Marco Bortolato, M.D., Ph.D.
Professor
About Marco Bortolato
Marco Bortolato joined the UF College of Pharmacy in November 2024 as a professor of pharmacodynamics. He previously served eight years at the University of Utah, four years at the University of Kansas and seven years at the University of Southern California. Bortolato is a member of several professional organizations, including the International Society for Psychoneuroendocrinology, the International Behavioral and Neural Genetics Society, and the International Society for Behavioral Neuroscience. A native of Italy, he earned his B.S., M.D. and Ph.D. from the University of Cagliarai.
From the beginning of Bortolato’s career as a neurologist, as well as an experimental and clinical pharmacologist, his research has focused on translational studies for the understanding of the pathophysiology of tic disorders, or TDs, and other neurodevelopmental disorders, including autism-spectrum disorder and disruptive behavior disorders. The key focus of his research has consistently been on the generation of animal models of these conditions, with the goal of developing novel therapies. His expertise encompasses behavioral and neurochemical analyses to study the pathophysiology of neurodevelopmental disorders using animal models. In addition, he has performed clinical studies for the validation of novel therapies for these disorders.
Teaching Profile
Courses Taught
2024
PHA6910 Supervised Research
Publications
Academic Articles
2024
“Weeding out” violence? Translational perspectives on the neuropsychobiological links between cannabis and aggression.
Aggression and violent behavior.
78
[DOI] 10.1016/j.avb.2024.101948.
[PMID] 38828012.
2024
A novel naïve Bayes approach to identifying grooming behaviors in the force-plate actometric platform.
Journal of neuroscience methods.
403
[DOI] 10.1016/j.jneumeth.2023.110026.
[PMID] 38029972.
2024
Activation of M4 muscarinic receptors in the striatum reduces tic-like behaviours in two distinct murine models of Tourette syndrome.
British journal of pharmacology.
181(17):3064-3081
[DOI] 10.1111/bph.16392.
[PMID] 38689378.
2024
Colitis reduces active social engagement in mice and is ameliorated by supplementation with human microbiota members.
Nature communications.
15(1)
[DOI] 10.1038/s41467-024-46733-7.
[PMID] 38553486.
2024
Effect of 5-alpha reductase inhibitors in animal models of Parkinson’s disease.
Frontiers in neuroendocrinology.
75
[DOI] 10.1016/j.yfrne.2024.101156.
[PMID] 39353534.
2024
Exploring persistence in animal models: The sinking platform test.
Journal of neuroscience methods.
415
[DOI] 10.1016/j.jneumeth.2024.110352.
[PMID] 39681208.
2024
The role of neuroactive steroids in tic disorders.
Neuroscience and biobehavioral reviews.
160
[DOI] 10.1016/j.neubiorev.2024.105637.
[PMID] 38519023.
2024
The sinking platform test: a novel paradigm to measure persistence in animal models.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
49(9):1373-1382
[DOI] 10.1038/s41386-024-01827-0.
[PMID] 38396257.
2023
A novel naïve Bayes approach to identifying grooming behaviors in the force-plate actometric platform.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.07.08.548198.
[PMID] 37503098.
2023
A preliminary transcriptomic analysis of the orbitofrontal cortex of antisocial individuals.
CNS neuroscience & therapeutics.
29(11):3173-3182
[DOI] 10.1111/cns.14283.
[PMID] 37269073.
2023
Elevated levels of serotonin 5-HT2A receptors in the orbitofrontal cortex of antisocial individuals.
European archives of psychiatry and clinical neuroscience.
273(2):411-425
[DOI] 10.1007/s00406-022-01480-y.
[PMID] 36094569.
2023
Endocannabinoid-dependent decrease of GABAergic transmission on dopaminergic neurons is associated with susceptibility to cocaine stimulant effects in pre-adolescent male MAOA hypomorphic mice exposed to early life stress.
Neuropharmacology.
233
[DOI] 10.1016/j.neuropharm.2023.109548.
[PMID] 37080337.
2023
Prefrontal allopregnanolone mediates the adverse effects of acute stress in a mouse model of tic pathophysiology.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
48(9):1288-1299
[DOI] 10.1038/s41386-023-01603-6.
[PMID] 37198434.
2023
Prefrontal allopregnanolone synergizes with D1 receptor activation to disrupt sensorimotor gating in male Sprague-Dawley rats.
Psychopharmacology.
240(6):1359-1372
[DOI] 10.1007/s00213-023-06375-x.
[PMID] 37129616.
2023
Psychological resilience and hyperthymia: Is there a link?
Journal of affective disorders.
338:187-188
[DOI] 10.1016/j.jad.2023.06.021.
[PMID] 37301294.
2022
Acute stress impairs sensorimotor gating via the neurosteroid allopregnanolone in the prefrontal cortex.
Neurobiology of stress.
21
[DOI] 10.1016/j.ynstr.2022.100489.
[PMID] 36532377.
2022
Allopregnanolone: The missing link to explain the effects of stress on tic exacerbation?
Journal of neuroendocrinology.
34(2)
[DOI] 10.1111/jne.13022.
[PMID] 34423500.
2022
Combined Antagonism of 5-HT2 and NMDA Receptors Reduces the Aggression of Monoamine Oxidase a Knockout Mice.
Pharmaceuticals (Basel, Switzerland).
15(2)
[DOI] 10.3390/ph15020213.
[PMID] 35215325.
2022
Editorial: Behavioral Addictions, Risk-Taking, and Impulsive Choice.
Frontiers in behavioral neuroscience.
16
[DOI] 10.3389/fnbeh.2022.924030.
[PMID] 35615567.
2022
Models predicting the role of emotion reactivity in the link between reasons for not using and lifetime substance use.
Journal of American college health : J of ACH.
70(2):527-535
[DOI] 10.1080/07448481.2020.1756828.
[PMID] 32407218.
2022
Relationship between adverse childhood experiences and symptom severity in adult men with Tourette Syndrome.
Journal of psychiatric research.
155:252-259
[DOI] 10.1016/j.jpsychires.2022.08.024.
[PMID] 36113395.
2022
Serotonin 5-HT2A receptor polymorphisms are associated with irritability and aggression in conduct disorder.
Progress in neuro-psychopharmacology & biological psychiatry.
117
[DOI] 10.1016/j.pnpbp.2022.110542.
[PMID] 35257831.
2022
The mediating role of impulsivity in the associations between child maltreatment types and past month substance use.
Child abuse & neglect.
128
[DOI] 10.1016/j.chiabu.2022.105591.
[PMID] 35306342.
2022
The steroidogenic inhibitor finasteride reverses pramipexole-induced alterations in probability discounting.
Brain research bulletin.
181:157-166
[DOI] 10.1016/j.brainresbull.2022.01.020.
[PMID] 35122898.
2022
Top2a promotes the development of social behavior via PRC2 and H3K27me3.
Science advances.
8(47)
[DOI] 10.1126/sciadv.abm7069.
[PMID] 36417527.
2021
“Himalayan Bridge”: A New Unstable Suspended Bridge to Investigate Rodents’ Venturesome Behavior.
Frontiers in behavioral neuroscience.
15
[DOI] 10.3389/fnbeh.2021.637074.
[PMID] 33994967.
2021
Neuroactive Type-A γ-Aminobutyric Acid Receptor Allosteric Modulator Steroids from the Hypobranchial Gland of Marine Mollusk, Conus geographus.
Journal of medicinal chemistry.
64(10):7033-7043
[DOI] 10.1021/acs.jmedchem.1c00562.
[PMID] 33949869.
2021
The 5α-reductase inhibitor finasteride reduces opioid self-administration in animal models of opioid use disorder.
The Journal of clinical investigation.
131(10)
[DOI] 10.1172/JCI143990.
[PMID] 33848264.
2021
The α6 GABAA Receptor Positive Allosteric Modulator DK-I-56-1 Reduces Tic-Related Behaviors in Mouse Models of Tourette Syndrome.
Biomolecules.
11(2)
[DOI] 10.3390/biom11020175.
[PMID] 33525455.
2020
Association between dopaminergic medications and REM sleep behavior disorder in Parkinson’s disease: a preliminary cohort study.
Journal of neurology.
267(10):2926-2931
[DOI] 10.1007/s00415-020-09956-4.
[PMID] 32472180.
2020
Detention in Juvenile Correctional Facilities Is Associated with Higher Platelet Monoamine Oxidase B Activity in Males.
Biomolecules.
10(11)
[DOI] 10.3390/biom10111555.
[PMID] 33203099.
2020
Isoallopregnanolone reduces tic-like behaviours in the D1CT-7 mouse model of Tourette syndrome.
Journal of neuroendocrinology.
32(1)
[DOI] 10.1111/jne.12754.
[PMID] 31175669.
2020
Neurobehavioural complications of sleep deprivation: Shedding light on the emerging role of neuroactive steroids.
Journal of neuroendocrinology.
32(1)
[DOI] 10.1111/jne.12792.
[PMID] 31505075.
2020
The adverse effects of pramipexole on probability discounting are not reversed by acute D2 or D3 receptor antagonism.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
32:104-119
[DOI] 10.1016/j.euroneuro.2020.01.005.
[PMID] 31983530.
2020
The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men.
Progress in neurobiology.
194
[DOI] 10.1016/j.pneurobio.2020.101875.
[PMID] 32574581.
2020
What drugs modify the risk of iatrogenic impulse-control disorders in Parkinson’s disease? A preliminary pharmacoepidemiologic study.
PloS one.
15(1)
[DOI] 10.1371/journal.pone.0227128.
[PMID] 31910240.
2019
5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction.
Neurobiology of disease.
121:120-130
[DOI] 10.1016/j.nbd.2018.09.018.
[PMID] 30261284.
2019
Allopregnanolone is required for prepulse inhibition deficits induced by D1 dopamine receptor activation.
Psychoneuroendocrinology.
108:53-61
[DOI] 10.1016/j.psyneuen.2019.06.009.
[PMID] 31228750.
2019
Dysfunctional mesocortical dopamine circuit at pre-adolescence is associated to aggressive behavior in MAO-A hypomorphic mice exposed to early life stress.
Neuropharmacology.
159
[DOI] 10.1016/j.neuropharm.2019.01.032.
[PMID] 30738037.
2019
Gene-environment interactions in antisocial behavior are mediated by early-life 5-HT2A receptor activation.
Neuropharmacology.
159
[DOI] 10.1016/j.neuropharm.2019.01.028.
[PMID] 30716416.
2019
Repurposing steroidogenesis inhibitors for the therapy of neuropsychiatric disorders: Promises and caveats.
Neuropharmacology.
147:55-65
[DOI] 10.1016/j.neuropharm.2018.05.013.
[PMID] 29907425.
2019
Sex-Dimorphic Interactions of MAOA Genotype and Child Maltreatment Predispose College Students to Polysubstance Use.
Frontiers in genetics.
10
[DOI] 10.3389/fgene.2019.01314.
[PMID] 32010186.
2019
The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli.
Biomolecules.
9(11)
[DOI] 10.3390/biom9110749.
[PMID] 31752360.
2019
Tobacco and cannabis use in college students are predicted by sex-dimorphic interactions between MAOA genotype and child abuse.
CNS neuroscience & therapeutics.
25(1):101-111
[DOI] 10.1111/cns.13002.
[PMID] 29952131.
2018
A descriptive study on selected growth parameters and growth hormone receptor gene in healthy young adults from the American Midwest.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
41:48-53
[DOI] 10.1016/j.ghir.2018.02.004.
[PMID] 29459141.
2018
Associations between emotional abuse and neglect and dimensions of alexithymia: The moderating role of sex.
Psychological trauma : theory, research, practice and policy.
10(3):300-308
[DOI] 10.1037/tra0000279.
[PMID] 28414491.
2018
Behavioral fragmentation in the D1CT-7 mouse model of Tourette’s syndrome.
CNS neuroscience & therapeutics.
24(8):703-711
[DOI] 10.1111/cns.12789.
[PMID] 29314714.
2018
From aggression to autism: new perspectives on the behavioral sequelae of monoamine oxidase deficiency.
Journal of neural transmission (Vienna, Austria : 1996).
125(11):1589-1599
[DOI] 10.1007/s00702-018-1888-y.
[PMID] 29748850.
2018
Prevention of Severe Hypoglycemia-Induced Brain Damage and Cognitive Impairment With Verapamil.
Diabetes.
67(10):2107-2112
[DOI] 10.2337/db18-0008.
[PMID] 29724724.
2018
Steroid 5α-reductase 2 deficiency leads to reduced dominance-related and impulse-control behaviors.
Psychoneuroendocrinology.
91:95-104
[DOI] 10.1016/j.psyneuen.2018.02.007.
[PMID] 29544191.
2017
Allopregnanolone mediates the exacerbation of Tourette-like responses by acute stress in mouse models.
Scientific reports.
7(1)
[DOI] 10.1038/s41598-017-03649-1.
[PMID] 28611376.
2017
Assessment of gait and sensorimotor deficits in the D1CT-7 mouse model of Tourette syndrome.
Journal of neuroscience methods.
292:37-44
[DOI] 10.1016/j.jneumeth.2017.01.009.
[PMID] 28099872.
2017
Delay discounting as impaired valuation: Delayed rewards in an animal obesity model.
Journal of the experimental analysis of behavior.
108(2):171-183
[DOI] 10.1002/jeab.275.
[PMID] 28940395.
2017
Editorial on Special Issue: Animal models of Tourette syndrome.
Journal of neuroscience methods.
292
[DOI] 10.1016/j.jneumeth.2017.10.008.
[PMID] 29038076.
2017
Impulsivity as a moderator of the associations between child maltreatment types and body mass index.
Child abuse & neglect.
67:137-146
[DOI] 10.1016/j.chiabu.2017.02.029.
[PMID] 28262605.
2017
Links between stressful life events and proactive and reactive functions of aggression.
Journal of aggression, maltreatment & trauma.
26(6):691-699
[DOI] 10.1080/10926771.2017.1322658.
[PMID] 31223229.
2017
Manic symptom severity correlates with COMT activity in the striatum: A post-mortem study.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
18(3):247-254
[DOI] 10.1080/15622975.2016.1208844.
[PMID] 27458023.
2017
Modeling tics in rodents: Conceptual challenges and paths forward.
Journal of neuroscience methods.
292:12-19
[DOI] 10.1016/j.jneumeth.2017.02.007.
[PMID] 28237575.
2017
Pramipexole enhances disadvantageous decision-making: Lack of relation to changes in phasic dopamine release.
Neuropharmacology.
114:77-87
[DOI] 10.1016/j.neuropharm.2016.11.014.
[PMID] 27889491.
2017
The 5-alpha reductase inhibitor finasteride reduces dyskinesia in a rat model of Parkinson’s disease.
Experimental neurology.
291:1-7
[DOI] 10.1016/j.expneurol.2017.01.012.
[PMID] 28131725.
2017
The Neurosteroidogenic Enzyme 5α-Reductase Mediates Psychotic-Like Complications of Sleep Deprivation.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
42(11):2196-2205
[DOI] 10.1038/npp.2017.13.
[PMID] 28102229.
2017
What makes you tic? Translational approaches to study the role of stress and contextual triggers in Tourette syndrome.
Neuroscience and biobehavioral reviews.
76(Pt A):123-133
[DOI] 10.1016/j.neubiorev.2016.10.003.
[PMID] 27939782.
2016
Accounting for the associations between child maltreatment and internalizing problems: The role of alexithymia.
Child abuse & neglect.
52:20-8
[DOI] 10.1016/j.chiabu.2015.12.008.
[PMID] 26774529.
2016
Exploring the neural mechanisms of finasteride: a proteomic analysis in the nucleus accumbens.
Psychoneuroendocrinology.
74:387-396
[DOI] 10.1016/j.psyneuen.2016.10.001.
[PMID] 27750143.
2016
Selective activation of D1 dopamine receptors impairs sensorimotor gating in Long-Evans rats.
British journal of pharmacology.
173(13):2122-34
[DOI] 10.1111/bph.13232.
[PMID] 26101934.
2016
The D1CT-7 mouse model of Tourette syndrome displays sensorimotor gating deficits in response to spatial confinement.
British journal of pharmacology.
173(13):2111-21
[DOI] 10.1111/bph.13243.
[PMID] 26171666.
2016
The neurosteroidogenic enzyme 5α-reductase modulates the role of D1 dopamine receptors in rat sensorimotor gating.
Psychoneuroendocrinology.
63:59-67
[DOI] 10.1016/j.psyneuen.2015.09.014.
[PMID] 26415119.
2016
The Role of Hostile Attributions in the Associations between Child Maltreatment and Reactive and Proactive Aggression.
Journal of aggression, maltreatment & trauma.
25(10):1043-1057
[DOI] 10.1080/10926771.2016.1231148.
[PMID] 29386881.
2016
The role of monoamine oxidase A in aggression: Current translational developments and future challenges.
Progress in neuro-psychopharmacology & biological psychiatry.
69:90-100
[DOI] 10.1016/j.pnpbp.2016.01.001.
[PMID] 26776902.
2015
Adverse effects of 5α-reductase inhibitors: What do we know, don’t know, and need to know?
Reviews in endocrine & metabolic disorders.
16(3):177-98
[DOI] 10.1007/s11154-015-9319-y.
[PMID] 26296373.
2015
Monoamine Oxidase A is Required for Rapid Dendritic Remodeling in Response to Stress.
The international journal of neuropsychopharmacology.
18(9)
[DOI] 10.1093/ijnp/pyv035.
[PMID] 25857821.
2015
Paraphilias and paraphilic disorders in Parkinson’s disease: A systematic review of the literature.
Movement disorders : official journal of the Movement Disorder Society.
30(5):604-13
[DOI] 10.1002/mds.26157.
[PMID] 25759330.
2015
Targeting neurosteroid synthesis as a therapy for schizophrenia-related alterations induced by early psychosocial stress.
Schizophrenia research.
168(3):640-8
[DOI] 10.1016/j.schres.2015.04.044.
[PMID] 25999042.
2015
The enzymatic activities of brain catechol-O-methyltransferase (COMT) and methionine sulphoxide reductase are correlated in a COMT Val/Met allele-dependent fashion.
Neuropathology and applied neurobiology.
41(7):941-51
[DOI] 10.1111/nan.12219.
[PMID] 25640985.
2014
Animal models of tic disorders: a translational perspective.
Journal of neuroscience methods.
238:54-69
[DOI] 10.1016/j.jneumeth.2014.09.008.
[PMID] 25244952.
2014
Association of low-activity MAOA allelic variants with violent crime in incarcerated offenders.
Journal of psychiatric research.
58:69-75
[DOI] 10.1016/j.jpsychires.2014.07.006.
[PMID] 25082653.
2014
Gene-sex interactions in schizophrenia: focus on dopamine neurotransmission.
Frontiers in behavioral neuroscience.
8
[DOI] 10.3389/fnbeh.2014.00071.
[PMID] 24639636.
2014
Inhibition of 17α-hydroxylase/C17,20 lyase reduces gating deficits consequent to dopaminergic activation.
Psychoneuroendocrinology.
39:204-213
[DOI] 10.1016/j.psyneuen.2013.09.014.
[PMID] 24140269.
2014
Juvenile cannabinoid treatment induces frontostriatal gliogenesis in Lewis rats.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
24(6):974-85
[DOI] 10.1016/j.euroneuro.2013.12.011.
[PMID] 24630433.
2014
Methionine sulfoxide reductase regulates brain catechol-O-methyl transferase activity.
The international journal of neuropsychopharmacology.
17(10):1707-13
[DOI] 10.1017/S1461145714000467.
[PMID] 24735585.
2014
Positive allosteric modulation of GABAB receptors ameliorates sensorimotor gating in rodent models.
CNS neuroscience & therapeutics.
20(7):679-84
[DOI] 10.1111/cns.12261.
[PMID] 24703381.
2014
The aggression and behavioral abnormalities associated with monoamine oxidase A deficiency are rescued by acute inhibition of serotonin reuptake.
Journal of psychiatric research.
56:1-9
[DOI] 10.1016/j.jpsychires.2014.04.014.
[PMID] 24882701.
2014
The re-organization of functional brain networks in pharmaco-resistant epileptic patients who respond to VNS.
Neuroscience letters.
580:153-7
[DOI] 10.1016/j.neulet.2014.08.010.
[PMID] 25123446.
2013
Chronic tryptophan deprivation attenuates gating deficits induced by 5-HT(1A), but not 5-HT₂ receptor activation.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
23(10):1329-35
[DOI] 10.1016/j.euroneuro.2012.10.009.
[PMID] 23141373.
2013
Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice.
Proceedings of the National Academy of Sciences of the United States of America.
110(31):12816-21
[DOI] 10.1073/pnas.1308037110.
[PMID] 23858446.
2013
Early postnatal inhibition of serotonin synthesis results in long-term reductions of perseverative behaviors, but not aggression, in MAO A-deficient mice.
Neuropharmacology.
75:223-32
[DOI] 10.1016/j.neuropharm.2013.07.003.
[PMID] 23871843.
2013
Inhibition of 5α-reductase attenuates behavioral effects of D1-, but not D2-like receptor agonists in C57BL/6 mice.
Psychoneuroendocrinology.
38(4):542-51
[DOI] 10.1016/j.psyneuen.2012.07.014.
[PMID] 22877998.
2013
Long-term CB₁ receptor blockade enhances vulnerability to anxiogenic-like effects of cannabinoids.
Neuropharmacology.
70:268-77
[DOI] 10.1016/j.neuropharm.2013.02.009.
[PMID] 23462228.
2013
Monoamine oxidase A and A/B knockout mice display autistic-like features.
The international journal of neuropsychopharmacology.
16(4):869-88
[DOI] 10.1017/S1461145712000715.
[PMID] 22850464.
2013
Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin.
The international journal of neuropsychopharmacology.
16(5):1059-70
[DOI] 10.1017/S1461145712000909.
[PMID] 23174033.
2013
Prenatal exposure to urban air nanoparticles in mice causes altered neuronal differentiation and depression-like responses.
PloS one.
8(5)
[DOI] 10.1371/journal.pone.0064128.
[PMID] 23734187.
2013
Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders.
Alcoholism, clinical and experimental research.
37(1):8-15
[DOI] 10.1111/j.1530-0277.2012.01846.x.
[PMID] 22671690.
2013
Regional distribution of 5α-reductase type 2 in the adult rat brain: an immunohistochemical analysis.
Psychoneuroendocrinology.
38(2):281-93
[DOI] 10.1016/j.psyneuen.2012.06.008.
[PMID] 22776423.
2013
Sociocommunicative and sensorimotor impairments in male P2X4-deficient mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
38(10):1993-2002
[DOI] 10.1038/npp.2013.98.
[PMID] 23604007.
2013
The implication of neuroactive steroids in Tourette’s syndrome pathogenesis: A role for 5α-reductase?
Journal of neuroendocrinology.
25(11):1196-208
[DOI] 10.1111/jne.12066.
[PMID] 23795653.
2013
The role of the serotonergic system at the interface of aggression and suicide.
Neuroscience.
236:160-85
[DOI] 10.1016/j.neuroscience.2013.01.015.
[PMID] 23333677.
2013
VNS induced desynchronization in gamma bands correlates with positive clinical outcome in temporal lobe pharmacoresistant epilepsy.
Neuroscience letters.
536:14-8
[DOI] 10.1016/j.neulet.2012.12.044.
[PMID] 23333601.
2012
Altered cerebellar organization and function in monoamine oxidase A hypomorphic mice.
Neuropharmacology.
63(7):1208-17
[DOI] 10.1016/j.neuropharm.2012.08.003.
[PMID] 22971542.
2012
Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives.
Recent patents on CNS drug discovery.
7(1):25-40
[PMID] 22280339.
2012
Finasteride attenuates pathological gambling in patients with Parkinson disease.
Journal of clinical psychopharmacology.
32(3):424-5
[DOI] 10.1097/JCP.0b013e3182549c2a.
[PMID] 22534502.
2012
Inhibition of 5α-reductase in the nucleus accumbens counters sensorimotor gating deficits induced by dopaminergic activation.
Psychoneuroendocrinology.
37(10):1630-45
[DOI] 10.1016/j.psyneuen.2011.09.018.
[PMID] 22029952.
2012
Ivermectin reduces alcohol intake and preference in mice.
Neuropharmacology.
63(2):190-201
[DOI] 10.1016/j.neuropharm.2012.03.014.
[PMID] 22465817.
2012
NMDARs mediate the role of monoamine oxidase A in pathological aggression.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
32(25):8574-82
[DOI] 10.1523/JNEUROSCI.0225-12.2012.
[PMID] 22723698.
2011
A preliminary study of finasteride in Tourette syndrome.
Movement disorders : official journal of the Movement Disorder Society.
26(11):2146-7
[DOI] 10.1002/mds.23810.
[PMID] 21618612.
2011
Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence.
International review of neurobiology.
100:13-42
[DOI] 10.1016/B978-0-12-386467-3.00002-9.
[PMID] 21971001.
2011
Isolation rearing-induced reduction of brain 5α-reductase expression: relevance to dopaminergic impairments.
Neuropharmacology.
60(7-8):1301-8
[DOI] 10.1016/j.neuropharm.2011.01.013.
[PMID] 21256141.
2011
Maladaptive defensive behaviours in monoamine oxidase A-deficient mice.
The international journal of neuropsychopharmacology.
14(9):1195-207
[DOI] 10.1017/S1461145710001483.
[PMID] 21156093.
2011
Social deficits and perseverative behaviors, but not overt aggression, in MAO-A hypomorphic mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
36(13):2674-88
[DOI] 10.1038/npp.2011.157.
[PMID] 21832987.
2011
Steroid 5α-reductase as a novel therapeutic target for schizophrenia and other neuropsychiatric disorders.
Current pharmaceutical design.
17(2):151-67
[PMID] 21361868.
2010
Animal models of virus-induced neurobehavioral sequelae: recent advances, methodological issues, and future prospects.
Interdisciplinary perspectives on infectious diseases.
2010
[DOI] 10.1155/2010/380456.
[PMID] 20490350.
2010
Dissociation between neurovegetative signs and subjective symptoms in a case of idiopathic pilomotor seizures.
Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology.
23(4):274-7
[DOI] 10.1097/WNN.0b013e3181e61ccc.
[PMID] 21042209.
2010
GABAB receptor activation exacerbates spontaneous spike-and-wave discharges in DBA/2J mice.
Seizure.
19(4):226-31
[DOI] 10.1016/j.seizure.2010.02.007.
[PMID] 20233662.
2010
Involvement of GABA in mirror focus: a case report.
Epilepsy research.
90(3):300-3
[DOI] 10.1016/j.eplepsyres.2010.05.012.
[PMID] 20558041.
2010
Methamphetamine neurotoxicity increases brain expression and alters behavioral functions of CB₁ cannabinoid receptors.
Journal of psychiatric research.
44(14):944-55
[DOI] 10.1016/j.jpsychires.2010.03.002.
[PMID] 20378129.
2010
Social isolation and chronic handling alter endocannabinoid signaling and behavioral reactivity to context in adult rats.
Neuroscience.
168(2):371-86
[DOI] 10.1016/j.neuroscience.2010.04.007.
[PMID] 20394803.
2010
Treatment of benign essential blepharospasm with finasteride: a case report.
Clinical neuropharmacology.
33(4):207-8
[DOI] 10.1097/WNF.0b013e3181dca96f.
[PMID] 20386102.
2010
Vulnerability Factors for the Psychiatric and Behavioral Effects of Cannabis.
Pharmaceuticals (Basel, Switzerland).
3(9):2799-2820
[PMID] 27713377.
2009
Behavioral disinhibition and reduced anxiety-like behaviors in monoamine oxidase B-deficient mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
34(13):2746-57
[DOI] 10.1038/npp.2009.118.
[PMID] 19710633.
2009
Combined EEG/fMRI recording in musicogenic epilepsy.
Epilepsy research.
84(1):77-81
[DOI] 10.1016/j.eplepsyres.2008.11.019.
[PMID] 19155156.
2009
Gating deficits in isolation-reared rats are correlated with alterations in protein expression in nucleus accumbens.
Journal of neurochemistry.
108(3):611-20
[DOI] 10.1111/j.1471-4159.2008.05806.x.
[PMID] 19054277.
2009
Methamphetamine induces long-term alterations in reactivity to environmental stimuli: correlation with dopaminergic and serotonergic toxicity.
Neurotoxicity research.
15(3):232-45
[DOI] 10.1007/s12640-009-9024-2.
[PMID] 19384596.
2008
Antipsychotic-like properties of 5-alpha-reductase inhibitors.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
33(13):3146-56
[DOI] 10.1038/npp.2008.39.
[PMID] 18354385.
2008
Effects of tryptophan deficiency on prepulse inhibition of the acoustic startle in rats.
Psychopharmacology.
198(2):191-200
[DOI] 10.1007/s00213-008-1116-9.
[PMID] 18330544.
2008
Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates.
Biological psychiatry.
64(11):930-7
[DOI] 10.1016/j.biopsych.2008.08.008.
[PMID] 18814866.
2008
Improvement of general symptoms in a chronic psychotic patient treated with finasteride: case report.
Pharmacopsychiatry.
41(3):115-6
[DOI] 10.1055/s-2008-1058110.
[PMID] 18484553.
2008
Monoamine oxidase inactivation: from pathophysiology to therapeutics.
Advanced drug delivery reviews.
60(13-14):1527-33
[DOI] 10.1016/j.addr.2008.06.002.
[PMID] 18652859.
2008
Novel monoamine oxidase A knock out mice with human-like spontaneous mutation.
Neuroreport.
19(7):739-43
[DOI] 10.1097/WNR.0b013e3282fd6e88.
[PMID] 18418249.
2008
Sleep deprivation disrupts prepulse inhibition of the startle reflex: reversal by antipsychotic drugs.
The international journal of neuropsychopharmacology.
11(7):947-55
[DOI] 10.1017/S1461145708008900.
[PMID] 18477413.
2007
Activation of GABA(B) receptors reverses spontaneous gating deficits in juvenile DBA/2J mice.
Psychopharmacology.
194(3):361-9
[PMID] 17604981.
2007
Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress.
Biological psychiatry.
62(10):1103-10
[PMID] 17511970.
2007
Cannabinoid receptor antagonists counteract sensorimotor gating deficits in the phencyclidine model of psychosis.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
32(10):2098-107
[PMID] 17299506.
2007
Effects of topiramate on the prepulse inhibition of the acoustic startle in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
32(2):320-31
[PMID] 16794573.
2007
Levetiracetam attenuates spontaneous spike-and-wave discharges in DBA/2J mice.
Epilepsy research.
75(2-3):224-7
[PMID] 17624733.
2007
The price of seizure control: dynorphins in interictal and postictal psychosis.
Psychiatry research.
151(1-2):139-43
[PMID] 17395273.
2007
Treatment of Tourette’s syndrome with finasteride.
The American journal of psychiatry.
164(12):1914-5
[PMID] 18056252.
2006
Anxiolytic-like properties of the anandamide transport inhibitor AM404.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
31(12):2652-9
[PMID] 16541083.
2006
Modulation of neuropathic and inflammatory pain by the endocannabinoid transport inhibitor AM404 [N-(4-hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide].
The Journal of pharmacology and experimental therapeutics.
317(3):1365-71
[PMID] 16510698.
2006
Prenatal exposure to a cannabinoid receptor agonist does not affect sensorimotor gating in rats.
European journal of pharmacology.
531(1-3):166-70
[PMID] 16423346.
2005
Activation of D1, but not D2 receptors potentiates dizocilpine-mediated disruption of prepulse inhibition of the startle.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
30(3):561-74
[PMID] 15328529.
2005
Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis.
Proceedings of the National Academy of Sciences of the United States of America.
102(51):18620-5
[PMID] 16352709.
2005
Kappa opioid receptor activation disrupts prepulse inhibition of the acoustic startle in rats.
Biological psychiatry.
57(12):1550-8
[PMID] 15953492.
2005
The CB receptor agonist WIN 55,212-2 fails to elicit disruption of prepulse inhibition of the startle in Sprague-Dawley rats.
Psychopharmacology.
177(3):264-71
[PMID] 15290008.
2004
Baclofen reverses the reduction in prepulse inhibition of the acoustic startle response induced by dizocilpine, but not by apomorphine.
Psychopharmacology.
171(3):322-30
[PMID] 13680072.
2001
gamma-Hydroxybutyric acid and baclofen decrease extracellular acetylcholine levels in the hippocampus via GABA(B) receptors.
European journal of pharmacology.
430(2-3):261-3
[PMID] 11711039.
Contact Details
Phones:
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