Sihem Bihorel

Sihem Bihorel Ph.D., Pharm.D., M.S.

Assistant Professor

Department: Pharmaceutics
Business Phone: (407) 313-7037
Business Email: sihem.bihorel@cop.ufl.edu

About Sihem Bihorel

Dr. Bihorel graduated with a master’s and a Pharm.D. degree from the University of Paris-Descartes in France and a Ph.D. degree from the Department of Pharmaceutical Sciences at SUNY at Buffalo. She published several peer reviewed papers and has been awarded prestigious awards including, the PROSPER Excellence award from the College of Pharmacy at UF, the PhRMA Foundation starter grant award in translational medicine and therapeutics, and the scholar award from the Center for Protein Therapeutics at Buffalo.

Research Profile

Dr. Sihem Bihorel joined the Center for Pharmacometrics & Systems Pharmacology and the Department of Pharmaceutics at the University of Florida College of Pharmacy as an Assistant Professor in July 2015. Her laboratory is located on the Medical City campus in Lake Nona (Orlando), where she conducts experimental and computational research focusing on the following areas:

Translational quantitative systems pharmacology (QSP) and enhanced pharmacodynamics (ePD) of anti-cancer drugs in general and in particular immuno-oncology drugs. Dr. Bihorel integrates QSP models with systems PK/ePD models to advance drug discovery and development, leverage the understanding of drugs mechanisms of action (efficacy and toxicity), and identify promising combination therapies as well as novel targets and biomarkers.

Bihorel’s group develops novel anti-cancer drug delivery systems such as tri-functional lipid nanoparticles to enhance the delivery of drugs to solid tumors through targeted immunotherapy to overcome treatment resistance and toxicity in difficult-to-treat cancers.

Bihorel’s group utilizes cutting edge experimental and computational techniques to rationally optimize sequence combination therapies of anti-cancer drugs.

Her group generates molecular, cellular, and xenograft animal responses data to uniquely inform QSP models and bridge them with systems PK/ePD models, then translate mechanistic research insights into clinically relevant dosage regimens.

Grants

September 2019ACTIVE
AFPE Pre-Doctoral Fellowship in Pharmaceutical Sciences Application
AMER FOU FOR PHARM EDU (AFPE) · Mentor
October 2017ACTIVE
Investigation of the Utility of a Novel Dynamic Cell Culture in Vitro System in combination with mathematical modeling
F Hoffmann La Roche LTD · Principal Investigator
October 2017 – January 2018
Prostate cancer familial cohort of Cameroonian men in the United States and in Cameroon
H LEE MOFFITT CANCER CTR · Principal Investigator
January 2017ACTIVE
Systems Pharmacology Network Approach for Exploring Drug Targets and Treatment Optimization Strategies in Inflammatory Bowel Diseases
BOEHRINGER INGELHEIM PHARM INC · Principal Investigator

Education

2010
Ph.D.
SUNY at Buffalo & Paris-Descartes University
2006
Pharm.D.
Paris-Descartes University
2006
M.S.
Paris-Descartes University
2002
M.S.
Paris-Descartes University
2001
M.S.
Paris-Descartes University