About Sihem Bihorel
Dr. Bihorel graduated with a master’s and a Pharm.D. degree from the University of Paris-Descartes in France and a Ph.D. degree from the Department of Pharmaceutical Sciences at SUNY at Buffalo. She published several peer reviewed papers and has been awarded prestigious awards including, the PROSPER Excellence award from the College of Pharmacy at UF, the PhRMA Foundation starter grant award in translational medicine and therapeutics, and the scholar award from the Center for Protein Therapeutics at Buffalo.
Dr. Sihem Bihorel joined the Center for Pharmacometrics & Systems Pharmacology and the Department of Pharmaceutics at the University of Florida College of Pharmacy as an Assistant Professor in July 2015. Her laboratory is located on the Medical City campus in Lake Nona (Orlando), where she conducts experimental and computational research focusing on the following areas:
Translational quantitative systems pharmacology (QSP) and enhanced pharmacodynamics (ePD) of anti-cancer drugs in general and in particular immuno-oncology drugs. Dr. Bihorel integrates QSP models with systems PK/ePD models to advance drug discovery and development, leverage the understanding of drugs mechanisms of action (efficacy and toxicity), and identify promising combination therapies as well as novel targets and biomarkers.
Bihorel’s group develops novel anti-cancer drug delivery systems such as tri-functional lipid nanoparticles to enhance the delivery of drugs to solid tumors through targeted immunotherapy to overcome treatment resistance and toxicity in difficult-to-treat cancers.
Bihorel’s group utilizes cutting edge experimental and computational techniques to rationally optimize sequence combination therapies of anti-cancer drugs.
Her group generates molecular, cellular, and xenograft animal responses data to uniquely inform QSP models and bridge them with systems PK/ePD models, then translate mechanistic research insights into clinically relevant dosage regimens.