMA. 320(16):1670-1677 [DOI] 10.1001/jama.2018.14955. [PMID] 30357299.
2018
Clinical application of pharmacogenetics in pain management.
Personalized medicine. 15(2):117-126 [DOI] 10.2217/pme-2017-0032. [PMID] 29714124.
2018
Clinical implementation of rapid CYP2C19 genotyping to guide antiplatelet therapy after percutaneous coronary intervention.
Journal of translational medicine. 16(1) [DOI] 10.1186/s12967-018-1469-8. [PMID] 29642909.
2018
Design and rational for the precision medicine guided treatment for cancer pain pragmatic clinical trial.
Contemporary clinical trials. 68:7-13 [DOI] 10.1016/j.cct.2018.03.001. [PMID] 29535047.
2018
Endothelial nitric oxide synthase genotype is associated with pulmonary hypertension severity in left heart failure patients.
Pulmonary circulation. 8(2) [DOI] 10.1177/2045894018773049. [PMID] 29718770.
2018
Facilitators and Barriers to the Adoption of Pharmacogenetic Testing in an Inner-City Population.
Pharmacotherapy. 38(2):205-216 [DOI] 10.1002/phar.2077. [PMID] 29286540.
2018
Generic Cost-Effectiveness Models: A Proof of Concept of a Tool for Informed Decision-Making for Public Health Precision Medicine.
Public health genomics. 21(5-6):217-227 [DOI] 10.1159/000500725. [PMID] 31189173.
2018
Implementation of Standardized Clinical Processes for TPMT Testing in a Diverse Multidisciplinary Population: Challenges and Lessons Learned.
Clinical and translational science. 11(2):175-181 [DOI] 10.1111/cts.12533. [PMID] 29351371.
2018
Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.
JACC. Cardiovascular interventions. 11(2):181-191 [DOI] 10.1016/j.jcin.2017.07.022. [PMID] 29102571.
2018
Multisite Investigation of Strategies for the Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy.
Clinical pharmacology and therapeutics. 104(4):664-674 [DOI] 10.1002/cpt.1006. [PMID] 29280137.
2018
Optimization of Voriconazole Therapy for the Treatment of Invasive Fungal Infections in Adults.
Clinical pharmacology and therapeutics. 104(5):957-965 [DOI] 10.1002/cpt.1012. [PMID] 29315506.
2018
Pharmacogenetic and clinical predictors of response to clopidogrel plus aspirin after acute coronary syndrome in Egyptians.
Pharmacogenetics and genomics. 28(9):207-213 [DOI] 10.1097/FPC.0000000000000349. [PMID] 30188374.
2018
Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects.
Clinical pharmacology and therapeutics. 103(5):778-786 [DOI] 10.1002/cpt.1048. [PMID] 29460415.
2018
Role of genetic testing in patients undergoing percutaneous coronary intervention.
Expert review of clinical pharmacology. 11(2):151-164 [DOI] 10.1080/17512433.2017.1353909. [PMID] 28689434.
2017
Anticoagulation endpoints with clinical implementation of warfarin pharmacogenetic dosing in a real-world setting: A proposal for a new pharmacogenetic dosing approach.
Clinical pharmacology and therapeutics. 101(5):675-683 [DOI] 10.1002/cpt.558. [PMID] 28032893.
2017
Association of the HLA-B alleles with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in the Javanese and Sundanese population of Indonesia: the important role of the HLA-B75 serotype.
Pharmacogenomics. 18(18):1643-1648 [DOI] 10.2217/pgs-2017-0103. [PMID] 29053440.
2017
Challenges and strategies for implementing genomic services in diverse settings: experiences from the Implementing GeNomics In pracTicE (IGNITE) network.
BMC medical genomics. 10(1) [DOI] 10.1186/s12920-017-0273-2. [PMID] 28532511.
2017
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update.
Clinical pharmacology and therapeutics. 102(3):397-404 [DOI] 10.1002/cpt.668. [PMID] 28198005.
2017
Correlations between the enantio- and regio-selective metabolisms of warfarin.
Pharmacogenomics. 18(2):133-142 [DOI] 10.2217/pgs-2016-0149. [PMID] 27995809.
2017
Cross-Validation of High-Resolution Melting Analysis-Based Genotyping Platform.
Genetic testing and molecular biomarkers. 21(4):259-264 [DOI] 10.1089/gtmb.2016.0317. [PMID] 28384046.
2017
Genetic Determinants of P2Y12 Inhibitors and Clinical Implications.
Interventional cardiology clinics. 6(1):141-149 [DOI] 10.1016/j.iccl.2016.08.010. [PMID] 27886818.
2017
Genotype-guided dosing of warfarin through modeling and simulation.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 109S:S9-S14 [DOI] 10.1016/j.ejps.2017.05.017. [PMID] 28502675.
2017
Impact of the CYP2C19 genotype on voriconazole exposure in adults with invasive fungal infections.
Pharmacogenetics and genomics. 27(5):190-196 [DOI] 10.1097/FPC.0000000000000277. [PMID] 28306618.
2017
Institutional profile: University of Florida Health Personalized Medicine Program.
Pharmacogenomics. 18(5):421-426 [DOI] 10.2217/pgs-2017-0028. [PMID] 28346068.
2017
Integrated analysis of genetic variation and gene expression reveals novel variant for increased warfarin dose requirement in African Americans.
Journal of thrombosis and haemostasis : JTH. 15(4):735-743 [DOI] 10.1111/jth.13639. [PMID] 28135054.
2017
Is universal HLA-B*15:02 screening a cost-effective option in an ethnically diverse population? A case study of Malaysia.
The British journal of dermatology. 177(4):1102-1112 [DOI] 10.1111/bjd.15498. [PMID] 28346659.
2017
Matrix Metalloproteinase Polymorphisms in Patients with Floppy Mitral Valve/Mitral Valve Prolapse (FMV/MVP) and FMV/MVP Syndrome.
Cardiology. 138(3):179-185 [DOI] 10.1159/000477656. [PMID] 28750369.
2017
Personalizing antiplatelet prescribing using genetics for patients undergoing percutaneous coronary intervention.
Expert review of cardiovascular therapy. 15(8):581-589 [DOI] 10.1080/14779072.2017.1355236. [PMID] 28699807.
2017
Population differences in S-warfarin pharmacokinetics among African Americans, Asians and whites: their influence on pharmacogenetic dosing algorithms.
The pharmacogenomics journal. 17(6):494-500 [DOI] 10.1038/tpj.2016.57. [PMID] 27503578.
2017
Preemptive Panel-Based Pharmacogenetic Testing: The Time is Now.
Pharmaceutical research. 34(8):1551-1555 [DOI] 10.1007/s11095-017-2163-x. [PMID] 28466392.
2017
The IGNITE Pharmacogenetics Working Group: An Opportunity for Building Evidence with Pharmacogenetic Implementation in a Real-World Setting.
Clinical and translational science. 10(3):143-146 [DOI] 10.1111/cts.12456. [PMID] 28294551.
2017
The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Outcomes and Metrics of Pharmacogenetic Implementations Across Diverse Healthcare Systems.
Clinical pharmacology and therapeutics. 102(3):502-510 [DOI] 10.1002/cpt.630. [PMID] 28090649.
2017
Time to revisit warfarin pharmacogenetics.
Future cardiology. 13(6):511-513 [DOI] 10.2217/fca-2017-0061. [PMID] 28967279.
2017
Warfarin Pharmacogenomics in Diverse Populations.
Pharmacotherapy. 37(9):1150-1163 [DOI] 10.1002/phar.1982. [PMID] 28672100.
2016
Cardiovascular Pharmacogenomics–Implications for Patients With CKD.
Advances in chronic kidney disease. 23(2):82-90 [DOI] 10.1053/j.ackd.2015.12.001. [PMID] 26979147.
2016
Circulating Procollagen Type III N-Terminal Peptide and Mortality Risk in African Americans With Heart Failure.
Journal of cardiac failure. 22(9):692-9 [DOI] 10.1016/j.cardfail.2015.12.016. [PMID] 26721774.
2016
Clopidogrel pharmacogenetics: from evidence to implementation.
Future cardiology. 12(5):511-4 [DOI] 10.2217/fca-2016-0045. [PMID] 27539287.
2016
Effects of Using Personal Genotype Data on Student Learning and Attitudes in a Pharmacogenomics Course.
American journal of pharmaceutical education. 80(7) [PMID] 27756930.
View on: PubMed
2016
Impact of GGCX, STX1B and FPGS Polymorphisms on Warfarin Dose Requirements in European-Americans and Egyptians.
Clinical and translational science. 9(1):36-42 [DOI] 10.1111/cts.12385. [PMID] 26751406.
2016
Implementation of inpatient models of pharmacogenetics programs.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 73(23):1944-1954 [PMID] 27864202.
View on: PubMed
2016
Implementing Pharmacogenomics at Your Institution: Establishment and Overcoming Implementation Challenges.
Clinical and translational science. 9(5):233-245 [DOI] 10.1111/cts.12404. [PMID] 27214750.
2016
Novel genetic predictors of venous thromboembolism risk in African Americans.
Blood. 127(15):1923-9 [DOI] 10.1182/blood-2015-09-668525. [PMID] 26888256.
2016
Population-specific single-nucleotide polymorphism confers increased risk of venous thromboembolism in African Americans.
Molecular genetics & genomic medicine. 4(5):513-20 [DOI] 10.1002/mgg3.226. [PMID] 27652279.
2016
The IGNITE network: a model for genomic medicine implementation and research.
BMC medical genomics. 9 [DOI] 10.1186/s12920-015-0162-5. [PMID] 26729011.
2015
Factors influencing pharmacokinetics of warfarin in African-Americans: implications for pharmacogenetic dosing algorithms.
Pharmacogenomics. 16(3):217-25 [DOI] 10.2217/pgs.14.160. [PMID] 25712185.
2015
Genes affecting warfarin response-interactive or additive?
Journal of clinical pharmacology. 55(3):258-60 [DOI] 10.1002/jcph.425. [PMID] 25385663.
2015
Genome-wide association study of warfarin maintenance dose in a Brazilian sample.
Pharmacogenomics. 16(11):1253-63 [DOI] 10.2217/PGS.15.73. [PMID] 26265036.
2015
Pharmacogenomics in cardiology–genetics and drug response: 10 years of progress.
Future cardiology. 11(3):281-6 [DOI] 10.2217/fca.15.20. [PMID] 26021633.
2015
Pharmacogenomics of hypertension and heart disease.
Current hypertension reports. 17(9) [DOI] 10.1007/s11906-015-0586-5. [PMID] 26272307.
2015
Poor warfarin dose prediction with pharmacogenetic algorithms that exclude genotypes important for African Americans.
Pharmacogenetics and genomics. 25(2):73-81 [DOI] 10.1097/FPC.0000000000000108. [PMID] 25461246.
2015
Warfarin pharmacogenetics.
Trends in cardiovascular medicine. 25(1):33-41 [DOI] 10.1016/j.tcm.2014.09.001. [PMID] 25282448.
2014
Addition of Cyp2C9{*}5,{*}6,{*}8,{*}11 and Rs12777823 Genotypes Into An Existing Warfarin Dosing Algorithm Improves Algorithm Performance for African Americans.
Pharmacotherapy. 34(10):E220-E221
2014
Barriers To Implementing Pharmacogenetic Testing in An Urban Population.
Pharmacotherapy. 34(10)
2014
Ethnicity-specific pharmacogenetics: the case of warfarin in African Americans.
The pharmacogenomics journal. 14(3):223-8 [DOI] 10.1038/tpj.2013.34. [PMID] 24018621.
2014
Genetic variant in folate homeostasis is associated with lower warfarin dose in African Americans.
Blood. 124(14):2298-305 [DOI] 10.1182/blood-2014-04-568436. [PMID] 25079360.
2014
Genotype-guided dosing of vitamin K antagonists.
The New England journal of medicine. 370(18) [DOI] 10.1056/NEJMc1402521. [PMID] 24785218.
2014
Pyrosequencing of the CYP2C9 -1766T>C polymorphism as a means of detecting the CYP2C9*8 allele.
Pharmacogenomics. 15(13):1717-22 [DOI] 10.2217/pgs.14.130. [PMID] 25410896.
2014
Stakeholder views on pharmacogenomic testing.
Pharmacotherapy. 34(2):151-65 [DOI] 10.1002/phar.1364. [PMID] 24167008.
2014
Warfarin dose requirements in a patient with the CYP2C9*14 allele.
Pharmacogenomics. 15(7):909-14 [DOI] 10.2217/pgs.14.47. [PMID] 24956244.
2014
Warfarin pharmacogenetics: an illustration of the importance of studies in minority populations.
Clinical pharmacology and therapeutics. 95(3):242-4 [DOI] 10.1038/clpt.2013.209. [PMID] 24548987.
2014
Warfarin pharmacogenetics: to genotype or not to genotype, that is the question.
Clinical pharmacology and therapeutics. 96(1):22-4 [DOI] 10.1038/clpt.2014.78. [PMID] 24942399.
2013
A pharmacogenetics service experience for pharmacy students, residents, and fellows.
American journal of pharmaceutical education. 77(8) [DOI] 10.5688/ajpe778175. [PMID] 24159216.
2013
Association of aldosterone synthase polymorphism (CYP11B2 -344T>C) and genetic ancestry with atrial fibrillation and serum aldosterone in African Americans with heart failure.
PloS one. 8(7) [DOI] 10.1371/journal.pone.0071268. [PMID] 23936266.
2013
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Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.
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2012
Tailoring drug therapy based on genotype.
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2012
The future of warfarin pharmacogenetics in under-represented minority groups.
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2011
Association of apolipoprotein E genotype with duration of time to achieve a stable warfarin dose in African-American patients.
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2011
Bleeding incidence with concomitant use of antidepressants and warfarin.
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2011
Pharmacogenomics of warfarin dose requirements in Hispanics.
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2011
Pharmacogenomics: application to the management of cardiovascular disease.
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2011
Role of cytochrome P450 genotype in the steps toward personalized drug therapy.
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2011
Role of pharmacogenomics in the management of traditional and novel oral anticoagulants.
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2011
The missing association: sequencing-based discovery of novel SNPs in VKORC1 and CYP2C9 that affect warfarin dose in African Americans.
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2010
A polymorphism in the VKORC1 regulator calumenin predicts higher warfarin dose requirements in African Americans.
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2010
Association of aldosterone concentration and mineralocorticoid receptor genotype with potassium response to spironolactone in patients with heart failure.
Pharmacotherapy. 30(1):1-9 [DOI] 10.1592/phco.30.1.1. [PMID] 20030467.
2010
Clopidogrel and proton pump inhibitors: between a rock and a hard place.
Pharmacotherapy. 30(8):762-5 [DOI] 10.1592/phco.30.8.762. [PMID] 20653351.
2010
Genetic and clinical predictors of warfarin dose requirements in African Americans.
Clinical pharmacology and therapeutics. 87(4):459-64 [DOI] 10.1038/clpt.2009.223. [PMID] 20072124.
2010
Warfarin dosing in patients with impaired kidney function.
American journal of kidney diseases : the official journal of the National Kidney Foundation. 56(5):823-31 [DOI] 10.1053/j.ajkd.2010.05.023. [PMID] 20709439.
2010
Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups.
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2009
Effect of a warfarin adherence aid on anticoagulation control in an inner-city anticoagulation clinic population.
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2009
Genomics and the efficacy of aspirin in the treatment of cerebrovascular disease.
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2009
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2009
Predictors of unstable anticoagulation in African Americans.
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2009
The pharmacokinetics of codeine and its metabolites in Blacks with sickle cell disease.
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2009
Warfarin pharmacogenomics.
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2008
Beta-adrenergic receptor gene polymorphisms and hemodynamic response to dobutamine during dobutamine stress echocardiography.
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2007
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Grants

Aug 2020 ACTIVE
Identifying Predictors of Spironolactone Response in Patients with Heart Failure with Preserved Ejection Fraction
Role: Other
Funding: NATL INST OF HLTH NHLBI
Jul 2020 ACTIVE
Precision antiplatelet therapy after percutaneous coronary intervention
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Sep 2018 ACTIVE
Sparking Advancements in Genomic Medicine?
Role: Principal Investigator
Funding: NATL INST OF HLTH NHGRI
Apr 2018 – Sep 2019
Genotype-Guided Pain Management in Patients Undergoing Arthroplasty Surgery
Role: Principal Investigator
Funding: UF HEALTH SHANDS HOSPITAL
Apr 2018 – Jul 2019
Together: Transforming and Translating Discovery to Improve Health
Role: Project Manager
Funding: NATL INST OF HLTH NCATS
Jan 2018 ACTIVE
Training Program for Applied Research and Development in Genomic Medicine
Role: Other
Funding: NATL INST OF HLTH NHGRI
Apr 2017 – Jun 2021
OoR CTSI Institutional Matching Support
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Jun 2016 – Oct 2018
Development and analytic validation of a customized pharmacogenomics panel
Role: Principal Investigator
Funding: CANON BIOMEDICAL INC
Sep 2015 – Aug 2016
2015 Mallinckrodt Research Fellowship Award
Role: Principal Investigator
Funding: MALLINCKRODT PHARMACEUTICALS-Bankrupt
Sep 2014 – Feb 2019
Pharmacokinetic and Pharmacodynamic (PK-PD) Studies of Cardiovascular Drugs
Role: Principal Investigator
Funding: US FOOD AND DRUG ADMN

Education

Doctor of Pharmacy
1997 · University of Georgia

Teaching Profile

Courses Taught
2019-2020
PHA5930 Sem Pharm Research
2016-2018,2020
PHA5878C Pt Care 3: Cv and Pulm
2015-2016,2018-2021
PHA7980 Research for Doctoral Dissertation
2015-2021
PHA7979 Advanced Research
2020
PHA6910 Supervised Research
2020-2021
PHA6935 Selected Topics in Pharmacy
2017-2019
PHA5012 App Personalized Med
2017-2018
PHA5788C Patient Care 6
2018
ANG7980 Research for Doctoral Dissertation
2018
PHA5907 Research in Phar Prac
2018
PHA5876C Pt Care 8 Complex Pts
2016,2018-2021,2021
PHA6938 Research Seminar
2016,2021
PHA6971 Research for Master’s Thesis
2014-2015
PHA5782 Pharmacotherapy 2
2014-2015
PHA5113 Personalized Medicine
2015
PHA6633 Medication Therapy Management: A Cardiovascular Focus
2021
PHA6894 Introduction to Graduate Studies

Contact Details

Phones:
Business:
(352) 273-8245
Emails: